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Volumn 22, Issue 11, 2016, Pages 1260-1267

Determinants of HIV-1 broadly neutralizing antibody induction

(62)  Rusert, Peter a   Kouyos, Roger D a,b   Kadelka, Claus a,b   Ebner, Hanna a   Schanz, Merle a   Huber, Michael a   Braun, Dominique L a,b   Hozé, Nathanael c   Scherrer, Alexandra a,b   Magnus, Carsten a,c   Weber, Jacqueline a   Uhr, Therese a   Cippa, Valentina a   Thorball, Christian W d,e   Kuster, Herbert a,b   Cavassini, Matthias f   Bernasconi, Enos g   Hoffmann, Matthias h   Calmy, Alexandra i   Battegay, Manuel j   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BROADLY NEUTRALIZING ANTIBODY; CD4 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; POLYSACCHARIDE; VIRUS RNA;

EID: 84988698013     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4187     Document Type: Article
Times cited : (128)

References (59)
  • 1
    • 84929896699 scopus 로고    scopus 로고
    • Antibody responses to envelope glycoproteins in HIV-1 infection
    • Burton, D.R. & Mascola, J.R. Antibody responses to envelope glycoproteins in HIV-1 infection. Nat. Immunol. 16, 571-576 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 571-576
    • Burton, D.R.1    Mascola, J.R.2
  • 2
    • 84883796903 scopus 로고    scopus 로고
    • Antibodies in HIV-1 vaccine development and therapy
    • Klein, F. et al. Antibodies in HIV-1 vaccine development and therapy. Science 341, 1199-1204 (2013).
    • (2013) Science , vol.341 , pp. 1199-1204
    • Klein, F.1
  • 3
    • 84879302728 scopus 로고    scopus 로고
    • HIV-1 neutralizing antibodies: Understanding nature's pathways
    • Mascola, J.R. & Haynes, B.F. HIV-1 neutralizing antibodies: understanding nature's pathways. Immunol. Rev. 254, 225-244 (2013).
    • (2013) Immunol. Rev. , vol.254 , pp. 225-244
    • Mascola, J.R.1    Haynes, B.F.2
  • 4
    • 84925844719 scopus 로고    scopus 로고
    • Virological features associated with the development of broadly neutralizing antibodies to HIV-1
    • Moore, P.L., Williamson, C. & Morris, L. Virological features associated with the development of broadly neutralizing antibodies to HIV-1. Trends Microbiol. 23, 204-211 (2015).
    • (2015) Trends Microbiol. , vol.23 , pp. 204-211
    • Moore, P.L.1    Williamson, C.2    Morris, L.3
  • 5
    • 84928405730 scopus 로고    scopus 로고
    • Viremia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
    • Caskey, M. et al. Viremia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature 522, 487-491 (2015).
    • (2015) Nature , vol.522 , pp. 487-491
    • Caskey, M.1
  • 6
    • 84954445565 scopus 로고    scopus 로고
    • Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
    • Lynch, R.M. et al. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Sci. Transl. Med. 7, 319ra206 (2015).
    • (2015) Sci. Transl. Med. , vol.7 , pp. 319ra206
    • Lynch, R.M.1
  • 7
    • 20944446452 scopus 로고    scopus 로고
    • Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
    • Trkola, A. et al. Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies. Nat. Med. 11, 615-622 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 615-622
    • Trkola, A.1
  • 8
    • 84976406858 scopus 로고    scopus 로고
    • HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption
    • Scheid, J.F. et al. HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature 535, 556-560 (2016).
    • (2016) Nature , vol.535 , pp. 556-560
    • Scheid, J.F.1
  • 9
    • 84857084577 scopus 로고    scopus 로고
    • Longitudinal analysis of early HIV-1-specifc neutralizing activity in an elite neutralizer and in fve patients who developed cross-reactive neutralizing activity
    • Euler, Z. et al. Longitudinal analysis of early HIV-1-specifc neutralizing activity in an elite neutralizer and in fve patients who developed cross-reactive neutralizing activity. J. Virol. 86, 2045-2055 (2012).
