Mechanosensitive Gq/11 Protein–Coupled Receptors Mediate Myogenic Vasoconstriction

Microcirculation

Volumn 23, Issue 8, 2016, Pages 621-625

  Mederos y Schnitzler, Michael ^a,b   Storch, Ursula ^a,b   Gudermann, Thomas ^a,b,c  

^a UNIVERSITY OF MUNICH   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^c German Center for Lung Research   (Germany)

Author keywords

GPCRs; mechanosensation; myogenic vasoconstriction

Indexed keywords

ANGIOTENSIN 1A RECEPTOR; ANGIOTENSIN 1B RECEPTOR; ANGIOTENSIN 2 RECEPTOR; CYSTEINYL LEUKOTRIENE 1 RECEPTOR; DEGENERIN SODIUM CHANNEL; G PROTEIN COUPLED RECEPTOR; GQ11 PROTEIN COUPLED RECEPTOR; MESSENGER RNA; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; RECEPTOR; UNCLASSIFIED DRUG; ANGIOTENSIN 1 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; LEUKOTRIENE D4 RECEPTOR; LEUKOTRIENE RECEPTOR;

BLOOD VESSEL TONE; CONFORMATIONAL TRANSITION; HUMAN; INTESTINE PRESSURE; MECHANOSENSATION; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MYOGENIC TONE; MYOGENIC VASOCONSTRICTION; PODOCYTE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BLOCKING; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE CELL; VASOCONSTRICTION; ANIMAL; BIOMECHANICS; MECHANORECEPTOR; MECHANOTRANSDUCTION; MOUSE; PHYSIOLOGY; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE;

ANIMALS; BIOMECHANICAL PHENOMENA; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; MECHANORECEPTORS; MECHANOTRANSDUCTION, CELLULAR; MICE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LEUKOTRIENE; VASOCONSTRICTION;

EID: 84997611315     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1111/micc.12293     Document Type: Review

References (27)

