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Volumn 17, Issue 9, 2016, Pages 849-861

Factors affecting the pharmacokinetics, biodistribution and toxicity of gold nanoparticles in drug delivery

Author keywords

Biodistribution; Blood brain barrier; Drug delivery; Gold nanoparticles; Pharmacokinetics; Physicochemical properties; Toxicity

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GOLD NANOPARTICLE; REACTIVE OXYGEN METABOLITE; GOLD; METAL NANOPARTICLE;

EID: 84996588069     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/1389200217666160629114941     Document Type: Review
Times cited : (33)

References (73)
  • 2
    • 84929353410 scopus 로고    scopus 로고
    • Current trends in using polymer coated gold nanoparticles for cancer therapy
    • Muddineti, O.S.; Ghosh, B.; Biswas, S. Current trends in using polymer coated gold nanoparticles for cancer therapy. Int. J. Pharm., 2015, 484(1-2), 252-267.
    • (2015) Int. J. Pharm , vol.484 , Issue.1-2 , pp. 252-267
    • Muddineti, O.S.1    Ghosh, B.2    Biswas, S.3
  • 3
    • 76749093968 scopus 로고    scopus 로고
    • Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging
    • Veiseh, O.; Gunn, J.W.; Zhang, M. Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv. Drug Deliv. Rev., 2010, 62(3), 284-304.
    • (2010) Adv. Drug Deliv. Rev , vol.62 , Issue.3 , pp. 284-304
    • Veiseh, O.1    Gunn, J.W.2    Zhang, M.3
  • 4
    • 79851500107 scopus 로고    scopus 로고
    • Selective targeting of gold nanorods at the mitochondria of cancer cells: Implications for cancer therapy
    • Wang, L.; Liu, Y.; Li, W.; Jiang, X.; Ji, Y.; Wu, X.; Xu, L.; Qiu, Y.; Zhao, K.; Wei, T.; Li, Y.; Zhao, Y.; Chen, C. Selective targeting of gold nanorods at the mitochondria of cancer cells: Implications for cancer therapy. Nano. Lett., 2011, 11(2), 772-780.
    • (2011) Nano. Lett , vol.11 , Issue.2 , pp. 772-780
    • Wang, L.1    Liu, Y.2    Li, W.3    Jiang, X.4    Ji, Y.5    Wu, X.6    Xu, L.7    Qiu, Y.8    Zhao, K.9    Wei, T.10    Li, Y.11    Zhao, Y.12    Chen, C.13
  • 7
    • 77952242785 scopus 로고    scopus 로고
    • Nanotechnology in head and neck cancer: The race is on
    • El-Sayed, I.H. Nanotechnology in head and neck cancer: The race is on. Curr. Oncol. Rep., 2010, 12(2), 121-128.
    • (2010) Curr. Oncol. Rep , vol.12 , Issue.2 , pp. 121-128
    • El-Sayed, I.H.1
  • 11
    • 74449089602 scopus 로고    scopus 로고
    • Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats
    • Balasubramanian, S.K.; Jittiwat, J.; Manikandan, J.; Ong, C.N.; Yu, L.E.; Ong, W.Y. Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats. Biomaterials, 2010, 31(8), 2034-2042.
    • (2010) Biomaterials , vol.31 , Issue.8 , pp. 2034-2042
    • Balasubramanian, S.K.1    Jittiwat, J.2    Manikandan, J.3    Ong, C.N.4    Yu, L.E.5    Ong, W.Y.6
  • 14
    • 79951921750 scopus 로고    scopus 로고
    • Biodistribution and toxicity of engineered gold nanoparticles: A review of in vitro and in vivo studies
    • Khlebtsov, N.; Dykman, L. Biodistribution and toxicity of engineered gold nanoparticles: A review of in vitro and in vivo studies. Chem. Soc. Rev., 2011, 40(3), 1647-1671.
