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Volumn 45, Issue 5, 2016, Pages 1135-1147

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

(31)  De Simone, Marco a   Arrigoni, Alberto a   Rossetti, Grazisa a   Gruarin, Paola a   Ranzani, Valeria a   Politano, Claudia a   Bonnal, Raoul J P a   Provasi, Elena a   Sarnicola, Maria Lucia a   Panzeri, Ilaria a   Moro, Monica a   Crosti, Mariacristina a   Mazzara, Saveria a   Vaira, Valentina a,b,c   Bosari, Silvano b,c   Palleschi, Alessandro b   Santambrogio, Luigi b,c   Bovo, Giorgio d   Zucchini, Nicola d   Totis, Mauro d   more..


Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD134 ANTIGEN; CD30 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR8; COMPLEMENTARY DNA; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1 RECEPTOR TYPE II; LAYN PROTEIN; MAGEH1 PROTEIN; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; TRANSCRIPTION FACTOR NFAT5; UNCLASSIFIED DRUG; TRANSCRIPTOME;

EID: 84999673353     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.10.021     Document Type: Article
Times cited : (520)

References (56)
  • 2
    • 84874741556 scopus 로고    scopus 로고
    • CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data
    • Bindea, G., Galon, J., Mlecnik, B., CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data. Bioinformatics 29 (2013), 661–663.
    • (2013) Bioinformatics , vol.29 , pp. 661-663
    • Bindea, G.1    Galon, J.2    Mlecnik, B.3
  • 4
    • 0032547737 scopus 로고    scopus 로고
    • Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles
    • Borowsky, M.L., Hynes, R.O., Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles. J. Cell Biol. 143 (1998), 429–442.
    • (1998) J. Cell Biol. , vol.143 , pp. 429-442
    • Borowsky, M.L.1    Hynes, R.O.2
  • 5
    • 84905966344 scopus 로고    scopus 로고
    • Biochemical signaling of PD-1 on T cells and its functional implications
    • Boussiotis, V.A., Chatterjee, P., Li, L., Biochemical signaling of PD-1 on T cells and its functional implications. Cancer J. 20 (2014), 265–271.
    • (2014) Cancer J. , vol.20 , pp. 265-271
    • Boussiotis, V.A.1    Chatterjee, P.2    Li, L.3
  • 7
    • 79251500661 scopus 로고    scopus 로고
    • Phenotypical and functional specialization of FOXP3+ regulatory T cells
    • Campbell, D.J., Koch, M.A., Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat. Rev. Immunol. 11 (2011), 119–130.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 119-130
    • Campbell, D.J.1    Koch, M.A.2
  • 9
    • 79953747613 scopus 로고    scopus 로고
    • CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3
    • Chen, J., Yao, Y., Gong, C., Yu, F., Su, S., Chen, J., Liu, B., Deng, H., Wang, F., Lin, L., et al. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 19 (2011), 541–555.
    • (2011) Cancer Cell , vol.19 , pp. 541-555
    • Chen, J.1    Yao, Y.2    Gong, C.3    Yu, F.4    Su, S.5    Chen, J.6    Liu, B.7    Deng, H.8    Wang, F.9    Lin, L.10
  • 10
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
    • Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S.E., Benoist, C., Mathis, D., PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 486 (2012), 549–553.
    • (2012) Nature , vol.486 , pp. 549-553
    • Cipolletta, D.1    Feuerer, M.2    Li, A.3    Kamei, N.4    Lee, J.5    Shoelson, S.E.6    Benoist, C.7    Mathis, D.8
  • 11
    • 84861039642 scopus 로고    scopus 로고
    • Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
    • Duhen, T., Duhen, R., Lanzavecchia, A., Sallusto, F., Campbell, D.J., Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood 119 (2012), 4430–4440.
