메뉴 건너뛰기




Volumn 10, Issue 6, 2016, Pages 534-548

The clinical profile of benralizumab in the management of severe eosinophilic asthma

Author keywords

anti interleukin 5 monoclonal antibodies; benralizumab; biomarkers; cytokines; eosinophils; interleukin 5; severe asthma

Indexed keywords

BENRALIZUMAB; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 5; MEPOLIZUMAB; OMALIZUMAB; PLACEBO; RESLIZUMAB; TRANSCRIPTION FACTOR RUNX2; ANTIASTHMATIC AGENT; MONOCLONAL ANTIBODY;

EID: 85000799154     PISSN: 17534658     EISSN: 17534666     Source Type: Journal    
DOI: 10.1177/1753465816667659     Document Type: Review
Times cited : (29)

References (83)
  • 1
    • 77951666051 scopus 로고    scopus 로고
    • Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: A prospective study using multiple samples
    • Al-Samri M., Benedetti A., Préfontaine D., Olivenstein R., Lemière C., Nair P., et al. (2010) Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: a prospective study using multiple samples. J Allergy Clin Immunol 125: 1161-1163.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1161-1163
    • Al-Samri, M.1    Benedetti, A.2    Préfontaine, D.3    Olivenstein, R.4    Lemière, C.5    Nair, P.6
  • 2
    • 84907216438 scopus 로고    scopus 로고
    • Blood eosinophil guided prednisolone therapy for exacerbations of COPD: A further analysis
    • Bafadhel M., Davies L., Calverley P., Aaron S., Brightling C., Pavord I., (2014) Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis. Eur Respir J 44: 789-791.
    • (2014) Eur Respir J , vol.44 , pp. 789-791
    • Bafadhel, M.1    Davies, L.2    Calverley, P.3    Aaron, S.4    Brightling, C.5    Pavord, I.6
  • 3
    • 84926512802 scopus 로고    scopus 로고
    • Multifaceted roles of cysteinyl leukotrienes in eliciting eosinophil granule protein secretion
    • Baptista-dos-Reis R., Muniz V., Neves J., (2015) Multifaceted roles of cysteinyl leukotrienes in eliciting eosinophil granule protein secretion. Biomed Res Int 2015: 848762.
    • (2015) Biomed Res Int , vol.2015 , pp. 848762
    • Baptista-Dos-Reis, R.1    Muniz, V.2    Neves, J.3
  • 4
    • 78650915946 scopus 로고    scopus 로고
    • Costs of asthma in the United States: 2002-2007
    • Barnett S., Nurmagambetov T., (2011) Costs of asthma in the United States: 2002-2007. J Allergy Clin Immunol 127: 145-52.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 145-152
    • Barnett, S.1    Nurmagambetov, T.2
  • 6
    • 84907423833 scopus 로고    scopus 로고
    • SIRIUS Investigators (2014) Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma
    • Bel E., Wenzel S., Thompson P., Prazma C., Keene O., et al. SIRIUS Investigators (2014) Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med 371: 1189-1197.
    • N Engl J Med , vol.371 , pp. 1189-1197
    • Bel, E.1    Wenzel, S.2    Thompson, P.3    Prazma, C.4    Keene, O.5
  • 7
    • 84955407770 scopus 로고    scopus 로고
    • Eosinophils: Important players in humoral immunity
    • Berek C., (2016) Eosinophils: important players in humoral immunity. Clin Exp Immunol 183: 57-64.
    • (2016) Clin Exp Immunol , vol.183 , pp. 57-64
    • Berek, C.1
  • 8
    • 84924117461 scopus 로고    scopus 로고
    • A randomized phase 3 study of the efficacy and safety of reslizumab in subjects with asthma with elevated eosinophils
    • Bjermer C., Maspero J., Ciesielska M., O'Brien C., Zangrilli J., (2014) A randomized phase 3 study of the efficacy and safety of reslizumab in subjects with asthma with elevated eosinophils. Eur Resp J 44: 299.