    • (2011) Chem. Soc. Rev , vol.40 , Issue.3 , pp. 1647-1671
    • Khlebtsov, N.1    Dykman, L.2
  • 15
    • 84862323547 scopus 로고    scopus 로고
    • In vivo tumor targeting of gold nanoparticles: Effect of particle type and dosing strategy
    • Puvanakrishnan, P.; Park, J.; Chatterjee, D.; Krishnan, S.; Tunnell, J.W. In vivo tumor targeting of gold nanoparticles: Effect of particle type and dosing strategy. Int. J. Nanomed., 2012, 7, 1251-1258.
    • (2012) Int. J. Nanomed , vol.7 , pp. 1251-1258
    • Puvanakrishnan, P.1    Park, J.2    Chatterjee, D.3    Krishnan, S.4    Tunnell, J.W.5
  • 16
    • 79952312283 scopus 로고    scopus 로고
    • Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages
    • Arnida; Janat-Amsbury, M.M.; Ray, A.; Peterson, C.M.; Ghandehari, H. Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages. Eur. J. Pharm. Biopharm., 2011, 77(3), 417-423.
    • (2011) Eur. J. Pharm. Biopharm , vol.77 , Issue.3 , pp. 417-423
    • Janat-Amsbury, M.M.1    Ray, A.2    Peterson, C.M.3    Ghandehari, H.4
  • 17
    • 76749151847 scopus 로고    scopus 로고
    • Characterization of gold nanorods in vivo by integrated analytical techniques: Their uptake, retention, and chemical forms
    • Wang, L.; Li, Y.F.; Zhou, L.; Liu, Y.; Meng, L.; Zhang, K.; Wu, X.; Zhang, L.; Li, B.; Chen, C. Characterization of gold nanorods in vivo by integrated analytical techniques: Their uptake, retention, and chemical forms. Anal. Bioanal. Chem., 2010, 396(3), 1105-1114.
    • (2010) Anal. Bioanal. Chem , vol.396 , Issue.3 , pp. 1105-1114
    • Wang, L.1    Li, Y.F.2    Zhou, L.3    Liu, Y.4    Meng, L.5    Zhang, K.6    Wu, X.7    Zhang, L.8    Li, B.9    Chen, C.10
  • 18
    • 81755187274 scopus 로고    scopus 로고
    • Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration
    • Chauhan, V.P.; Popovic, Z.; Chen, O.; Cui, J.; Fukumura, D.; Bawendi, M.G.; Jain, R.K. Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. Angew. Chem. Int. Ed. Engl., 2011, 50(48), 11417-11420.
    • (2011) Angew. Chem. Int. Ed. Engl , vol.50 , Issue.48 , pp. 11417-11420
    • Chauhan, V.P.1    Popovic, Z.2    Chen, O.3    Cui, J.4    Fukumura, D.5    Bawendi, M.G.6    Jain, R.K.7
  • 19
    • 84867850384 scopus 로고    scopus 로고
    • A review on approaches to bio distribution studies about gold and silver engineered nanoparticles by inductively coupled plasma mass spectrometry
    • Krystek, P. A review on approaches to bio distribution studies about gold and silver engineered nanoparticles by inductively coupled plasma mass spectrometry. Microchem. J., 2012, 105, 39-43.
    • (2012) Microchem. J , vol.105 , pp. 39-43
    • Krystek, P.1
  • 22
    • 84864670257 scopus 로고    scopus 로고
    • Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, Multicellular Spheroids, and Tumors in vivo
    • Huang, K.; Ma, H.; Liu, J.; Huo, S.; Kumar, A.; Wei, T.; Zhang, X.; Jin, S.; Gan, Y.; Wang, P.C.; He, S.; Zhang, X.; Liang, XJ. Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, Multicellular Spheroids, and Tumors in vivo. ACSNANO, 2012, 6(5), 4483-4493.
