Very low-depth sequencing in a founder population identifies a cardioprotective APOC3 signal missed by genome-wide imputation

Human Molecular Genetics

Volumn 25, Issue 11, 2016, Pages 2360-2365

  Gilly, Arthur ^a   Ritchie, Graham Rs ^a,b   Southam, Lorraine ^a,c   Farmaki, Aliki Eleni ^d   Tsafantakis, Emmanouil ^e   Dedoussis, George ^d   Zeggini, Eleftheria ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d HAROKOPIO UNIVERSITY   (Greece)

^e Anogia Health Center   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

TRIACYLGLYCEROL; APOLIPOPROTEIN C3;

APOC3 GENE; ARTICLE; FOUNDER EFFECT; GENE SEQUENCE; GENOME ANALYSIS; GENOTYPE; GREECE; HEART PROTECTION; HUMAN; LOSS OF FUNCTION MUTATION; MARKER GENE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; ALLELE; BLOOD; CARDIOVASCULAR DISEASE; CAUCASIAN; FEMALE; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HIGH THROUGHPUT SEQUENCING; HUMAN GENOME; MALE; META ANALYSIS; MUTATION; PATHOLOGY; POPULATION GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; APOLIPOPROTEIN C-III; CARDIOVASCULAR DISEASES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FOUNDER EFFECT; GENETICS, POPULATION; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GREECE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; TRIGLYCERIDES;

EID: 84998978801     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddw088     Document Type: Article

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