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Volumn 12, Issue 11, 2016, Pages

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality

Author keywords

[No Author keywords available]

Indexed keywords

ACVR2A GENE; ADULT; AGE RELATED DISEASE; AGED; ALLELE; ARTICLE; CANCER RISK; CANDIDATE GENE METHOD; CARDIOVASCULAR RISK; CAUCASIAN; CEREBROVASCULAR ACCIDENT; CHROMOSOME 2Q; CHROMOSOME 2Q22; CHROMOSOME BAND; CONTROLLED STUDY; DEGENERATIVE DISEASE; DIABETES MELLITUS; DISEASES; ENDOPHENOTYPE; GENE; GENE CONTROL; GENE FREQUENCY; GENE LOCATION; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CONSERVATION; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HEART FAILURE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MIDDLE AGED; MORTALITY RISK; PLEIOTROPY; SINGLE NUCLEOTIDE POLYMORPHISM; ZEB2 GENE; ATHEROSCLEROSIS; CHROMOSOME 2; CORONARY ARTERY DISEASE; FEMALE; GENETIC ASSOCIATION STUDY; GENETIC DISORDER; GENETICS; MALE; META ANALYSIS; MORTALITY; RISK FACTOR;

EID: 85000399291     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006314     Document Type: Article
Times cited : (23)

References (68)
  • 1
    • 85029335269 scopus 로고    scopus 로고
    • ().:., 428 p. p
    • Robine J-M, (2003) Determining health expectancies. Chichester, West Sussex, England; Hoboken, NJ, USA: Wiley. xiii, 428 p. p.
    • (2003) , pp. xiii
    • Robine, J.-M.1
  • 2
    • 0020109436 scopus 로고
    • Changing concepts of morbidity and mortality in the elderly population
    • 6919770,().: –
    • Manton KG, (1982) Changing concepts of morbidity and mortality in the elderly population. Milbank Mem Fund Q Health Soc60: 183–244. 6919770
    • (1982) Milbank Mem Fund Q Health Soc , vol.60 , pp. 183-244
    • Manton, K.G.1
  • 3
    • 0018876664 scopus 로고
    • Aging, natural death, and the compression of morbidity
    • 7383070,().: –
    • Fries JF, (1980) Aging, natural death, and the compression of morbidity. N Engl J Med303: 130–135. doi: 10.1056/NEJM1980071730303047383070
    • (1980) N Engl J Med , vol.303 , pp. 130-135
    • Fries, J.F.1
  • 4
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • 16862161,.().: –
    • Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet38: 904–909. doi: 10.1038/ng184716862161
    • (2006) Nat Genet , vol.38 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5
  • 5
    • 80052740749 scopus 로고    scopus 로고
    • Next-generation genome-wide association studies: time to focus on phenotype?
    • 21846867,(): –
    • MacRae CA, Vasan RS, (2011) Next-generation genome-wide association studies: time to focus on phenotype?Circ Cardiovasc Genet4: 334–336. doi: 10.1161/CIRCGENETICS.111.96076521846867
    • (2011) Circ Cardiovasc Genet , vol.4 , pp. 334-336
    • MacRae, C.A.1    Vasan, R.S.2
  • 7
    • 0037052454 scopus 로고    scopus 로고
    • Demography. Broken limits to life expectancy
    • 12004104,().: –
    • Oeppen J, Vaupel JW, (2002) Demography. Broken limits to life expectancy. Science296: 1029–1031. doi: 10.1126/science.106967512004104
    • (2002) Science , vol.296 , pp. 1029-1031
    • Oeppen, J.1    Vaupel, J.W.2
  • 8
    • 84907958813 scopus 로고    scopus 로고
    • Aging and cardiovascular diseases: the role of gene-diet interactions
    • 25159268,().: –
