Human chorionic gonadotropin protects vascular endothelial cells from oxidative stress by apoptosis inhibition, cell survival signalling activation and mitochondrial function protection

Cellular Physiology and Biochemistry

Volumn 36, Issue 6, 2015, Pages 2108-2120

  Surico, Daniela ^a   Farruggio, Serena ^a   Marotta, Patrizia ^a   Raina, Giulia ^a   Mary, David ^a,b   Surico, Nicola ^a   Vacca, Giovanni ^a,b   Grossini, Elena ^a,b  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b Azienda Ospedaliera Universitaria Maggiore Della Carita   (Italy)

Author keywords

Cell death; Mitochondria; Nitric oxide; Peroxidation

Indexed keywords

CASPASE 3; CASPASE 9; CHORIONIC GONADOTROPIN; CYTOCHROME C; DYE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; HYDROGEN PEROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE; PROTEIN BAX; PROTEIN KINASE B; ANTIOXIDANT; MITOGEN ACTIVATED PROTEIN KINASE; PROTECTIVE AGENT;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PEROXIDATION; PRIORITY JOURNAL; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; DRUG EFFECTS; ENZYMOLOGY; LIPID PEROXIDATION; METABOLISM; MITOCHONDRION; SIGNAL TRANSDUCTION;

ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL SURVIVAL; CHORIONIC GONADOTROPIN; CYTOCHROMES C; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84939617856     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430178     Document Type: Article

References (37)

