Acute and chronic administration of gold nanoparticles cause DNA damage in the cerebral cortex of adult rats

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 766-767, Issue , 2014, Pages 25-30

  Cardoso, Eria ^a,b   Rezin, Gislaine Tezza ^d   Zanoni, Elton Torres ^a   de Souza Notoya, Frederico ^a   Leffa, Daniela Dimer ^a   Damiani, Adriani Paganini ^a   Daumann, Francine ^a   Rodriguez, Juan Carlos Ortiz ^c   Benavides, Roberto ^c   da Silva, Luciano ^a   Andrade, Vanessa M ^a   Da Silva Paula, Marcos Marques ^a  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^b Department of Electrical Engineering of Federal University   (Brazil)

^c CENTRO DE INVESTIGACIÓN EN QUÍMICA APLICADA   (Mexico)

^d UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

Author keywords

Comet assay; Damage frequency; Damage index; DNA damage; Genotoxicity; Gold nanoparticles

Indexed keywords

GOLD NANOPARTICLE; GOLD; METAL NANOPARTICLE;

ACUTE DRUG ADMINISTRATION; ADULT; ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHRONIC DRUG ADMINISTRATION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; MALE; NANOANALYSIS; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; AGE; ANIMAL; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECTS; ENERGY METABOLISM; METABOLISM; WISTAR RAT;

AGE FACTORS; ANIMALS; CEREBRAL CORTEX; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENERGY METABOLISM; GOLD; MALE; METAL NANOPARTICLES; RATS; RATS, WISTAR;

EID: 84904596368     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2014.05.009     Document Type: Article

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