    • Corella D, Ordovas JM, (2014) Aging and cardiovascular diseases: the role of gene-diet interactions. Ageing Res Rev18: 53–73. doi: 10.1016/j.arr.2014.08.00225159268
    • (2014) Ageing Res Rev , vol.18 , pp. 53-73
    • Corella, D.1    Ordovas, J.M.2
  • 9
    • 84882355149 scopus 로고    scopus 로고
    • Unraveling genetic origin of aging-related traits: evolving concepts
    • 23768105,().: –
    • Kulminski AM, (2013) Unraveling genetic origin of aging-related traits: evolving concepts. Rejuvenation Res16: 304–312. doi: 10.1089/rej.2013.144123768105
    • (2013) Rejuvenation Res , vol.16 , pp. 304-312
    • Kulminski, A.M.1
  • 10
    • 14544271073 scopus 로고    scopus 로고
    • Genetics of longevity and aging
    • 15660509,().: –
    • Vijg J, Suh Y, (2005) Genetics of longevity and aging. Annu Rev Med56: 193–212. doi: 10.1146/annurev.med.56.082103.10461715660509
    • (2005) Annu Rev Med , vol.56 , pp. 193-212
    • Vijg, J.1    Suh, Y.2
  • 11
    • 76549129054 scopus 로고    scopus 로고
    • Evolution in health and medicine Sackler colloquium: Comparative genomics of autism and schizophrenia
    • 19955444,().: –
    • Crespi B, Stead P, Elliot M, (2010) Evolution in health and medicine Sackler colloquium: Comparative genomics of autism and schizophrenia. Proc Natl Acad Sci U S A107Suppl 1: 1736–1741. doi: 10.1073/pnas.090608010619955444
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1736-1741
    • Crespi, B.1    Stead, P.2    Elliot, M.3
  • 12
    • 84860758536 scopus 로고    scopus 로고
    • Stochastic modulations of the pace and patterns of ageing: impacts on quasi-stochastic distributions of multiple geriatric pathologies
    • 21963385,().: –
    • Martin GM, (2012) Stochastic modulations of the pace and patterns of ageing: impacts on quasi-stochastic distributions of multiple geriatric pathologies. Mech Ageing Dev133: 107–111. doi: 10.1016/j.mad.2011.09.00121963385
    • (2012) Mech Ageing Dev , vol.133 , pp. 107-111
    • Martin, G.M.1
  • 13
    • 77954140531 scopus 로고    scopus 로고
    • Common SNPs explain a large proportion of the heritability for human height
    • 20562875,.().: –
    • Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, et al. (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet42: 565–569. doi: 10.1038/ng.60820562875
    • (2010) Nat Genet , vol.42 , pp. 565-569
    • Yang, J.1    Benyamin, B.2    McEvoy, B.P.3    Gordon, S.4    Henders, A.K.5
  • 14
    • 84955421696 scopus 로고    scopus 로고
    • Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants
    • 26306600,.().: –
    • Ukraintseva S, Yashin A, Arbeev K, Kulminski A, Akushevich I, et al. (2016) Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants. Biogerontology17: 109–127. doi: 10.1007/s10522-015-9600-126306600
    • (2016) Biogerontology , vol.17 , pp. 109-127
    • Ukraintseva, S.1    Yashin, A.2    Arbeev, K.3    Kulminski, A.4    Akushevich, I.5
  • 15
    • 84927138135 scopus 로고    scopus 로고
    • Genetic Structures of Population Cohorts Change with Increasing Age: Implications for Genetic Analyses of Human aging and Life Span
    • Yashin AI, Wu D, Arbeev KG, Arbeeva LS, Akushevich I, et al. (2014) Genetic Structures of Population Cohorts Change with Increasing Age: Implications for Genetic Analyses of Human aging and Life Span. Ann Gerontol Geriatr Res1.
