Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome

Science

Volumn 343, Issue 6174, 2014, Pages 1002-1005

  Colak, Dilek ^a   Zaninovic, Nikica ^a   Cohen, Michael S ^a,d   Rosenwaks, Zev ^a   Yang, Wang Yong ^b   Gerhardt, Jeannine ^c   Disney, Matthew D ^b   Jaffrey, Samie R ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; AFF2 PROTEIN, HUMAN; FMR1 PROTEIN, HUMAN; FRAGILE X MENTAL RETARDATION PROTEIN; NUCLEAR PROTEIN; SMALL INTERFERING RNA;

DISEASE PREVALENCE; GENE EXPRESSION; GENETIC ANALYSIS; HYBRIDIZATION; NUCLEIC ACID;

ARTICLE; DNA RNA HYBRIDIZATION; EPIGENETICS; FRAGILE X MENTAL RETARDATION 1 GENE; FRAGILE X SYNDROME; GENE; GENE SILENCING; HUMAN; PRIORITY JOURNAL; TRINUCLEOTIDE REPEAT; ANIMAL; CELL LINE; DNA METHYLATION; EMBRYONIC STEM CELL; GENETICS; METABOLISM; MOUSE; NERVE CELL; NONOBESE DIABETIC MOUSE; PROMOTER REGION; SCID MOUSE;

ANIMALS; CELL LINE; DNA METHYLATION; EMBRYONIC STEM CELLS; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; GENE SILENCING; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; NEURONS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; RNA, SMALL INTERFERING; TRINUCLEOTIDE REPEATS;

EID: 84896732761     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1245831     Document Type: Article

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