    • (2012) ACSNANO , vol.6 , Issue.5 , pp. 4483-4493
    • Huang, K.1    Ma, H.2    Liu, J.3    Huo, S.4    Kumar, A.5    Wei, T.6    Zhang, X.7    Jin, S.8    Gan, Y.9    Wang, P.C.10    He, S.11    Zhang, X.12    Liang, X.J.13
  • 26
    • 77955231885 scopus 로고    scopus 로고
    • Tuning payload delivery in tumour cylindroids using gold nanoparticles
    • Kim, B.; Han, G.; Toley, B.J.; Kim, C.K.; Rotello, V.M.; Forbes, N.S. Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat. Nanotechnol., 2010, 5(6), 465-472.
    • (2010) Nat. Nanotechnol , vol.5 , Issue.6 , pp. 465-472
    • Kim, B.1    Han, G.2    Toley, B.J.3    Kim, C.K.4    Rotello, V.M.5    Forbes, N.S.6
  • 27
    • 77955769029 scopus 로고    scopus 로고
    • Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods
    • Qiu, Y.; Liu, Y.; Wang, L.; Xu, L.; Bai, R.; Ji, Y.; Wu, X.; Zhao, Y.; Li, Y.; Chen, C. Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods. Biomaterials, 2010, 31(30), 7606-7619.
    • (2010) Biomaterials , vol.31 , Issue.30 , pp. 7606-7619
    • Qiu, Y.1    Liu, Y.2    Wang, L.3    Xu, L.4    Bai, R.5    Ji, Y.6    Wu, X.7    Zhao, Y.8    Li, Y.9    Chen, C.10
  • 28
    • 84862785762 scopus 로고    scopus 로고
    • In vivo renal clearance, biodistribution, toxicity of gold nanoclusters
    • Zhang, X.D.; Wu, D.; Shen, X.; Liu, P.X.; Fan, F.Y.; Fan, S.J. In vivo renal clearance, biodistribution, toxicity of gold nanoclusters. Biomaterials, 2012, 33(18), 4628-4638.
    • (2012) Biomaterials , vol.33 , Issue.18 , pp. 4628-4638
    • Zhang, X.D.1    Wu, D.2    Shen, X.3    Liu, P.X.4    Fan, F.Y.5    Fan, S.J.6
  • 29
    • 78049351925 scopus 로고    scopus 로고
    • A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands
    • Huang, X.; Peng, X.; Wang, Y.; Wang, Y.; Shin, D.M.; El-Sayed, M.A.; Nie, S. ElSayed, Shuming, N. A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands. ACS Nano, 2010, 4 (2010), 5887-5596.
    • (2010) ACS Nano , vol.4 , Issue.2010 , pp. 5887-5896
    • Huang, X.1    Peng, X.2    Wang, Y.3    Wang, Y.4    Shin, D.M.5    El-Sayed, M.A.6    Nie, S.7    Shuming, N.8
  • 30
    • 80053184892 scopus 로고    scopus 로고
    • Cancer nanotheranostics: Improving imaging and therapy by targeted delivery across biological barriers
    • Kievit, F.M.; Zhang, M. Cancer nanotheranostics: Improving imaging and therapy by targeted delivery across biological barriers. Adv. Mater., 2011, 23(36), H217-247.
    • (2011) Adv. Mater , vol.23 , Issue.36 , pp. H217-H247
    • Kievit, F.M.1    Zhang, M.2
  • 34
    • 82255186416 scopus 로고    scopus 로고
    • Design and potential application of PEGylated gold nanoparticles with sizedependent permeation through brain microvasculature
    • Etame, A.B.; Smith, C.A.; Chan, W.C.; Rutka, J.T. Design and potential application of PEGylated gold nanoparticles with sizedependent permeation through brain microvasculature. Nanomedicine, 2011, 7(6), 992-1000.