    • (2012) J. Virol. , vol.86 , pp. 2045-2055
    • Euler, Z.1
  • 10
    • 67650453747 scopus 로고    scopus 로고
    • Human immunodefciency virus type 1 elite neutralizers: Individuals with broad and potent neutralizing activity identifed by using a high-throughput neutralization assay together with an analytical selection algorithm
    • Simek, M.D. et al. Human immunodefciency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identifed by using a high-throughput neutralization assay together with an analytical selection algorithm. J. Virol. 83, 7337-7348 (2009).
    • (2009) J. Virol. , vol.83 , pp. 7337-7348
    • Simek, M.D.1
  • 11
    • 84867630116 scopus 로고    scopus 로고
    • A blueprint for HIV vaccine discovery
    • Burton, D.R. et al. A blueprint for HIV vaccine discovery. Cell Host Microbe 12, 396-407 (2012).
    • (2012) Cell Host Microbe , vol.12 , pp. 396-407
    • Burton, D.R.1
  • 12
    • 79955389756 scopus 로고    scopus 로고
    • + T cell decline and high viral load during acute infection
    • + T cell decline and high viral load during acute infection. J. Virol. 85, 4828-4840 (2011).
    • (2011) J. Virol. , vol.85 , pp. 4828-4840
    • Gray, E.S.1
  • 13
    • 58149487645 scopus 로고    scopus 로고
    • Factors associated with the development of cross-reactive neutralizing antibodies during human immunodefciency virus type 1 infection
    • Sather, D.N. et al. Factors associated with the development of cross-reactive neutralizing antibodies during human immunodefciency virus type 1 infection. J. Virol. 83, 757-769 (2009).
    • (2009) J. Virol. , vol.83 , pp. 757-769
    • Sather, D.N.1
  • 14
    • 84956714697 scopus 로고    scopus 로고
    • Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort
    • Landais, E. et al. Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort. PLoS Pathog. 12, e1005369 (2016).
    • (2016) PLoS Pathog. , vol.12 , pp. e1005369
    • Landais, E.1
  • 15
    • 84875759341 scopus 로고    scopus 로고
    • Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization
    • Klein, F. et al. Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell 153, 126-138 (2013).
    • (2013) Cell , vol.153 , pp. 126-138
    • Klein, F.1
  • 16
    • 84866495323 scopus 로고    scopus 로고
    • Human antibodies that neutralize HIV-1: Identifcation, structures and B cell ontogenies
    • Kwong, P.D. & Mascola, J.R. Human antibodies that neutralize HIV-1: identifcation, structures and B cell ontogenies. Immunity 37, 412-425 (2012).
    • (2012) Immunity , vol.37 , pp. 412-425
    • Kwong, P.D.1    Mascola, J.R.2
  • 17
    • 73949084963 scopus 로고    scopus 로고
    • Breadth of human-immunodefciency-virus-specifc neutralizing activity in sera: Clustering analysis and association with clinical variables
    • Doria-Rose, N.A. et al. Breadth of human-immunodefciency-virus-specifc neutralizing activity in sera: clustering analysis and association with clinical variables. J. Virol. 84, 1631-1636 (2010).
    • (2010) J. Virol. , vol.84 , pp. 1631-1636
    • Doria-Rose, N.A.1
  • 18
    • 84869155712 scopus 로고    scopus 로고
    • Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape
    • Moore, P.L. et al. Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape. Nat. Med. 18, 1688-1692 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1688-1692
    • Moore, P.L.1
  • 19
    • 84946576244 scopus 로고    scopus 로고
    • Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies
    • Bhiman, J.N. et al. Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies. Nat. Med. 21, 1332-1336 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 1332-1336
    • Bhiman, J.N.1
  • 20
    • 84899991983 scopus 로고    scopus 로고
    • Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
    • Doria-Rose, N.A. et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature 509, 55-62 (2014).
