Poly(lactic acid) blends in biomedical applications

Advanced Drug Delivery Reviews

Volumn 107, Issue , 2016, Pages 47-59

  Saini, P ^a   Arora, M ^a   Kumar, M N V Ravi ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Biocompatible; Biodegradable; Blends; Drug delivery; Tissue engineering

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADABILITY; BLENDING; CONTROLLED DRUG DELIVERY; DEGRADATION; DRUG DELIVERY; LACTIC ACID; MEDICAL APPLICATIONS; NATURAL POLYMERS; TARGETED DRUG DELIVERY; TISSUE; TISSUE ENGINEERING;

BIOCOMPATIBLE; BIODEGRADABLE; BIOMEDICAL APPLICATIONS; POLY LACTIC ACID; PROCESSING TECHNIQUE; SLOW DEGRADATION; SYNTHETIC POLYMERS; TARGET APPLICATION;

POLYMERIC IMPLANTS;

BIOMATERIAL; DRUG CARRIER; POLYLACTIC ACID; POLYMER; SOLVENT; LACTIC ACID; POLYESTER; POLYLACTIDE;

BIOCOMPATIBILITY; BIODEGRADABILITY; BIOMEDICINE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COMMERCIAL PHENOMENA; DEGRADATION; DRUG DELIVERY SYSTEM; HYDROPHOBICITY; IMPLANT; LOW IMPACT TOUGHNESS; MECHANICAL STRENGTH; PHYSICAL PARAMETERS; PRIORITY JOURNAL; PROCESSABILITY; REVIEW; SUTURE; SYNTHESIS; THERMODYNAMICS; TISSUE ENGINEERING; CHEMISTRY; HUMAN;

BIOCOMPATIBLE MATERIALS; DRUG DELIVERY SYSTEMS; HUMANS; LACTIC ACID; POLYESTERS; POLYMERS; TISSUE ENGINEERING;

EID: 84998995926     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2016.06.014     Document Type: Review

References (193)

1. [1] Conn, R.E., Kolstad, J.J., Borzelleca, J.F., Dixler, D.S., Filer, L.J. Jr., LaDu, B.N. Jr., Pariza, M.W., Safety assessment of polylactide (PLA) for use as a food-contact polymer. Food Chem. Toxicol. 33 (1995), 273–283.
2. [2] Sodergard, A., Stolt, M., Properties of lactic acid based polymers and their correlation with composition. Prog. Polym. Sci. 27 (2002), 1123–1163.
3. [3] Chanfreau, S., Mena, M., Porras-Domingues, J.R., Ramirez-Gilly, M., Gimeno, M., Roquero, P., Tecante, A., Barzana, E., Enzymatic synthesis of poly-L-lactide and poly-L-lactide-co-glycolide in an ionic liquid. Bioprocess Biosyst. Eng. 33 (2010), 629–638.
4. [4] Omay, D., Guvenilir, Y., Synthesis and characterization of poly(D,L-lactic acid) via enzymatic ring opening polymerization by using free and immobilized lipase. Biocatal. Biotransform. 31 (2013), 132–140.
5. [5] Zeng, J.B., Li, K.A., Du, A.K., Compatibilization strategies in poly(lactic acid)-based blends. RSC Adv. 5 (2015), 32546–32565.
6. [6] Zhang, W., Wang, Y., Synthesis and properties of high molecular weight poly(lactic acid) and its resultant fibers. Chin. J. Polym. Sci. 26 (2008), 425–432.
7. [7] Lu, L., Mikos, A.G., Poly(lactic acid). Mark, J.E., (eds.) Polymer Data Handbook, 1999, Oxford University Press, New York, 627–633.
8. [8] Garlotta, D., A literature review of poly(lactic acid). J. Polym. Environ. 9 (2001), 63–84.
9. [9] Xiao, L., Wang, B., Yang, G., Gauthier, M., Modification of PLA. Ghista, D.N., (eds.) Biomedical Science, Engineering and Technology, 2012, InTech, Rijeka, Croatia, 255–259.
10. [10] Pawar, R.P., Tekale, S.U., Shisodia, S.U., Totre, J.T., Domb, A.J., Biomedical applications of poly(lactic acid). Recent Pat. Regen. Med. 4 (2014), 40–51.
11. [11] Averous, L., Polylactic acid: synthesis, properties and applications. Belgacem, M.N., Gandini, A., (eds.) Monomers, Polymers and Composites From Renewable Resources, 2008, Elsevier, Oxford, 433–450.
12. [12] Auras, R.A., Lim, L.T., Selke, S.E.M., Tsuji, H., Poly(lactic acid): synthesis, structures, properties, processing and applications. Grossman, R.F., Nwabunma, D., (eds.) Wiley Series in Polymer Engineering and Technology, 2010, John Wiley & Sons, Hoboken.
13. [13] Lasprilla, A.J., Martinez, G.A., Lunelli, B.H., Jardini, A.L., Filho, R.M., Poly-lactic acid synthesis for application in biomedical devices — a review. Biotechnol. Adv. 30 (2012), 321–328.
14. [14] Athanasiou, K.A., Agrawal, C.M., Barber, F.A., Burkhart, S.S., Orthopaedic applications for PLA–PGA biodegradable polymers. Arthroscopy 14 (1998), 726–737.
15. [15] Kfoury, G., Raquez, J.M., Hassouna, F., Odent, J., Toniazzo, V., Ruch, D., Dubois, P., Recent advances in high performance poly(lactide): from “green” plasticization to super-tough materials via (reactive) compounding. Front. Chem., 1, 2013, 32.
16. [16] Nair, N.R., Nampoothiri, K.M., Pandey, A., Preparation of poly(L-lactide) blends and biodegradation by Lentzea waywayandensis. Biotechnol. Lett. 34 (2012), 2031–2035.
17. [17] Takayama, T., Todo, M., Tsuji, H., Effect of annealing on the mechanical properties of PLA/PCL and PLA/PCL/LTI polymer blends. J. Mech. Behav. Biomed. Mater. 4 (2011), 255–260.
