Knockdown of corticotropin-releasing factor in the central amygdala reverses persistent viscerosomatic hyperalgesia

Translational Psychiatry

Volumn 5, Issue 3, 2015, Pages

  Johnson, A C ^a   Tran, L ^a   Greenwood Van Meerveld, B ^a,b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR;

ANALYSIS OF VARIANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CENTRAL NUCLEUS (AMYGDALA); CHEMICALLY INDUCED; DISEASE MODEL; FISCHER 344 RAT; HYPERALGESIA; MALE; METABOLISM; NOCICEPTIVE PAIN; PATHOPHYSIOLOGY; RAT;

ANALYSIS OF VARIANCE; ANIMALS; CENTRAL AMYGDALOID NUCLEUS; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; DISEASE MODELS, ANIMAL; HYPERALGESIA; MALE; NOCICEPTIVE PAIN; RATS; RATS, INBRED F344;

EID: 84996622784     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/TP.2015.16     Document Type: Article

References (51)

1. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006; 130: 1480–1491.
2. Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006; 130: 1377–1390.
3. Kim SE, Chang L. Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms? Neurogastroenterol Motil 2012; 24: 895–913.
4. Mayer EA, Naliboff BD, Chang L, Coutinho SV. V. Stress and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 2001; 280: G519–G524.
5. Wilder-Smith CH. The balancing act: endogenous modulation of pain in functional gastrointestinal disorders. Gut 2011; 60: 1589–1599.
6. McEwen BS. Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin Neurosci 2006; 8: 367–381.
7. Schulkin J, Gold PW, McEwen BS. Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load. Psychoneuroendocrinology 1998; 23: 219–243.
8. Shepard JD, Barron KW, Myers DA. Stereotaxic localization of corticosterone to the amygdala enhances hypothalamo-pituitary-adrenal responses to behavioral stress. Brain Res 2003; 963: 203–213.
9. Dinan TG, Quigley EM, Ahmed SM, Scully P, O'Brien S, O'Mahony L et al. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? Gastroenterology 2006; 130: 304–311.
10. Riedel W, Schlapp U, Leck S, Netter P, Neeck G. Blunted ACTH and cortisol responses to systemic injection of corticotropin-releasing hormone (CRH) in fibromyalgia: role of somatostatin and CRH-binding protein. Ann N Y Acad Sci 2002; 966: 483–490.
11. Greenwood-Van Meerveld B, Gibson M, Gunter W, Shepard J, Foreman R, Myers D. Stereotaxic delivery of corticosterone to the amygdala modulates colonic sensitivity in rats. Brain Res 2001; 893: 135–142.
12. Myers DA, Gibson M, Schulkin J, Greenwood Van-Meerveld B. Corticosterone implants to the amygdala and type 1 CRH receptor regulation: effects on behavior and colonic sensitivity. Behav Brain Res 2005; 161: 39–44.
13. Myers B, Dittmeyer K, Greenwood-Van Meerveld B. Involvement of amygdaloid corticosterone in altered visceral and somatic sensation. Behav Brain Res 2007; 181: 163–167.
14. Myers B, Greenwood-Van Meerveld B. Elevated corticosterone in the amygdala leads to persistent increases in anxiety-like behavior and pain sensitivity. Behav Brain Res 2010; 214: 465–469.
15. Tran L, Greenwood-Van Meerveld B. Altered expression of glucocorticoid receptor and corticotropin-releasing factor in the central amygdala in response to elevated corticosterone. Behav Brain Res 2012; 234: 380–385.
16. Myers B, Greenwood-Van Meerveld B. Differential involvement of amygdala corticosteroid receptors in visceral hyperalgesia following acute or repeated stress. Am J Physiol Gastrointest Liver Physiol 2012; 302: G260–G266.
17. Tran L, Chaloner A, Sawalha AH, Greenwood Van-Meerveld B. Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress. Psychoneuroendocrinology 2013; 38: 898–906.
18. Johnson AC, Tran L, Schulkin J, Greenwood-Van Meerveld B. Importance of stress receptor-mediated mechanisms in the amygdala on visceral pain perception in an intrinsically anxious rat. Neurogastroenterol Motil 2012; 24: 479–486, e219.
19. Pitts MW, Todorovic C, Blank T, Takahashi LK. The central nucleus of the amygdala and corticotropin-releasing factor: insights into contextual fear memory. J Neurosci 2009; 29: 7379–7388.
20. Myers B, Greenwood-Van Meerveld B. Divergent effects of amygdala glucocorticoid and mineralocorticoid receptors in the regulation of visceral and somatic pain. Am J Physiol Gastrointest Liver Physiol 2010; 298: G295–G303.
21. Tran L, Wiskur B, Greenwood-Van Meerveld B. The role of the anteriolateral bed nucleus of the stria terminalis in stress-induced nociception. Am J Physiol Gastrointest Liver Physiol 2012; 302: G1301–G1309.
22. Tran L, Schulkin J, Greenwood-Van Meerveld B. Importance of CRF receptormediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain. Neuropsychopharmacology 2014; 39: 2633–2645.
23. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 6th edn. Academic Press/Elsevier: Amsterdam, The Netherlands/Boston, MA, USA, 2007.
24. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402–408.
25. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3: RESEARCH0034.
26. Landgraf R, Naruo T, Vecsernyes M, Neumann I. Neuroendocrine and behavioral effects of antisense oligonucleotides. Eur J Endocrinol 1997; 137: 326–335.