    • (2014) Eur Resp J , vol.44 , pp. 299
    • Bjermer, C.1    Maspero, J.2    Ciesielska, M.3    O'Brien, C.4    Zangrilli, J.5
  • 9
    • 34249799929 scopus 로고    scopus 로고
    • Predicting and evaluating response to omalizumab in patients with severe allergic asthma
    • Bousquet J., Rabe K., Humbert M., Chung K., Berger W., Fox H., et al. (2007) Predicting and evaluating response to omalizumab in patients with severe allergic asthma. Respir Med 101: 1483-1492.
    • (2007) Respir Med , vol.101 , pp. 1483-1492
    • Bousquet, J.1    Rabe, K.2    Humbert, M.3    Chung, K.4    Berger, W.5    Fox, H.6
  • 10
    • 84918798923 scopus 로고    scopus 로고
    • Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: A randomised, double-blind, placebo-controlled, phase 2a study
    • Brightling C., Bleecker E., Panettieri R. Jr, Bafadhel M., She D., Ward C., et al. (2014) Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study. Lancet Respir Med 2: 891-901.
    • (2014) Lancet Respir Med , vol.2 , pp. 891-901
    • Brightling, C.1    Bleecker, E.2    Panettieri, R.3    Bafadhel, M.4    She, D.5    Ward, C.6
  • 11
    • 84962715855 scopus 로고    scopus 로고
    • FDA panel backs mepolizumab for severe eosinophilic asthma
    • Brown T., (2015) FDA panel backs mepolizumab for severe eosinophilic asthma. Medscape Medical News 11.
    • (2015) Medscape Medical News , vol.11
    • Brown, T.1
  • 12
    • 77952683218 scopus 로고    scopus 로고
    • Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase i study of subjects with mild asthma
    • Busse W., Katial R., Gossage D., Sari S., Wang B., Kolbeck R., et al. (2010) Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol 125: 1237-1244.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1237-1244
    • Busse, W.1    Katial, R.2    Gossage, D.3    Sari, S.4    Wang, B.5    Kolbeck, R.6
  • 13
    • 81455155725 scopus 로고    scopus 로고
    • Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study
    • Castro M., Mathur S., Hargreave F., Boulet L., Xie F., Young J., et al. (2011) Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med 184: 1125-1132.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1125-1132
    • Castro, M.1    Mathur, S.2    Hargreave, F.3    Boulet, L.4    Xie, F.5    Young, J.6
  • 14
    • 84919382915 scopus 로고    scopus 로고
    • Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: A phase 2b randomised dose-ranging study
    • Castro M., Wenzel S., Bleecker E., Pizzichini E., Kuna P., Busse W., et al. (2014) Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. Lancet Respir Med 2: 879-890.
    • (2014) Lancet Respir Med , vol.2 , pp. 879-890
    • Castro, M.1    Wenzel, S.2    Bleecker, E.3    Pizzichini, E.4    Kuna, P.5    Busse, W.6
  • 15
    • 0025344322 scopus 로고
    • Regulation of human eosinophil precursor production by cytokines: A comparison of recombinant human interleukin-1 (rhIL-1), rhIL-3, rhIL-5, rhIL-6, and rh granulocyte-macrophage colony-stimulating factor
    • Clutterbuck E., Sanderson C., (1990) Regulation of human eosinophil precursor production by cytokines: a comparison of recombinant human interleukin-1 (rhIL-1), rhIL-3, rhIL-5, rhIL-6, and rh granulocyte-macrophage colony-stimulating factor. Blood 75: 1774-1779.
    • (1990) Blood , vol.75 , pp. 1774-1779
    • Clutterbuck, E.1    Sanderson, C.2
  • 16
    • 84937725327 scopus 로고    scopus 로고
    • Evaluation and differential diagnosis of persistent marked eosinophilia
    • Curtis C., Ogbogu P., (2015) Evaluation and differential diagnosis of persistent marked eosinophilia. Immunol Allergy Clin North Am 35: 387-402.
    • (2015) Immunol Allergy Clin North Am , vol.35 , pp. 387-402
    • Curtis, C.1    Ogbogu, P.2
  • 17
    • 84931322042 scopus 로고    scopus 로고
    • Relationship between serum total IgE and disease severity in patients with allergic asthma in Spain
    • Davila I., Valero A., Entrenas L., Valveny N., Herráez L., (2015) Relationship between serum total IgE and disease severity in patients with allergic asthma in Spain. J Investig Allergol Clin Immunol 25 (2): 120-127.