    • (2014) Nature , vol.509 , pp. 55-62
    • Doria-Rose, N.A.1
  • 21
    • 84876797103 scopus 로고    scopus 로고
    • Coevolution of a broadly neutralizing HIV-1 antibody and founder virus
    • Liao, H.X. et al. Coevolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature 496, 469-476 (2013).
    • (2013) Nature , vol.496 , pp. 469-476
    • Liao, H.X.1
  • 22
    • 80052942203 scopus 로고    scopus 로고
    • Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing
    • Wu, X. et al. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science 333, 1593-1602 (2011).
    • (2011) Science , vol.333 , pp. 1593-1602
    • Wu, X.1
  • 23
    • 84887270287 scopus 로고    scopus 로고
    • Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes
    • Wibmer, C.K. et al. Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes. PLoS Pathog. 9, e1003738 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003738
    • Wibmer, C.K.1
  • 24
    • 84938808649 scopus 로고    scopus 로고
    • The broad neutralizing antibody responses after HIV-1 superinfection are not dominated by antibodies directed to epitopes common in single infection
    • Cortez, V. et al. The broad neutralizing antibody responses after HIV-1 superinfection are not dominated by antibodies directed to epitopes common in single infection. PLoS Pathog. 11, e1004973 (2015).
    • (2015) PLoS Pathog. , vol.11 , pp. e1004973
    • Cortez, V.1
  • 25
    • 84941703210 scopus 로고    scopus 로고
    • Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising
    • Luo, S. & Perelson, A.S. Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising. Proc. Natl. Acad. Sci. USA 112, 11654-11659 (2015).
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 11654-11659
    • Luo, S.1    Perelson, A.S.2
  • 26
    • 70349298392 scopus 로고    scopus 로고
    • Breadth of neutralizing antibody response to human immunodefciency virus type 1 is affected by factors early in infection but does not infuence disease progression
    • Piantadosi, A. et al. Breadth of neutralizing antibody response to human immunodefciency virus type 1 is affected by factors early in infection but does not infuence disease progression. J. Virol. 83, 10269-10274 (2009).
    • (2009) J. Virol. , vol.83 , pp. 10269-10274
    • Piantadosi, A.1
  • 27
    • 84898538468 scopus 로고    scopus 로고
    • Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection
    • Derdeyn, C.A., Moore, P.L. & Morris, L. Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection. Curr. Opin. HIV AIDS 9, 210-216 (2014).
    • (2014) Curr. Opin. HIV AIDS , vol.9 , pp. 210-216
    • Derdeyn, C.A.1    Moore, P.L.2    Morris, L.3
  • 28
    • 84885743368 scopus 로고    scopus 로고
    • FH cells are highly functional and correlate with broadly neutralizing HIV antibody responses
    • FH cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity 39, 758-769 (2013).
    • (2013) Immunity , vol.39 , pp. 758-769
    • Locci, M.1
  • 29
    • 78149370844 scopus 로고    scopus 로고
    • Cohort profle: The Swiss HIV Cohort study
    • Schoeni-Affolter, F. et al. Cohort profle: the Swiss HIV Cohort study. Int. J. Epidemiol. 39, 1179-1189 (2010).
    • (2010) Int. J. Epidemiol. , vol.39 , pp. 1179-1189
    • Schoeni-Affolter, F.1
  • 30
    • 81855211496 scopus 로고    scopus 로고
    • Characterization of human immunodefciency virus type 1 (HIV-1) diversity and tropism in 145 patients with primary HIV-1 infection
    • Rieder, P. et al. Characterization of human immunodefciency virus type 1 (HIV-1) diversity and tropism in 145 patients with primary HIV-1 infection. Clin. Infect. Dis. 53, 1271-1279 (2011).
