Detection of EML4-ALK in lung adenocarcinoma using pleural effusion with FISH, IHC, and RT-PCR methods

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Liu, Leilei ^a   Zhan, Ping ^b   Zhou, Xiaodie ^a   Song, Yong ^a   Zhou, Xiaojun ^a   Yu, Like ^b   Wang, Jiandong ^a  

^a NANJING UNIVERSITY   (China)

^b Nanjing Thoracic Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; EML4-ALK FUSION PROTEIN, HUMAN; ONCOPROTEIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; EML4 ALK GENE; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEASIBILITY STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE IDENTIFICATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; LUNG ADENOCARCINOMA; MAJOR CLINICAL STUDY; MALE; NON SMALL CELL LUNG CANCER; PLEURA EFFUSION; PLEURA FLUID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; ADENOCARCINOMA; BIOSYNTHESIS; LUNG TUMOR; MALIGNANT PLEURA EFFUSION; METABOLISM; MIDDLE AGED; PATHOLOGY; PROCEDURES;

ECHINODERMATA;

ADENOCARCINOMA; ADULT; AGED; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LUNG NEOPLASMS; MALE; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; PLEURAL EFFUSION, MALIGNANT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84925400673     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117032     Document Type: Article

References (37)

1. Long J, Luo GP, Xiao ZW, Liu ZQ, Guo M, et al. (2014) Cancer statistics: current diagnosis and treatment of pancreatic cancer in Shanghai, China. Cancer Lett 346: 273-277. doi: 10.1016/j.canlet.2014. 01.004 PMID: 24462819
2. Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics, 2014. CA Cancer J Clin 64: 9-29. doi: 10. 3322/caac.21208 PMID: 24399786
3. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, et al. (2007) Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448: 561-566. PMID: 17625570
4. Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, et al. (2008) Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res 68: 4971-4976. doi: 10.1158/ 0008-5472.CAN-07-6158 PMID: 18593892
5. Inamura K, Takeuchi K, Togashi Y, Nomura K, Ninomiya H, et al. (2008) EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol 3: 13 -17. doi: 10.1097/JTO. 0b013e31815e8b60 PMID: 18166835
6. Koivunen JP, Mermel C, Zejnullahu K, Murphy C, Lifshits E, et al. (2008) EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 14: 4275-4283. doi: 10.1158/1078-0432.CCR-08-0168 PMID: 18594010
7. Horn L, PaoW(2009) EML4-ALK: honing in on a new target in non-small-cell lung cancer. J Clin Oncol 27: 4232-4235. doi: 10.1200/JCO.2009.23.6661 PMID: 19667260
8. Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, et al. (2009) Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 27: 4247-4253. doi: 10.1200/JCO.2009.22.6993 PMID: 19667264
9. Govindan R (2011) Hope without hype: EML4-ALK inhibition for treatment of lung cancer. Lancet Oncol 12: 983-984. doi: 10.1016/S1470-2045(11)70253-4 PMID: 21933750
10. Soda M, Isobe K, Inoue A, Maemondo M, Oizumi S, et al. (2012) A prospective PCR-based screening for the EML4-ALK oncogene in non-small cell lung cancer. Clin Cancer Res 18: 5682-5689. doi: 10. 1158/1078-0432.CCR-11-2947 PMID: 22908099
11. Aoki T, Ebihara A, Yogo Y, Suemasu K, Sakamaki F (2014) Analysis of continuous first-line treatment with docetaxel and carboplatin for advanced non-small cell lung cancer. Oncol Lett 7: 1771-1777. PMID: 24932231