    • (2015) J Investig Allergol Clin Immunol , vol.25 , Issue.2 , pp. 120-127
    • Davila, I.1    Valero, A.2    Entrenas, L.3    Valveny, N.4    Herráez, L.5
  • 18
    • 0030294245 scopus 로고    scopus 로고
    • Bronchoscopy as a research tool for the study of asthma pathogenesis and effects of antiasthma drugs
    • discussion S64-S66
    • Djukanov R., (1996) Bronchoscopy as a research tool for the study of asthma pathogenesis and effects of antiasthma drugs. J Allergy Clin Immunol 98 (5 Pt 2): S41-5; discussion S64-S66.
    • (1996) J Allergy Clin Immunol , vol.98 , Issue.5 , pp. S41-S45
    • Djukanov, R.1
  • 19
    • 0001269056 scopus 로고    scopus 로고
    • Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity
    • Egan R., Athwal D., Bodmer M., Carter J., Chapman R., Chou C., et al. (1999) Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity. Arzneimittelforschung 49: 779-790.
    • (1999) Arzneimittelforschung , vol.49 , pp. 779-790
    • Egan, R.1    Athwal, D.2    Bodmer, M.3    Carter, J.4    Chapman, R.5    Chou, C.6
  • 20
    • 10744231300 scopus 로고    scopus 로고
    • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma
    • European Network for Understanding Mechanisms of Severe Asthma
    • European Network for Understanding Mechanisms of Severe Asthma (2003) The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur Respir J 22: 470-477.
    • (2003) Eur Respir J , vol.22 , pp. 470-477
  • 21
    • 0037320195 scopus 로고    scopus 로고
    • Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease
    • Fabbri L., Romagnoli M., Corbetta L., Casoni G., Busljetic K., Turato G., et al. (2003) Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med 167: 418-424.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 418-424
    • Fabbri, L.1    Romagnoli, M.2    Corbetta, L.3    Casoni, G.4    Busljetic, K.5    Turato, G.6
  • 22
    • 67049144615 scopus 로고    scopus 로고
    • Eosinophilic and neutrophilic inflammation in asthma: Insights from clinical studies
    • Fahy J., (2009) Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc 6: 256-259.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 256-259
    • Fahy, J.1
  • 23
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page P., Menzies-Gow A., Kay A., Robinson D., (2003) Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 167: 199-204.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.1    Menzies-Gow, A.2    Kay, A.3    Robinson, D.4
  • 25
    • 84953439931 scopus 로고    scopus 로고
    • Eosinophilic airway inflammation: Role in asthma and chronic obstructive pulmonary disease
    • George L., Brightling C., (2016) Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease. Ther Adv Chronic Dis 7: 34-51.
    • (2016) Ther Adv Chronic Dis , vol.7 , pp. 34-51
    • George, L.1    Brightling, C.2
  • 26
    • 33750508779 scopus 로고    scopus 로고
    • Nasal IL-5 levels deterthe response to anti-IL-5 treatment in patients with nasal polyps
    • Gevaert P., Lang-Loidolt D., Lackner A., et al. (2006) Nasal IL-5 levels deterthe response to anti-IL-5 treatment in patients with nasal polyps. J Allergy Clin Immunol 118 (5): 1133-1141.
    • (2006) J Allergy Clin Immunol , vol.118 , Issue.5 , pp. 1133-1141
    • Gevaert, P.1    Lang-Loidolt, D.2    Lackner, A.3
  • 27
    • 85000634338 scopus 로고    scopus 로고
    • Global Asthma Report. Available at: (accessed 4 July 2016)
    • Global Asthma Report (2014) Global burden of disease due to asthma. Available at: http://www.globalasthmareport.org/burden/burden.php (. accessed 4 July 2016).
