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Atopic dermatitis
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2 Egawa, G., Kabashima, K., Multifactorial skin barrier deficiency and atopic dermatitis: essential topics to prevent the atopic march. J Allergy Clin Immunol 138 (2016), 350–358.e1.
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3 Thaci, D., Simpson, E.L., Beck, L.A., Bieber, T., Blauvelt, A., Papp, K., et al. Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial. Lancet 387 (2016), 40–52.
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5 Henriksen, L., Simonsen, J., Haerskjold, A., Linder, M., Kieler, H., Thomsen, S.F., et al. Incidence rates of atopic dermatitis, asthma, and allergic rhinoconjunctivitis in Danish and Swedish children. J Allergy Clin Immunol 136 (2015), 360–366.e2.
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Neonatal adiposity increases the risk of atopic dermatitis during the first year of life
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6 O'Donovan, S.M., Hourihane, J.O.'B., Murray, D.M., Kenny, L.C., Khashan, A.S., Chaoimh, C.N., et al. Neonatal adiposity increases the risk of atopic dermatitis during the first year of life. J Allergy Clin Immunol 137 (2016), 108–117.
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Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes
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7 Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Folster-Holst, R., Rodriguez, E., et al. Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. J Allergy Clin Immunol 137 (2016), 130–136.
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Schmitt, J.1
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“Inflammatory skin march”: IL-1-mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events
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8 Yamanaka, K., Mizutani, H., “Inflammatory skin march”: IL-1-mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events. J Allergy Clin Immunol 136 (2015), 823–824.
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Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum
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9 Gao, L., Bin, L., Rafaels, N.M., Huang, L., Potee, J., Ruczinski, I., et al. Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. J Allergy Clin Immunol 136 (2015), 1591–1600.
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Gao, L.1
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Nocturnal eczema: review of sleep and circadian rhythms in children with atopic dermatitis and future research directions
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10 Fishbein, A.B., Vitaterna, O., Haugh, I.M., Bavishi, A.A., Zee, P.C., Turek, F.W., et al. Nocturnal eczema: review of sleep and circadian rhythms in children with atopic dermatitis and future research directions. J Allergy Clin Immunol 136 (2015), 1170–1177.
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Fishbein, A.B.1
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Association between childhood eczema and headaches: an analysis of 19 US population-based studies
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11 Silverberg, J.I., Association between childhood eczema and headaches: an analysis of 19 US population-based studies. J Allergy Clin Immunol 137 (2016), 492–499.e5.
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Silverberg, J.I.1
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Eczema and cardiovascular risk factors in 2 US adult population studies
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12 Silverberg, J.I., Greenland, P., Eczema and cardiovascular risk factors in 2 US adult population studies. J Allergy Clin Immunol 135 (2015), 721–728.e6.
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Genome-wide association study of recalcitrant atopic dermatitis in Korean children
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13 Kim, K.W., Myers, R.A., Lee, J.H., Igartua, C., Lee, K.E., Kim, Y.H., et al. Genome-wide association study of recalcitrant atopic dermatitis in Korean children. J Allergy Clin Immunol 136 (2015), 678–684.e4.
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Kim, K.W.1
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14
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A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis
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14 Schaarschmidt, H., Ellinghaus, D., Rodriguez, E., Kretschmer, A., Baurecht, H., Lipinski, S., et al. A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis. J Allergy Clin Immunol 136 (2015), 802–806.
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Schaarschmidt, H.1
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15
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Whole-exome sequencing of Ethiopian patients with ichthyosis vulgaris and atopic dermatitis
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15 Taylan, F., Nilsson, D., Asad, S., Lieden, A., Wahlgren, C.F., Winge, M.C., et al. Whole-exome sequencing of Ethiopian patients with ichthyosis vulgaris and atopic dermatitis. J Allergy Clin Immunol 136 (2015), 507–509.e19.
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Taylan, F.1
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16
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RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications
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16 Suarez-Farinas, M., Ungar, B., Correa da Rosa, J., Ewald, D.A., Rozenblit, M., Gonzalez, J., et al. RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications. J Allergy Clin Immunol 135 (2015), 1218–1227.
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17
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Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin
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17 McAleer, M.A., Pohler, E., Smith, F.J., Wilson, N.J., Cole, C., MacGowan, S., et al. Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin. J Allergy Clin Immunol 136 (2015), 1268–1276.
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McAleer, M.A.1
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18
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Claudin-1 polymorphism modifies the effect of mold exposure on the development of atopic dermatitis and production of IgE
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18 Yu, H.S., Kang, M.J., Kwon, J.W., Lee, S.Y., Lee, E., Yang, S.I., et al. Claudin-1 polymorphism modifies the effect of mold exposure on the development of atopic dermatitis and production of IgE. J Allergy Clin Immunol 135 (2015), 827–830.e5.
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19
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Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin
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19 Correa da Rosa, J., Malajian, D., Shemer, A., Rozenblit, M., Dhingra, N., Czarnowicki, T., et al. Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin. J Allergy Clin Immunol 135 (2015), 712–720.