    • (2011) Clin. Infect. Dis. , vol.53 , pp. 1271-1279
    • Rieder, P.1
  • 31
    • 1842296349 scopus 로고    scopus 로고
    • + lymphocytes as prognostic markers of HIV-1 infection
    • + lymphocytes as prognostic markers of HIV-1 infection. Ann. Intern. Med. 126, 946-954 (1997).
    • (1997) Ann. Intern. Med. , vol.126 , pp. 946-954
    • Mellors, J.W.1
  • 32
    • 4644219803 scopus 로고    scopus 로고
    • Deliberate removal of T cell help improves virus-neutralizing antibody production
    • Recher, M. et al. Deliberate removal of T cell help improves virus-neutralizing antibody production. Nat. Immunol. 5, 934-942 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 934-942
    • Recher, M.1
  • 33
    • 84929247213 scopus 로고    scopus 로고
    • Immune system regulation in the induction of broadly neutralizing HIV-1 antibodies
    • Kelsoe, G., Verkoczy, L. & Haynes, B.F. immune system regulation in the induction of broadly neutralizing HIV-1 antibodies. Vaccines (Basel) 2, 1-14 (2014).
    • (2014) Vaccines (Basel) , vol.2 , pp. 1-14
    • Kelsoe, G.1    Verkoczy, L.2    Haynes, B.F.3
  • 34
    • 79951832982 scopus 로고    scopus 로고
    • Ambiguous nucleotide calls from population-based sequencing of HIV-1 are a marker for viral diversity and the age of infection
    • Kouyos, R.D. et al. Ambiguous nucleotide calls from population-based sequencing of HIV-1 are a marker for viral diversity and the age of infection. Clin. Infect. Dis. 52, 532-539 (2011).
    • (2011) Clin. Infect. Dis. , vol.52 , pp. 532-539
    • Kouyos, R.D.1
  • 35
    • 0032710838 scopus 로고    scopus 로고
    • Consistent viral evolutionary changes associated with the progression of human immunodefciency virus type 1 infection
    • Shankarappa, R. et al. Consistent viral evolutionary changes associated with the progression of human immunodefciency virus type 1 infection. J. Virol. 73, 10489-10502 (1999).
    • (1999) J. Virol. , vol.73 , pp. 10489-10502
    • Shankarappa, R.1
  • 36
    • 77951882045 scopus 로고    scopus 로고
    • Molecular epidemiology reveals long-term changes in HIV type 1 subtype B transmission in Switzerland
    • Kouyos, R.D. et al. Molecular epidemiology reveals long-term changes in HIV type 1 subtype B transmission in Switzerland. J. Infect. Dis. 201, 1488-1497 (2010).
    • (2010) J. Infect. Dis. , vol.201 , pp. 1488-1497
    • Kouyos, R.D.1
  • 37
    • 80052417284 scopus 로고    scopus 로고
    • The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland
    • von Wyl, V. et al. The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland. J. Infect. Dis. 204, 1095-1103 (2011).
    • (2011) J. Infect. Dis. , vol.204 , pp. 1095-1103
    • Von Wyl, V.1
  • 38
    • 9444255221 scopus 로고    scopus 로고
    • Demographic factors that infuence the neutralizing antibody response in recipients of recombinant HIV-1 gp120 vaccines
    • Montefori, D.C. et al. Demographic factors that infuence the neutralizing antibody response in recipients of recombinant HIV-1 gp120 vaccines. J. Infect. Dis. 190, 1962-1969 (2004).
    • (2004) J. Infect. Dis. , vol.190 , pp. 1962-1969
    • Montefori, D.C.1
  • 39
    • 84883381602 scopus 로고    scopus 로고
    • Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains
    • Chuang, G.Y. et al. Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains. J. Virol. 87, 10047-10058 (2013).
    • (2013) J. Virol. , vol.87 , pp. 10047-10058
    • Chuang, G.Y.1
  • 40
    • 84877618448 scopus 로고    scopus 로고
    • Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization
    • Georgiev, I.S. et al. Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization. Science 340, 751-756 (2013).