    • (2014) Global Burden of Disease Due to Asthma
  • 28
    • 84055209328 scopus 로고    scopus 로고
    • A multiple ascending subcutaneous dose study of MEDI-563, A humanized anti-IL-5RA monoclonal antibody, in adult asthmatics (clinicaltrails.gov Identifier: NCT00783289)
    • Gossage D., Geba G., Gillen A., (2010). A multiple ascending subcutaneous dose study of MEDI-563, A humanized anti-IL-5RA monoclonal antibody, in adult asthmatics (clinicaltrails.gov Identifier: NCT00783289). Annual Congress of the European Respiratory Society (ERS).
    • (2010) Annual Congress of the European Respiratory Society (ERS)
    • Gossage, D.1    Geba, G.2    Gillen, A.3
  • 29
    • 84963785191 scopus 로고    scopus 로고
    • Year in review 2015: Asthma and chronic obstructive pulmonary disease
    • Grainge C., Thomas P., Mak J., Benton M., Lim T., Ko F., (2016) Year in review 2015: asthma and chronic obstructive pulmonary disease. Respirology 21: 765-775.
    • (2016) Respirology , vol.21 , pp. 765-775
    • Grainge, C.1    Thomas, P.2    Mak, J.3    Benton, M.4    Lim, T.5    Ko, F.6
  • 31
    • 84876883293 scopus 로고    scopus 로고
    • Exploring the effects of omalizumab in allergic asthma: An analysis of biomarkers in the EXTRA study
    • Hanania N., Wenzel S., Rosén K., Hsieh H., Mosesova S., Choy D., et al. (2013) Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med 187 (8): 804-811.
    • (2013) Am J Respir Crit Care Med , vol.187 , Issue.8 , pp. 804-811
    • Hanania, N.1    Wenzel, S.2    Rosén, K.3    Hsieh, H.4    Mosesova, S.5    Choy, D.6
  • 32
    • 17844393640 scopus 로고    scopus 로고
    • Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys
    • Hart T., Cook R., Zia-Amirhosseini P., Minthorn E., Sellers T., Maleeff B., et al. (2001) Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys. J Allergy Clin Immunol 108: 250-257.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 250-257
    • Hart, T.1    Cook, R.2    Zia-Amirhosseini, P.3    Minthorn, E.4    Sellers, T.5    Maleeff, B.6
  • 33
    • 84941744814 scopus 로고    scopus 로고
    • Prevalence of eosinophilia in hospitalized patients with asthma exacerbation
    • Hasegawa K., Stoll S., Ahn J., Bittner J., Camargo C. Jr, (2015) Prevalence of eosinophilia in hospitalized patients with asthma exacerbation. Respir Med 109: 1230-1232.
    • (2015) Respir Med , vol.109 , pp. 1230-1232
    • Hasegawa, K.1    Stoll, S.2    Ahn, J.3    Bittner, J.4    Camargo, C.5
  • 34
    • 47949119866 scopus 로고    scopus 로고
    • Pathogenesis of asthma
    • Holgate S., (2008) Pathogenesis of asthma. Clin Exp Allergy 38: 872-897.
    • (2008) Clin Exp Allergy , vol.38 , pp. 872-897
    • Holgate, S.1
  • 35
    • 20044362008 scopus 로고    scopus 로고
    • Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
    • Humbert M., Beasley R., Ayres J., Slavin R., Hébert J., Bousquet J., et al. (2005) Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy 60: 309-316.
    • (2005) Allergy , vol.60 , pp. 309-316
    • Humbert, M.1    Beasley, R.2    Ayres, J.3    Slavin, R.4    Hébert, J.5    Bousquet, J.6
  • 36
    • 33646740982 scopus 로고    scopus 로고
    • Nonfucosylated therapeutic IgG1 antibody can evade the inhibitory effect of serum immunoglobulin G on antibody-dependent cellular cytotoxicity through its high binding to FcgammaRIIIa
    • Iida S., Misaka H., Inoue M., Shibata M., Nakano R., Yamane-Ohnuki N., et al. (2006) Nonfucosylated therapeutic IgG1 antibody can evade the inhibitory effect of serum immunoglobulin G on antibody-dependent cellular cytotoxicity through its high binding to FcgammaRIIIa. Clin Cancer Res 12: 2879-2887.