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Correa da Rosa, J.1
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20
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Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets
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20 Czarnowicki, T., Esaki, H., Gonzalez, J., Malajian, D., Shemer, A., Noda, S., et al. Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets. J Allergy Clin Immunol 136 (2015), 941–951.e3.
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Atopic dermatitis: age and race do matter!
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21 Leung, D.Y., Atopic dermatitis: age and race do matter!. J Allergy Clin Immunol 136 (2015), 1265–1267.
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Leung, D.Y.1
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The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization
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22 Noda, S., Suarez-Farinas, M., Ungar, B., Kim, S.J., de Guzman Strong, C., Xu, H., et al. The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization. J Allergy Clin Immunol 136 (2015), 1254–1264.
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Noda, S.1
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23
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Skin-homing and systemic T-cell subsets show higher activation in atopic dermatitis versus psoriasis
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23 Czarnowicki, T., Malajian, D., Shemer, A., Fuentes-Duculan, J., Gonzalez, J., Suarez-Farinas, M., et al. Skin-homing and systemic T-cell subsets show higher activation in atopic dermatitis versus psoriasis. J Allergy Clin Immunol 136 (2015), 208–211.
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24
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Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population
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24 Czarnowicki, T., Gonzalez, J., Shemer, A., Malajian, D., Xu, H., Zheng, X., et al. Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population. J Allergy Clin Immunol 136 (2015), 104–115.e7.
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Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function
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25 Mitson-Salazar, A., Yin, Y., Wansley, D.L., Young, M., Bolan, H., Arceo, S., et al. Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function. J Allergy Clin Immunol 137 (2016), 907–918.e9.
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26
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Diverse activation and differentiation of multiple B-cell subsets in patients with atopic dermatitis but not in patients with psoriasis
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26 Czarnowicki, T., Gonzalez, J., Bonifacio, K.M., Shemer, A., Xiangyu, P., Kunjravia, N., et al. Diverse activation and differentiation of multiple B-cell subsets in patients with atopic dermatitis but not in patients with psoriasis. J Allergy Clin Immunol 137 (2016), 118–129.e5.
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Differential cytokine induction by the human skin-associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy control subjects
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27 Hradetzky, S., Roesner, L.M., Heratizadeh, A., Crameri, R., Garbani, M., Scheynius, A., et al. Differential cytokine induction by the human skin-associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy control subjects. J Allergy Clin Immunol 135 (2015), 1378–1380 e1-5.
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Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity
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28 Saunders, S.P., Moran, T., Floudas, A., Wurlod, F., Kaszlikowska, A., Salimi, M., et al. Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity. J Allergy Clin Immunol 137 (2016), 482–491.
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Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis
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29 Mashiko, S., Bouguermouh, S., Rubio, M., Baba, N., Bissonnette, R., Sarfati, M., Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis. J Allergy Clin Immunol 136 (2015), 351–359.e1.
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30 Wang, Q., Du, J., Zhu, J., Yang, X., Zhou, B., Thymic stromal lymphopoietin signaling in CD4(+) T cells is required for TH2 memory. J Allergy Clin Immunol 135 (2015), 781–791.e3.
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Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin
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31 Fornasa, G., Tsilingiri, K., Caprioli, F., Botti, F., Mapelli, M., Meller, S., et al. Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin. J Allergy Clin Immunol 136 (2015), 413–422.
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32 Harden, J.L., Lewis, S.M., Lish, S.R., Suarez-Farinas, M., Gareau, D., Lentini, T., et al. The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases. J Allergy Clin Immunol 137 (2016), 1830–1840.
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Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year
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33 Kelleher, M., Dunn-Galvin, A., Hourihane, J.O., Murray, D., Campbell, L.E., McLean, W.H., et al. Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year. J Allergy Clin Immunol 135 (2015), 930–935.e1.
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Staphylococcus aureus density on lesional and nonlesional skin is strongly associated with disease severity in atopic dermatitis
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34 Tauber, M., Balica, S., Hsu, C.Y., Jean-Decoster, C., Lauze, C., Redoules, D., et al. Staphylococcus aureus density on lesional and nonlesional skin is strongly associated with disease severity in atopic dermatitis. J Allergy Clin Immunol 137 (2016), 1272–1274.e3.
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35 Song, H., Yoo, Y., Hwang, J., Na, Y.C., Kim, H.S., Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis. J Allergy Clin Immunol 137 (2016), 852–860.
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Frequent occurrence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments
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36 Campana, R., Moritz, K., Marth, K., Neubauer, A., Huber, H., Henning, R., et al. Frequent occurrence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments. J Allergy Clin Immunol 137 (2016), 601–609.e8.
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Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection
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37 Esaki, H., Ewald, D.A., Ungar, B., Rozenblit, M., Zheng, X., Xu, H., et al. Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection. J Allergy Clin Immunol 135 (2015), 153–163.
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Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber
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38 Werfel, T., Heratizadeh, A., Niebuhr, M., Kapp, A., Roesner, L.M., Karch, A., et al. Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber. J Allergy Clin Immunol 136 (2015), 96–103.e9.
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