Depletion of the Fragile X Mental Retardation Protein in Embryonic Stem Cells Alters the Kinetics of Neurogenesis

Stem Cells

Volumn 35, Issue 2, 2017, Pages 374-385

  Khalfallah, Olfa ^a,b,c   Jarjat, Marielle ^a,b,c   Davidovic, Laetitia ^a,b   Nottet, Nicolas ^a,b   Cestèle, Sandrine ^a,b   Mantegazza, Massimo ^a,b   Bardoni, Barbara ^a,b,c  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

^b INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c CNRS   (France)

Author keywords

Autism; Embryonic stem cells; Fragile X syndrome; Intellectual disability; Neurogenesis; Therapeutic window

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA TUBULIN; BETAIII TUBULIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FRAGILE X MENTAL RETARDATION PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; NEURON SPECIFIC NUCLEAR PROTEIN; PROTEIN; PROTEIN FMRP; PROTEIN FXR1P; PROTEIN FXR2P; UNCLASSIFIED DRUG; ASCL1 PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASCL1 GENE; CELL LINE; CONTROLLED STUDY; EMBRYO; FRAGILE X SYNDROME; GENE; GENE EXPRESSION; GENE SILENCING; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE EMBRYONIC STEM CELL; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN PROCESSING; UPREGULATION; ANIMAL; CELL DIFFERENTIATION; CELL SHAPE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; KINETICS; METABOLISM; NERVE CELL; SIGNAL TRANSDUCTION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL SHAPE; FRAGILE X MENTAL RETARDATION PROTEIN; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; KINETICS; MICE; MICE, KNOCKOUT; MOUSE EMBRYONIC STEM CELLS; NEUROGENESIS; NEURONS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 85000347719     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2505     Document Type: Article

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