    • (2006) Clin Cancer Res , vol.12 , pp. 2879-2887
    • Iida, S.1    Misaka, H.2    Inoue, M.3    Shibata, M.4    Nakano, R.5    Yamane-Ohnuki, N.6
  • 38
    • 0031900026 scopus 로고    scopus 로고
    • Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma
    • Jatakanon A., Lim S., Kharitonov S., Chung K., Barnes P., (1998) Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax 53: 91-95.
    • (1998) Thorax , vol.53 , pp. 91-95
    • Jatakanon, A.1    Lim, S.2    Kharitonov, S.3    Chung, K.4    Barnes, P.5
  • 39
    • 84865696394 scopus 로고    scopus 로고
    • Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
    • Jia G., Erickson R., Choy D., Mosesova S., Wu L., Solberg O., et al. (2012) Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol 130: 647-654.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 647-654
    • Jia, G.1    Erickson, R.2    Choy, D.3    Mosesova, S.4    Wu, L.5    Solberg, O.6
  • 40
    • 0025740304 scopus 로고
    • The cytokine receptor superfamily
    • Kaczmarski R., Mufti G., (1991) The cytokine receptor superfamily. Blood Rev 5: 193-203.
    • (1991) Blood Rev , vol.5 , pp. 193-203
    • Kaczmarski, R.1    Mufti, G.2
  • 41
    • 84903608027 scopus 로고    scopus 로고
    • Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma
    • Katz L., Gleich G., Hartley B., Yancey S., Ortega H., (2014) Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma. Ann Am Thorac Soc 11: 531-536.
    • (2014) Ann Am Thorac Soc , vol.11 , pp. 531-536
    • Katz, L.1    Gleich, G.2    Hartley, B.3    Yancey, S.4    Ortega, H.5
  • 42
    • 0038643527 scopus 로고    scopus 로고
    • Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study
    • Kips J., O'Connor B., Langley S., et al. (2003) Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am J Respir Crit Care Med 167: 1655-1659.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1655-1659
    • Kips, J.1    O'Connor, B.2    Langley, S.3
  • 43
    • 84860343753 scopus 로고    scopus 로고
    • Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma
    • Klein Wolterink R., Kleinjan A., van Nimwegen M., Bergen I., de Bruijn M., Levani Y., et al. (2012) Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma. Eur J Immunol 42: 1106-1116.
    • (2012) Eur J Immunol , vol.42 , pp. 1106-1116
    • Klein Wolterink, R.1    Kleinjan, A.2    Van Nimwegen, M.3    Bergen, I.4    De Bruijn, M.5    Levani, Y.6
  • 44
    • 77952733788 scopus 로고    scopus 로고
    • MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
    • Kolbeck R., Kozhich A., Koike M., Peng L., Andersson C., Damschroder M., et al. (2010) MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol 125: 1344-1353.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1344-1353
    • Kolbeck, R.1    Kozhich, A.2    Koike, M.3    Peng, L.4    Andersson, C.5    Damschroder, M.6
  • 45
    • 70450175479 scopus 로고    scopus 로고
    • IL-5- and eosinophil-mediated inflammation: From discovery to therapy
    • Kouro T., Takatsu K., (2009) IL-5- and eosinophil-mediated inflammation: from discovery to therapy. Int Immunol 21: 1303-1309.
    • (2009) Int Immunol , vol.21 , pp. 1303-1309
    • Kouro, T.1    Takatsu, K.2
  • 47
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie M., ten Brinke A., Khan J., Diamant Z., O'Connor B., Walls C., et al. (2000) Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356: 2144-2148.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.1    Ten Brinke, A.2    Khan, J.3    Diamant, Z.4    O'Connor, B.5    Walls, C.6
  • 48
    • 84871187792 scopus 로고    scopus 로고
    • Importance of fiberoptic bronchoscopy in identifying asthma phenotypes to direct personalized therapy
    • Lommatzsch S., Martin R., Good J. Jr, (2013) Importance of fiberoptic bronchoscopy in identifying asthma phenotypes to direct personalized therapy. Curr Opin Pulm Med 19: 42-48.
