Targeted inhibition of the Shroom3-Rho kinase protein-protein interaction circumvents Nogo66 to promote axon outgrowth

BMC Neuroscience

Volumn 16, Issue 1, 2015, Pages

  Dickson, Heather M ^a   Wilbur, Amanda ^a   Reinke, Ashley A ^a   Young, Mathew A ^a   Vojtek, Anne B ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Neural regeneration; NogoA; PirB; POSH; Protein protein interaction inhibitors; ROCK; Shroom3

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CCG 17444; PROTEIN NOGO A; PROTEIN NOGO66; REGULATOR PROTEIN; RHO KINASE; RHO KINASE INHIBITOR; SHROOM3 PROTEIN; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; CCG-17444; MYELIN PROTEIN; PROTEIN KINASE INHIBITOR; PROTEIN NOGO; PYRIMIDINONE DERIVATIVE; QUINOLONE DERIVATIVE; RECOMBINANT PROTEIN; RTN4 PROTEIN, MOUSE; SHRM PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TARGETING; ENZYME INHIBITION; IC50; IN VITRO STUDY; MOUSE; NERVE FIBER GROWTH; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; AXON; CELL CULTURE; CELL ENLARGEMENT; CEREBELLUM; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; AXONS; CELL ENLARGEMENT; CELL LINE, TUMOR; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; HIGH-THROUGHPUT SCREENING ASSAYS; MICE; MICROFILAMENT PROTEINS; MYELIN PROTEINS; NOGO PROTEINS; PROTEIN KINASE INHIBITORS; PYRIMIDINONES; QUINOLONES; RECOMBINANT PROTEINS; RHO-ASSOCIATED KINASES;

EID: 84931261490     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/s12868-015-0171-5     Document Type: Article

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