18. [18] Tang, X., Thankappan, S.K., Lee, P., Fard, S.E., Harmon, M.D., Tran, K., Yu, X., Natural polymers in tissue engineering and regenerative medicine. Kumar, S.G., Laurencin, C.T., DEng, M., (eds.) Natural and Synthetic Biomedical Polymers, 2014, Elsevier, Burlington, MA, 352–358.
19. [19] Sionkowska, A., Introduction. Dumitriu, S., Popa, V., (eds.) Polymeric Biomaterials: Structure and Function, 2013, CRC Press, Boca Raton, FL, 311.
20. [20] Armentano, I., Fortunati, E., Burgos, N., Dominici, F., Luzi, F., Fiori, S., Jimenez, A., Yoon, K., Ahn, J., Kang, S., Kenny, J.M., Processing and characterization of plasticized PLA/PHB blends for biodegradable multiphase systems. Express Polym Lett 9 (2015), 583–596.
21. [21] Song, J.J., Chang, H.H., Naguib, H.E., Biocompatible shape memory polymer actuators with high force capabilities. Eur. Polym. J. 67 (2015), 186–198.
22. [22] Mi, H.Y., Salick, M.R., Jing, X., Jacques, B.R., Crone, W.C., Peng, X.F., Turng, L.S., Characterization of thermoplastic polyurethane/polylactic acid (TPU/PLA) tissue engineering scaffolds fabricated by microcellular injection molding. Mater. Sci. Eng. C Mater. Biol. Appl. 33 (2013), 4767–4776.
23. [23] Song, J.J., Chang, H.H., Naguib, H.E., Design and characterization of biocomaptible shape memory polymer (SMP) blend foams with a dynamic structure. Polymer 56 (2015), 86–92.
24. [24] Sankaran, K.K., Krishnan, U.M., Sethuraman, S., Axially aligned 3D nanofibrous grafts of PLA–PCL for small diameter cardiovascular applications. J. Biomater. Sci. Polym. Ed. 25 (2014), 1791–1812.
25. [25] Sun, M., Kingham, P.J., Reid, A.J., Armstrong, S.J., Terenghi, G., Downes, S., In vitro and in vivo testing of novel ultrathin PCL and PCL/PLA blend films as peripheral nerve conduit. J. Biomed. Mater. Res. A 93 (2010), 1470–1481.
26. [26] Ramdhanie, L.I., Aubuchon, S.R., Boland, E.D., Knapp, D.C., Barnes, C.P., Simpson, D.G., Wnek, G.E., Bowlin, G.L., Thermal and mechanical characterization of electrospun blends of poly(lactic acid) and poly(glycolic acid). Polym. J. 38 (2006), 1137–1145.
27. [27] Mainaedes, R.M., Khalil, N.M., Gremiao, M.P.D., Intranasal delivery of zidovudine by PLA and PLA–PEG blend nanoparticles. Int. J. Pharm. 395 (2010), 266–271.
28. 2 foaming and particle leaching. Polym. Eng. Sci. 55 (2015), 1339–1348.
29. [29] Wu, C.S., Liao, H.T., A new biodegradable blends prepared from polylactide and hyaluronic acid. Polymer 46 (2005), 10017–10026.
30. [30] Boonkong, W., Petsom, A., Thongchul, N., Rapidly stopping hemorrhage by enhancing blood clotting at an opened wound using chitosan/polylactic acid/polycaprolactone wound dressing device. J. Mater. Sci. 24 (2013), 1581–1593.
31. [31] Domenek, S., Louaifi, A., Guinault, A., Baumberger, S., Potential of lignins as antioxidant additive in active biodegradable packaging materials. J. Polym. Environ. 21 (2013), 692–701.
32. [32] Zhong, B., Al-Saigh, Z.Y., Characterization of biodegradable polymers by inverse gas chromatography. III. Blends of amylopectin and poly(L-lactide). J. Appl. Polym. Sci. 123 (2012), 2616–2627.
33. [33] dong, Q., Bian, Y., Li, Y., Han, C., Dong, L., Miscibility and crystallisation behaviors of stereocomplex-type poly(L- and D-lactide)/poly(methyl methacrylate) blends. J. Therm. Anal. 118 (2014), 359–367.
34. [34] Hao, X., Kaschta, J., Liu, X., Pan, Y., Shubert, D.W., Entanglement network formed in miscible PLA/PMMA blends and its role in rheological thermo-mechanical properties of the blends. Polymer 80 (2015), 38–45.
35. [35] van de Witte, P., Dijkstra, P.J., van den Berg, J.W.A., Feijen, J., Phase separation processes in polymer solutions in relation to membrane formation. J. Membr. 117 (1996), 1–31.
36. [36] Robeson, L., Historical perspective of advances in the science and technology of polymer blends. Polymers 6 (2014), 1251–1265.
37. [37] Li, S.H., Woo, E.M., Immiscibility–miscibility phase transitions in blends of poly(L-lactide) with poly(methyl methacrylate). Polym. Int. 57 (2008), 1242–1251.
38. [38] Arrighi, V., Cowie, J.M.G., Furhman, S., Abdelsallem, Y., Miscibility criterion in polymer blend and its determination. Isayev, A.I., (eds.) Encyclopedia of Polymer Blends, 2010, Wiley-VCH Verlag GmbH & Co., Weinheim, Germany, 158.
39. [39] Dil, E.J., Carreau, P.J., Favis, B.D., Morphology, miscibility and continuity development in poly(lactic acid)/poly(butylene adipate-co-terephthalate) blends. Polymer 68 (2015), 202–212.
40. [40] Hashim, N., Rerenam, K., Somderam, S., Yousoh, K., Effect of processing method on thermal behavior in PLA/PEG melt blending. Adv. Mater. Res. 1134 (2016), 185–190.
41. [41] Miuller, P., Imre, B., Bere, J., Moczo, J., Pukanszsky, B., Physical ageing and molecular mobility in PLA blends and composites. J. Therm. Anal. 122 (2015), 1423–1433.
42. [42] Zhang, G., Zhang, J., Wang, S., Shen, D., Miscibility and phase structure of binary blends of polylactide and poly(methyl methacryalte). J. Polym. Sci. B Polym. Phys. 41 (2003), 23–30.