    • (2013) Science , vol.340 , pp. 751-756
    • Georgiev, I.S.1
  • 41
    • 84902131373 scopus 로고    scopus 로고
    • Early development of broadly neutralizing antibodies in HIV-1-infected infants
    • Goo, L., Chohan, V., Nduati, R. & Overbaugh, J. Early development of broadly neutralizing antibodies in HIV-1-infected infants. Nat. Med. 20, 655-658 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 655-658
    • Goo, L.1    Chohan, V.2    Nduati, R.3    Overbaugh, J.4
  • 42
    • 84921606536 scopus 로고    scopus 로고
    • Insights into the trimeric HIV-1 envelope glycoprotein structure
    • Ward, A.B. & Wilson, I.A. Insights into the trimeric HIV-1 envelope glycoprotein structure. Trends Biochem. Sci. 40, 101-107 (2015).
    • (2015) Trends Biochem. Sci. , vol.40 , pp. 101-107
    • Ward, A.B.1    Wilson, I.A.2
  • 43
    • 84934915200 scopus 로고    scopus 로고
    • Assessing the paradox between transmitted and acquired HIV type 1 drug resistance mutations in the Swiss HIV Cohort Study from 1998 to 2012
    • Yang, W.L. et al. Assessing the paradox between transmitted and acquired HIV type 1 drug resistance mutations in the Swiss HIV Cohort Study from 1998 to 2012. J. Infect. Dis. 212, 28-38 (2015).
    • (2015) J. Infect. Dis. , vol.212 , pp. 28-38
    • Yang, W.L.1
  • 44
    • 77951879238 scopus 로고    scopus 로고
    • HIV-1 transmission after cessation of early antiretroviral therapy among men having sex with men
    • Rieder, P. et al. HIV-1 transmission after cessation of early antiretroviral therapy among men having sex with men. AIDS 24, 1177-1183 (2010).
    • (2010) AIDS , vol.24 , pp. 1177-1183
    • Rieder, P.1
  • 45
    • 84864921292 scopus 로고    scopus 로고
    • Genetic diversity as a marker for timing infection in HIV-infected patients: Evaluation of a 6-month window and comparison with BED
    • Ragonnet-Cronin, M. et al. Genetic diversity as a marker for timing infection in HIV-infected patients: evaluation of a 6-month window and comparison with BED. J. Infect. Dis. 206, 756-764 (2012).
    • (2012) J. Infect. Dis. , vol.206 , pp. 756-764
    • Ragonnet-Cronin, M.1
  • 46
    • 84879405000 scopus 로고    scopus 로고
    • Evaluation of sequence ambiguities of the HIV-1 pol gene as a method to identify recent HIV-1 infection in transmitted drug resistance surveys
    • Andersson, E. et al. Evaluation of sequence ambiguities of the HIV-1 pol gene as a method to identify recent HIV-1 infection in transmitted drug resistance surveys. Infect. Genet. Evol. 18, 125-131 (2013).
    • (2013) Infect. Genet. Evol. , vol.18 , pp. 125-131
    • Andersson, E.1
  • 47
    • 53849134195 scopus 로고    scopus 로고
    • A joint back-calculation model for the imputation of the date of HIV infection in a prevalent cohort
    • Taffé, P. & May, M. A joint back-calculation model for the imputation of the date of HIV infection in a prevalent cohort. Stat. Med. 27, 4835-4853 (2008).
    • (2008) Stat. Med. , vol.27 , pp. 4835-4853
    • Taffé, P.1    May, M.2
  • 48
    • 0027122957 scopus 로고
    • 1993 Revised classifcation system for HIV infection and expanded surveillance case defnition for AIDS among adolescents and adults
    • CDC
    • Castro, K.G. et al. 1993 Revised classifcation system for HIV infection and expanded surveillance case defnition for AIDS among adolescents and adults. MMWR 41, RR-17 (CDC, 1992).