    • (2014) Ann Gerontol Geriatr Res , vol.1
    • Yashin, A.I.1    Wu, D.2    Arbeev, K.G.3    Arbeeva, L.S.4    Akushevich, I.5
  • 16
    • 84927129819 scopus 로고    scopus 로고
    • Genetics of aging, health, and survival: dynamic regulation of human longevity related traits
    • 25918517,.().:
    • Yashin AI, Wu D, Arbeeva LS, Arbeev KG, Kulminski AM, et al. (2015) Genetics of aging, health, and survival: dynamic regulation of human longevity related traits. Front Genet6: 122. doi: 10.3389/fgene.2015.0012225918517
    • (2015) Front Genet , vol.6 , pp. 122
    • Yashin, A.I.1    Wu, D.2    Arbeeva, L.S.3    Arbeev, K.G.4    Kulminski, A.M.5
  • 17
    • 79953733858 scopus 로고    scopus 로고
    • The effect of next-generation sequencing technology on complex trait research
    • 21155765,().: –
    • Day-Williams AG, Zeggini E, (2011) The effect of next-generation sequencing technology on complex trait research. Eur J Clin Invest41: 561–567. doi: 10.1111/j.1365-2362.2010.02437.x21155765
    • (2011) Eur J Clin Invest , vol.41 , pp. 561-567
    • Day-Williams, A.G.1    Zeggini, E.2
  • 18
    • 84859506440 scopus 로고    scopus 로고
    • Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans
    • 22494468,.().:
    • Kidambi S, Ghosh S, Kotchen JM, Grim CE, Krishnaswami S, et al. (2012) Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans. BMC Med Genet13: 27. doi: 10.1186/1471-2350-13-2722494468
    • (2012) BMC Med Genet , vol.13 , pp. 27
    • Kidambi, S.1    Ghosh, S.2    Kotchen, J.M.3    Grim, C.E.4    Krishnaswami, S.5
  • 19
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: a network-based approach to human disease
    • 21164525,().: –
    • Barabasi AL, Gulbahce N, Loscalzo J, (2011) Network medicine: a network-based approach to human disease. Nat Rev Genet12: 56–68. doi: 10.1038/nrg291821164525
    • (2011) Nat Rev Genet , vol.12 , pp. 56-68
    • Barabasi, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 20
    • 84920858732 scopus 로고    scopus 로고
    • Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension
    • 25500260,.().: –
    • Zhu X, Feng T, Tayo BO, Liang J, Young JH, et al. (2015) Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension. Am J Hum Genet96: 21–36. doi: 10.1016/j.ajhg.2014.11.01125500260
    • (2015) Am J Hum Genet , vol.96 , pp. 21-36
    • Zhu, X.1    Feng, T.2    Tayo, B.O.3    Liang, J.4    Young, J.H.5
  • 21
    • 84949035121 scopus 로고    scopus 로고
    • Healthy aging: The ultimate preventative medicine
    • 26785476,().: –
    • Kaeberlein M, Rabinovitch PS, Martin GM, (2015) Healthy aging: The ultimate preventative medicine. Science350: 1191–1193. doi: 10.1126/science.aad326726785476
    • (2015) Science , vol.350 , pp. 1191-1193
    • Kaeberlein, M.1    Rabinovitch, P.S.2    Martin, G.M.3
  • 22
    • 79958206937 scopus 로고    scopus 로고
    • Franklin H. Epstein Lecture: Sirtuins, aging, and medicine
    • 21651395,().: –
    • Guarente L, (2011) Franklin H. Epstein Lecture: Sirtuins, aging, and medicine. N Engl J Med364: 2235–2244. doi: 10.1056/NEJMra110083121651395
    • (2011) N Engl J Med , vol.364 , pp. 2235-2244
    • Guarente, L.1
  • 23
    • 84962548621 scopus 로고    scopus 로고
    • Editorial: Should We Treat Aging as a Disease? Academic, Pharmaceutical, Healthcare Policy, and Pension Fund Perspectives
    • Zhavoronkov A, Moskalev A, (2016) Editorial: Should We Treat Aging as a Disease? Academic, Pharmaceutical, Healthcare Policy, and Pension Fund Perspectives. Frontiers in Genetics7.