43. [43] Lu, S., Gu, J., Cao, J., Tan, H., Zhang, Y., Effect of annealing on the thermal properties of poly(lactic acid)/starch blends. Int. J. Biol. Macromol. 74 (2015), 297–303.
44. [44] Anakabe, J., Huici, A.M.Z., Eceiza, A., Arbelaiz, A., Melt blending of polylactide and poly(methylmethacrylate): thermal and mechanical properties and phase morphology characterization. J. Appl. Polym. Sci. 132 (2015), 42677–42685.
45. [45] Jing, X., Mi, H.Y., Peng, X.F., Turng, L.-S., The morphology, properties, and shape memory behavior of polylactic acid/thermoplastic polyurethane blends. Polym. Eng. Sci. 55 (2015), 70–80.
46. [46] Zhao, H., Zhao, G., Mechanical and thermal properties of conventional and microcellular injection molded (lactic acid)/poly(ε-caprolactone) blends. J. Mech. Behav. Biomed. Mater. 53 (2016), 59–67.
47. [47] Ferri, J.M., Fenollar, O., Jorda-Vilaplana, A., Garcia-Sanoguera, D., Balart, R., Effect of miscibility on mechanical and thermal properties of poly(lactic acid)/polycaprolactone blends. Polym. Int. 65 (2016), 453–463.
48. [48] Yang, Y., Tang, Z., Xiong, Z., Zhu, J., Preparation and characterization of thermoplastic starches and their blends with poly(lactic acid). Int. J. Biol. Macromol. 77 (2015), 273–279.
49. [49] Shirai, M.A., Olivato, J.B., Garcia, P.S., Muller, C.M., Grossmann, M.V., Yamashita, F., Thermoplastic starch/polyester films: effects of extrusion process and poly(lactic acid) addition. Mater. Sci. Eng. C Mater. Biol. Appl. 33 (2013), 4112–4117.
50. [50] Shirai, M.A., Grossmann, M.V., Mali, S., Yamashita, F., Garcia, P.S., Muller, C.M., Development of biodegradable flexible films of starch and poly(lactic acid) plasticized with adipate or citrate esters. Carbohydr. Polym. 92 (2013), 19–22.
51. [51] Preechawong, D., Peesan, M., Supaphol, P., Rujiravanit, R., Preparation and characterization of starch/poly(L-lactic acid) hybrid foams. Carbohydr. Polym. 59 (2005), 329–337.
52. [52] Wootthikanokkkan, J., Wongta, N., Sombatsompop, N., Kositchaiyong, A., Wong-On, J., Ayutthaya, S.I.n., Kaabbuathong, N., Effect of blending conditions on mechanical, thermal, and rheological properties of plasticized poly(lactic acid)/maleated thermoplastic strach blends. J. Appl. Polym. Sci. 124 (2012), 1012–1019.
53. [53] Zhang, J., Jiang, L., Zhu, L., Morphology and properties of soy protein and polylactide blends. Biomacromolecules 7 (2006), 1551–1561.
54. [54] Imre, B., Pukanszky, B., Compatibilization in bio-based and biodegradable polymer blends. Eur. Polym. J. 49 (2013), 1215–1233.
55. [55] Yu, L., Petinakis, E., Dean, K., Liu, H., Yuan, Q., Enhancing compatibilizer function by controlled distribution in hydrophobic polylactic acid/hydrophilic starch blends. J. Appl. Polym. Sci. 119 (2011), 2189–2195.
56. [56] Wypych, G., Expectations from plasticizers. Wypych, G., (eds.) Handbook of Plasticizers, 2012, ChemTec Publishing, Toronto, 2–4.
57. [57] Sungsanit, K., Kao, N., Bhattacharya, S.N., Properties of linear poly(lactic acid)/polyethylene glycol blends. Polym. Eng. Sci. 52 (2011), 108–116.
58. [58] Byung-Sik, P., Song, J.C., Park, D.H., Yoon, K.-B., PLA/chain extended PEG blends with improved ductility. J. Appl. Polym. Sci. 123 (2011), 2360–2367.
59. [59] Zubrowska, A., Piorkowska, E., Kowalewska, A., Cichorek, M., Novel blends of polylactide with ethylene glycol derivatives of POSS. Colloid Polym. Sci. 293 (2015), 23–33.
60. [60] Jia, Z., Tan, J., Han, C., Yang, Y., Dong, L., Poly(ethylene glycol-co-propylene glycol) as a macromolecular plasticizing agent for polylactide: thermomechanical properties and aging. J. Appl. Polym. Sci. 114 (2009), 1105–1117.
61. [61] Li, H.Z., Chen, S.C., Wang, Y.Z., Thermoplastic PVA/PLA blends with improved processability and hydrophobicity. Ind. Eng. Chem. Res. 53 (2014), 17355–17361.
62. [62] Clasen, S.H., Muller, C.M.O., Pires, A.T.N., Maleic anhydride as a compatibilizer and plasticizer in TPS/PLA blends. J. Braz. Chem. Soc. 26 (2015), 1583–1590.
63. [63] Jaso, V., Glenn, G., Klamczynski, A., Petrovic, Z.S., Biodegradability study of polylactic acid/thermoplastic polyurethane blends. Polym. Test. 47 (2015), 1–3.
64. [64] Malwela, T., Ray, S.S., Enzymatic degradation behavior of nanoclay reinforced biodegradable PLA/PBSA blend composites. Int. J. Biol. Macromol. 77 (2015), 131–142.
65. [65] Vieira, A.F.C., Modeling hydrolytic degradation of PLA devices: chemistry, research and applications. Piemonte, V., (eds.) Polylactic Acid: Synthesis, Properties and Applications, 2012, Nova Science Publishers.
66. [66] Shasteen, C., Choy, Y., Controlling degradation rate of poly(lactic acid) for its biomedical applications. Biomed. Eng. Lett. 1 (2011), 163–167.
67. [67] Tsuji, H., Poly(lactide) stereocomplexes: formation, structure, properties, degradation, and applications. Macromol. Biosci. 5 (2005), 569–597.
