Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages - a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

Journal for ImmunoTherapy of Cancer

Volumn 4, Issue 1, 2016, Pages

  Montalbán del Barrio, Itsaso ^a   Penski, Cornelia ^b,c   Schlahsa, Laura ^a   Stein, Roland G ^a   Diessner, Joachim ^a   Wöckel, Achim ^a   Dietl, Johannes ^a   Lutz, Manfred B ^a   Mittelbronn, Michel ^b,c   Wischhusen, Jörg ^a   Häusler, Sebastian F M ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

Adenosine; CD39; CD73; Immune escape; Ovarian cancer; Tumor associated macrophages

Indexed keywords

RNA 18S;

ARTICLE; CANCER PROGNOSIS; CELL MIGRATION ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MRNA EXPRESSION ASSAY; NATURAL KILLER CELL; OVARY CANCER; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE;

EID: 84997848422     PISSN: None     EISSN: 20511426     Source Type: Journal    
DOI: 10.1186/s40425-016-0154-9     Document Type: Article

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