In vivo toxicity, biodistribution, and clearance of glutathione-coated gold nanoparticles

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 9, Issue 2, 2013, Pages 257-263

  Simpson, Carrie A ^a   Salleng, Kenneth J ^b   Cliffel, David E ^b   Feldheim, Daniel L ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Glutathione; Mouse; Nanoparticle

Indexed keywords

ANIMAL STUDIES; BINDING INTERACTION; BIODISTRIBUTIONS; CELLULAR INTERNALIZATION; GLUTATHIONES; GOLD NANOPARTICLES; ICP-MS ANALYSIS; IN-VIVO; MOUSE; NANOPARTICLE SURFACE; NANOSCALE THERAPEUTICS; PEGYLATED; POLYETHYLENE GLYCOL (PEG); THERAPEUTIC DELIVERY; THIOL MONOLAYER; TIOPRONIN;

BINDING ENERGY; CYTOTOXICITY; GOLD; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; MONOLAYERS; NANOPARTICLES; PEPTIDES; POLYETHYLENE GLYCOLS;

METAL NANOPARTICLES;

GLUTATHIONE[_DLNK DRUG TOXICITY]; GOLD NANOPARTICLE; MACROGOL; NANOCOATING[_DLNK DRUG TOXICITY]; UNCLASSIFIED DRUG;

ADSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOCOMPATIBILITY; BLOOD ANALYSIS; BLOOD CELL COUNT; CYTOTOXICITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; ERYTHROCYTE COUNT; FEMALE; IMMUNE RESPONSE; IMMUNOGENICITY; IN VIVO STUDY; INTERNALIZATION; KIDNEY CLEARANCE; LEUKOCYTE COUNT; MASS SPECTROMETRY; MOUSE; NONHUMAN; OPSONIZATION; ORGAN DISTRIBUTION; PROTEIN TARGETING; TARGET ORGAN; URINALYSIS;

ANIMALS; ERYTHROCYTE COUNT; GLUTATHIONE; GOLD; KIDNEY; LEUKOCYTE COUNT; MICE; MICE, INBRED BALB C; NANOPARTICLES;

ANIMALIA;

EID: 84873720901     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2012.06.002     Document Type: Article

References (36)

