Cholesterol metabolism and efflux in human THP-1 macrophages

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 10, 1998, Pages 1589-1599

  Kritharides, Leonard ^a   Christian, Aimee ^b   Stoudt, Genevieve ^b   Morel, Dianne ^b   Rothblat, George H ^b  

^a HEART RESEARCH INSTITUTE   (Australia)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Atherosclerosis; Cholesterol; Cyclodextrin; Macrophage; Triglyceride

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTER; TRIACYLGLYCEROL;

ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL ESTERIFICATION; CHOLESTEROL METABOLISM; FOAM CELL; HUMAN; HUMAN CELL; HYDROLYSIS; KINETICS; MACROPHAGE; PRIORITY JOURNAL;

EID: 0031719098     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.10.1589     Document Type: Article

References (11)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
2. Geng Y-J, Holm J, Nygren S, Bruzelius M, Stemme S, Hansson GK. Expression of the macrophage scavenger receptor in atheroma: relationship to immune activation and the T-cell cytokine Interferon-γ. Arteriosc1er Thromb Vasc Biol. 1995;15:1995-2002.
3. Tabas I, Rosoff WJ, Boykow GC. Acyl coenzyme A:cholesteryl transferase in macrophages utilizes a cellular pool of cholesterol oxidase-accessible cholesterol as substrate. J Biol Chem. 1988;263:1266-1272.
4. Tabas I. The stimulation of the cholesterol esterification pathway by atherogenic lipoproteins in macrophages. Curr Opin Lipidol. 1995;6:260-268.
5. Auwerx J. The human leukemia cell line THP-1: a multifacetted model for the study of monocyte-macrophage differentiation. Experientia. 1991;47:22-31.
6. Gaffney EV, Dell'Aquila ML, Lingenfelter SE, Huffnagle GB, Wiest DL. Characterization of a colony-stimulating factor produced by the human monocytic leukemia cell line, THP-1. J Leukoc Biol. 1986;39:409-421.
7. Menju M, Tajima S, Yamamoto A. Expression of the apolipoprotein E gene in a human macrophage-like cell line, THP-1. J Biochem. 1989;106:505-510.
8. Terkeltaub R, Solan J, Barry M, Santoro D, Bokoch GM. Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocyte cells. J Leukoc Biol. 1994;55:749-755.
9. Wang N, Tabas I, Winchester R, Ravalli S, Rabbani LE, Tall A. Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma. J Biol Chem. 1996;271:8837-8842.
10. Kodama T, Reddy P, Kishimoto C, Krieger M. Purification and characterization of a bovine acetyl low density lipoprotein receptor. Proc Natl Acad Sci USA. 1988;85:9238-9242.
11. Via DP, Pons L, Dennison DK, Fanslow AE, Bernini F. Induction of acetyl-LDL receptor activity by phorbol ester in human monocyte cell line THP-1. J Lipid Res. 1989;30:1515-1524.