68. [68] Viera, A.C., Guedes, R.M., Tita, V., Damage-induces hydrolyses modelling of biodegradable polymers for tendons and ligaments repair. J. Biomech. 48 (2015), 3478–3485.
69. [69] Cai, Q., Bei, J., Wang, S., In vitro study on the drug release behavior from polylactide-based blend matrices. Polym. Adv. Technol. 13 (2002), 534–540.
70. [70] Kim, Y., Dalhaimer, P., Christian, D.A., Discher, D.E., Polymeric worm micelles as nano-carriers for drug delivery. Nanotechnology 16 (2005), S484–S491.
71. [71] Zhu, X., Zhong, T., Huang, R., Wan, A., Preparation of hydrophilic poly(lactid acid) tissue engineering scaffold via (PLA)–(PLA-β-PEG)-(PEG) solution casting and thermal induced surface structural transformation. J. Biomater. Sci. Polym. Ed. 26 (2015), 1286–1296.
72. [72] Yue, M., Chian, K.S., Polymer blending. Cheremisinoff, N.P., (eds.) Multiphase Reactor and Polymerization System Hydrodynamics, 1996, Gulf Publishing Company, Houston, TX, 749.
73. [73] Shaw, M.T., Casting from common solvents. Walsh, D.J., Higgins, J.S., Maconnachie, A., (eds.) Polymer Blends and Mixtures, 1985, Martinus Nijhoff, Dordecht, 60.
74. [74] Famri, L., Migliaresi, C., Fibers. Auras, R., Lim, L.T., Selke, S.E.M., Tsuji, H., (eds.) Poly(lactic acid): Synthesis, Properties, Processing and Application, 2010, John Wiley & Sons Inc., Hoboken, NJ, 119–121.
75. [75] Yolles, S., Leafe, T.D., Woodland, J.H., Meyer, F.J., Long acting delivery systems for narcotic antagonists II: release rates of naltrexone from poly(lactic acid) composites. J. Pharm. Sci. 64 (1975), 348–349.
76. [76] Woodland, J.H., Yolles, S., Blake, D.A., Helrich, M., Meyer, F.J., Long-acting delivery systems for narcotic antagonists. J. Med. Chem. 16 (1973), 897–901.
77. [77] Park, T.G., Cohen, S., Langer, R., Controlled protein release from polyethyleneimine-coated poly(L-lactic acid)/pluronic blend matrices. Pharm. Res. 9 (1992), 37–39.
78. [78] Ljungberg, N., Wesslen, B., Preparation and properties of plasticized poly(lactic acid) films. Biomacromolecules 6 (2005), 1789–1796.
79. [79] Kenawy el, R., Bowlin, G.L., Mansfield, K., Layman, J., Simpson, D.G., Sanders, E.H., Wnek, G.E., Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. J. Control. Release 81 (2002), 57–64.
80. [80] Bie, P., Liu, P., Yu, L., Li, X., Chen, L., Xie, F., The properties of antimicrobial films derived from poly(lactic acid)/starch/chitosan blended matrix. Carbohydr. Polym. 98 (2013), 959–966.
81. [81] Kulkarni, R.K., Moore, E.G., Hegyeli, A.F., Leonard, F., Biodegradable poly(lactic acid) polymers. J. Biomed. Mater. Res. 5 (1971), 169–181.
82. [82] Kim, H.W., Yu, H.S., Lee, H.H., Nanofibrous matrices of poly(lactic acid) and gelatin polymeric blends for the improvement of cellular responses. J. Biomed. Mater. Res. A 87 (2008), 25–32.
83. [83] Hossain, K.M., Hasan, M.S., Boyd, D., Rudd, C.D., Ahmed, I., Thielemans, W., Effect of cellulose nanowhiskers on surface morphology, mechanical properties, and cell adhesion of melt-drawn polylactic acid fibers. Biomacromolecules 15 (2014), 1498–1506.
84. [84] Peesan, M., Rujiravanit, R., Supaphol, P., Electrospinning of hexanoyl chitosan/polylactide blends. J. Biomater. Sci. Polym. Ed. 17 (2006), 547–565.
85. [85] Xiong, X., Li, Q., Lu, J.W., Guo, Z.X., Sun, Z.H., Yu, J., Fibrous scaffolds made by co-electrospinning soluble eggshell membrane protein with biodegradable synthetic polymers. J. Biomater. Sci. Polym. Ed. 23 (2012), 1217–1230.
86. [86] He, Y., Hu, Z., Ren, M., Ding, C., Chen, P., Gu, Q., Wu, Q., Evaluation of PHBHHx and PHBV/PLA fibers used as medical sutures. J. Mater. Sci. Mater. Med. 25 (2014), 561–571.
87. [87] Goffin, A.L., Habibi, Y., Raquez, J.M., Dubois, P., Polyester-grafted cellulose nanowhiskers: a new approach for tuning the microstructure of immiscible polyester blends. ACS Appl. Mater. Interfaces 4 (2012), 3364–3371.
88. [88] Valarezo, E., Tammaro, L., Malagon, O., Gonzalez, S., Armijos, C., Vittoria, V., Fabrication and characterization of poly(lactic acid)/poly(epsilon–caprolactone) blend electrospun fibers loaded with amoxicillin for tunable delivering. J. Nanosci. Nanotechnol. 15 (2015), 4706–4712.
89. [89] Mohamed, F., Van der Walle, C.F., Engineering biodegradable polyester particles with specific drug targeting and drug release properties. J. Pharm. Sci. 97 (2008), 71–87.
90. [90] Lassalle, V., Farreira, M.L., PLA nano- and microparticles for drug delivery: An overview of methods of preparation. Micromol. Biosci. 7 (2007), 767–783.
91. [91] Salerno, A., Levato, R., Mateos-Timoneda, M.A., Engel, E., Netti, P.A., Planell, J.A., Modular polylactic acid microparticle-based scaffolds prepared via microfluidic emulsion/solvent displacement process: fabrication, characterization, and in vitro mesenchymal stem cells interaction study. J. Biomed. Mater. Res. A 101 (2013), 720–732.
92. [92] Ma, G., Microencapsulation of protein drugs for drug delivery: strategy, preparation, and applications. J. Control. Release 193 (2014), 324–340.