    • (2016) Frontiers in Genetics , vol.7
    • Zhavoronkov, A.1    Moskalev, A.2
  • 24
    • 65749097288 scopus 로고    scopus 로고
    • Changing course in ageing research: The healthy ageing phenotype
    • 19282116,.().: –
    • Franco OH, Karnik K, Osborne G, Ordovas JM, Catt M, et al. (2009) Changing course in ageing research: The healthy ageing phenotype. Maturitas63: 13–19. doi: 10.1016/j.maturitas.2009.02.00619282116
    • (2009) Maturitas , vol.63 , pp. 13-19
    • Franco, O.H.1    Karnik, K.2    Osborne, G.3    Ordovas, J.M.4    Catt, M.5
  • 26
    • 35948967250 scopus 로고    scopus 로고
    • Pursuing the longevity dividend: scientific goals for an aging world
    • 17986572,().: –
    • Olshansky SJ, Perry D, Miller RA, Butler RN, (2007) Pursuing the longevity dividend: scientific goals for an aging world. Ann N Y Acad Sci1114: 11–13. doi: 10.1196/annals.1396.05017986572
    • (2007) Ann N Y Acad Sci , vol.1114 , pp. 11-13
    • Olshansky, S.J.1    Perry, D.2    Miller, R.A.3    Butler, R.N.4
  • 27
    • 85029336231 scopus 로고
    • ().,:., 319 p. p
    • Fisher RA, (1932) Statistical methods for research workers. Edinburgh,: Oliver and Boyd. xiii, 319 p. p.
    • (1932) , pp. xiii
    • Fisher, R.A.1
  • 28
    • 84942882007 scopus 로고    scopus 로고
    • Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies
    • 26295473,.().:
    • Kulminski AM, Culminskaya I, Arbeev KG, Arbeeva L, Ukraintseva SV, et al. (2015) Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies. PLoS One10: e0136319. doi: 10.1371/journal.pone.013631926295473
    • (2015) PLoS One , vol.10 , pp. e0136319
    • Kulminski, A.M.1    Culminskaya, I.2    Arbeev, K.G.3    Arbeeva, L.4    Ukraintseva, S.V.5
  • 29
    • 84881581499 scopus 로고    scopus 로고
    • Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course
    • 23669352,.().: –
    • Graff M, Ngwa JS, Workalemahu T, Homuth G, Schipf S, et al. (2013) Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet22: 3597–3607. doi: 10.1093/hmg/ddt20523669352
    • (2013) Hum Mol Genet , vol.22 , pp. 3597-3607
    • Graff, M.1    Ngwa, J.S.2    Workalemahu, T.3    Homuth, G.4    Schipf, S.5
  • 30
    • 84901048488 scopus 로고    scopus 로고
    • Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals
    • 24809632,.().: –
    • Nygaard M, Lindahl-Jacobsen R, Soerensen M, Mengel-From J, Andersen-Ranberg K, et al. (2014) Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals. Exp Gerontol57: 41–46. doi: 10.1016/j.exger.2014.04.01824809632
    • (2014) Exp Gerontol , vol.57 , pp. 41-46
    • Nygaard, M.1    Lindahl-Jacobsen, R.2    Soerensen, M.3    Mengel-From, J.4    Andersen-Ranberg, K.5
  • 31
    • 84896719770 scopus 로고    scopus 로고
    • Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the apolipoprotein e4 allele on lifespan
    • 24497847,.().:
    • Kulminski AM, Arbeev KG, Culminskaya I, Arbeeva L, Ukraintseva SV, et al. (2014) Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the apolipoprotein e4 allele on lifespan. PLoS Genet10: e1004141. doi: 10.1371/journal.pgen.100414124497847
    • (2014) PLoS Genet , vol.10 , pp. e1004141
    • Kulminski, A.M.1    Arbeev, K.G.2    Culminskaya, I.3    Arbeeva, L.4    Ukraintseva, S.V.5
  • 32
    • 84878901058 scopus 로고    scopus 로고
    • The role of lipid-related genes, aging-related processes, and environment in healthspan
    • 23320904,.().: –
    • Kulminski AM, Culminskaya I, Arbeev KG, Ukraintseva SV, Stallard E, et al. (2013) The role of lipid-related genes, aging-related processes, and environment in healthspan. Aging Cell12: 237–246. doi: 10.1111/acel.1204623320904
    • (2013) Aging Cell , vol.12 , pp. 237-246
    • Kulminski, A.M.1    Culminskaya, I.2    Arbeev, K.G.3    Ukraintseva, S.V.4    Stallard, E.5
  • 33
    • 0027971798 scopus 로고
    • Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects
