The UK adult twin registry (twinsUK resource)

Twin Research and Human Genetics

Volumn 16, Issue 1, 2013, Pages 144-149

  Moayyeri, Alireza ^a   Hammond, Christopher J ^a   Hart, Deborah J ^a   Spector, Timothy D ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

epigenomics; gene expression analysis; genetic epidemiology; genome wide association studies; genomics; longitudinal studies; metabolomics; microbiomics; next generation sequencing; twin studies

Indexed keywords

RNA;

ARTICLE; BEHAVIOR; BLOOD ANALYSIS; CARDIOVASCULAR DISEASE; CLINICAL FEATURE; DIZYGOTIC TWINS; EPIGENETICS; EXOME; EYE DISEASE; FEMALE; GENE EXPRESSION; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MALE; METABOLIC DISORDER; MONOZYGOTIC TWINS; MUSCULOSKELETAL DISEASE; PHENOTYPE; PRIORITY JOURNAL; QUESTIONNAIRE; REGISTER; RNA SEQUENCE; SOCIOECONOMICS; TELOMERE; UNITED KINGDOM; URINALYSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DISEASES IN TWINS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GREAT BRITAIN; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; REGISTRIES; TWINS; YOUNG ADULT;

EID: 84873889689     PISSN: 18324274     EISSN: None     Source Type: Journal    
DOI: 10.1017/thg.2012.89     Document Type: Article

References (35)