    • (2012) Blood , vol.119 , pp. 4430-4440
    • Duhen, T.1    Duhen, R.2    Lanzavecchia, A.3    Sallusto, F.4    Campbell, D.J.5
  • 12
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: impact on clinical outcome
    • Fridman, W.H., Pagès, F., Sautès-Fridman, C., Galon, J., The immune contexture in human tumours: impact on clinical outcome. Nat. Rev. Cancer 12 (2012), 298–306.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pagès, F.2    Sautès-Fridman, C.3    Galon, J.4
  • 13
    • 84956607773 scopus 로고    scopus 로고
    • Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents
    • Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., Kroemer, G., Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. Cancer Cell 28 (2015), 690–714.
    • (2015) Cancer Cell , vol.28 , pp. 690-714
    • Galluzzi, L.1    Buqué, A.2    Kepp, O.3    Zitvogel, L.4    Kroemer, G.5
  • 16
    • 84935883931 scopus 로고    scopus 로고
    • Colorectal Cancer Biomarkers: Where Are We Now?
    • Gonzalez-Pons, M., Cruz-Correa, M., Colorectal Cancer Biomarkers: Where Are We Now?. BioMed Res. Int., 2015, 2015, 149014.
    • (2015) BioMed Res. Int. , vol.2015 , pp. 149014
    • Gonzalez-Pons, M.1    Cruz-Correa, M.2
  • 19
    • 84947483881 scopus 로고    scopus 로고
    • Immune Checkpoint Modulation in Colorectal Cancer: What's New and What to Expect
    • Jacobs, J., Smits, E., Lardon, F., Pauwels, P., Deschoolmeester, V., Immune Checkpoint Modulation in Colorectal Cancer: What's New and What to Expect. J. Immunol. Res., 2015, 2015, 158038.
    • (2015) J. Immunol. Res. , vol.2015 , pp. 158038
    • Jacobs, J.1    Smits, E.2    Lardon, F.3    Pauwels, P.4    Deschoolmeester, V.5
  • 21
    • 84898681799 scopus 로고    scopus 로고
    • Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
    • Joller, N., Lozano, E., Burkett, P.R., Patel, B., Xiao, S., Zhu, C., Xia, J., Tan, T.G., Sefik, E., Yajnik, V., et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 40 (2014), 569–581.
    • (2014) Immunity , vol.40 , pp. 569-581
    • Joller, N.1    Lozano, E.2    Burkett, P.R.3    Patel, B.4    Xiao, S.5    Zhu, C.6    Xia, J.7    Tan, T.G.8    Sefik, E.9    Yajnik, V.10
  • 22
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • Josefowicz, S.Z., Lu, L.F., Rudensky, A.Y., Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 30 (2012), 531–564.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 23
    • 84903574951 scopus 로고    scopus 로고
    • Bayesian approach to single-cell differential expression analysis
    • Kharchenko, P.V., Silberstein, L., Scadden, D.T., Bayesian approach to single-cell differential expression analysis. Nat. Methods 11 (2014), 740–742.
    • (2014) Nat. Methods , vol.11 , pp. 740-742
    • Kharchenko, P.V.1    Silberstein, L.2    Scadden, D.T.3
  • 24
    • 84944460796 scopus 로고    scopus 로고
    • Colorectal cancer: the first neoplasia found to be under immunosurveillance and the last one to respond to immunotherapy?
    • Kroemer, G., Galluzzi, L., Zitvogel, L., Fridman, W.H., Colorectal cancer: the first neoplasia found to be under immunosurveillance and the last one to respond to immunotherapy?. OncoImmunology, 4, 2015, e1058597.
    • (2015) OncoImmunology , vol.4 , pp. e1058597
    • Kroemer, G.1    Galluzzi, L.2    Zitvogel, L.3    Fridman, W.H.4
  • 26
    • 82455167972 scopus 로고    scopus 로고
    • PD-L2 is predominantly expressed by Th2 cells
    • Lesterhuis, W.J., Steer, H., Lake, R.A., PD-L2 is predominantly expressed by Th2 cells. Mol. Immunol. 49 (2011), 1–3.
