Necrotic myocardial cells release Damage-Associated Molecular Patterns that provoke fibroblast activation in vitro and trigger myocardial inflammation and fibrosis in vivo

Journal of the American Heart Association

Volumn 4, Issue 6, 2015, Pages

  Zhang, Weili ^a   Lavine, Kory J ^a   Epelman, Slava ^a   Evans, Sarah A ^a   Weinheimer, Carla J ^a   Barger, Philip M ^a   Mann, Douglas L ^a  

^a NONE

Author keywords

Damage associated molecular patterns; Fibroblasts; Inflammation; Innate immunity; Myocardial fibrosis

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ALPHA SMOOTH MUSCLE ACTIN; CALGRANULIN B; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA1; COLLAGEN TYPE 3; COLLAGEN TYPE 3 ALPHA1; GALECTIN 3; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN S100B; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; ACTIN; COLLAGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CARDIAC MUSCLE CELL; CELL MOTILITY; CELL PROLIFERATION; CELL STIMULATION; CELL WOUNDING ASSAY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FIBROBLAST; FREEZE THAWING; HEART MUSCLE FIBROSIS; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF QUANTITATION; MOUSE; MYOCARDITIS; NECROTIC MYOCARDIAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; 3T3 CELL LINE; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; CYTOLOGY; GENE EXPRESSION; LIVER; METABOLISM; NECROSIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

ACTINS; ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; COLLAGEN; FIBROBLASTS; GENE EXPRESSION; IN VITRO TECHNIQUES; LIVER; MICE; MICE, INBRED C57BL; MYOCARDITIS; MYOCARDIUM; NECROSIS; NIH 3T3 CELLS;

EID: 85001122938     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.001993     Document Type: Article

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