    • 7813899,.().: –
    • Jarvik GP, Austin MA, Fabsitz RR, Auwerx J, Reed T, et al. (1994) Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects. Genet Epidemiol11: 375–384. doi: 10.1002/gepi.13701104077813899
    • (1994) Genet Epidemiol , vol.11 , pp. 375-384
    • Jarvik, G.P.1    Austin, M.A.2    Fabsitz, R.R.3    Auwerx, J.4    Reed, T.5
  • 34
    • 33646251112 scopus 로고    scopus 로고
    • Lipoprotein genotype and conserved pathway for exceptional longevity in humans
    • 16602826,.().:
    • Atzmon G, Rincon M, Schechter CB, Shuldiner AR, Lipton RB, et al. (2006) Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol4: e113. doi: 10.1371/journal.pbio.004011316602826
    • (2006) PLoS Biol , vol.4 , pp. e113
    • Atzmon, G.1    Rincon, M.2    Schechter, C.B.3    Shuldiner, A.R.4    Lipton, R.B.5
  • 35
    • 0033358596 scopus 로고    scopus 로고
    • Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity
    • 10486337,.().: –
    • Yashin AI, De Benedictis G, Vaupel JW, Tan Q, Andreev KF, et al. (1999) Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity. Am J Hum Genet65: 1178–1193. doi: 10.1086/30257210486337
    • (1999) Am J Hum Genet , vol.65 , pp. 1178-1193
    • Yashin, A.I.1    De Benedictis, G.2    Vaupel, J.W.3    Tan, Q.4    Andreev, K.F.5
  • 36
    • 33747097918 scopus 로고    scopus 로고
    • Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study
    • 16785337,.().: –
    • Fox CS, Pencina MJ, Meigs JB, Vasan RS, Levitzky YS, et al. (2006) Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study. Circulation113: 2914–2918. doi: 10.1161/CIRCULATIONAHA.106.61382816785337
    • (2006) Circulation , vol.113 , pp. 2914-2918
    • Fox, C.S.1    Pencina, M.J.2    Meigs, J.B.3    Vasan, R.S.4    Levitzky, Y.S.5
  • 37
    • 84954349438 scopus 로고    scopus 로고
    • A Cross-Sectional Analysis of Late-Life Cardiovascular Factors and Their Relation to Clinically Defined Neurodegenerative Diseases
    • Dugger BN, Malek-Ahmadi M, Monsell SE, Kukull WA, Woodruff BK, et al. (2016) A Cross-Sectional Analysis of Late-Life Cardiovascular Factors and Their Relation to Clinically Defined Neurodegenerative Diseases. Alzheimer Dis Assoc Disord.
    • (2016) Alzheimer Dis Assoc Disord
    • Dugger, B.N.1    Malek-Ahmadi, M.2    Monsell, S.E.3    Kukull, W.A.4    Woodruff, B.K.5
  • 38
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • 11181995,.().: –
    • Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, et al. (2001) The sequence of the human genome. Science291: 1304–1351. doi: 10.1126/science.105804011181995
    • (2001) Science , vol.291 , pp. 1304-1351
    • Venter, J.C.1    Adams, M.D.2    Myers, E.W.3    Li, P.W.4    Mural, R.J.5
  • 39
    • 20244378058 scopus 로고    scopus 로고
    • Generation and annotation of the DNA sequences of human chromosomes 2 and 4
    • 15815621,.().: –
    • Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, et al. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature434: 724–731. doi: 10.1038/nature0346615815621
    • (2005) Nature , vol.434 , pp. 724-731
    • Hillier, L.W.1    Graves, T.A.2    Fulton, R.S.3    Fulton, L.A.4    Pepin, K.H.5
  • 40
    • 12744261452 scopus 로고    scopus 로고
    • Evolution and functional classification of vertebrate gene deserts
    • 15590943,.().: –
    • Ovcharenko I, Loots GG, Nobrega MA, Hardison RC, Miller W, et al. (2005) Evolution and functional classification of vertebrate gene deserts. Genome Res15: 137–145. doi: 10.1101/gr.301550515590943
    • (2005) Genome Res , vol.15 , pp. 137-145
    • Ovcharenko, I.1    Loots, G.G.2    Nobrega, M.A.3    Hardison, R.C.4    Miller, W.5
  • 41
    • 19444364990 scopus 로고    scopus 로고
    • Clues to function in gene deserts
    • 15922077,().: –
    • Taylor J, (2005) Clues to function in gene deserts. Trends Biotechnol23: 269–271. doi: 10.1016/j.tibtech.2005.04.00315922077