27. Pitts MW, Takahashi LK. The central amygdala nucleus via corticotropin-releasing factor is necessary for time-limited consolidation processing but not storage of contextual fear memory. Neurobiol Learn Mem 2011; 95: 86–91.
28. Makino S, Gold PW, Schulkin J. Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus. Brain Res 1994; 640: 105–112.
29. Shepard JD, Barron KW, Myers DA. Corticosterone delivery to the amygdala increases corticotropin-releasing factor mRNA in the central amygdaloid nucleus and anxiety-like behavior. Brain Res 2000; 861: 288–295.
30. Nishii H, Nomura M, Aono H, Fujimoto N, Matsumoto T. Up-regulation of galanin and corticotropin-releasing hormone mRNAs in the key hypothalamic and amygdaloid nuclei in a mouse model of visceral pain. Regul Pept 2007; 141: 105–112.
31. Ulrich-Lai YM, Xie W, Meij JT, Dolgas CM, Yu L, Herman JP. Limbic and HPA axis function in an animal model of chronic neuropathic pain. Physiol Behav 2006; 88: 67–76.
32. McNally GP, Akil H. Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal. Neuroscience 2002; 112: 605–617.
33. Iwasaki-Sekino A, Mano-Otagiri A, Ohata H, Yamauchi N, Shibasaki T. Gender differences in corticotropin and corticosterone secretion and corticotropinreleasing factor mRNA expression in the paraventricular nucleus of the hypothalamus and the central nucleus of the amygdala in response to footshock stress or psychological stress in rats. Psychoneuroendocrinology 2009; 34: 226–237.
34. Ji G, Neugebauer V. Pro-and anti-nociceptive effects of corticotropin-releasing factor (CRF) in central amygdala neurons are mediated through different receptors. J Neurophysiol 2008; 99: 1201–1212.
35. Gue M, Del Rio-Lacheze C, Eutamene H, Theodorou V, Fioramonti J, Bueno L. Stress-induced visceral hypersensitivity to rectal distension in rats: role of CRF and mast cells. Neurogastroenterol Motil 1997; 9: 271–279.
36. Myers B, Greenwood-Van Meerveld B. Corticosteroid receptor-mediated mechanisms in the amygdala regulate anxiety and colonic sensitivity. Am J Physiol Gastrointest Liver Physiol 2007; 292: G1622–G1629.
37. Shepard JD, Schulkin J, Myers DA. Chronically elevated corticosterone in the amygdala increases corticotropin releasing factor mRNA in the dorsolateral bed nucleus of stria terminalis following duress. Behav Brain Res 2006; 174: 193–196.
38. Ji G, Fu Y, Adwanikar H, Neugebauer V. Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses. Mol Pain 2013; 9: 2.
39. Bourbia N, Ansah OB, Pertovaara A. Corticotropin-releasing factor in the rat amygdala differentially influences sensory-discriminative and emotional-like pain response in peripheral neuropathy. J Pain 2010; 11: 1461–1471.
40. Baiamonte BA, Valenza M, Roltsch EA, Whitaker AM, Baynes BB, Sabino V et al. Nicotine dependence produces hyperalgesia: role of corticotropin-releasing factor-1 receptors (CRF1Rs) in the central amygdala (CeA). Neuropharmacology 2014; 77: 217–223.
41. Marchant NJ, Densmore VS, Osborne PB. Coexpression of prodynorphin and corticotrophin-releasing hormone in the rat central amygdala: evidence of two distinct endogenous opioid systems in the lateral division. J Comp Neurol 2007; 504: 702–715.
42. Retson TA, Van Bockstaele EJ. Coordinate regulation of noradrenergic and serotonergic brain regions by amygdalar neurons. J Chem Neuroanat 2013; 52: 9–19.
43. Kravets JL, Reyes BA, Unterwald EM, Van Bockstaele EJ. Direct targeting of peptidergic amygdalar neurons by noradrenergic afferents: linking stress-integrative circuitry. Brain Struct Funct 2013; 220: 541–558.
44. Yarushkina NI, Bagaeva TR, Filaretova LP. Analgesic actions of corticotropinreleasing factor (CRF) on somatic pain sensitivity: involvement of glucocorticoid and CRF-2 receptors. Neurosci Behav Physiol 2009; 39: 819–823.
45. Yarushkina NI, Bagaeva TR, Filaretova LP. Central corticotropin-releasing factor (CRF) may attenuate somatic pain sensitivity through involvement of glucocorticoids. J Physiol Pharmacol 2011; 62: 541–548.
46. Vit JP, Clauw DJ, Moallem T, Boudah A, Ohara PT, Jasmin L. Analgesia and hyperalgesia from CRF receptor modulation in the central nervous system of Fischer and Lewis rats. Pain 2006; 121: 241–260.
47. Tran L, Schulkin J, Ligon CO, Greenwood Van-Meerveld B. Epigenetic modulation of chronic anxiety and pain by histone deacetylation. Mol Psychiatry; 2015, doi: 10.1038/mp.2014.122 (in press).
48. Venkova K, Johnson AC, Myers B, Greenwood-Van Meerveld B. Exposure of the amygdala to elevated levels of corticosterone alters colonic motility in response to acute psychological stress. Neuropharmacology 2010; 58: 1161–1167.
49. Bradesi S, Schwetz I, Ennes HS, Lamy CM, Ohning G, Fanselow M et al. Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia. Am J Physiol Gastrointest Liver Physiol 2005; 289: G42–G53.
50. Larauche M, Bradesi S, Million M, McLean P, Tache Y, Mayer EA et al. Corticotropinreleasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats. Am J Physiol Gastrointest Liver Physiol 2008; 294: G1033–G1040.
51. Hong S, Zheng G, Wiley JW. Epigenetic regulation of genes that modulate chronic stress-induced visceral pain in the peripheral nervous system. Gastroenterology 2014; 148: 148–157.