93. [93] Hadinoto, K., Sundaresan, A., Cheow, W.S., Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review. Eur. J. Pharm. Biopharm. 85 (2013), 427–443.
94. [94] Wang, W., Chen, S., Zhang, L., Wu, X., Wang, J., Chen, J.F., Le, Y., Poly(lactic acid)/chitosan hybrid nanoparticles for controlled release of anticancer drug. Mater. Sci. Eng. C Mater. Biol. Appl. 46 (2015), 514–520.
95. [95] Das, G.S., Rao, G.H., Wilson, R.F., Chandy, T., Colchicine encapsulation within poly(ethylene glycol)-coated poly(lactic acid)/poly(epsilon–caprolactone) microspheres-controlled release studies. Drug Deliv. 7 (2000), 129–138.
96. [96] Lindner Gda, R., Dalmolin, L.F., Khalil, N.M., Mainardes, R.M., Influence of the formulation parameters on the particle size and encapsulation efficiency of resveratrol in PLA and PLA-PEG blend nanoparticles: a factorial design. J. Nanosci. Nanotechnol. 15 (2015), 10173–10182.
97. [97] Perez, E., Benito, M., Teijon, C., Olmo, R., Teijon, J.M., Blanco, M.D., Tamoxifen-loaded nanoparticles based on a novel mixture of biodegradable polyesters: characterization and in vitro evaluation as sustained release systems. J. Microencapsul. 29 (2012), 309–322.
98. [98] Sahoo, S.K., Panda, A.K., Labhasetwar, V., Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells. Biomacromolecules 6 (2005), 1132–1139.
99. [99] Min, N.G., Kim, B., Lee, T.Y., Kim, D., Lee, D.C., Kim, S.H., Anisotropic microparticles created by phase separation of polymer blends confined in monodisperse emulsion drops. Langmuir 31 (2015), 937–943.
100. [100] Sacchetin, P.S., Setti, R.F., Rosa Pde, T., Moraes, A.M., Properties of PLA/PCL particles as vehicles for oral delivery of the androgen hormone 17-alpha-methyltestosterone. Mater. Sci. Eng. C Mater. Biol. Appl. 58 (2016), 870–881.
101. [101] Takami, T., Murakami, Y., Development of PEG-PLA/PLGA microparticles for pulmonary drug delivery prepared by a novel emulsification technique assisted with amphiphilic block copolymers. Colloids Surf. B: Biointerfaces 87 (2011), 433–438.
102. [102] Cai, Q., Yang, J., Bei, J., Wang, S., A novel porous cells scaffold made of polylactide–dextran blend by combining phase-separation and particle-leaching techniques. Biomaterials 23 (2002), 4483–4492.
103. [103] Sadiasa, A., Nguyen, T.H., Lee, B.T., In vitro and in vivo evaluation of porous PCL–PLLA 3D polymer scaffolds fabricated via salt leaching method for bone tissue engineering applications. J. Biomater. Sci. Polym. Ed. 25 (2014), 150–167.
104. [104] Xiang, Z., Sarazin, P., Favis, B.D., Controlling burst and final drug release times from porous polylactide devices derived from co-continuous polymer blends. Biomacromolecules 10 (2009), 2053–2066.
105. [105] Bhamidipati, M., Scurto, A.M., Detamore, M.S., The future of carbon dioxide for polymer processing in tissue engineering. Tissue Eng. B Rev. 19 (2013), 221–232.
106. 2 batch foamed poly(lactic acid)/poly(ethylene glycol) scaffold for tissue engineering application. J. Appl. Polym. Sci., 2013, 3066–3073.
107. [107] Zhou, C., Ma, L., Li, W., Yao, D., Fabrication of tissue engineering scaffolds through solid-state foaming of immiscible polymer blends. Biofabrication, 3, 2011, 045003.
108. [108] Kola, I., Landis, J., Can the pharmaceutical industry reduce attrition rates. Nat. Rev. Drug Discov. 3 (2004), 711–716.
109. [109] Waring, M.J., Arrowsmith, J., Leach, A.R., Leeson, P.D., Mandrell, S., Owen, R.M., Pairaudeau, G., Pennie, W.D., Pickett, S.D., Wang, J., Wallace, O., Weir, A., An analysis of the attrition of drug candidates from four major pharmaceutical companies. Nat. Rev. Drug Discov. 14 (2015), 475–486.
110. [110] Davis, S.S., Illum, L., Drug delivery systems for challenging molecules. Int. J. Pharm. 176 (1998), 1–8.
111. [111] Horspool, K.R., Lipinski, C.A., Enabling strategies: advancing new drug delivery concepts to gain the lead. J. Drug Deliv. Sci. Technol. 3 (2003), 34–46.
112. [112] Tan, D.S., Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat. Chem. Biol. 1 (2005), 74–84.
113. [113] Dong, Y., Feng, S.S., Nanoparticles of poly(D,L-lactide)/methoxy poly(ethylene glycol)-poly(D,L-lactide) blends for controlled release of paclitaxel. J. Biomed. Mater. Res. A 78 (2006), 12–19.
114. [114] Grande, R., Carvalho, A.J., Compatible ternary blends of chitosan/poly(vinyl alcohol)/poly(lactic acid) produced by oil-in-water emulsion processing. Biomacromolecules 12 (2011), 907–914.
115. [115] Betancourt, T., Byrne, J.D., Sunaryo, N., Crowder, S.W., Kadapakkam, M., Patel, S., Casciato, S., Brannon-Peppas, L., PEGylation strategies for active targeting of PLA/PLGA nanoparticles. J. Biomed. Mater. Res. A 91 (2009), 263–276.
116. [116] Gref, R., Minamitake, Y., Peracchia, M.T., Trubetskoy, V., Torchilin, V., Langer, R., Biodegradable long-circulating polymeric nanospheres. Science 263 (1994), 1600–1603.
117. [117] Italia, J.L., Bhardwaj, V., Kumar, M.N.V., Disease, destination, dose and delivery aspects of ciclosporin: the state of the art. Drug Discov. Today 11 (2006), 846–854.