1. Lopata A, Oliva PG, Stanton DM, Robertson DM: Analysis of chorionic gonadotrophin secreted by cultured human blastocysts. Mol Hum Reprod 1997;3:517-521.
2. Grossini E, Surico D, Mary DA, Molinari C, Surico N, Vacca G: In anesthetized pigs human chorionic gonadotropin increases myocardial perfusion and function through a β-adrenergic-related pathway and nitric oxide. J Appl Physiol 2013;15:422-435.
3. Hermsteiner M, Zoltan DR, Doetsch J, Rascher W, Kuenzel W: Human chorionic gonadotropin dilates uterine and mesenteric resistance arteries in pregnant and nonpregnant rats. Pflugers Arch 1999;439:186-194.
4. Roberts JM, Lain KY: Recent insights into the pathogenesis of preeclampsia. Placenta 2002;23: 359-372.
5. Roberts JM, Cooper DW: Pathogenesis and genetics of preeclampsia. Lancet 2001;357:53-56.
6. Lyall F, Myatt L: The role of the placenta in preeclampsia-A workshop report. Placenta 2002; 23:S142-S145.
7. Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA: Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation 2002;9:147-160.
8. Hubel CA: Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med 1999; 222:222-235.
9. Vaughan JE, Walsh SW: Oxidative stress reproduces placental abnormalities of preeclampsia. Hypertens Pregnancy 2002;21:205-223.
10. Kajihara T, Uchino S, Suzuki M, Itakura A, Brosens JJ, Ishihara O: Human chorionic gonadotropin confers resistance to oxidative stress-induced apoptosis in decidualizing human endometrial stromal cells. Fertil Steril 2011;95:1302-1307.
11. Dantzer V, Leach L, Leiser R: Angiogenesis and placental vasculature-A workshop report. Placenta 2000;21:S69-S70.
12. Zygmunt M, Hahn D, Munstedt K, Bischof P, Lang U: Invasion of cytotrophoblastic JEG-3 cells is stimulated by hCG in vitro. Placenta 1998;19:587-593.
13. Jaffe EA, Nachman RL, Becker CG, Minick CR: Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973; 52:2745-2756.
14. Grossini E, Molinari C, Caimmi PP, Uberti F, Vacca G: Levosimendan induces NO production through p38 MAPK, ERK and Akt in porcine coronary endothelial cells: role for mitochondrial KATP channel. Br J Pharmacol 2009;156:250-261.
15. Grossini E, Caimmi P, Molinari C, Uberti F, Mary D, Vacca G: CCK receptors-related signaling involved in nitric oxide production caused by gastrin 17 in porcine coronary endothelial cells. Mol Cell Endocrinol 2012;350:20-30.
16. Grossini E, Gramaglia C, Farruggio S, Bellofatto K, Anchisi C, Mary D, Vacca G, Zeppegno P: Asenapine increases nitric oxide release and protects porcine coronary artery endothelial cells against peroxidation. Vascul Pharmacol 2014;60:127-141.
17. Uberti F, Caimmi PP, Molinari C, Mary D, Vacca G, Grossini E: Levosimendan modulates programmed forms of cell death through K(ATP) channels and nitric oxide. J Cardiovasc Pharmacol 2011;57:246-258.
18. Wisdom SJ, R. Wilson R, McKillop JH, Walker JJ: Antioxidant systems in normal pregnancy and in pregnancy-induced hypertension. Am J Obstet Gynecol 1991;165:1701-1704.
19. Llurba E, Gratacs E, Martn-Galln P, Cabero L, Dominguez L: A comprehensive study of oxidative stress and antioxidant status in preeclampsia and normal pregnancy Free Radic Biol Med 2004;37:557-570.
20. Myatt L, Cui XL: Oxidative stress in the placenta Histochem. Cell Biol 2004;122:369-382.
21. Shaker OG, Sadik NA: Pathogenesis of preeclampsia: Implications of apoptotic markers and oxidative stress. Hum Exp Toxicol 2013;32:1170-1178.
22. Cappellano G, Uberti F, Caimmi PP, Pietronave S, Mary DA, Dianzani C, Micalizzi E, Melensi M, Boldorini R, Nicosia G, Crosio E, Chiocchetti A, Aina F, Prat M, Dianzani U, Vacca G, Ariatti C, Grossini E: Different expression and function of the endocannabinoid system in human epicardial adipose tissue in relation to heart disease. Can J Cardiol 2013;29:499-509.
23. Liaudet L, Soriano FG, Szab C: Biology of nitric oxide signaling. Crit Care Med 2000;28: N37-52.
24. Razavi HM, Hamilton JA, Feng Q: Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure. Pharmacol Ther 2005;106:147-162.
25. Thomas SR, Chen K, Keaney JF Jr: Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem 2002;277:6017-6024.
26. Zadeh MS, Kolb JP, Geromin D, D'Anna R, Boulmerka A, Marconi A, Dugas B, Marsac C, D'Alessio P: Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase. J Leukoc Biol 2000;67:327-334.
27. Crabtree MJ, Brixey R, Batchelor H, Hale AB, Channon KM: Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling. J Biol Chem 2013;288:561-569.
28. Anteby EY, Hurwitz A, Korach O, Revel A, Simon A, Finci-Yeheskel Z, Mayer M, Laufer N: Human follicular nitric oxide pathway: relationship to follicular size, oestradiol concentrations and ovarian blood flow. Hum Reprod 1996;11:1947-1951.
29. Ben-Shlomo I, Adashi EY, Paync DW: The morphogenic/cytotoxic and prostaglandin stimulating activities of interleukin-1b in the rat ovary are NO independent. J Clin Invest 1994;49: 1463-1469.
30. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-142.
31. Anggard E: Nitric oxide: mediator, murderer, and medicine. Lancet 1994;343:1199-1206.
32. Battaglia C, Regnani G, Marsella T, Facchinetti F, Volpe A, Venturoli S, Flamigni C: Adjuvant L-arginine treatment in controlled ovarian hyperstimulation: a double-blind, randomized study. Hum Reprod 2002;17:659-665.
33. Green DR, Reed JC: Mitochondria and apoptosis. Science 1998;281:1309-1312.
34. Kanter M, Gurbuz H, Okman TK: Endothelial nitric oxide synthase immunreactivity and the ultrastructure of endothelial cells of umbilical artery in normal and preeclamptic pregnancies. Clin Exp Hypertens 2010;32:458-463.
35. Illsinger S, Janzen N, Sander S, Schmidt KH, Bednarczyk J, Mallunat L, Bode J, Hagebölling F, Hoy L, Lcke T, Hass R, Das AM: Preeclampsia and HELLP syndrome: impaired mitochondrial function in umbilical endothelial cells. Reprod Sci 2010;17:219-226.
36. Kharfi A, Gigure Y, De Grandpr P, Moutquin JM, Forest JC: Human chorionic gonadotropin (hCG) may be a marker of systemic oxidative stress in normotensive and preeclamptic term pregnancies. Clin Biochem 2005;38:717-721.
37. Kharfi A, Leblanc S, Ouellet A, Moutquin JM: Dual action of H2O2 on placental hCG secretion: implications for oxidative stress in preeclampsia. Clin Biochem 2007;40:94-97.