Structure of the Shroom-Rho kinase complex reveals a binding interface with monomeric shroom that regulates cell morphology and stimulates kinase activity

Journal of Biological Chemistry

Volumn 291, Issue 49, 2016, Pages 25364-25374

  Zalewski, Jenna K ^a   Mo, Joshua H ^a   Heber, Simone ^a   Heroux, Annie ^b   Gardner, Richard G ^c   Hildebrand, Jeffrey D ^a   VanDemark, Andrew P ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; DIGITAL STORAGE; ENZYMES; MORPHOLOGY; TISSUE;

BINDING INTERFACE; CELLULAR MORPHOLOGY; CYTOSKELETAL DYNAMICS; KINASE ACTIVITY; MOLECULAR INSIGHTS; ROCK INTERFACES; SUBCELLULAR LOCALIZATIONS; TISSUE MORPHOLOGY;

ROCKS;

CYTOSKELETON PROTEIN; RHO KINASE; SHROOM PROTEIN; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; GRK1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MULTIPROTEIN COMPLEX; MYOSIN II; RHODOPSIN KINASE; SHROOM1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DROSOPHILA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STOICHIOMETRY; STRUCTURE ANALYSIS; CHEMISTRY; GENETICS; METABOLISM; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

G-PROTEIN-COUPLED RECEPTOR KINASE 1; HUMANS; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; MULTIPROTEIN COMPLEXES; MYOSIN TYPE II; PROTEIN DOMAINS; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85001959418     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.738559     Document Type: Article

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