Elevated corticosterone in the amygdala leads to persistant increases in anxiety-like behavior and pain sensitivity

Behavioural Brain Research

Volumn 214, Issue 2, 2010, Pages 465-469

  Myers, Brent ^a   Greenwood Van Meerveld, Beverley ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Amygdala; Corticotropin releasing factor; Glucocorticoid; Somatic sensitivity; Stress; Visceral sensitivity

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1;

ALLODYNIA; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; COLON DILATATION; CONTROLLED STUDY; ENTERITIS; EXPLORATORY BEHAVIOR; LIMBIC SYSTEM; MALE; NEUROENDOCRINE SYSTEM; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; VISCERAL PAIN;

AMINOPYRIDINES; AMYGDALA; ANIMALS; ANXIETY; COLON; CORTICOSTERONE; DRUG IMPLANTS; INJECTIONS, INTRAVENTRICULAR; MALE; MAZE LEARNING; PAIN THRESHOLD; RATS; RATS, INBRED F344;

EID: 77955275041     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.05.049     Document Type: Article

References (32)

1. Chang L., Sundaresh S., Elliot J., Anton P.A., Baldi P., Licudine A., et al. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterol Motil 2009, 21(2):149-159.
2. Chen Y.L., Obach R.S., Braselton J., Corman M.L., Forman J., Freeman J., et al. 2-Aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem 2008, 51(5):1385-1392.
3. Cummings S., Elde R., Ells J., Lindall A. Corticotropin-releasing factor immunoreactivity is widely distributed within the central nervous system of the rat: an immunohistochemical study. J Neurosci 1983, 3(7):1355-1368.
4. Dallman M.F., Jones M.T. Corticosteroid feedback control of ACTH secretion: effect of stress-induced corticosterone secretion on subsequent stress responses in the rat. Endocrinology 1973, 92(5):1367-1375.
5. Davis M. Are different parts of the extended amygdala involved in fear versus anxiety?. Biol Psychiatry 1998, 44(12):1239-1247.
6. Dinan T., Quigley E., Ahmed S., Scully P., O'Brien S., O'Mahony L., et al. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker. Gastroenterology 2006, 130:304-311.
7. Fu Y., Neugebauer V. Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior. J Neurosci 2008, 28(15):3861-3876.
8. Gerges N.Z., Aleisa A.M., Schwarz L.A., Alkadhi K.A. Reduced basal CaMKII levels in hippocampal CA1 region: possible cause of stress-induced impairment of LTP in chronically stressed rats. Hippocampus 2004, 14(3):402-410.
9. Gray T.S., Magnuson D.J. Neuropeptide neuronal efferents from the bed nucleus of the stria terminalis and central amygdaloid nucleus to the dorsal vagal complex in the rat. J Comp Neurol 1987, 262(3):365-374.
10. Greenwood-Van Meerveld B., Johnson A.C., Cochrane S., Schulkin J., Myers D.A. Corticotropin-releasing factor 1 receptor-mediated mechanisms inhibit colonic hypersensitivity in rats. Neurogastroenterol Motil 2005, 17(3):415-422.
11. Ji G., Neugebauer V. Pro- and anti-nociceptive effects of corticotropin-releasing factor (CRF) in central amygdala neurons are mediated through different receptors. J Neurophysiol 2008, 99(3):1201-1212.
12. Koob G.F., Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 2001, 24(2):97-129.
13. Makino S., Gold P.W., Schulkin J. Effects of corticosterone on CRH mRNA content in the bed nucleus of the stria terminalis; comparison with the effects in the central nucleus of the amygdala and the paraventricular nucleus of the hypothalamus. Brain Res 1994, 657(1-2):141-149.
14. Morsink M.C., Steenbergen P.J., Vos J.B., Karst H., Joels M., De Kloet E.R., et al. Acute activation of hippocampal glucocorticoid receptors results in different waves of gene expression throughout time. J Neuroendocrinol 2006, 18:239-252.
15. Myers B., Greenwood-Van Meerveld B. Corticosteroid receptor-mediated mechanisms in the amygdala regulate anxiety and colonic sensitivity. Am J Physiol Gastrointest Liver Physiol 2007, 292(6):G1622-G1629.
16. Myers B., Dittmeyer K., Greenwood-Van Meerveld B. Involvement of amygdaloid corticosterone in altered visceral and somatic sensation. Behav Brain Res 2007, 181(1):163-167.
17. Myers B., Greenwood-Van Meerveld B. Divergent effects of amygdala glucocorticoid and mineralocorticoid receptors in the regulation of visceral and somatic pain. Am J Physiol Gastrointest Liver Physiol 2010, 298(2):G295-G303.
18. Nair S.M., Werkman T.R., Craig J., Finnell R., Joëls M., Eberwine J.H. Corticosteroid regulation of ion channel conductances and mRNA levels in individual hippocampal CA1 neurons. J Neurosci 1998, 18(7):2685-2696.
19. Naliboff B.D., Derbyshire S.W., Munakata J., Berman S., Mandelkern M., Chang L., et al. Cerebral activation in patients with irritable bowel syndrome and control subjects during rectosigmoid stimulation. Psychosom Med 2001, 36(3):365-375.
20. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, New York, Academic. 4th ed.
21. Rainnie D.G., Bergeron R., Sajdyk T.J., Patil M., Gehlert D.R., Shekhar A. Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disorders. J Neurosci 2004, 24(14):3471-3479.
22. Sakanaka M., Shibasaki T., Lederis K. Distribution and efferent projections of corticotropin-releasing factor-like immunoreactivity in the rat amygdaloid complex. Brain Res 1986, 382(2):213-238.
23. Schulkin J., Gold P.W., McEwen B.S. Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load. Psychoneuroendocrinology 1998, 23(3):219-243.
24. Shepard J.D., Barron K.W., Myers D.A. Corticosterone delivery to the amygdala increases corticotropin-releasing factor mRNA in the central amygdaloid nucleus and anxiety-like behavior. Brain Res 2000, 861(2):288-295.
25. Shepard J.D., Barron K.W., Myers D.A. Stereotaxic localization of corticosterone to the amygdala enhances hypothalamo-pituitary-adrenal responses to behavioral stress. Brain Res 2003, 963(1-2):203-213.
26. Shepard J.D., Schulkin J., Myers D.A. Chronically elevated corticosterone in the amygdala increases corticotropin releasing factor mRNA in the dorsolateral bed nucleus of stria terminalis following duress. Behav Brain Res 2006, 174(1):193-196.
27. Swanson L.W., Sawchenko P.E., Rivier J., Vale W.W. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 1983, 36(3):165-186.
28. Talley N., Zinsmeister A., Van Dyke C, Melton L. Epidemiology of colonic symptoms and the irritable bowel syndrome. Gastroenterology 1992, 101:927-934.
29. Ulrich-Lai Y.M., Herman J.P. Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 2009, 10(6):397-409.
30. Watts A.G., Sanchez-Watts G. Region-specific regulation of neuropeptide mRNAs in rat limbic forebrain neurones by aldosterone and corticosterone. J Physiol 1995, 484:721-736.
31. Whitehead W.E., Crowell M.D., Robinson J.C., Heller B.R., Schuster M.M. Effects of stressful life events on the bowel symptoms: subjects with irritable bowel syndrome compared with subjects without irritable bowel dysfunction. Gut 1992, 30:825-830.
32. Whitehead W.E., Palsson O., Jones K.R. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications. Gastroenterology 2002, 122:1140-1156.