An injection molding process for manufacturing highly porous and interconnected biodegradable polymer matrices for use as tissue engineering scaffolds

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 92, Issue 2, 2010, Pages 366-376

  Kramschuster, Adam ^a   Turng, Lih Sheng ^a  

^a University of Wisconsin Madison   (United States)

Author keywords

Manufacturing; Microcellular injection molding; Porous; Scaffolds; Tissue engineering

Indexed keywords

BIODEGRADABLE POLYMER MATRICES; CONTINUOUS BLENDING; INJECTION MOLDING PROCESS; INTERCONNECTED PORES; INTERCONNECTED STRUCTURES; INTERCONNECTIVITY; LOW PROCESSING TEMPERATURE; MATRIX; MICROCELLULAR INJECTION MOLDING; MOLDABILITY; NOVEL MATERIALS; PARTICULATE LEACHING; POLYLACTIDES; POROUS SCAFFOLD; SCAFFOLDS FOR TISSUE ENGINEERING; SUPERCRITICAL FLUID PROCESSING; SUPERCRITICAL STATE; TEMPERATURE-SENSITIVE; TISSUE ENGINEERING SCAFFOLD; TISSUE GROWTH; ULTRA-HIGH;

BIODEGRADABLE POLYMERS; BLENDING; CARBON DIOXIDE; EFFLUENT TREATMENT; INDUSTRIAL RESEARCH; INJECTION MOLDING; INTERCONNECTION NETWORKS; LEACHING; MICROCELLULAR RADIO SYSTEMS; ORGANIC SOLVENTS; PLASTIC MOLDS; PLASTICIZERS; PROCESSING; SCAFFOLDS; SUPERCRITICAL FLUIDS; TISSUE;

TISSUE ENGINEERING;

CARBON DIOXIDE; POLYLACTIDE; POLYMER; POLYVINYL ALCOHOL; SODIUM CHLORIDE; TISSUE SCAFFOLD;

ARTICLE; BIOCOMPATIBILITY; BIODEGRADABLE IMPLANT; COMPRESSIVE STRENGTH; POROSITY; SURFACE PROPERTY; TEMPERATURE; TENSILE STRENGTH; TISSUE ENGINEERING; TISSUE GROWTH; YOUNG MODULUS;

ABSORBABLE IMPLANTS; ALGORITHMS; CARBON DIOXIDE; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPRESSIVE STRENGTH; GUIDED TISSUE REGENERATION; LACTIC ACID; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; POLYGLYCOLIC ACID; POLYVINYL ALCOHOL; POROSITY; PROSTHESIS DESIGN; SODIUM CHLORIDE; TEMPERATURE; THERMOGRAVIMETRY; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 74749107477     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31523     Document Type: Article

References (57)

1. Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-926.
2. Yang S, Leong K, Du Z, Chua C. The design of scaffolds for use in tissue engineering. I. Traditional factors. Tissue Eng 2001;7:679-689.
3. Thomson RC, Shung AK, Yaszemski MJ, Mikos AG. Polymer scaffold processing. In: Lanza RP, Langer R, Vacanti JP, editors. Principles of Tissue Engineering. San Diego: Academic Press; 2000. pp 251-262.
4. Cheung H, Lau K, Lu T, Hui D. A critical review on polymer-based bio-engineered materials for scaffold development. Composites B 2007;38:291-300.
5. Hutmacher DW. Polymers for medical applications. In: Buschow KHJ, Cahn RW, Flemings MC, Ilschner B, Kramer EJ, Mahajan S, editors. Encyclopedia of Materials: Science and Technology. Oxford: Elsevier Science; 2001. pp 7664-7673.
6. Martina M, Hutmacher DW. Biodegradable polymers applied in tissue engineering research: A review. Polym Int 2007;56:145-157.
7. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000;21:2529-2543.
8. Freed LE, Vunjaknovakovic G, Biron RJ, Eagles DB, Lesnoy DC, Barlow SK, Langer R. Biodegradable polymer scaffolds for tissue engineering. Biotechnology 1994;12:689-693.
9. Whang K, Healy KE, Elenz DR, Nam EK, Tsai DC, Thomas CH, Nuber GW, Glorieux FH, Travers R, Sprague SM. Engineering bone regeneration with bioabsorbable scaffolds with novel microarchitecture. Tissue Eng 1999;5:35-51.
10. Sherwood JK, Riley SL, Palazzolo R, Brown SC, Monkhouse DC, Coates M, Griffith LG, Landeen LK, Ratcliffe A. A three-dimensional osteochondral composite scaffold for articulate cartilage repair. Biomaterials 2002;23:4739-4751.
11. Shao XX, Hutmacher DW, Ho ST, Goh J, Lee EH. Evaluation of a hybrid scaffold/cell construct in repair of high-loadbearing osteochondral defects in rabbits. Biomaterials 2006;27:1071-1080.
12. Karande TS, Ong JL, Agrawal CM. Diffusion in musculoskeletal tissue engineering scaffolds: Design issues related to porosity, permeability, architecture, and nutrient mixing. Ann Biomed Eng 2004;32:1728-1743.
13. Agrawal CM, Ray RB. Biodegradable polymeric scaffolds for muskuloskeletal tissue engineering. J Biomed Mater 2001;55:141-150.
14. Mikos AG, Temenoff JS. Formation of highly porous biodegradable scaffolds for tissue engineering. Electron J Biotech 2000;3:114-119.
15. Middleton JC, Tipton AJ. Synthetic biodegradable polymers as orthopedic devices. Biomaterials 2000;21:2335-2346.
16. Miller RA, Brady JM, Cutright DE. Degradation rates of oral resorbable implants (polylactates and polyglycolates): Rate modification with changes in PLA/PGA copolymer ratios. J Biomed Mater Res 1977;11:711-719.
17. Mooney DJ. Tissue engineering with biodegradable polymer matrices. Southern Biomedical Engineering Conference Proceedings, Dayton, OH, 1996. pp 537-540.
18. Boyan BD, Hummert TW, Dean DD, Schwartz Z. Role of material surfaces in regulating bone and cartilage cell response. Biomaterials 1996;17:137-146.
19. Oh SH, Kang SG, Kim ES, Cho SH, Lee JH. Fabrication and characterization of hydrophilic poly(lactic-co-glycolic acid)/ poly(vinyl alcohol) blend cell scaffolds by melt-molding particulate leaching method. Biomaterials 2003;24:4011-4021.
20. Saltzman WM. Cell Interactions with polymers. In: Lanza RP, Langer R, Vacanti JP, editors. Principles of Tissue Engineering. San Diego: Academic Press; 2000. pp 221-235.
21. Liu X, Ma PX. Polymeric scaffolds for bone tissue engineering. Ann Biomed Eng 2004;32:477-486.
22. Cao Y, Croll TI, Cooper-White JJ, O'Connor AJ, Stevens GW. Production and surface modification of polylactide-based polymeric scaffolds for soft tissue engineering. Methods Mol Biol 2004;238:87-112.
23. Agrawal CM, Carter J, Ong JL. Basics of polymeric scaffolds for tissue engineering. J ASTM Int 2006;3:1-10.
24. Baji A, Wong S-C, Srivatsan TS, Njus GO, Mathur G. Processing methodologies for polycaprolactone-hydroxyapatite composites: A review. Mater Manuf Process 2006;21:211-218.
25. Nerem RM. The challenge of imitating nature. In: Lanza RP, Langer R, Vacanti JP, editors. Principles of Tissue Engineering. San Diego: Academic Press; 2000. pp 9-15.
26. Golstein AS, Zhu GM, Morris GE, Meszlenyi RK, Mikos AG. Effect of osteoblastic culture conditions on the structure of poly(DL-lactic- co-glycolic acid) foam scaffolds. Tissue Eng 1999;5:421-433.
27. Washburn NR, Simon CG Jr, Karim A, Amis EJ. Development of biodegradable polymer scaffolds using co-extrusion. Mater Res Soc Symp Proc 2001;662:LL1.6.1-LL1.6.5.
28. Washburn NR, Simon CG Jr, Tona A, Elgendy HM, Karim A, Amis EJ. Co-extrusion of biocompatible polymers for scaffolds with co-continuous morphology. J Biomed Mater Res 2002;60:20-29.
29. Reignier J, Huneault MA. Preparation of interconnected poly(ε-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching. Polymer 2006;47:4703-4717.
