Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres

Brain Pathology

Volumn 26, Issue 6, 2016, Pages 713-723

  Natsumeda, Manabu ^a,b   Maitani, Kosuke ^a   Liu, Yang ^a   Miyahara, Hiroaki ^a   Kaur, Harpreet ^a   Chu, Qian ^a,c   Zhang, Hongyan ^a   D Kahlert, Ulf ^a,d   Eberhart, Charles G ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b NIIGATA UNIVERSITY   (Japan)

^c Tongji Hospital   (China)

^d Institute of Pathology   (Germany)

Author keywords

autophagy; chloroquine; combination treatment; gamma secretase inhibitor; glioblastoma

Indexed keywords

CHLOROQUINE; GAMMA SECRETASE INHIBITOR; MRK 003; NOTCH RECEPTOR; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; KI 67 ANTIGEN; SULFOXIDE; THIADIAZOLE DERIVATIVE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL GROWTH; CELL PROLIFERATION; CLONOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; GLIOBLASTOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NERVE CELL; NEUROSPHERE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CANCER STEM CELL; CELL CYCLE; CFU COUNTING; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; STARVATION; TUMOR CELL LINE;

ANTIMALARIALS; AUTOPHAGY; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CHLOROQUINE; COLONY-FORMING UNITS ASSAY; CYCLIC S-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; KI-67 ANTIGEN; NEOPLASTIC STEM CELLS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STARVATION; THIADIAZOLES;

EID: 84996671185     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12343     Document Type: Article

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