    • (2013) Curr Opin Pulm Med , vol.19 , pp. 42-48
    • Lommatzsch, S.1    Martin, R.2    Good, J.3
  • 49
    • 2342590065 scopus 로고    scopus 로고
    • The global burden of asthma: Executive summary of the GINA Dissemination Committee report
    • Masoli M., Fabian D., Holt S., Beasley R., (2012) The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59: 469-478.
    • (2012) Allergy , vol.59 , pp. 469-478
    • Masoli, M.1    Fabian, D.2    Holt, S.3    Beasley, R.4
  • 52
    • 84905911746 scopus 로고    scopus 로고
    • A budget impact analysis of bronchial thermoplasty for severe asthma in clinical practice
    • Menzella F., Zucchi L., Piro R., Galeone C., Castagnetti C., Facciolongo N., (2014) A budget impact analysis of bronchial thermoplasty for severe asthma in clinical practice. Adv Ther 31: 751-761.
    • (2014) Adv Ther , vol.31 , pp. 751-761
    • Menzella, F.1    Zucchi, L.2    Piro, R.3    Galeone, C.4    Castagnetti, C.5    Facciolongo, N.6
  • 53
    • 0037393468 scopus 로고    scopus 로고
    • Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
    • Menzies-Gow A., Flood-Page P., Sehmi R., Burman J., Hamid Q., Robinson D., et al. (2003) Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J Allergy Clin Immunol 111: 714-719.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 714-719
    • Menzies-Gow, A.1    Flood-Page, P.2    Sehmi, R.3    Burman, J.4    Hamid, Q.5    Robinson, D.6
  • 56
    • 84918571425 scopus 로고    scopus 로고
    • A randomized trial of benralizumab, an antiinterleukin 5 receptor α monoclonal antibody, after acute asthma
    • Nowak R., Parker J., Silverman R., Rowe B., Smithline H., Khan F., et al. (2015) A randomized trial of benralizumab, an antiinterleukin 5 receptor α monoclonal antibody, after acute asthma. Am J Emerg Med 33: 14-20.
    • (2015) Am J Emerg Med , vol.33 , pp. 14-20
    • Nowak, R.1    Parker, J.2    Silverman, R.3    Rowe, B.4    Smithline, H.5    Khan, F.6
  • 58
    • 84964267747 scopus 로고    scopus 로고
    • A phase 2a study of benralizumab for patients with eosinophilic asthma in South Korea and Japan
    • Park H., Kim M., Imai N., Nakanishi T., Adachi M., Ohta K., et al. (2016) A phase 2a study of benralizumab for patients with eosinophilic asthma in South Korea and Japan. Int Arch Allergy Immunol 169: 135-145.
    • (2016) Int Arch Allergy Immunol , vol.169 , pp. 135-145
    • Park, H.1    Kim, M.2    Imai, N.3    Nakanishi, T.4    Adachi, M.5    Ohta, K.6
  • 59
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
    • Pavord I., Korn S., Howarth P., Bleecker E., Buhl R., Keene O., (2012) Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 380: 651-659.
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.1    Korn, S.2    Howarth, P.3    Bleecker, E.4    Buhl, R.5    Keene, O.6
  • 61
    • 84959475061 scopus 로고    scopus 로고
    • Reductions in eosinophil biomarkers by benralizumab in patients with asthma
    • Pham T., Damera G., Newbold P., Ranade K., (2016) Reductions in eosinophil biomarkers by benralizumab in patients with asthma. Respir Med 111: 21-29.
    • (2016) Respir Med , vol.111 , pp. 21-29
    • Pham, T.1    Damera, G.2    Newbold, P.3    Ranade, K.4
  • 62
    • 84919774163 scopus 로고    scopus 로고
    • Characterisation of an OCS-dependent severe asthma population treated with mepolizumab
    • Prazma C., Wenzel S., Barnes N., Douglass J., Hartley B., Ortega H., (2014) Characterisation of an OCS-dependent severe asthma population treated with mepolizumab. Thorax 69 (12): 1141-1142.