    • (2011) Mol. Immunol. , vol.49 , pp. 1-3
    • Lesterhuis, W.J.1    Steer, H.2    Lake, R.A.3
  • 28
    • 80051940011 scopus 로고    scopus 로고
    • PD-L2 is expressed on activated human T cells and regulates their function
    • Messal, N., Serriari, N.E., Pastor, S., Nunès, J.A., Olive, D., PD-L2 is expressed on activated human T cells and regulates their function. Mol. Immunol. 48 (2011), 2214–2219.
    • (2011) Mol. Immunol. , vol.48 , pp. 2214-2219
    • Messal, N.1    Serriari, N.E.2    Pastor, S.3    Nunès, J.A.4    Olive, D.5
  • 29
    • 84947804600 scopus 로고    scopus 로고
    • Immune suppressive mechanisms in the tumor microenvironment
    • Munn, D.H., Bronte, V., Immune suppressive mechanisms in the tumor microenvironment. Curr. Opin. Immunol. 39 (2016), 1–6.
    • (2016) Curr. Opin. Immunol. , vol.39 , pp. 1-6
    • Munn, D.H.1    Bronte, V.2
  • 30
    • 84879689439 scopus 로고    scopus 로고
    • Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks
    • Murphy, T.L., Tussiwand, R., Murphy, K.M., Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks. Nat. Rev. Immunol. 13 (2013), 499–509.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 499-509
    • Murphy, T.L.1    Tussiwand, R.2    Murphy, K.M.3
  • 31
    • 77954721060 scopus 로고    scopus 로고
    • Regulatory T cells in tumor immunity
    • Nishikawa, H., Sakaguchi, S., Regulatory T cells in tumor immunity. Int. J. Cancer 127 (2010), 759–767.
    • (2010) Int. J. Cancer , vol.127 , pp. 759-767
    • Nishikawa, H.1    Sakaguchi, S.2
  • 33
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D.M., The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12 (2012), 252–264.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 34
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs, K.S., Quezada, S.A., Chambers, C.A., Korman, A.J., Allison, J.P., Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J. Exp. Med. 206 (2009), 1717–1725.
    • (2009) J. Exp. Med. , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 36
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi, S., Yamaguchi, T., Nomura, T., Ono, M., Regulatory T cells and immune tolerance. Cell 133 (2008), 775–787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 38
    • 84871124115 scopus 로고    scopus 로고
    • A converse 4-1BB and CD40 ligand expression pattern delineates activated regulatory T cells (Treg) and conventional T cells enabling direct isolation of alloantigen-reactive natural Foxp3+ Treg
    • Schoenbrunn, A., Frentsch, M., Kohler, S., Keye, J., Dooms, H., Moewes, B., Dong, J., Loddenkemper, C., Sieper, J., Wu, P., et al. A converse 4-1BB and CD40 ligand expression pattern delineates activated regulatory T cells (Treg) and conventional T cells enabling direct isolation of alloantigen-reactive natural Foxp3+ Treg. J. Immunol. 189 (2012), 5985–5994.
    • (2012) J. Immunol. , vol.189 , pp. 5985-5994
    • Schoenbrunn, A.1    Frentsch, M.2    Kohler, S.3    Keye, J.4    Dooms, H.5    Moewes, B.6    Dong, J.7    Loddenkemper, C.8    Sieper, J.9    Wu, P.10
  • 39
    • 22144451076 scopus 로고    scopus 로고
    • Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes
    • Schutyser, E., Richmond, A., Van Damme, J., Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. J. Leukoc. Biol. 78 (2005), 14–26.
    • (2005) J. Leukoc. Biol. , vol.78 , pp. 14-26
    • Schutyser, E.1    Richmond, A.2    Van Damme, J.3
  • 40
    • 84878936788 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
    • Selby, M.J., Engelhardt, J.J., Quigley, M., Henning, K.A., Chen, T., Srinivasan, M., Korman, A.J., Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol. Res. 1 (2013), 32–42.