    • (2005) Trends Biotechnol , vol.23 , pp. 269-271
    • Taylor, J.1
  • 42
    • 0142084743 scopus 로고    scopus 로고
    • Scanning human gene deserts for long-range enhancers
    • 14563999,().:
    • Nobrega MA, Ovcharenko I, Afzal V, Rubin EM, (2003) Scanning human gene deserts for long-range enhancers. Science302: 413. doi: 10.1126/science.108832814563999
    • (2003) Science , vol.302 , pp. 413
    • Nobrega, M.A.1    Ovcharenko, I.2    Afzal, V.3    Rubin, E.M.4
  • 43
    • 84870794209 scopus 로고    scopus 로고
    • A novel long-range enhancer regulates postnatal expression of Zeb2: implications for Mowat-Wilson syndrome phenotypes
    • 23001561,().: –
    • El-Kasti MM, Wells T, Carter DA, (2012) A novel long-range enhancer regulates postnatal expression of Zeb2: implications for Mowat-Wilson syndrome phenotypes. Hum Mol Genet21: 5429–5442. doi: 10.1093/hmg/dds38923001561
    • (2012) Hum Mol Genet , vol.21 , pp. 5429-5442
    • El-Kasti, M.M.1    Wells, T.2    Carter, D.A.3
  • 44
    • 84903388630 scopus 로고    scopus 로고
    • Integrating diverse datasets improves developmental enhancer prediction
    • 24967590,.().:
    • Erwin GD, Oksenberg N, Truty RM, Kostka D, Murphy KK, et al. (2014) Integrating diverse datasets improves developmental enhancer prediction. PLoS Comput Biol10: e1003677. doi: 10.1371/journal.pcbi.100367724967590
    • (2014) PLoS Comput Biol , vol.10 , pp. e1003677
    • Erwin, G.D.1    Oksenberg, N.2    Truty, R.M.3    Kostka, D.4    Murphy, K.K.5
  • 45
    • 84937968733 scopus 로고    scopus 로고
    • A novel interstitial deletion of 2q22.3 q23.3 in a patient with dysmorphic features, epilepsy, aganglionosis, pure red cell aplasia, and skeletal malformations
    • 25988649,.().: –
    • Bravo-Oro A, Lurie IW, Elizondo-Cardenas G, Pena-Zepeda C, Salazar-Martinez A, et al. (2015) A novel interstitial deletion of 2q22.3 q23.3 in a patient with dysmorphic features, epilepsy, aganglionosis, pure red cell aplasia, and skeletal malformations. Am J Med Genet A167A: 1865–1871. doi: 10.1002/ajmg.a.3680625988649
    • (2015) Am J Med Genet A , vol.167A , pp. 1865-1871
    • Bravo-Oro, A.1    Lurie, I.W.2    Elizondo-Cardenas, G.3    Pena-Zepeda, C.4    Salazar-Martinez, A.5
  • 46
    • 84862909357 scopus 로고    scopus 로고
    • The miR-200 family regulates TGF-beta1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression
    • 22012804,.().: –
    • Xiong M, Jiang L, Zhou Y, Qiu W, Fang L, et al. (2012) The miR-200 family regulates TGF-beta1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression. Am J Physiol Renal Physiol302: F369–379. doi: 10.1152/ajprenal.00268.201122012804
    • (2012) Am J Physiol Renal Physiol , vol.302 , pp. F369-379
    • Xiong, M.1    Jiang, L.2    Zhou, Y.3    Qiu, W.4    Fang, L.5
  • 47
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • 18381893,().: –
    • Park SM, Gaur AB, Lengyel E, Peter ME, (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev22: 894–907. doi: 10.1101/gad.164060818381893
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 48
    • 41149112564 scopus 로고    scopus 로고
    • A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition
    • 18347095,.().: –
    • Beltran M, Puig I, Pena C, Garcia JM, Alvarez AB, et al. (2008) A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. Genes Dev22: 756–769. doi: 10.1101/gad.45570818347095
    • (2008) Genes Dev , vol.22 , pp. 756-769
    • Beltran, M.1    Puig, I.2    Pena, C.3    Garcia, J.M.4    Alvarez, A.B.5
  • 49
    • 67649417877 scopus 로고    scopus 로고
    • Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB
    • 19424592,().: –
    • Katoh M, Katoh M, (2009) Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB. Int J Oncol34: 1737–1742. 19424592
    • (2009) Int J Oncol , vol.34 , pp. 1737-1742
    • Katoh, M.1    Katoh, M.2
  • 50
