A review of recent evidence relating to sugars, insulin resistance and diabetes

European Journal of Nutrition

Volumn 55, Issue , 2016, Pages 17-23

  Macdonald, I A ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Diabetes mellitus; Fructose; Glucose; HFCS; Insulin resistance; Sucrose; Sugars

Indexed keywords

FRUCTOSE; INSULIN; SUCROSE; SUGAR; SUGAR INTAKE; TRIACYLGLYCEROL;

CALORIC INTAKE; CARBOHYDRATE DIET; DIABETES MELLITUS; EVIDENCE BASED PRACTICE; GLYCEMIC CONTROL; GLYCEMIC LOAD; HUMAN; INSULIN RESISTANCE; META ANALYSIS (TOPIC); METABOLISM; NONHUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SUGAR INTAKE; SYSTEMATIC REVIEW (TOPIC); ADVERSE EFFECTS; ANIMAL; BLOOD; EVIDENCE BASED MEDICINE; FATTY LIVER; GLYCEMIC INDEX; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIETARY SUCROSE; ENERGY INTAKE; EVIDENCE-BASED MEDICINE; FATTY LIVER; FRUCTOSE; GLYCEMIC INDEX; HUMANS; INSULIN RESISTANCE; OBESITY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRIGLYCERIDES;

EID: 84996805897     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-016-1340-8     Document Type: Review

References (26)

1. SACN Carbohydrates and Health Report (2015) Published for public health England under licence from the Controller of Her Majesty’s Stationery Office. ISBN: 978 0 11 708284 7
2. Himsworth HP (1935) The dietetic factor determining the glucose tolerance and sensitivity to insulin of healthy men. Clin Sci 2:67–94
3. USDA (2015) Scientific Report of the 2015 Dietary Guidelines Advisory Committee
4. WHO (2015) Guideline: sugars intake for adults and children. WHO. ISBN: 978 92 4 154902 8
5. Yudkin J (1972) Pure, white and deadly: the new facts about the sugar you eat as a cause of heart disease, diabetes and other killers. Davis-Poynter Limited. SBN 0706700562, ISBN13: 9780706700565
6. Hauner H, Bechthold A, Boeing H, Brönstrup A, Buyken A, Leschik-Bonnet E, Linseisen J, Schulze M, Strohm D, Wolfram G (2012) Evidence-based guideline of the german nutrition society: carbohydrate intake and prevention of nutrition-related diseases. Ann Nutr Metab 60(suppl 1):1–58
7. Fiorito LM, Marini M, Francis LA, Smiciklas-Wright H, Birch LL (2009) Beverage intake of girls at age 5 y predicts adiposity and weight status in childhood and adolescence. Am J Clin Nutr 90:935–942
8. Nissinen K, Mikkila V, Mannisto S, Lahti-Koski M, Rasanen L, Viikari J, Raitakari O (2009) Sweets and sugar-sweetened soft drink intake in childhood in relation to adult BMI and overweight. The cardiovascular risk in young finns study. Public Health Nutr 12:2018–2020
9. Johnson RJ, Nakagawa T, Sanchez-Lozada G, Shafiu M, Sundaram S, Le M, Ishimoto T, Sautin YY, Lanaspa MA (2013) Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes 62:3307–3315
10. Basu S, Yoffe P, Hills N, Lustig RH (2013) The relationship of sugar to population level diabetes prevalence: an econometric analysis of repeated cross-sectional data. PLoS ONE 8:e57873
11. Sánchez-Lozada LG, Mu W, Roncal C, Sautin YY, Abdelmalek M, Reungjui S, Le M, Nakagawa T, Lan HY, Yu X, Johnson RJ (2010) Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. Eur J Nutr 49:1–9
12. Sakamoto E, Seino Y, Fukami A, Mizutani N, Tsunekawa S, Ishikawa K, Ogata H, Uenishi E, Kamiya H, Hamada Y, Sato H, Harada N, Toyoda Y, Miwa I, Nakamura J, Inagaki N, Oiso Y, Ozaki N (2012) Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion. J Diabetes Investig 3:432–440
13. Klurfeld DM, Foreyt J, Angelopoulos TJ, Rippe JM (2013) Lack of evidence for high fructose corn syrup as the cause of the obesity epidemic. Int J Obes 37:771–773
14. Tappy L, Mittendorfer B (2012) Fructose toxicity: is the science ready for public health actions? Curr Opin Clin Nutr Metab Care 15:357–361
15. Bravo S, Lowndes J, Sinnett S, Yu Z, Rippe J (2013) Consumption of sucrose and high-fructose corn syrup does not increase liver fat or ectopic fat deposition in muscles. Appl Physiol Nutr Metab 38:681–688
16. Heden TD, Liu Y, Park YM, Nyhoff LM, Winn NC, Kanaley JA (2014) Moderate amounts of fructose- or glucose-sweetened beverages do not differentially alter metabolic health in male and female adolescents. Am J Clin Nutr 100:796–805
17. Aeberli I, Hochuli M, Gerber PA, Sze L, Murer SB, Tappy L, Spinas GA, Berneis K (2013) Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men. Diabetes Care 36:150–156
18. Hokayem M, Blond E, Vidal H, Lambert K, Meugnier E, Feillet-Coudray C, Coudray C, Pesenti S, Luyton C, Lambert-Porcheron S, Sauvinet V, Fedou C, Brun JF, Rieusset J, Bisbal C, Sultan A, Mercier J, Goudable J, Dupuy AM, Cristol JP, Laville M, Avignon A (2013) Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients. Diabetes Care 36:1454–1461
19. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ (2009) Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 119:1322–1334
20. Lecoultre V, Egli L, Carrel G, Theytaz F, Kreis R, Schneiter P, Boss A, Zwygart K, Lê KA, Bortolotti M, Boesch C, Tappy L (2013) Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans. Obesity 21:782–785
21. Stanhope KL, Medici V, Bremer AA, Lee V, Lam HD, Nunez MV, Chen GX, Keim NL, Havel PJ (2015) A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. Am J Clin Nutr 101:1144–1154
22. Johnston RD, Stephenson MC, Crossland H, Cordon SM, Palcidi E, Cox EF, Taylor MA, Aithal GP, Macdonald IA (2013) No difference between high fructose and high glucose diets on liver triacylglycerol or biochemistry in healthy overweight men. Gastroenterology 145:1016–1025
23. Te Morenga L, Mallard S, Mann J (2013) Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ 346:e7492
24. van Buul VJ, Tappy L, Brouns FJ (2014) Misconceptions about fructose-containing sugars and their role in the obesity epidemic. Nutr Res Rev 27:119–130
25. Bawden S, Stephenson M, Falcone Y, Lingaya M, Ciampi E, Hunter K, Bligh F, Schirra J, Taylor M, Morris P, Macdonald I, Gowland P, Marciani L, Aithal G (2016) Increased liver fat and glycogen stores following high compared with low glycaemic index food: a randomized cross over study. Diabetes Obes Metab. doi:10.1111/dom.12784
26. Atkinson FS, Foster-Powell K, Brand-Miller JC (2008) International tables of glycemic index and glycemic load values: 2008. Diabetes Care 31:2281–2283