1. Bayliss WM. On the local reactions of the arterial wall to changes of internal pressure. J Physiol 28: 220–231, 1902.
2. Blodow S, Schneider H, Storch U, Wizemann R, Forst AL, Gudermann T, Mederos y Schnitzler M. Novel role of mechanosensitive AT1B receptors in myogenic vasoconstriction. Pflugers Arch 466: 1343–1353, 2014.
3. Chen X, Li W, Yoshida H, Tsuchida S, Nishimura H, Takemoto F, Okubo S, Fogo A, Matsusaka T, Ichikawa I. Targeting deletion of angiotensin type 1B receptor gene in the mouse. Am J Physiol 272: F299–F304, 1997.
4. Davis MJ, Hill MA. Signaling mechanisms underlying the vascular myogenic response. Physiol Rev 79: 387–423, 1999.
5. Davis MJ, Sikes PJ. Myogenic responses of isolated arterioles: test for a rate-sensitive mechanism. Am J Physiol 259: H1890–H1900, 1990.
6. Davisson RL, Oliverio MI, Coffman TM, Sigmund CD. Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest 106: 103–106, 2000.
7. Forst AL, Olteanu VS, Mollet G, Wlodkowski T, Schaefer F, Dietrich A, Reiser J, Gudermann T, Mederos y Schnitzler M, Storch U. Podocyte purinergic P2X4 channels are mechanotransducers that mediate cytoskeletal disorganization. J Am Soc Nephrol 27: 848–862, 2016.
8. Hill-Eubanks DC, Gonzales AL, Sonkusare SK, Nelson MT. Vascular TRP channels: performing under pressure and going with the flow. Physiology (Bethesda, Md) 29: 343–360, 2014.
9. Ito M, Oliverio MI, Mannon PJ, Best CF, Maeda N, Smithies O, Coffman TM. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci USA 92: 3521–3525, 1995.
10. Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399: 789–793, 1999.
11. Mederos y Schnitzler M, Storch U, Gudermann T. AT1 receptors as mechanosensors. Curr Opin Pharmacol 11: 112–116, 2011.
12. Mederos y Schnitzler M, Storch U, Meibers S, Nurwakagari P, Breit A, Essin K, Gollasch M, Gudermann T. Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J 27: 3092–3103, 2008.
13. Nishimura A, Kitano K, Takasaki J, Taniguchi M, Mizuno N, Tago K, Hakoshima T, Itoh H. Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule. Proc Natl Acad Sci USA 107: 13666–13671, 2010.
14. Retailleau K, Duprat F, Arhatte M, Ranade SS, Peyronnet R, Martins JR, Jodar M, Moro C, Offermanns S, Feng Y, Demolombe S, Patel A, Honore E. Piezo1 in smooth muscle cells is involved in hypertension-dependent arterial remodeling. Cell Rep 13: 1161–1171, 2015.
15. Schleifenbaum J, Kassmann M, Szijarto IA, Hercule HC, Tano JY, Weinert S, Heidenreich M, Pathan AR, Anistan YM, Alenina N, Rusch NJ, Bader M, Jentsch TJ, Gollasch M. Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries. Circ Res 115: 263–272, 2014.
16. Singh RK, Gupta S, Dastidar S, Ray A. Cysteinyl leukotrienes and their receptors: molecular and functional characteristics. Pharmacology 85: 336–349, 2010.
17. Storch U, Blodow S, Gudermann T, Mederos y Schnitzler M. Cysteinyl leukotriene 1 receptors as novel mechanosensors mediating myogenic tone together with angiotensin II type 1 receptors-brief report. Arterioscler Thromb Vasc Biol 35: 121–126, 2015.
18. Storch U, Mederos y Schnitzler M, Gudermann T. G protein-mediated stretch reception. Am J Physiol Heart Circ Physiol 302: H1241–H1249, 2012.
19. Sugaya T, Nishimatsu S, Tanimoto K, Takimoto E, Yamagishi T, Imamura K, Goto S, Imaizumi K, Hisada Y, Otsuka A, et al. Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J Biol Chem 270: 18719–18722, 1995.
20. Takasaki J, Saito T, Taniguchi M, Kawasaki T, Moritani Y, Hayashi K, Kobori M. A novel Galphaq/11-selective inhibitor. J Biol Chem 279: 47438–47445, 2004.
21. Taniguchi M, Nagai K, Arao N, Kawasaki T, Saito T, Moritani Y, Takasaki J, Hayashi K, Fujita S, Suzuki K, Tsukamoto S. YM-254890, a novel platelet aggregation inhibitor produced by Chromobacterium sp. QS3666. J Antibiot (Tokyo) 56: 358–363, 2003.
22. Tian Y, Baukal AJ, Sandberg K, Bernstein KE, Balla T, Catt KJ. Properties of AT1a and AT1b angiotensin receptors expressed in adrenocortical Y-1 cells. Am J Physiol 270: E831–E839, 1996.
23. Walsh MP, Cole WC. The role of actin filament dynamics in the myogenic response of cerebral resistance arteries. J Cereb Blood Flow Metab 33: 1–12, 2013.
24. Yasuda N, Miura S, Akazawa H, Tanaka T, Qin Y, Kiya Y, Imaizumi S, Fujino M, Ito K, Zou Y, Fukuhara S, Kunimoto S, Fukuzaki K, Sato T, Ge J, Mochizuki N, Nakaya H, Saku K, Komuro I. Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation. EMBO Rep 9: 179–186, 2008.
25. Yoshida H, Kakuchi J, Guo DF, Furuta H, Iwai N, Meer-de Jong van der R, Inagami T. Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human). Biochem Biophys Res Commun 186: 1042–1049, 1992.
26. Zhou J, Ernsberger P, Douglas JG. A novel angiotensin receptor subtype in rat mesangium. Coupling to adenylyl cyclase. Hypertension 21: 1035–1038, 1993.
27. Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol 6: 499–506, 2004.