    • 84880048839 scopus 로고    scopus 로고
    • The TGFbeta superfamily signaling pathway
    • 23799630,().: –
    • Weiss A, Attisano L, (2013) The TGFbeta superfamily signaling pathway. Wiley Interdiscip Rev Dev Biol2: 47–63. doi: 10.1002/wdev.8623799630
    • (2013) Wiley Interdiscip Rev Dev Biol , vol.2 , pp. 47-63
    • Weiss, A.1    Attisano, L.2
  • 52
    • 10744220219 scopus 로고    scopus 로고
    • Further delineation of the phenotype associated with heterozygous mutations in ZFHX1B
    • 12784289,.().: –
    • Wilson M, Mowat D, Dastot-Le Moal F, Cacheux V, Kaariainen H, et al. (2003) Further delineation of the phenotype associated with heterozygous mutations in ZFHX1B. Am J Med Genet A119A: 257–265. doi: 10.1002/ajmg.a.2005312784289
    • (2003) Am J Med Genet A , vol.119A , pp. 257-265
    • Wilson, M.1    Mowat, D.2    Dastot-Le Moal, F.3    Cacheux, V.4    Kaariainen, H.5
  • 53
    • 67649945780 scopus 로고    scopus 로고
    • Cytogenetic, FISH and array-CGH characterization of a complex chromosomal rearrangement carried by a mentally and language impaired patient
    • 19236961,.().: –
    • Ballarati L, Recalcati MP, Bedeschi MF, Lalatta F, Valtorta C, et al. (2009) Cytogenetic, FISH and array-CGH characterization of a complex chromosomal rearrangement carried by a mentally and language impaired patient. Eur J Med Genet52: 218–223. doi: 10.1016/j.ejmg.2009.02.00419236961
    • (2009) Eur J Med Genet , vol.52 , pp. 218-223
    • Ballarati, L.1    Recalcati, M.P.2    Bedeschi, M.F.3    Lalatta, F.4    Valtorta, C.5
  • 55
    • 0026741830 scopus 로고
    • The Atherosclerosis Risk in Communities (ARIC) Study. Introduction and objectives of the hemostasis component
    • 1342297,().: –
    • Sharrett AR, (1992) The Atherosclerosis Risk in Communities (ARIC) Study. Introduction and objectives of the hemostasis component. Ann Epidemiol2: 467–469. 1342297
    • (1992) Ann Epidemiol , vol.2 , pp. 467-469
    • Sharrett, A.R.1
  • 57
    • 34247579476 scopus 로고    scopus 로고
    • The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination
    • 17372189,.().: –
    • Splansky GL, Corey D, Yang Q, Atwood LD, Cupples LA, et al. (2007) The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol165: 1328–1335. doi: 10.1093/aje/kwm02117372189
    • (2007) Am J Epidemiol , vol.165 , pp. 1328-1335
    • Splansky, G.L.1    Corey, D.2    Yang, Q.3    Atwood, L.D.4    Cupples, L.A.5
  • 58
    • 71249112490 scopus 로고    scopus 로고
    • Genetics Analysis Workshop 16 Problem 2: the Framingham Heart Study data
    • 20018020,().:
    • Cupples LA, Heard-Costa N, Lee M, Atwood LD, (2009) Genetics Analysis Workshop 16 Problem 2: the Framingham Heart Study data. BMC Proc3Suppl 7: S3. 20018020
    • (2009) BMC Proc , vol.3 , pp. S3
    • Cupples, L.A.1    Heard-Costa, N.2    Lee, M.3    Atwood, L.D.4
  • 59
    • 0035864632 scopus 로고    scopus 로고
    • Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study
    • 11257253,.().: –
    • Lahoz C, Schaefer EJ, Cupples LA, Wilson PW, Levy D, et al. (2001) Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis154: 529–537. 11257253
    • (2001) Atherosclerosis , vol.154 , pp. 529-537
    • Lahoz, C.1    Schaefer, E.J.2    Cupples, L.A.3    Wilson, P.W.4    Levy, D.5
  • 60
    • 0029664414 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study
    • 8618665,.().: –
    • Myers RH, Schaefer EJ, Wilson PW, D'Agostino R, Ordovas JM, et al. (1996) Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study. Neurology46: 673–677. 8618665
    • (1996) Neurology , vol.46 , pp. 673-677
    • Myers, R.H.1    Schaefer, E.J.2    Wilson, P.W.3    D'Agostino, R.4    Ordovas, J.M.5
  • 61
    • 0000366020 scopus 로고
    • An overview of the health and retirement study
    • Juster FT, Suzman R, (1995) An overview of the health and retirement study. Journal of Human Resources30: S7–S56.
