Cyto and genotoxicity of gold nanoparticles in human hepatocellular carcinoma and peripheral blood mononuclear cells

Toxicology Letters

Volumn 215, Issue 2, 2012, Pages 119-125

  Paino, Iêda Maria Martinez ^a   Marangoni, Valéria Spolon ^a   de Oliveira, Rita de Cássia Silva ^a   Antunes, Lusânia Maria Greggi ^a   Zucolotto, Valtencir ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Comet assay; Cytotoxicity; Human hepatocarcinoma cell; Human peripheral blood mononuclear cells; Nanomedicine; Nanotoxicity

Indexed keywords

CITRATE SODIUM; GOLD NANOPARTICLE; POLYAMIDOAMINE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

ARTICLE; CARCINOMA CELL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDRODYNAMICS; IN VITRO STUDY; LIVER CELL CARCINOMA; MALE; PARTICLE SIZE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; CITRATES; COMET ASSAY; DENDRIMERS; DNA DAMAGE; GOLD; HEP G2 CELLS; HUMANS; LEUKOCYTES, MONONUCLEAR; LIVER NEOPLASMS; METAL NANOPARTICLES; MICROSCOPY, ELECTRON, TRANSMISSION;

LONCHOCARPUS GLAUCIFOLIUS;

EID: 84868332187     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.09.025     Document Type: Article

References (32)