    • (2013) Cancer Immunol. Res. , vol.1 , pp. 32-42
    • Selby, M.J.1    Engelhardt, J.J.2    Quigley, M.3    Henning, K.A.4    Chen, T.5    Srinivasan, M.6    Korman, A.J.7
  • 41
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
    • Sharma, P., Allison, J.P., Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161 (2015), 205–214.
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 43
    • 84952638542 scopus 로고    scopus 로고
    • Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy
    • Śledzińska, A., Menger, L., Bergerhoff, K., Peggs, K.S., Quezada, S.A., Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy. Mol. Oncol. 9 (2015), 1936–1965.
    • (2015) Mol. Oncol. , vol.9 , pp. 1936-1965
    • Śledzińska, A.1    Menger, L.2    Bergerhoff, K.3    Peggs, K.S.4    Quezada, S.A.5
  • 45
    • 78049243425 scopus 로고    scopus 로고
    • Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth
    • Teng, M.W., Ngiow, S.F., von Scheidt, B., McLaughlin, N., Sparwasser, T., Smyth, M.J., Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer Res. 70 (2010), 7800–7809.
    • (2010) Cancer Res. , vol.70 , pp. 7800-7809
    • Teng, M.W.1    Ngiow, S.F.2    von Scheidt, B.3    McLaughlin, N.4    Sparwasser, T.5    Smyth, M.J.6
  • 46
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: a common denominator approach to cancer therapy
    • Topalian, S.L., Drake, C.G., Pardoll, D.M., Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27 (2015), 450–461.
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 49
    • 84860436621 scopus 로고    scopus 로고
    • Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial
    • van den Eertwegh, A.J., Versluis, J., van den Berg, H.P., Santegoets, S.J., van Moorselaar, R.J., van der Sluis, T.M., Gall, H.E., Harding, T.C., Jooss, K., Lowy, I., et al. Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol. 13 (2012), 509–517.
    • (2012) Lancet Oncol. , vol.13 , pp. 509-517
    • van den Eertwegh, A.J.1    Versluis, J.2    van den Berg, H.P.3    Santegoets, S.J.4    van Moorselaar, R.J.5    van der Sluis, T.M.6    Gall, H.E.7    Harding, T.C.8    Jooss, K.9    Lowy, I.10
  • 50
    • 84885121967 scopus 로고    scopus 로고
    • Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function
    • Voo, K.S., Bover, L., Harline, M.L., Vien, L.T., Facchinetti, V., Arima, K., Kwak, L.W., Liu, Y.J., Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function. J. Immunol. 191 (2013), 3641–3650.
    • (2013) J. Immunol. , vol.191 , pp. 3641-3650
    • Voo, K.S.1    Bover, L.2    Harline, M.L.3    Vien, L.T.4    Facchinetti, V.5    Arima, K.6    Kwak, L.W.7    Liu, Y.J.8
  • 52
    • 84940732703 scopus 로고    scopus 로고
    • The MAGE protein family and cancer
    • Weon, J.L., Potts, P.R., The MAGE protein family and cancer. Curr. Opin. Cell Biol. 37 (2015), 1–8.
    • (2015) Curr. Opin. Cell Biol. , vol.37 , pp. 1-8
    • Weon, J.L.1    Potts, P.R.2
  • 53
    • 84867095369 scopus 로고    scopus 로고
    • Mining SOM expression portraits: feature selection and integrating concepts of molecular function
    • Wirth, H., von Bergen, M., Binder, H., Mining SOM expression portraits: feature selection and integrating concepts of molecular function. BioData Min., 5, 2012, 18.
    • (2012) BioData Min. , vol.5 , pp. 18
    • Wirth, H.1    von Bergen, M.2    Binder, H.3
  • 56
    • 84880747672 scopus 로고    scopus 로고
    • Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance
    • Zitvogel, L., Galluzzi, L., Smyth, M.J., Kroemer, G., Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity 39 (2013), 74–88.
    • (2013) Immunity , vol.39 , pp. 74-88
    • Zitvogel, L.1    Galluzzi, L.2    Smyth, M.J.3    Kroemer, G.4


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