    • (2014) Thorax , vol.69 , Issue.12 , pp. 1141-1142
    • Prazma, C.1    Wenzel, S.2    Barnes, N.3    Douglass, J.4    Hartley, B.5    Ortega, H.6
  • 64
    • 40949146020 scopus 로고    scopus 로고
    • Mepolizumab HES Study Group. Treatment of patients with the hypereosinophilic syndrome with mepolizumab
    • Rothenberg M., Klion A., Roufosse F., Kahn J., Weller P., Simon H., et al. (2008) Mepolizumab HES Study Group. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N Engl J Med 358: 1215-1228.
    • (2008) N Engl J Med , vol.358 , pp. 1215-1228
    • Rothenberg, M.1    Klion, A.2    Roufosse, F.3    Kahn, J.4    Weller, P.5    Simon, H.6
  • 66
    • 0033840032 scopus 로고    scopus 로고
    • Effect of oral glucocorticoid treatment on serum inflammatory markers in acute asthma
    • Sahid El-Radhi A., Hogg C., Bungre J., Bush A., Corrigan C,. (2000) Effect of oral glucocorticoid treatment on serum inflammatory markers in acute asthma. Arch Dis Child 83: 158-162.
    • (2000) Arch Dis Child , vol.83 , pp. 158-162
    • Sahid El-Radhi, A.1    Hogg, C.2    Bungre, J.3    Bush, A.4    Corrigan, C.5
  • 67
    • 78649530294 scopus 로고    scopus 로고
    • Exhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a cohort of unselected patients with asthma
    • Schleich F., Seidel L., Sele J., Manise M., Quaedvlieg V., Michils A., et al. (2010) Exhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a cohort of unselected patients with asthma. Thorax 65: 1039-1044.
    • (2010) Thorax , vol.65 , pp. 1039-1044
    • Schleich, F.1    Seidel, L.2    Sele, J.3    Manise, M.4    Quaedvlieg, V.5    Michils, A.6
  • 68
    • 33645101537 scopus 로고    scopus 로고
    • Inflammatory subtypes in asthma: Assessment and identification using induced sputum
    • Simpson J., Scott R., Boyle M., Gibson P., (2006) Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 11: 54-61.
    • (2006) Respirology , vol.11 , pp. 54-61
    • Simpson, J.1    Scott, R.2    Boyle, M.3    Gibson, P.4
  • 69
    • 84986223146 scopus 로고    scopus 로고
    • What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion
    • DOI: 10.1183/13993003.00436-2016
    • Sin D., Miravitlles M., Mannino D., Soriano J., Price D., Celli B., et al. (2016) What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion. Eur Respir J 23. DOI: 10.1183/13993003.00436-2016.
    • (2016) Eur Respir J , vol.23
    • Sin, D.1    Miravitlles, M.2    Mannino, D.3    Soriano, J.4    Price, D.5    Celli, B.6
  • 70
    • 44649103777 scopus 로고    scopus 로고
    • Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels
    • Stein M., Villanueva J., Buckmeier B., Yamada Y., Filipovich A., Assa'ad A., et al. (2008) Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels. J Allergy Clin Immunol 121: 1473-1483.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 1473-1483
    • Stein, M.1    Villanueva, J.2    Buckmeier, B.3    Yamada, Y.4    Filipovich, A.5    Assa'Ad, A.6
  • 71
    • 0025769977 scopus 로고
    • Effects of IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophils in vitro
    • Tai P., Sun L., Spry C., (1991) Effects of IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophils in vitro. Clin Exp Immunol 85: 312-316.
    • (1991) Clin Exp Immunol , vol.85 , pp. 312-316
    • Tai, P.1    Sun, L.2    Spry, C.3
  • 72
    • 0028918543 scopus 로고
    • Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunitconstitutively
    • Takagi M., Hara T., Ichihara M., Takatsu K., Miyajima A., (1995) Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunitconstitutively. J Exp Med 181: 889-899.
    • (1995) J Exp Med , vol.181 , pp. 889-899
    • Takagi, M.1    Hara, T.2    Ichihara, M.3    Takatsu, K.4    Miyajima, A.5
  • 74
    • 0033104165 scopus 로고    scopus 로고
    • Novel technique for the direct flow cytofluorometric analysis of human basophils in unseparated blood and bone marrow, and the characterization of phenotype and peroxidase of human basophils
    • Toba K., Koike T., Shibata A., Hashimoto S., Takahashi M., Masuko M., et al. (1999) Novel technique for the direct flow cytofluorometric analysis of human basophils in unseparated blood and bone marrow, and the characterization of phenotype and peroxidase of human basophils. Cytometry 35: 249-259.