    • (2011) Nanomedicine , vol.7 , Issue.6 , pp. 992-1000
    • Etame, A.B.1    Smith, C.A.2    Chan, W.C.3    Rutka, J.T.4
  • 35
    • 84921805367 scopus 로고    scopus 로고
    • Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors
    • Dixit, S.; Novak, T.; Miller, K.; Zhu, Y.; Kenney, M.E.; Broome, A.M. Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors. Nanoscale, 2015, 7(5), 1782-1790.
    • (2015) Nanoscale , vol.7 , Issue.5 , pp. 1782-1790
    • Dixit, S.1    Novak, T.2    Miller, K.3    Zhu, Y.4    Kenney, M.E.5    Broome, A.M.6
  • 36
    • 79953011676 scopus 로고    scopus 로고
    • Luminescent gold nanoparticles with efficient renal clearance
    • Zhou, C.; Long, M.; Qin, Y.; Sun, X.; Zheng, J. Luminescent gold nanoparticles with efficient renal clearance. Angew. Chem. Int. Ed. Engl., 2011, 50(14), 3168-3172.
    • (2011) Angew. Chem. Int. Ed. Engl , vol.50 , Issue.14 , pp. 3168-3172
    • Zhou, C.1    Long, M.2    Qin, Y.3    Sun, X.4    Zheng, J.5
  • 37
    • 78649233643 scopus 로고    scopus 로고
    • Caspase sensitive gold nanoparticle for apoptosis imaging in live cells
    • Sun, I.C.; Lee, S.; Koo, H.; Kwon, I.C.; Choi, K.; Ahn, C.H.; Kim, K. Caspase sensitive gold nanoparticle for apoptosis imaging in live cells. Bioconjug. Chem., 2010, 21, 1939-1942.
    • (2010) Bioconjug. Chem , vol.21 , pp. 1939-1942
    • Sun, I.C.1    Lee, S.2    Koo, H.3    Kwon, I.C.4    Choi, K.5    Ahn, C.H.6    Kim, K.7
  • 39
    • 84873720901 scopus 로고    scopus 로고
    • In vivo toxicity, biodistribution, and clearance of glutathione-coated gold nanoparticles
    • Simpson, C.A.; Salleng, K.J.; Cliffel, D.E.; Feldheim, D.L. In vivo toxicity, biodistribution, and clearance of glutathione-coated gold nanoparticles. Nanomedicine, 2013, 9(2), 257-263.
    • (2013) Nanomedicine , vol.9 , Issue.2 , pp. 257-263
    • Simpson, C.A.1    Salleng, K.J.2    Cliffel, D.E.3    Feldheim, D.L.4
  • 40
    • 84903463411 scopus 로고    scopus 로고
    • Surface chemistry of gold nanoparticles mediates their exocytosis in macrophages
    • Park, N.O.J.-H. Surface chemistry of gold nanoparticles mediates their exocytosis in macrophages. ASCNANO, 2014, 8(6), 6232-6241.
    • (2014) ASCNANO , vol.8 , Issue.6 , pp. 6232-6241
    • Park, N.O.J.-H.1
  • 43
    • 84869497639 scopus 로고    scopus 로고
    • Differential response of macrophages to core-shell Fe3O4@Au nanoparticles and nanostars
    • Xia, W.; Song, H.M.; Wei, Q.; Wei, A. Differential response of macrophages to core-shell Fe3O4@Au nanoparticles and nanostars. Nanoscale, 2012, 4(22), 7143-7148.
    • (2012) Nanoscale , vol.4 , Issue.22 , pp. 7143-7148
    • Xia, W.1    Song, H.M.2    Wei, Q.3    Wei, A.4
  • 44
    • 84875802005 scopus 로고    scopus 로고
    • Enhancement of lipopolysaccharide-induced nitric oxide and interleukin- 6 production by PEGylated gold nanoparticles in RAW264.7 cells
    • Liu, Z.; Li, W.; Wang, F.; Sun, C.; Wang, L.; Wang, J.; Sun, F. Enhancement of lipopolysaccharide-induced nitric oxide and interleukin- 6 production by PEGylated gold nanoparticles in RAW264.7 cells. Nanoscale, 2012, 4(22), 7135-7142.