118. [118] Mitragotri, S., Burke, P.A., Langer, R., Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nat. Rev. Drug Discov. 13 (2014), 655–672.
119. [119] Aggarwal, P., Hall, J.B., McLeland, C.B., Dobrovolskaia, M.A., McNeil, S.E., Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv. Drug Deliv. Rev. 61 (2009), 428–437.
120. [120] Nottelet, B., Darcos, V., Coudane, J., Aliphatic polyesters for medical imaging and theranostic applications. Eur. J. Pharm. Biopharm. 97:Part B (2015), 350–370.
121. [121] Kamaly, N., Xiao, Z., Valencia, P.M., Radovic-Moreno, A.F., Farokhzad, O.C., Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem. Soc. Rev. 41 (2012), 2971–3010.
122. [122] Zhang, Q., Ko, N.R., Oh, J.K., Recent advances in stimuli-responsive degradable block copolymer micelles: synthesis and controlled drug delivery applications. Chem. Commun. (Camb.) 48 (2012), 7542–7552.
123. [123] Zhao, J., Mi, Y., Liu, Y., Feng, S.S., Quantitative control of targeting effect of anticancer drugs formulated by ligand-conjugated nanoparticles of biodegradable copolymer blend. Biomaterials 33 (2012), 1948–1958.
124. [124] Pan, J., Feng, S.S., Targeted delivery of paclitaxel using folate-decorated poly(lactide)-vitamin E TPGS nanoparticles. Biomaterials 29 (2008), 2663–2672.
125. [125] Cunningham, A., Ko, N.R., Oh, J.K., Synthesis and reduction-responsive disassembly of PLA-based mono-cleavable micelles. Colloids Surf. B: Biointerfaces 122 (2014), 693–700.
126. [126] Yu, Y., Chen, C.K., Law, W.C., Weinheimer, E., Sengupta, S., Prasad, P.N., Cheng, C., Polylactide-graft-doxorubicin nanoparticles with precisely controlled drug loading for pH-triggered drug delivery. Biomacromolecules 15 (2014), 524–532.
127. [127] Mura, S., Nicolas, J., Couvreur, P., Stimuli-responsive nanocarriers for drug delivery. Nat. Mater. 12 (2013), 991–1003.
128. [128] Cheng, C.J., Tietjen, G.T., Saucier-Sawyer, J.K., Saltzman, W.M., A holistic approach to targeting disease with polymeric nanoparticles. Nat. Rev. Drug Discov. 14 (2015), 239–247.
129. [129] Prabhakar, M.N., Sudhakara, P., Subha, M.C.S., Rao, K.C., Song, J.I., Novel thermoresponsive biodegradable nanocomposite hydrogels for dual function in biomedical applications. Polym.-Plast. Technol. Eng. 54 (2015), 1704–1714.
130. [130] Zhong, T., Deng, C., Gao, Y., Chen, M., Zuo, B., Studies of in situ-forming hydrogels by blending PLA–PEG–PLA copolymer with silk fibroin solution. J. Biomed. Mater. Res. A 100 (2012), 1983–1989.
131. [131] Kenawy, E.-R., Bowlin, G.L., Mansfield, K., Layman, J., Simpson, D.G., Sanders, E.H., Wnek, G.E., Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. J. Control. Release, 81, 2002, 57.
132. [132] Boonkong, W., Petsom, A., Thongchul, N., Rapidly stopping hemorrhage by enhancing blood clotting at an opened wound using chitosan/polylactic acid/polycaprolactone wound dressing device. J. Mater. Sci. Mater. Med. 24 (2013), 1581–1593.
133. [133] Taylor, C.J., Paclitaxel attachment to PLA–PHA blend films. Technical Papers, Regional Technical Conference — Society of Plastics Engineers, 2008, 912–916.
134. [134] Gwan Park, T., Cohen, S., Langer, R., Controlled protein release from polyethyleneimine-coated poly(L-lactic acid)/pluronic blend matrices. Pharm. Res. 9 (1992), 37–39.
135. [135] Haroosh, H.J., Dong, Y., Ingram, G.D., Synthesis, morphological structures, and material characterization of electrospun PLA:PCL/magnetic nanoparticle composites for drug delivery. J. Polym. Sci. B Polym. Phys. 51 (2013), 1607–1617.
136. [136] Haroosh, H., Dong, Y., Lau, K., Tetracycline hydrochloride (TCH)-loaded drug carrier based on PLA:PCL nanofibre mats: experimental characterisation and release kinetics modelling. J. Mater. Sci. 49 (2014), 6270–6281.
137. [137] Valarezo, E., Tammaro, L., Gonzalez, S., Malagon, O., Vittoria, V., Fabrication and sustained release properties of poly(ε-caprolactone) electrospun fibers loaded with layered double hydroxide nanoparticles intercalated with amoxicillin. Appl. Clay Sci. 72 (2013), 104–109.
138. [138] Liu, X., Lei, L., Hou, J.W., Tang, M.F., Guo, S.R., Wang, Z.M., Chen, K.M., Evaluation of two polymeric blends (EVA/PLA and EVA/PEG) as coating film materials for paclitaxel-eluting stent application. J. Mater. Sci. Mater. Med. 22 (2011), 327–337.
139. [139] Chitrattha, S., Phaechamud, T., Porous poly(DL-lactic acid) matrix film with antimicrobial activities for wound dressing application. Mater. Sci. Eng. C 58 (2016), 1122–1130.
140. [140] Siafaka, P.I., Barmbalexis, P., Bikiaris, D.N., Novel electrospun nanofibrous matrices prepared from poly(lactic acid)/poly(butylene adipate) blends for controlled release formulations of an anti-rheumatoid agent. Eur. J. Pharm. Sci. 88 (2016), 12–25.
141. [141] Lu, H.W., Nie, Q.L., Liu, G.Q., He, H., Synthesis of biodegradable chitosan-poly(D,L-lactide) hybrid amphiphiles via ring opening graft polymerization for efficient gene carrier. J. Macromol. Sci. A 50 (2013), 738–746.