    • (1992) MMWR , vol.41 , pp. RR-17
    • Castro, K.G.1
  • 49
    • 0037456827 scopus 로고    scopus 로고
    • Antibody neutralization and escape by HIV-1
    • Wei, X. et al. Antibody neutralization and escape by HIV-1. Nature 422, 307-312 (2003).
    • (2003) Nature , vol.422 , pp. 307-312
    • Wei, X.1
  • 50
    • 84979866871 scopus 로고    scopus 로고
    • CATNAP: A tool to compile, analyze and tally neutralizing antibody panels
    • Yoon, H. et al. CATNAP: a tool to compile, analyze and tally neutralizing antibody panels. Nucleic Acids Res. 43, W213-W219 (2015).
    • (2015) Nucleic Acids Res. , vol.43 , pp. W213-W219
    • Yoon, H.1
  • 51
    • 79960346105 scopus 로고    scopus 로고
    • Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies
    • Rusert, P. et al. Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies. J. Exp. Med. 208, 1419-1433 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1419-1433
    • Rusert, P.1
  • 52
    • 77958115264 scopus 로고    scopus 로고
    • A limited number of antibody specifcities mediate broad and potent serum neutralization in selected HIV-1-infected individuals
    • Walker, L.M. et al. A limited number of antibody specifcities mediate broad and potent serum neutralization in selected HIV-1-infected individuals. PLoS Pathog. 6, e1001028 (2010).
    • (2010) PLoS Pathog. , vol.6 , pp. e1001028
    • Walker, L.M.1
  • 53
    • 79551518897 scopus 로고    scopus 로고
    • Characteristics of the earliest cross-neutralizing antibody response to HIV-1
    • Mikell, I. et al. Characteristics of the earliest cross-neutralizing antibody response to HIV-1. PLoS Pathog. 7, e1001251 (2011).
    • (2011) PLoS Pathog. , vol.7 , pp. e1001251
    • Mikell, I.1
  • 54
    • 56449131391 scopus 로고    scopus 로고
    • Profling the specifcity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodefciency virus type 1 subtypes B and C
    • Binley, J.M. et al. Profling the specifcity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodefciency virus type 1 subtypes B and C. J. Virol. 82, 11651-11668 (2008).
    • (2008) J. Virol. , vol.82 , pp. 11651-11668
    • Binley, J.M.1
  • 55
    • 34249950588 scopus 로고    scopus 로고
    • Dissecting the neutralizing antibody specifcities of broadly neutralizing sera from human immunodefciency virus type 1-infected donors
    • Dhillon, A.K. et al. Dissecting the neutralizing antibody specifcities of broadly neutralizing sera from human immunodefciency virus type 1-infected donors. J. Virol. 81, 6548-6562 (2007).
    • (2007) J. Virol. , vol.81 , pp. 6548-6562
    • Dhillon, A.K.1
  • 56
    • 84907993259 scopus 로고    scopus 로고
    • Impact of clade, geography and age of the epidemic on HIV-1 neutralization by antibodies
    • Hraber, P. et al. Impact of clade, geography and age of the epidemic on HIV-1 neutralization by antibodies. J. Virol. 88, 12623-12643 (2014).
    • (2014) J. Virol. , vol.88 , pp. 12623-12643
    • Hraber, P.1
  • 57
    • 84892365659 scopus 로고    scopus 로고
    • Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection
    • Hraber, P. et al. Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection. AIDS 28, 163-169 (2014).
    • (2014) AIDS , vol.28 , pp. 163-169
    • Hraber, P.1
  • 59
    • 84950632109 scopus 로고
    • Objective criteria for evaluation of clustering methods
    • Rand, W.M. Objective criteria for evaluation of clustering methods. J. Am. Stat. Assoc. 66, 846-850 (1971).
    • (1971) J. Am. Stat. Assoc. , vol.66 , pp. 846-850
    • Rand, W.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.