    • (2012) Nanoscale , vol.4 , Issue.22 , pp. 7135-7142
    • Liu, Z.1    Li, W.2    Wang, F.3    Sun, C.4    Wang, L.5    Wang, J.6    Sun, F.7
  • 45
    • 77956010860 scopus 로고    scopus 로고
    • Gold nanoparticles attenuate LPS-induced NO production through the inhibition of NF-kappaB and IFN-beta/STAT1 pathways in RAW264.7 cells
    • Ma, J.S.; Kim, W.J.; Kim, J.J.; Kim, T.J.; Ye, S.K.; Song, M.D.; Kang, H.; Kim, D.W.; Moon, W.K.; Lee, K.H. Gold nanoparticles attenuate LPS-induced NO production through the inhibition of NF-kappaB and IFN-beta/STAT1 pathways in RAW264.7 cells. Nitric Oxide, 2010, 23(3), 214-219.
    • (2010) Nitric Oxide , vol.23 , Issue.3 , pp. 214-219
    • Ma, J.S.1    Kim, W.J.2    Kim, J.J.3    Kim, T.J.4    Ye, S.K.5    Song, M.D.6    Kang, H.7    Kim, D.W.8    Moon, W.K.9    Lee, K.H.10
  • 46
    • 3242775472 scopus 로고    scopus 로고
    • Toxicity of gold nanoparticles functionalized with cationic and anionic side chains
    • Goodman, C.M.; McCusker, C.D.; Yilmaz, T.; Rotello, V.M. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug. Chem., 2004, 15, 897-900.
    • (2004) Bioconjug. Chem , vol.15 , pp. 897-900
    • Goodman, C.M.1    McCusker, C.D.2    Yilmaz, T.3    Rotello, V.M.4
  • 49
    • 84873730090 scopus 로고    scopus 로고
    • Neoplastic cell response to tiopronin-coated gold nanoparticles
    • Cui, L.; Zahedi, P.; Saraceno, J.; Bristow, R.; Jaffray, D.; Allen, C. Neoplastic cell response to tiopronin-coated gold nanoparticles. Nanomedicine, 2013, 9(2), 264-273.
    • (2013) Nanomedicine , vol.9 , Issue.2 , pp. 264-273
    • Cui, L.1    Zahedi, P.2    Saraceno, J.3    Bristow, R.4    Jaffray, D.5    Allen, C.6
  • 50
    • 84868332187 scopus 로고    scopus 로고
    • Cyto and genotoxicity of gold nanoparticles in human hepatocellular carcinoma and peripheral blood mononuclear cells
    • Paino, I.M.; Marangoni, V.S.; de Oliveira Rde, C.; Antunes, L.M.; Zucolotto, V. Cyto and genotoxicity of gold nanoparticles in human hepatocellular carcinoma and peripheral blood mononuclear cells. Toxicol. Lett., 2012, 215(2), 119-125.
    • (2012) Toxicol. Lett , vol.215 , Issue.2 , pp. 119-125
    • Paino, I.M.1    Marangoni, V.S.2    De Oliveira Rde, C.3    Antunes, L.M.4    Zucolotto, V.5
  • 52
    • 84930711017 scopus 로고    scopus 로고
    • Uptake efficiency of surface modified gold nanoparticles does not correlate with functional changes and cytokine secretion in human dendritic cells in vitro
    • Fytianos, K.; Rodriguez-Lorenzo, L.; Clift, M.J.; Blank, F.; Vanhecke, D.; von Garnier, C.; Petri-Fink, A.; Rothen-Rutishauser, B. Uptake efficiency of surface modified gold nanoparticles does not correlate with functional changes and cytokine secretion in human dendritic cells in vitro. Nanomedicine, 2015, 11(3), 633-644.