12. Perkins SL, Pickering D, Lowe EJ, Zwick D, Abromowitch M, et al. (2005) Childhood anaplastic large cell lymphoma has a high incidence of ALK gene rearrangement as determined by immunohistochemical staining and fluorescent in situ hybridisation: a genetic and pathological correlation. Br J Haematol 131: 624-627. PMID: 16351638
13. Le Quesne J, Maurya M, Yancheva SG, O'Brien M, Popat S, et al. (2014) A comparison of immunohistochemical assays and FISH in detecting the ALK translocation in diagnostic histological and cytological lung tumor material. J Thorac Oncol 9: 769-774. doi: 10.1097/JTO.0000000000000157 PMID: 24787965
14. Franco R, Rocco G, Marino FZ, Pirozzi G, Normanno N, et al. (2013) Anaplastic lymphoma kinase: a glimmer of hope in lung cancer treatment? Expert Rev Anticancer Ther 13: 407-420. doi: 10.1586/era. 13.18 PMID: 23560836
15. Onn A, Bar J, Herbst RS (2014) Angiogenesis inhibition and lung-cancer therapy. Lancet Oncol 15: 124-125. doi: 10.1016/S1470-2045(14)70010-5 PMID: 24480554
16. Molina JR, Foster NR, Reungwetwattana T, Nelson GD, Grainger AV, et al. (2014) A phase II trial of the Src-kinase inhibitor saracatinib after four cycles of chemotherapy for patients with extensive stage small cell lung cancer: NCCTG trial N-0621. Lung Cancer 85: 245-250. doi: 10.1016/j.lungcan.2014. 03.004 PMID: 24957683
17. Mok T, Gorbunova V, Juhasz E, Szima B, Burdaeva O, et al. (2014) A correlative biomarker analysis of the combination of bevacizumab and carboplatin-based chemotherapy for advanced nonsquamous non-small-cell lung cancer: results of the phase II randomized ABIGAIL study (BO21015). J Thorac Oncol 9: 848-855. doi: 10.1097/JTO.0000000000000160 PMID: 24807156
18. Miyoshi S, Ito R, Katayama H, Kadowaki T, Yano S, et al. (2014) Phase II trial of S-1 as third-line or further chemotherapy in patients with advanced non-small-cell lung cancer. Int J Clin Oncol.
19. Strimpakos A, Politi E, Kainis E, Grapsa D, Siolos S, et al. (2014) The clinical significance of cytology versus histology-based diagnosis in small cell lung cancer: A retrospective study. Lung Cancer 85: 186-190. doi: 10.1016/j.lungcan.2014.04.015 PMID: 24854403
20. Shital P, Rujuta A, Sanjay M (2014) Transbronchial needle aspiration cytology (TBNA) in endobronchial lesions: a valuable technique during bronchoscopy in diagnosing lung cancer and it will decrease repeat bronchoscopy. J Cancer Res Clin Oncol 140: 809-815. doi: 10.1007/s00432-014-1602-x PMID: 24531973
21. Mazza F, Ferrari E, Maineri P, Dozin B, Ratto GB (2014) Pleural lavage cytology predicts recurrence and survival, even in early non-small cell lung cancer. Surg Today.
22. Liu C, Wen Z, Li Y, Peng L (2014) Application of ThinPrep bronchial brushing cytology in the early diagnosis of lung cancer: a retrospective study. PLoS One 9: e90163. doi: 10.1371/journal.pone.0090163 PMID: 24759600
23. Liu X, Lu Y, Zhu G, Lei Y, Zheng L, et al. (2013) The diagnostic accuracy of pleural effusion and plasma samples versus tumour tissue for detection of EGFR mutation in patients with advanced non-small cell lung cancer: comparison of methodologies. J Clin Pathol 66: 1065-1069. doi: 10.1136/jclinpath-2013- 201728 PMID: 23888061
24. Morgensztern D, Waqar S, Subramanian J, Trinkaus K, Govindan R (2012) Prognostic impact of malignant pleural effusion at presentation in patients with metastatic non-small-cell lung cancer. J Thorac Oncol 7: 1485-1489. doi: 10.1097/JTO.0b013e318267223a PMID: 22982649