142. [142] Fu, C., Sun, X., Liu, D., Chen, Z., Lu, Z., Zhang, N., Biodegradable tri-block copolymer poly(lactic acid)-poly(ethylene glycol)-poly(L-lysine)(PLA–PEG–PLL) as a non-viral vector to enhance gene transfection. Int. J. Mol. Sci. 12 (2011), 1371–1388.
143. [143] Nadeau, V., Hildgen, P., AFM study of a new carrier based on PLA and salen copolymers for gene therapy. Molecules 10 (2005), 105–113.
144. [144] Qian, X., Long, L., Shi, Z., Liu, C., Qiu, M., Sheng, J., Pu, P., Yuan, X., Ren, Y., Kang, C., Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma. Biomaterials 35 (2014), 2322–2335.
145. [145] Gaspar, V.M., Baril, P., Costa, E.C., De Melo-Diogo, D., Foucher, F., Queiroz, J.A., Sousa, F., Pichon, C., Correia, I.J., Bioreducible poly(2-ethyl-2-oxazoline)–PLA–PEI–SS triblock copolymer micelles for co-delivery of DNA minicircles and doxorubicin. J. Control. Release 213 (2015), 175–191.
146. [146] Pfeiffer, D., Stefanitsch, C., Wankhammer, K., Muller, M., Dreyer, L., Krolitzki, B., Zernetsch, H., Glasmacher, B., Lindner, C., Lass, A., Schwarz, M., Muckenauer, W., Lang, I., Endothelialization of electrospun polycaprolactone (PCL) small caliber vascular grafts spun from different polymer blends. J. Biomed. Mater. Res. A 102 (2014), 4500–4509.
147. [147] Kramschuster, A., Turng, L.S., An injection molding process for manufacturing highly porous and interconnected biodegradable polymer matrices for use as tissue engineering scaffolds. J. Biomed. Mater. Res. B Appl. Biomater. 92 (2010), 366–376.
148. [148] Serra, T., Ortiz-Hernandez, M., Engel, E., Planell, J.A., Navarro, M., Relevance of PEG in PLA-based blends for tissue engineering 3D-printed scaffolds. Mater. Sci. Eng. C Mater. Biol. Appl. 38 (2014), 55–62.
149. [149] Shabna, A., Saranya, V., Malathi, J., Shenbagarathai, R., Madhavan, H.N., Indigenously produced polyhydroxyalkanoate based co-polymer as cellular supportive biomaterial. J. Biomed. Mater. Res. A 102 (2014), 3470–3476.
150. [150] Frydrych, M., Román, S., Macneil, S., Chen, B., Biomimetic poly(glycerol sebacate)/poly(L-lactic acid) blend scaffolds for adipose tissue engineering. Acta Biomater. 18 (2015), 40–49.
151. [151] Hamad, K., Kaseem, M., Yang, H.W., Deri, F., Ko, Y.G., Properties and medical applications of polylactic acid: a review. Express Polym Lett 9 (2015), 435–455.
152. [152] Yu, L., Dean, K., Li, L., Polymer blends and composites from renewable resources. Prog. Polym. Sci. 31 (2006), 576–602.
153. [153] Armentano, I., Fortunati, E., Mattioli, S., Rescignano, N., Kenny, J.M., Tissue engineering. Jimenez, A., Peltzer, M.A., Ruseckaite, R.A., (eds.) Poly(lactic acid) Science and Technology, 2015, Royal Society of Chemistry, Cambridge, UK, 266.
154. [154] Adeosun, S.O., Lawal, G.I., Gbenebor, O.P., Characteristics of biodegradable implants. J. Miner. Mater. Charact. Eng. 2 (2014), 88–106.
155. [155] Morita, Y., Saino, H., Tojo, K., Polymer blend implant for ocular delivery of fluorometholone. Biol. Pharm. Bull. 21 (1998), 72–75.
156. [156] Chen, C.C., Chueh, J.Y., Tseng, H., Huang, H.M., Lee, S.Y., Preparation and characterization of biodegradable PLA polymeric blends. Biomaterials 24 (2003), 1167–1173.
157. [157] Garg, S., Bourantas, C., Serruys, P.W., New concepts in the design of drug-eluting coronary stents. Nat. Rev. Cardiol. 10 (2013), 248–260.
158. [158] Gupta, K.K., Pal, N., Mishra, P.K., Srivastava, P., Mohanty, S., Maiti, P., 5-Fluorouracil-loaded poly(lactic acid)–poly(caprolactone) hybrid scaffold: potential chemotherapeutic implant. J. Biomed. Mater. Res. A 102 (2014), 2600–2612.
159. [159] Mc Conville, C., Major, I., Friend, D.R., Clark, M.R., Woolfson, A.D., Malcolm, R.K., Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings. J. Biomed. Mater. Res. B Appl. Biomater. 100 (2012), 891–895.
160. [160] Chen, Y., Yuan, D., Xu, C., Dynamically vulcanized biobased polylactide/natural rubber blend material with continuous cross-linked rubber phase. ACS Appl. Mater. Interfaces 6 (2014), 3811–3816.
161. [161] Fang, H., Jiang, F., Wu, Q., Ding, Y., Wang, Z., Supertough polylactide materials prepared through in situ reactive blending with PEG-based diacrylate monomer. ACS Appl. Mater. Interfaces 6 (2014), 13552–13563.
162. [162] Zhao, Q., Wang, S., Kong, M., Geng, W., Li, R.K., Song, C., Kong, D., Phase morphology, physical properties, and biodegradation behavior of novel PLA/PHBHHx blends. J. Biomed. Mater. Res. B Appl. Biomater. 100 (2012), 23–31.
163. [163] Silverajah, V.S., Ibrahim, N.A., Zainuddin, N., Yunus, W.M., Hassan, H.A., Mechanical, thermal and morphological properties of poly(lactic acid)/epoxidized palm olein blend. Molecules 17 (2012), 11729–11747.
164. [164] Mihai, M., Huneault, M.A., Favis, B.D., Li, H., Extrusion foaming of semi-crystalline PLA and PLA/thermoplastic starch blends. Macromol. Biosci. 7 (2007), 907–920.