    • (1995) Journal of Human Resources , vol.30 , pp. S7-S56
    • Juster, F.T.1    Suzman, R.2
  • 62
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: a tool set for whole-genome association and population-based linkage analyses
    • 17701901,.().: –
    • Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet81: 559–575. doi: 10.1086/51979517701901
    • (2007) Am J Hum Genet , vol.81 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3    Thomas, L.4    Ferreira, M.A.5
  • 63
    • 85000454505 scopus 로고
    • Fisher RAS, (1970) Statistical methods for research workers. Edinburgh: Oliver and Boyd.
    • (1970)
    • Fisher, R.A.S.1
  • 64
    • 0017878954 scopus 로고
    • Retrospective studies and failure time models
    • Prentice R, Breslow N, (1978) Retrospective studies and failure time models. Biometrika65: 153–158.
    • (1978) Biometrika , vol.65 , pp. 153-158
    • Prentice, R.1    Breslow, N.2
  • 65
    • 71249140395 scopus 로고    scopus 로고
    • Application of three-level linear mixed-effects model incorporating gene-age interactions for association analysis of longitudinal family data
    • 20018085,().:
    • Shi G, Rice TK, Gu CC, Rao DC, (2009) Application of three-level linear mixed-effects model incorporating gene-age interactions for association analysis of longitudinal family data. BMC Proc3Suppl 7: S89. 20018085
    • (2009) BMC Proc , vol.3 , pp. S89
    • Shi, G.1    Rice, T.K.2    Gu, C.C.3    Rao, D.C.4
  • 66
    • 65949090748 scopus 로고    scopus 로고
    • Genomewide association studies of stroke
    • 19369658,.().: –
    • Ikram MA, Seshadri S, Bis JC, Fornage M, DeStefano AL, et al. (2009) Genomewide association studies of stroke. N Engl J Med360: 1718–1728. doi: 10.1056/NEJMoa090009419369658
    • (2009) N Engl J Med , vol.360 , pp. 1718-1728
    • Ikram, M.A.1    Seshadri, S.2    Bis, J.C.3    Fornage, M.4    DeStefano, A.L.5
  • 67
    • 84864428744 scopus 로고    scopus 로고
    • A simple unified approach for estimating natural direct and indirect effects
    • 22781427,().: –
    • Lange T, Vansteelandt S, Bekaert M, (2012) A simple unified approach for estimating natural direct and indirect effects. Am J Epidemiol176: 190–195. doi: 10.1093/aje/kwr52522781427
    • (2012) Am J Epidemiol , vol.176 , pp. 190-195
    • Lange, T.1    Vansteelandt, S.2    Bekaert, M.3
  • 68
    • 0033847784 scopus 로고    scopus 로고
    • Marginal structural models and causal inference in epidemiology
    • 10955408,().: –
    • Robins JM, Hernan MA, Brumback B, (2000) Marginal structural models and causal inference in epidemiology. Epidemiology11: 550–560. 10955408
    • (2000) Epidemiology , vol.11 , pp. 550-560
    • Robins, J.M.1    Hernan, M.A.2    Brumback, B.3


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