25. Masago K, Togashi Y, Fukudo M, Terada T, Irisa K, et al. (2011) Plasma and pleural fluid pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small-cell lung cancer with pleural effusion. Clin Lung Cancer 12: 307-312. doi: 10.1016/j.cllc.2011.06.004 PMID: 21775215
26. Zhang X, Zhao Y, Wang M, Yap WS, Chang AY (2008) Detection and comparison of epidermal growth factor receptor mutations in cells and fluid of malignant pleural effusion in non-small cell lung cancer. Lung Cancer 60: 175-182. PMID: 18061305
27. Cabillic F, Gros A, Dugay F, Begueret H, Mesturoux L, et al. (2014) Parallel FISH and immunohistochemical studies of ALK status in 3244 non-small-cell lung cancers reveal major discordances. J Thorac Oncol 9: 295-306. doi: 10.1097/JTO.0000000000000072 PMID: 24518086
28. Ren S, Hirsch FR, Varella-Garcia M, Aisner DL, Boyle T, et al. (2014) Atypical negative ALK breakapart FISH harboring a crizotinib-responsive ALK rearrangement in non-small-cell lung cancer. J Thorac Oncol 9: e21-23. doi: 10.1097/JTO.0000000000000013 PMID: 24518095
29. Li Y, Pan Y, Wang R, Sun Y, Hu H, et al. (2013) ALK-rearranged lung cancer in Chinese: a comprehensive assessment of clinicopathology, IHC, FISH and RT-PCR. PLoS One 8: e69016. doi: 10.1371/ journal.pone.0069016 PMID: 23922677
30. Wang J, Cai Y, Dong Y, Nong J, Zhou L, et al. (2014) Clinical Characteristics and Outcomes of Patients with Primary Lung Adenocarcinoma Harboring ALK Rearrangements Detected by FISH, IHC, and RTPCR. PLoS One 9: e101551. doi: 10.1371/journal.pone.0101551 PMID: 24992725
31. Wu YC, Chang IC, Wang CL, Chen TD, Chen YT, et al. (2013) Comparison of IHC, FISH and RT-PCR methods for detection of ALK rearrangements in 312 non-small cell lung cancer patients in Taiwan. PLoS One 8: e70839. doi: 10.1371/journal.pone.0070839 PMID: 23951022
32. Zhang YG, Jin ML, Li L, Zhao HY, Zeng X, et al. (2013) Evaluation of ALK rearrangement in Chinese non-small cell lung cancer using FISH, immunohistochemistry, and real-time quantitative RT- PCR on paraffin-embedded tissues. PLoS One 8: e64821. doi: 10.1371/journal.pone.0064821 PMID: 23741400
33. Tuononen K, Sarhadi VK, Wirtanen A, Ronty M, Salmenkivi K, et al. (2013) Targeted resequencing reveals ALK fusions in non-small cell lung carcinomas detected by FISH, immunohistochemistry, and real-time RT-PCR: a comparison of four methods. Biomed Res Int 2013: 757490. doi: 10.1155/2013/ 757490 PMID: 23484153
34. Bi L, Chen J, Yuan X, Jiang Z, ChenW(2013) Salvianolic acid A positively regulates PTEN protein level and inhibits growth of A549 lung cancer cells. Biomed Rep 1: 213-217. PMID: 24648921
35. Kim C, Gao YT, Xiang YB, Barone-Adesi F, Zhang Y, et al. (2014) Home kitchen ventilation, cooking fuels, and lung cancer risk in a prospective cohort of never smoking women in Shanghai, China. Int J Cancer.
36. Shinmura K, Kageyama S, Igarashi H, Kamo T, Mochizuki T, et al. (2010) EML4-ALK fusion transcripts in immunohistochemically ALK-positive non-small cell lung carcinomas. Exp Ther Med 1: 271-275. PMID: 22993539
37. Savic S, Bode B, Diebold J, Tosoni I, Barascud A, et al. (2013) Detection of ALK-positive non-small-cell lung cancers on cytological specimens: high accuracy of immunocytochemistry with the 5A4 clone. J Thorac Oncol 8: 1004-1011. doi: 10.1097/JTO.0b013e3182936ca9 PMID: 23689429