1. Alkilany A.M., Murphy C.J. Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?. Journal of Nanoparticle Research 2010, 12(7):2313-2333.
2. Chithrani B.D., Ghazani A.A., Chan W.C.W. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Letters 2006, 6(4):662-668.
3. Collins A.R. The comet assay for DNA damage and repair - principles, applications, and limitations. Molecular Biotechnology 2004, 26(3):249-261.
4. Connor E.E., Mwamuka J., Gole A., Murphy C.J., Wyatt M.D. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 2005, 1(3):325-327.
5. Crespilho F.N., Ghica M.E., Zucolotto V., Nart F.C., Oliveira O.N., Brett C.M.A. Electroactive nanostructured membranes (ENM): synthesis and electrochemical properties of redox mediator-modified gold nanoparticles using a dendrimer layer-by-layer approach. Electroanalysis 2007, 19(7-8):805-812.
6. Cutts S.M., Nudelman A., Rephaeli A., Phillips D.R. The power and potential of doxorubicin-DNA adducts. International Union of Biochemistry and Molecular Biology Life 2005, 57(2):73-81.
7. Fatisson J. Physicochemical characterization of engineered nanoparticles under physiological conditions: Effect of culture media components and particle surface coating. Colloids and Surfaces B: Biointerfaces 2012, 91:198-204.
8. Freshney R.I. Culture of Animal Cells: A Manual of Basic Technique 2000, John Wiley & Sons, New York, NY, USA.
9. Grabar K.C., Freeman R.G., Hommer M.B., Natan M.J. Preparation and characterization of Au colloid monolayers. Analytical Chemistry 1995, 67(4):735-743.
10. Johnston H.J., Semmler-Behnke M., Brown D.M., Kreyling W., Tran L., Stone V. Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro. Toxicology and Applied Pharmacology 2010, 242(1):66-78.
11. Kreuter J., Gelperina S. Use of nanoparticles for cerebral cancer. Tumori 2008, 94(2):271-277.
12. Lewinski N., Colvin V., Drezek R. Cytotoxicity of nanoparticles. Small 2008, 4(1):26-49.
13. Li J.J., Zou L., Hartono D., Ong C.N., Bay B.H., Yung L.Y.L. Gold nanoparticles induce oxidative damage in lung fibroblasts in vitro. Advanced Materials 2008, 20(1):138.
14. Maurer-Jones M.A., Bantz K.C., Love S.A., Marquis B.J., Haynes C.L. Toxicity of therapeutic nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine 2009, 4(2):219-241.
15. Mosmann T. Rapid colorimetric assay for cellular growth and survival - application to proliferation and cytotoxicity assays. Journal of Immunological Methods 1983, 65(1-2):55-63.
16. Nativo P., Prior I.A., Brust M. Uptake and intracellular fate of surface-modified gold nanoparticles. ACS Nano 2008, 2(8):1639-1644.
17. Ogawara K., Yoshida M., Higaki K., Kimura T., Shiraishi K., Nishikawa M. Hepatic uptake of polystyrene microspheres in rats: effect of particle size on intrahepatic distribution. Journal of Controlled Release 1999, 59(1):15-22.
18. Paino I.M., Miranda J.C., Marzocchi-Machado C.M., Cesarino E.J., de Castro F.A., de Souza A.M. Phagocytosis and nitric oxide levels in rheumatic inflammatory states in elderly women. Journal of Clinical Laboratory Analysis 2011, 25:47-51.
19. Pan Y., Leifert A., Ruau D., Neuss S., Bornemann J., Schmid G. Gold nanoparticles of diameter 1.4nm trigger necrosis by oxidative stress and mitochondrial damage. Small 2009, 5(18):2067-2076.
20. Patra H.K., Banerjee S., Chaudhuri U., Lahiri P., Dasgupta A.K. Cell selective response to gold nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine 2007, 3(2):111-119.
21. Pernodet N., Fang X.H., Sun Y., Bakhtina A., Ramakrishnan A., Sokolov J. Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts. Small 2006, 2(6):766-773.
22. Piperakis S.M. Comet assay: a brief history. Cell Biology and Toxicology 2009, 25(1):1-3.
23. Schipper M.L., Iyer G., Koh A.L., Cheng Z., Ebenstein Y., Aharoni A., et al. Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice. Small 2009, 5(1):126-134.
24. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low-levels of DNA damage in individual cells. Experimental Cell Research 1988, 175(1):184-191.
25. Sohaebuddin S.K., Thevenot P.T., Baker D., Eaton J.W., Tang L. Nanomaterial cytotoxicity is composition, size, and cell type dependent. Particle and Fibre Toxicology 2010, 21(7):22.
26. Sonavane G., Tomoda K., Makino K. Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size. Colloids and Surfaces B: Biointerfaces 2008, 66(2):274-280.
27. Suzuki H., Toyooka T., Ibuki Y. Simple and easy method to evaluate uptake potential of nanoparticles in mammalian cells using a flow cytometric light scatter analysis. Environmental Science and Technology 2007, 41:3018-3024.
28. Thakor A.S., Paulmurugan R., Kempen P., Zavaleta C., Sinclair R., Massoud T.F. Oxidative stress mediates the effects of Raman-active gold nanoparticles in human cells. Small 2011, 7(1):126-136.
29. Tomuleasa C., Soritau O., Orza A., Dudea M., Petrushev B., Mosteanu O., Susman S., Florea A., Pall E., Aldea M., Kacso G., Cristea V., Berindan-Neagoe I., Irimie A. Gold nanoparticles conjugated with cisplatin/doxorubicin/capecitabine lower the chemoresistance of hepatocellular carcinoma-derived cancer cells. Journal of Gastrointestinal and Liver Diseases: JGLD 2012, 21:187-196.
30. Tsoli M., Kuhn H., Brandau W., Esche H., Schmid G. Cellular uptake and toxicity of AU(55) clusters. Small 2005, 1(8-9):841-844.
31. Wei X.L., Mo Z.H., Li B., Wei J.M. Disruption of HepG2 cell adhesion by gold nanoparticle and Paclitaxel disclosed by in situ QCM measurement. Colloids and Surfaces B: Biointerfaces 2007, 59(1):100-104.
32. Zhao Y., Nalwa H.S. Nanotoxicology - Interactions of Nanomaterials with Biological Systems 2007, American Scientific Publishers, New York.