30. Gomes ME, Ribeiro AS, Malafaya PB, Reis RL, Cunha AM. A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: Morphology, mechanical and degradation behaviour. Biomaterials 2001;22:883-889.
31. Neves NM, Kouyumdzhiev A, Reis RL. The morphology, mechanical properties and ageing behavior of porous injection molded starch-based blends for tissue engineering scaffolding. Mater Sci Eng C 2005;25:195-200.
32. Leicher S, Will J, Haugen H, Wintermantel E. MuCell® technology for injection molding: A processing method for polyether-urethane scaffolds. J Mater Sci 2005;40:4613-4618.
33. Haugen H, Will J, Fuchs W, Wintermantel E. A novel processing method for injection-molded polyether-urethane scaffolds, Part 1: Processing. J Biomed Mater Res Part B 2006;77:65-72.
34. Wu L, Jing D, Ding J. A "room-temperature" injection molding/ particulate leaching approach for fabrication of biodegradable three-dimensional porous scaffolds. Biomaterials 2006;27:185-191.
35. Jawalkar SS, Aminabhavi TM. Molecular modeling simulations and thermodynamic approaches to investigate compatibility/ incompatibility of poly(L-lactide) and poly(vinyl alcohol) blends. Polymer 2006;47:8061-8071.
36. Shuai X, He Y, Asakawa N, Inoue Y.Miscibility and phase structure of binary blends of poly(L-lactide) and poly(vinyl alcohol). J Appl Polym Sci 2001;81:762-772.
37. Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R. Preparation and characterization of poly(L-lactic acid) foams. Polymer 1994;35:1068-1077.
38. Ma PX, Choi J-W. Biodegradable polymer scaffold with well-defined interconnected spherical pore network. Tissue Eng 2001;7:23-33.
39. Mikos AG, Georgios S, Leite SM, Vacanti JP, Langer R. Laminated three-dimensional biodegradable foams for use in tissue engineering. Biomaterials 1993;14:323-330.
40. Murphy WL, Dennis RG, Kileny JL, Mooney DJ. Salt fusion: An approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Eng 2002;8:43-52.
41. Widmer MS, Gupta PK, Lu L, Meszlenyi RK, Evans G, Brandt K, Savel T, Gurlek A, Patrick CW Jr, Mikos AG. Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration. Biomaterials 1998;19:1945-1955.
42. Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos AG, Langer R. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J Biomed Mater Res 1993;27:11-23.
43. Okamoto KT. Microcellular Processing. Cincinnati: Hanser Gardner; 2003.
44. Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R. Novel approach to fabricate porous sponges of poly(DL-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials 1996;17:1417-1422.
45. Wang X, Wei L, Kumar V. Solvent free fabrication of biodegradable porous polymers. ASME Manuf Eng Div 2004;15:595-602.
46. Kwag C, Manke CW, Gulari E. Rheology of molten polystyrene with dissolved supercritical and near-critical gases. J Polym Sci Part B: Polym Phys 1999;37:2771-2781.
47. Royer JR, Gay YJ, Desimone JM, Khan SA. High-pressure rheology of polystyrene melts plasticized with CO2: Experimental measurement and predictive scaling relationships. J Polym Sci Part B: Polym Phys 2000;38:3168-3180.
48. Kwag C, Manke CW, Gulari E. Effects of dissolved gas on viscoelastic scaling and glass transition temperature of polystyrene melts. Ind Eng Chem Res 2001;40:3048-3052.
49. Sundararaj U. Phase morphology development in polymer blends: Processing and experimental aspects. In: Harrats C, Thomas S, Groeninck, G, editors. Micro- and Nanostructured Multiphase Polymer Blend Systems. Boca Raton: CRC Press; 2006. pp 133-164.
50. Lu L, Mikos AG. Importance of new processing techniques in tissue engineering. MRS Bull 1996;21:28-32.
51. Omonov TS, Harrats C, Groeninckx G, Moldenaers P. Anisotropy and instability of the co-continuous phase morphology in uncompatibilized and reactively compatibilized polypropylene/polystyrene blends. Polymer 2007;48:5289-5302.
52. Tsuji H, Smith R, Bonfield W, Ikada Y. Porous biodegradable polyesters. I. Preparation of porous poly(L-lactide) films by extraction of poly(ethylene oxide) from their blends. J Appl Polym Sci 2000;75:629-637.
53. Harris LD, Kim B-S, Mooney DJ. Open pore biodegradable matrices formed with gas foaming. J Biomed Mater Res 1998;42:396-402.
54. Riddle KW, Mooney DJ. Role of poly(lactide-co-glycolide) particle size on gas-foamed scaffolds. J Biomed Mater Res Polym Ed 2004;15:1561-1570.
55. Sheridan MH, Shea LD, Peters MC, Mooney DJ. Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J Control Release 2000;64:91-102.
56. Nam YS, Yoon JJ, Park TG. A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive. J Biomed Mater Res Part B 2000;53:1-7.
57. Yoon JJ, Park TG. Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts. J Biomed Mater Res 2001;55:401-408.