Induced peroxidase and cytoprotective enzyme expressions support adaptation of HUVECs to sustain subsequent H₂O₂ exposure

Microvascular Research

Volumn 103, Issue , 2016, Pages 1-10

  Patel, Hemang ^a   Chen, Juan ^a   Kavdia, Mahendra ^a  

^a Wayne State University   (United States)

Author keywords

ASK1; Cytoprotection; Endothelial dysfunction; GPX1; HMOX1; HUVEC; Hydrogen peroxide; Redox homeostasis; Systems biology; TXNRD1; UCP1

Indexed keywords

HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; HEME OXYGENASE 1; HMOX1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; OXIDIZING AGENT; PEROXIDASE; PEROXIREDOXIN; PRDX1 PROTEIN, HUMAN; SUPEROXIDE; THIOREDOXIN REDUCTASE 1; TRANSCRIPTION FACTOR NRF2; TXNRD1 PROTEIN, HUMAN;

ARTICLE; ASK1 GENE; ATF2 GENE; CELL GROWTH; CELL PROLIFERATION; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; ELECTRON TRANSPORT; ENDOTHELIUM CELL; GENE; GENETIC REGULATION; GENOTYPE; GPX1 GENE; HMOX1 GENE; HUMAN; HUMAN CELL; IKBKB GENE; MITOCHONDRIAL MEMBRANE; NFE2L2 GENE; NOX1 GENE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRDX1 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOD1 GENE; SOD2 GENE; TXNRD1 GENE; UPREGULATION; VASODILATATION; ADAPTATION; BIOSYNTHESIS; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; ENZYME INDUCTION; ENZYMOLOGY; GENETICS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; TIME FACTOR; UMBILICAL VEIN ENDOTHELIAL CELL;

ADAPTATION, PHYSIOLOGICAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GLUTATHIONE PEROXIDASE; HEME OXYGENASE-1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-E2-RELATED FACTOR 2; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEROXIDASES; PEROXIREDOXINS; SUPEROXIDES; THIOREDOXIN REDUCTASE 1; TIME FACTORS;

EID: 84996590104     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2015.09.003     Document Type: Article

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