    • (2015) Nanomedicine , vol.11 , Issue.3 , pp. 633-644
    • Fytianos, K.1    Rodriguez-Lorenzo, L.2    Clift, M.J.3    Blank, F.4    Vanhecke, D.5    Von Garnier, C.6    Petri-Fink, A.7    Rothen-Rutishauser, B.8
  • 54
    • 84862831610 scopus 로고    scopus 로고
    • Susceptibility to gold nanoparticleinduced hepatotoxicity is enhanced in a mouse model of nonalcoholic steatohepatitis
    • Hwang, J.H.; Kim, S.J.; Kim, Y.H.; Noh, J.R.; Gang, G.T.; Chung, B.H.; Song, N.W.; Lee, C.H. Susceptibility to gold nanoparticleinduced hepatotoxicity is enhanced in a mouse model of nonalcoholic steatohepatitis. Toxicology, 2012, 294(1), 27-35.
    • (2012) Toxicology , vol.294 , Issue.1 , pp. 27-35
    • Hwang, J.H.1    Kim, S.J.2    Kim, Y.H.3    Noh, J.R.4    Gang, G.T.5    Chung, B.H.6    Song, N.W.7    Lee, C.H.8
  • 59
    • 84860469024 scopus 로고    scopus 로고
    • Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats
    • Schulz, M.; Ma-Hock, L.; Brill, S.; Strauss, V.; Treumann, S.; Groters, S.; Van Ravenzwaay, B.; Landsiedel, R. Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats. Mutat. Res., 2012, 745(1-2), 51-57.
    • (2012) Mutat. Res , vol.745 , Issue.1-2 , pp. 51-57
    • Schulz, M.1    Ma-Hock, L.2    Brill, S.3    Strauss, V.4    Treumann, S.5    Groters, S.6    Van Ravenzwaay, B.7    Landsiedel, R.8
  • 60
    • 78649529378 scopus 로고    scopus 로고
    • Gold nanoparticle platforms as drug and biomacromolecule delivery systems
    • Duncan, B.; Kim, C.; Rotello, V.M. Gold nanoparticle platforms as drug and biomacromolecule delivery systems. J. Control. Release, 2010, 148(1), 122-127.
    • (2010) J. Control. Release , vol.148 , Issue.1 , pp. 122-127
    • Duncan, B.1    Kim, C.2    Rotello, V.M.3
  • 61
    • 77953683770 scopus 로고    scopus 로고
    • Targeting nanoparticles to cancer
    • Wang, M.; Thanou, M. Targeting nanoparticles to cancer. Pharmacol. Res., 2010, 62(2), 90-99.
    • (2010) Pharmacol. Res , vol.62 , Issue.2 , pp. 90-99
    • Wang, M.1    Thanou, M.2
  • 66
    • 84922324826 scopus 로고    scopus 로고
    • Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles
    • Ruan, S.; Yuan, M.; Zhang, L.; Hu, G.; Chen, J.; Cun, X.; Zhang, Q.; Yang, Y.; He, Q.; Gao, H. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials, 2015, 37, 425-435.
    • (2015) Biomaterials , vol.37 , pp. 425-435
    • Ruan, S.1    Yuan, M.2    Zhang, L.3    Hu, G.4    Chen, J.5    Cun, X.6    Zhang, Q.7    Yang, Y.8    He, Q.9    Gao, H.10
  • 67
    • 50649113474 scopus 로고    scopus 로고
    • Biodistribution of colloidal gold nanoparticles after intravenous administration: Effect of particle size
    • Sonavane, G.; Tomoda, K.; Makino, K. Biodistribution of colloidal gold nanoparticles after intravenous administration: Effect of particle size. Colloids Surf. B Biointerf., 2008, 66(2), 274-280.
    • (2008) Colloids Surf. B Biointerf , vol.66 , Issue.2 , pp. 274-280
    • Sonavane, G.1    Tomoda, K.2    Makino, K.3


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