    • (1999) Cytometry , vol.35 , pp. 249-259
    • Toba, K.1    Koike, T.2    Shibata, A.3    Hashimoto, S.4    Takahashi, M.5    Masuko, M.6
  • 75
    • 84971667587 scopus 로고    scopus 로고
    • Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma
    • Trivedi A., Pavord I., Castro M., (2016) Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma. Lancet Respir Med 4: 585-592.
    • (2016) Lancet Respir Med , vol.4 , pp. 585-592
    • Trivedi, A.1    Pavord, I.2    Castro, M.3
  • 76
    • 0028587648 scopus 로고
    • The phenotype of human eosinophils, basophils, and mast cells
    • Valent P., (1994) The phenotype of human eosinophils, basophils, and mast cells. J Allergy Clin Immunol 94: 1177-1183.
    • (1994) J Allergy Clin Immunol , vol.94 , pp. 1177-1183
    • Valent, P.1
  • 77
    • 84921321823 scopus 로고    scopus 로고
    • External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma
    • Wagener A., de Nijs S., Lutter R., Sousa A., Weersink E., Bel E., et al. (2015) External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma. Thorax 70: 115-120.
    • (2015) Thorax , vol.70 , pp. 115-120
    • Wagener, A.1    De Nijs, S.2    Lutter, R.3    Sousa, A.4    Weersink, E.5    Bel, E.6
  • 78
    • 84876467969 scopus 로고    scopus 로고
    • Eosinophil apoptosis and clearance in asthma
    • Walsh G., (2013) Eosinophil apoptosis and clearance in asthma. J Cell Death 6: 17-25.
    • (2013) J Cell Death , vol.6 , pp. 17-25
    • Walsh, G.1
  • 79
    • 84964388893 scopus 로고    scopus 로고
    • Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: A post-hoc analysis of the WISDOM trial
    • Watz H., Tetzlaff K., Wouters E., Kirsten A., Magnussen H., Rodriguez-Roisin R., et al. (2016) Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trial. Lancet Respir Med 4: 390-398.
    • (2016) Lancet Respir Med , vol.4 , pp. 390-398
    • Watz, H.1    Tetzlaff, K.2    Wouters, E.3    Kirsten, A.4    Magnussen, H.5    Rodriguez-Roisin, R.6
  • 80
    • 0028302230 scopus 로고
    • The three-dimensional structure of human interleukin-5 at 2.4-angstroms resolution: Implication for the structures of other cytokines
    • Wells T., Graber P., Proudfoot A., Arod C., Jordan S., Lambert M., et al. (1994) The three-dimensional structure of human interleukin-5 at 2.4-angstroms resolution: implication for the structures of other cytokines. Ann N Y Acad Sci 28 (725): 118-127.
    • (1994) Ann N y Acad Sci , vol.28 , Issue.725 , pp. 118-127
    • Wells, T.1    Graber, P.2    Proudfoot, A.3    Arod, C.4    Jordan, S.5    Lambert, M.6
  • 81
    • 84942809764 scopus 로고    scopus 로고
    • Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes
    • Westerhof G., Korevaar D., Amelink M., de Nijs S., de Groot J., Wang J., et al. (2015) Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes. Eur Respir J 46: 688-696.
    • (2015) Eur Respir J , vol.46 , pp. 688-696
    • Westerhof, G.1    Korevaar, D.2    Amelink, M.3    De Nijs, S.4    De Groot, J.5    Wang, J.6
  • 83
    • 0032732953 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys
    • Zia-Amirhosseini P., Minthorn E., Benincosa L., Hart T., Hottenstein C., Tobia L., et al. (1999) Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys. J Pharmacol Exp Ther 291: 1060-1067.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 1060-1067
    • Zia-Amirhosseini, P.1    Minthorn, E.2    Benincosa, L.3    Hart, T.4    Hottenstein, C.5    Tobia, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.