1. Andrew, T., Hart, D.J., Snieder, H., de, L.M., Spector, T.D., & MacGregor, A.J.(2001).Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women.Twin Research, 4, 464-477.
2. Aulchenko, Y.S., Ripatti, S., Lindqvist, I., et al.(2009).Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.Nature Genetics, 41, 47-55.
3. Bell, J.T., & Spector, T.D.(2011).A twin approach to unraveling epigenetics.Trends in Genetics, 27, 116-125.
4. Bell, J.T., Tsai, P.C., Yang, T.P., Pidsley, R., Nisbet, J., Glass, D., & Deloukas, P.(2012).Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.PLoS Genetics, 8, e1002629.
5. Codd, V.,Mangino,M., van derHarst, P., Braund, P.S., Kaiser, M., Beveridge, A.J., & Samani, N.J.(2010).Common variants near TERC are associated with mean telomere length.Nature Genetics, 42, 197-199.
6. Dehghan, A., Dupuis, J., Barbalic,M., Bis, J.C., Eiriksdottir, G., Lu, C., Pellikka, N., & Chasman, D.I.(2011).Metaanalysis of genome-wide association studies in 80 000 subjects identifiesmultiple loci for C-reactive protein levels.Circulation, 123, 731-738.
7. Duffy, D.L., Iles, M.M., Glass, D., Zhu, G., Barrett, J.H., Hoiom, V., & Montgomery, G.W.(2010).IRF4 variants have age-specific effects on nevus count and predispose to melanoma.American Journal of Human Genetics, 87, 6-16.
8. Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A.U., ...Barroso, I., for the MAGIC investigators.(2010).New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.Nature Genetics, 42, 105-116.
9. Elks, C.E., Perry, J.R., Sulem, P., Chasman,D.I., Franceschini, N., He, C., & Murray, A.(2010).Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.Nature Genetics, 42, 1077-1085.
10. Evangelou, E.,Valdes, A.M., Kerkhof,H.J., et al.(2011).Metaanalysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.Annals of the Rheumatic Diseases, 70, 349-355.
11. Ganesh, S.K., Zakai, N.A., van Rooij, F.J., et al.(2009).Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.Nature Genetics, 41, 1191-1198.
12. Grundberg, E., Small, K.S.,Hedman, A.K., Nica, A.C., Buil, A., Keildson, S., ...Spector, T.D.(2012).Mapping cis- and trans-regulatory effects acrossmultiple tissues in twins.Nat.Genet, 44, 1084-1089.
13. Hysi, P.G., Young, T.L.,Mackey,D.A., et al.(2010).Agenomewide association study formyopia andrefractive error identifies a susceptibility locus at 15q25.Nature Genetics, 42, 902-905.
14. Kolz, M., Johnson, T., Sanna, S., et al.(2009).Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.PLoS Genetics, 5, e1000504.
15. Lango, A.H., Estrada, K., Lettre, G., et al.(2010).Hundreds of variants clustered in genomic loci and biological pathways affect human height.Nature, 467, 832-838.
16. Lindgren, C.M., Heid, I.M., Randall, J.C., et al.(2009).Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.PLoS Genetics, 5, e1000508.
17. Mangino, M., Richards, J.B., Soranzo, N., et al.(2009).A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length.Journal of Medical Genetics, 46, 451-454.
18. Moayyeri, A., Hammond, C.J., Hart, D.J., & Spector, T.D.(2012a).Effects of age on genetic influence on bone loss over 17 years in women: the Healthy Ageing Twin Study (HATS).J Bone Miner Res, 27, 2170-2178.
19. Moayyeri, A., Hammond, C.J., Valdes, A.M.., & Spector, T.D.(2012b).Cohort profile: TwinsUK andHealthy Ageing Twin Study.International Journal of Epidemiology.Available online, doi: 10.1093/ije/dyr207.
20. Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, M.D., Bochud, M., Coin, L, & Munroe, P.B.(2009).Genome-wide association study identifies eight loci associated with blood pressure.Nature Genetics, 41, 666-676.
21. Nica, A.C.,Parts,L., Glass,D., Nisbet, J., Barrett,A., Sekowska, M., ...Spector, T.D., & MuTHER Consortium.(2011).The architecture of gene regulatory variation across multiple human tissues: the MuTHER study.PLoS Genetics, 7, e1002003.
22. Nolte, I.M., Wallace, C., Newhouse, S.J., Waggott, D., Fu, J., Soranzo, N., & Bradbury, L.(2009).Common genetic variation near the phospholamban gene is associated with cardiac repolarisation:Meta-analysis of three genome-wide association studies.PLoS One, 4, e6138.
23. Padmanabhan, S.,Melander, O., Johnson, T., Di Blasio, A.M., Lee, W.K., Gentilini, D., & Dominiczak, A.F.(2010).Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.PLoS Genetics, 6, e1001177.
24. Panoutsopoulou, K., Southam, L., Elliott, K.S., Wrayner, N., Zhai, G., Beazley, C., & Loughlin, J.(2011).Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study.Annals of the Rheumatic Diseases, 70, 864-867.
25. Repapi, E., Sayers, I., Wain, L.V., Burton, P.R., Johnson, T., Obeidat, M., & Tobin, M.D.(2010).Genome-wide association study identifies five loci associated with lung function.Nature Genetics, 42, 36-44.
26. Richards, J.B.,Kawoura,F.K., Rivadeneira, F., Styrkarsdottir, U., Estrada,K.,Halldorsson, B.V., ...Spector, T.D., for the GEFOS Consortium.(2009a).Collaborativemeta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture.Annals of InternalMedicine, 151, 528-537.
27. Richards, J.B., Waterworth, D., O'Rahilly, S., Hivert, M.-F., Loos, R.J.F., Perry, J.R.B., ...Spector, T.D., & GIANT Consortium.(2009b).A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.PLoS Genetics, 5, e1000768.
28. Smith, N.L., Chen, M.H., Dehghan, A., Strachan, D.P., Basu, S., Soranzo, N., & O'Donnell, C.J.(2010).Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.Circulation, 121, 1382-1392.
29. Spector, T.D., & Williams, F.M.(2006).The UK Adult Twin Registry (TwinsUK).Twin Research & Human Genetics, 9, 899-906.
30. Speliotes, E.K., Willer, C.J., Berndt, S.I., et al.(2010).Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.Nature Genetics, 42, 937-948.
31. Suhre, K., Shin, S.Y., Petersen, A.K., Monda, K.L., Thorleifsson, G., Jackson, A.U., & Loos, R.J.(2011).Human metabolic individuality in biomedical and pharmaceutical research.Nature, 477, 54-60.
32. Willer, C.J., Speliotes, E.K., Loos, R.J., Li, S., Lindgren, C.M., Heid, I.M., ...Hirschhorn, J.N., & Genetic Investigation of Anthropometric Traits Consortium.(2009).Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.Nature Genetics, 41, 25-34.
33. Zhai, G., Teumer, A., Stolk, L., Perry, J.R., Vandenput, L., Coviello, A.D., & Wallaschofski, H.(2011).Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.PLoS Genetics, 7, e1002025.
34. Zhai, G., van Meurs, J.B., Livshits, G., Meulenbelt, I., Valdes, A.M., Soranzo,N., & Spector, T.D.(2009).A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.Journal of Medical Genetics, 46, 614-616.
35. Zhai, G., Wang-Sattler, R., Hart, D.J., Arden, N.K., Hakim, A.J., Illig, T., & Spector, T.D.(2010).Serum branchedchain amino acid to histidine ratio: A novel metabolomic biomarker of knee osteoarthritis.Annals of the Rheumatic Diseases, 69, 1227-1231.