165. [165] Kulinski, Z., Piorkowska, E., Gadzinowska, K., Stasiak, M., Plasticization of poly(L-lactide) with poly(propylene glycol). Biomacromolecules 7 (2006), 2128–2135.
166. [166] Jiang, L., Wolcott, M.P., Zhang, J., Study of biodegradable polylactide/poly(butylene adipate-co-terephthalate) blends. Biomacromolecules 7 (2006), 199–207.
167. [167] Dong, W., Zou, B., Yan, Y., Ma, P., Chen, M., Effect of chain-extenders on the properties and hydrolytic degradation behavior of the poly(lactide)/poly(butylene adipate-co-terephthalate) blends. Int. J. Mol. Sci. 14 (2013), 20189–20203.
168. [168] Samuel, C., Cayuela, J., Barakat, I., Muller, A.J., Raquez, J.M., Dubois, P., Stereocomplexation of polylactide enhanced by poly(methyl methacrylate): improved processability and thermomechanical properties of stereocomplexable polylactide-based materials. ACS Appl. Mater. Interfaces 5 (2013), 11797–11807.
169. [169] Ojijo, V., Sinha Ray, S., Sadiku, R., Role of specific interfacial area in controlling properties of immiscible blends of biodegradable polylactide and poly[(butylene succinate)-co-adipate]. ACS Appl. Mater. Interfaces 4 (2012), 6690–6701.
170. [170] Spinella, S., Cai, J., Samuel, C., Zhu, J., McCallum, S.A., Habibi, Y., Raquez, J.M., Dubois, P., Gross, R.A., Polylactide/poly(omega-hydroxytetradecanoic acid) reactive blending: a green renewable approach to improving polylactide properties. Biomacromolecules 16 (2015), 1818–1826.
171. [171] Liu, B., Jiang, L., Zhang, J., Study of effects of processing aids on properties of poly(lactic acid)/soy protein blends. J. Polym. Environ. 19 (2011), 239–247.
172. [172] Zhang, K., Mohanty, A.K., Misra, M., Fully biodegradable and biorenewable ternary blends from polylactide, poly(3-hydroxybutyrate-co-hydroxyvalerate) and poly(butylene succinate) with balanced properties. ACS Appl. Mater. Interfaces 4 (2012), 3091–3101.
173. [173] Nagarajan, V., Zhang, K., Misra, M., Mohanty, A.K., Overcoming the fundamental challenges in improving the impact strength and crystallinity of PLA biocomposites: influence of nucleating agent and mold temperature. ACS Appl. Mater. Interfaces 7 (2015), 11203–11214.
174. [174] Sin, L.T., Rahmat, A.R., Rahman, W.A.W.A., Market potential of biodegradable polymers and PLA. Ebnesajjad, S., (eds.) Handbook of Biopolymers and Biodegradable Plastics: Properties, Processing and Applications, 2013, William Andrew, Elsevier, Waltham, MA, 20.
175. [175] Lunt, J.A., Marketplace Opportunities for Integration of Biobased and Conventional Plastics. 2014, Agricultural Utilization Research Institute.
176. [176] Publications, European bioplastics. European-bioplastics.org, 2016.
177. [177] High heat PLA. corbion.com, 2015.
178. [178] NatureWorks and BioAmber from joint venture to commercialize new bio-based polymers. natureworksllc.com, 2012.
179. [179] Biostrength biopolymer impact mofiers. arkema.com, 2015.
180. [180] SUKANO bio-loy, products. sukano.com, 2015.
181. [181] Ecovio, product finder. basf.com, 2015.
182. [182] Kohn, J.B., Schachter, D.M., Pharmaceutical Formulation Composed of a Polymer Blend and an Active Compound for Time-controlled Release Rutgers. 2014, The State University of New Jersey, USA.
183. [183] Hunter, W.L., Machan, L.S., Arsenault, A.L., Burt, H.M., Jackson, J.J., Dordunoo, S.K., Anti-Angiogenic Nanoparticle Compositions. 2012, Angiotech Pharmaceuticals Inc., USA.
184. [184] Lavik, E., Kwon, Y.H., Kuehn, M., Saluja, S., Bertram, J., Huang, J., Sustained Intraocular Delivery of Drugs From Biodegradable Polymeric Microparticles. 2013, Yale University, University of Iowa Research Foundation, USA.
185. [185] Simpson, D.G., Bowlin, G.L., Wnek, G.E., Stevens, P.J., Carr, M.E., Matthews, J.A., Rajendran, S., Electroprocessed Collagen and Tissue Engineering. 2011, Virginia Commonwealth University Intellectual Property Foundation, USA.
186. [186] Mayes, A.M., Griffith, L.G., Irvine, D.J., Banerjee, P., Johnson, T.D., Comb Copolymers for Regulating Cell-surface Interactions. 2002, Massachusetts Institute of Technology, USA.
187. [187] Contiliano, J.H., Yuan, J.J., Tenhuisen, K.S., Polymer-based Orthopedic Screw and Driver System With Increased Insertion Torque Tolerance and Associated Method for Making and Using Same. 2010, Ethicon Inc., USA.
188. [188] McCarthy, S., Weinzweig, J., Biodegradable Bone Plates and Bonding Systems. 2014, University of Massachusetts Lowell, USA.
189. [189] Brown, M.W.R., Blend of Bioresorbable Polymers. 2003, Smith & Nephew PLC, USA.
190. [190] Schmitz, K.-P., Behrend, D., Sternberg, K., Grabow, N., Martin, D.P., Williams, S.F., Polymeric, Degradable Drug-eluting Stents and Coatings. 2009, Tepha Inc., USA.
191. [191] Bond, E.B., Autran, J.-P.M., Mackey, L.N., Noda, I., O'Donnell, H.J., Fibers Comprising Starch and Biodegradable Polymers. 2005, The Procter & Gamble Company, USA.
192. [192] Mathiowitz, E., Jong, Y.S., Beokelheide, K., Polymeric Gene Delivery System. 2003, Brown University Research Foundation, USA.
193. [193] Mather, P.T., Liu, C., Campo, C.J., Blends of Amorphous and Semicrystalline Polymers Having Shape Memory Properties. 2008, University of Connecticut, USA.