1. Jadzinsky P.D., Calero G., Ackerson C.J., Bushnell D.A., Kornberg R.D. Structure of a thiol monolayer-protected gold nanoparticle at 1.1 Å resolution. Science 2007, 318:430-433.
2. Verma A., Stellacci F. Effect of surface properties on nanoparticle-cell interactions. Small 2010, 6:12-21.
3. Hainfeld J.F., Slatkin D.N., Focella T.M., Smilowitz H.M. Gold nanoparticles: a new X-ray contrast agent. Br J Radiol 2006, 79:248-253.
4. Hainfeld J.F., Slatkin D.N., Smilowitz H.M. The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol 2004, 49:309-315.
5. Cheng M.M.C., Cuda G., Bunimovich Y.L., Gaspari M., Heath J.R., Hill H.D., et al. Nanotechnologies for biomolecular detection and medical diagnostics. Curr Opin Chem Biol 2006, 10:11-19.
6. Giljohann D.A., Mirkin C.A. Drivers of biodiagnostic development. Nature 2009, 462:461-464.
7. Storhoff J.J., Elghanian R., Mucic R.C., Mirkin C.A., Letsinger R.L. One-pot colorimetric differentiation of polynucleotides with single base imperfections using gold nanoparticle probes. J Am Chem Soc 1998, 120:1959-1964.
8. Conde J., Doria G., Baptista P. Noble metal nanoparticles applications in cancer. J Drug Deliv 2012, 2012. 751075.
9. Larguinho M., Baptista P. Gold and silver nanoparticles for clinical diagnostics-from genomics to proteomics. J Proteomics 2012, 75:2811-2823.
10. Tkachenko A.G., Xie H., Coleman D., Glomm W., Ryan J., Anderson M.F., et al. Multifunctional gold nanoparticle-peptide complexes for nuclear targeting. J Am Chem Soc 2003, 125:4700-4701.
11. Bresee J., Maier K.E., Melander C., Feldheim D.L. Identification of antibiotics using small molecule variable ligand display on gold nanocrystals. Chem Comm 2010, 46:7516-7518.
12. Bhattacharya R., Patra C.R., Earl A., Wang S., Katarya A., Lu L., et al. Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells. Nanomedicine 2007, 3:224-238.
13. Bhattacharya R., Patra C.R., Verma R., Kumar S., Greipp P.R., Mukherjee P. Gold nanoparticles inhibit the proliferation of multiple myeloma cells. Adv Mater 2007, 19:711.
14. Patra C.R., Bhattacharya R., Wang E.F., Katarya A., Lau J.S., Dutta S., et al. Targeted delivery of gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent. Cancer Res 2008, 68:1970-1978.
15. Lal S., Clare S.E., Halas N.J. Nanoshell-enabled photothermal cancer therapy: impending clinical impact. Acc Chem Res 2008, 41:1842-1851.
16. Sperling R.A., Parak W.J. Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Philos Transact A Math Phys Eng Sci 2010, 368:1333-1383.
17. Choi H.S., Liu W., Misra P., Tanaka E., Zimmer J.P., Ipe B.I., et al. Renal clearance of quantum dots. Nat Biotech 2007, 25:1165-1170.
18. Sonavane G., Tomoda K., Makino K. Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size. Colloids Surf B Biointerfaces 2008, 66:274-280.
19. Farrell N. Transition metal complexes as drugs and chemotherapeutic agents 1989, 11. Kluwer Academic Publishing, Boston, MA.
20. Herold D.M., Das I.J., Stobbe C.C., Iyer R.V., Chapman J.D. Gold microspheres: a selective technique for producing biologically effective dose enhancement. Int J Radiat Biol 2000, 76:1357-1364.
21. Bakri S.J., Pulido J.S., Mukherjee P., Marler R.J., Mukhopadhyay D. Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model. Retina 2008, 28:147-149.
22. Zhang L.W., Yu W.W., Colvin V.L., Monteiro-Riviere N.A. Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicol Appl Pharmacol 2008, 228:200-211.
23. De Jong W.H., Hagens W.I., Krystek P., Burger M.C., Sips A.J.A.M., Geertsma R.E. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 2008, 29:1912-1919.
24. Arvizo R.R., Miranda O.R., Moyano D.F., Walden C.A., Giri K., Bhattacharya R., et al. Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles. PLoS One 2011, 6:e24374.
25. Simpson C.A., Huffman B.J., Gerdon A.E., Cliffel D.E. Unexpected toxicity of mono layer protected gold clusters eliminated by PEG-Thiol place exchange reactions. Chem Res Toxicol 2010, 23:1608-1616.
26. Simpson C.A., Agrawal A.C., Balinski A., Harkness K.M., Cliffel D.E. Short-chain PEG mixed monolayer protected gold clusters increase clearance and red blood cell counts. ACS Nano 2011, 5:3577-3584.
27. Devi P.U., Saharan B.R. Chemical protection of mouse spermatocytes against gamma-rays with 2-mercaptopropionylglycine. Experientia 1978, 34:91-92.
28. Templeton A.C., Chen S., Gross S.M., Murray R.W. Water-soluble, isolable gold clusters protected by tiopronin and coenzyme A monolayers. Langmuir 1999, 15:66-76.
29. Templeton A.C., Wuelfing W.P., Murray R.W. Monolayer-protected cluster molecules. Acc Chem Res 2000, 33:27-36.
30. Golde W.T., Gollobin P., Rodriguez L.L. A rapid, simple, and humane method for submandibular bleeding of mice using a lancet. Lab Anim 2005, 34:39-43.
31. National Institutes of Health. Available at: , 2005, Vol. 1. Accessed October 24, 2011. http://oacu.od.nih.gov/ARAC/Bleeding.pdf.
32. Kurien B.T., Scofield R.H. Mouse urine collection using clear plastic wrap. Lab Anim 1999, 33:83-86.
33. Sadauskas E., Danscher G., Stoltenberg M., Vogel U., Larsen A., Wallin H. Protracted elimination of gold nanoparticles from mouse liver. Nanomedicine 2009, 5:162-169.
34. Bowman M.C., Ballard T.E., Ackerson C.J., Feldheim D.L., Margolis D.M., Melander C.J. Inhibition of HIV fusion with multivalent gold nanoparticles. J Am Chem Soc 2008, 130:6896-6897.
35. Al-Jamal W.T., Al-Jamal K.T., Cakebread A., Halket J.M., Kostarelos K. Blood circulation and tissue biodistribution of lipid-quantum dot (L-QD) hybrid vesicles intravenously administered in mice. Bioconjug Chem 2009, 20:1696-1702.
36. Kaneo Y., Kubo H., Tabata T., Matsuyama K., Noda A., Iguchi S. Tissue distribution of isoniazid and its metabolites in rats. J Pharmacobiodyn 1981, 4:590-595.