Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis

Cell Research

Volumn 26, Issue 12, 2016, Pages 1330-1344

  Zhang, Lin ^a,b   Xiao, Jianfeng ^c   Xu, Jianrong ^a   Fu, Tianran ^a   Cao, Zhiwei ^a   Zhu, Liang ^a,b   Chen, Hong Zhuan ^a,b   Shen, Xu ^c   Jiang, Hualiang ^c   Zhang, Liang ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Universities Collaborative Innovation Center for Translational Medicine   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

ACP; Complex structure; Dehydratase; Fatty acid biosynthesis

Indexed keywords

ACYL CARRIER PROTEIN; BACTERIAL PROTEIN; FATTY ACID; HYDROLYASE; PROTEIN BINDING;

BIOCATALYSIS; BIOSYNTHESIS; CHEMISTRY; DIMERIZATION; ENZYMOLOGY; GENETICS; HELICOBACTER PYLORI; METABOLISM; MOLECULAR MODEL; PHOTON CORRELATION SPECTROSCOPY; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SMALL ANGLE SCATTERING; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

ACYL CARRIER PROTEIN; BACTERIAL PROTEINS; BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DYNAMIC LIGHT SCATTERING; FATTY ACIDS; HELICOBACTER PYLORI; HYDRO-LYASES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SCATTERING, SMALL ANGLE; STATIC ELECTRICITY; X-RAY DIFFRACTION;

EID: 84996758786     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2016.136     Document Type: Article

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