Mfn1 deficiency in the liver protects against diet-induced insulin resistance and enhances the hypoglycemic effect of metformin

Diabetes

Volumn 65, Issue 12, 2016, Pages 3552-3560

  Maria, Isabel Hernandez Alvarez ^a   Kulkarni, Sameer S ^a   Joffraud, Magali ^a   Boutant, Marie ^a,b   Ratajczak, Joanna ^c   Gao, Arwen W ^b   Maclachlan, Catherine ^d,e,f   Raymond, Frédéric ^a   Metairon, Sylviane ^a   Descombes, Patrick ^a   Houtkooper, Riekelt H ^c   Zorzano, Antonio ^d,e,f   Cantó, Carles ^a,b  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b EPFL   (Switzerland)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^e UNIVERSITY OF BARCELONA   (Spain)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; CASPASE 3; METFORMIN; MITOFUSIN 1; MITOFUSIN 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ANTIDIABETIC AGENT; GUANOSINE TRIPHOSPHATASE; MFN1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOSE RESPONSE; DRUG EFFICACY; ENERGY RESOURCE; GENE DELETION; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; INSULIN RESISTANCE; LIPID DIET; LIPOLYSIS; LIVER METABOLISM; LIVER MITOCHONDRION; LIVER PROTECTION; LOW FAT DIET; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; ADVERSE EFFECTS; ANIMAL; DEFICIENCY; DRUG EFFECTS; GENETICS; HOMEOSTASIS; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

ANIMALS; DIET, HIGH-FAT; GTP PHOSPHOHYDROLASES; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; METFORMIN; MICE; MICE, KNOCKOUT; MITOCHONDRIA;

EID: 85000504307     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-1725     Document Type: Article

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