메뉴 건너뛰기




Volumn 1, Issue 2, 2016, Pages 133-146

Pathophysiology of irritable bowel syndrome

Author keywords

[No Author keywords available]

Indexed keywords

COLESTIPOL; COLESTYRAMINE; EBASTINE; ELOBIXIBAT; GLUTEN; LARAZOTIDE; LUBIPROSTONE; MEXILETINE; ONDANSETRON; PRUCALOPRIDE; RAMOSETRON; RIFAXIMIN;

EID: 84996523425     PISSN: 24681253     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2468-1253(16)30023-1     Document Type: Review
Times cited : (406)

References (135)
  • 2
    • 84862651150 scopus 로고    scopus 로고
    • Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis
    • 2 Lovell, RM, Ford, AC, Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin Gastroenterol Hepatol 10 (2012), 712–721.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 712-721
    • Lovell, R.M.1    Ford, A.C.2
  • 3
    • 84905442940 scopus 로고    scopus 로고
    • American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation
    • 3 Ford, AC, Moayyedi, P, Lacy, BE, et al. American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol 109:suppl 1 (2014), S2–26.
    • (2014) Am J Gastroenterol , vol.109 , pp. S2-26
    • Ford, A.C.1    Moayyedi, P.2    Lacy, B.E.3
  • 4
    • 84930761825 scopus 로고    scopus 로고
    • Therapeutic strategies for functional dyspepsia and irritable bowel syndrome based on pathophysiology
    • 4 Talley, NJ, Holtmann, G, Walker, MM, Therapeutic strategies for functional dyspepsia and irritable bowel syndrome based on pathophysiology. J Gastroenterol 50 (2015), 601–613.
    • (2015) J Gastroenterol , vol.50 , pp. 601-613
    • Talley, N.J.1    Holtmann, G.2    Walker, M.M.3
  • 5
    • 43549099537 scopus 로고    scopus 로고
    • Irritable bowel syndrome: a 10-year natural history of symptoms, and factors that influence consultation behavior
    • 5 Ford, AC, Forman, D, Bailey, AG, Axon, AT, Moayyedi, P, Irritable bowel syndrome: a 10-year natural history of symptoms, and factors that influence consultation behavior. Am J Gastroenterol 103 (2008), 1229–1239.
    • (2008) Am J Gastroenterol , vol.103 , pp. 1229-1239
    • Ford, A.C.1    Forman, D.2    Bailey, A.G.3    Axon, A.T.4    Moayyedi, P.5
  • 6
    • 84952688295 scopus 로고    scopus 로고
    • Burden of gastrointestinal, liver, and pancreatic diseases in the United States
    • 6 Peery, AF, Crockett, SD, Barritt, AS, et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology 149 (2015), 1731–1741.
    • (2015) Gastroenterology , vol.149 , pp. 1731-1741
    • Peery, A.F.1    Crockett, S.D.2    Barritt, A.S.3
  • 7
    • 77950519595 scopus 로고    scopus 로고
    • Impact of functional gastrointestinal disorders on survival in the community
    • 7 Chang, JY, Locke, GR, McNally, MA, et al. Impact of functional gastrointestinal disorders on survival in the community. Am J Gastroenterol 105 (2010), 822–832.
    • (2010) Am J Gastroenterol , vol.105 , pp. 822-832
    • Chang, J.Y.1    Locke, G.R.2    McNally, M.A.3
  • 8
    • 47649110843 scopus 로고    scopus 로고
    • Psychological comorbidity and complexity of gastrointestinal symptoms in clinically diagnosed irritable bowel syndrome patients
    • 8 Mikocka-Walus, A, Turnbull, D, Moulding, N, Wilson, I, Andrews, JM, Holtmann, G, Psychological comorbidity and complexity of gastrointestinal symptoms in clinically diagnosed irritable bowel syndrome patients. J Gastroenterol Hepatol 23 (2008), 1137–1143.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1137-1143
    • Mikocka-Walus, A.1    Turnbull, D.2    Moulding, N.3    Wilson, I.4    Andrews, J.M.5    Holtmann, G.6
  • 9
    • 84867099191 scopus 로고    scopus 로고
    • Prevalence of symptoms meeting criteria for irritable bowel syndrome in inflammatory bowel disease: systematic review and meta-analysis
    • 9 Halpin, SJ, Ford, AC, Prevalence of symptoms meeting criteria for irritable bowel syndrome in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol 107 (2012), 1474–1482.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1474-1482
    • Halpin, S.J.1    Ford, A.C.2
  • 10
    • 84875364069 scopus 로고    scopus 로고
    • Prevalence of irritable bowel syndrome-type symptoms in patients with celiac disease: a meta-analysis
    • 10 Sainsbury, A, Sanders, DS, Ford, AC, Prevalence of irritable bowel syndrome-type symptoms in patients with celiac disease: a meta-analysis. Clin Gastroenterol Hepatol 11 (2013), 359–365.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 359-365
    • Sainsbury, A.1    Sanders, D.S.2    Ford, A.C.3
  • 11
    • 84930479434 scopus 로고    scopus 로고
    • Systematic review with meta-analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea
    • 11 Slattery, SA, Niaz, O, Aziz, Q, Ford, AC, Farmer, AD, Systematic review with meta-analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea. Aliment Pharmacol Ther 42 (2015), 3–11.
    • (2015) Aliment Pharmacol Ther , vol.42 , pp. 3-11
    • Slattery, S.A.1    Niaz, O.2    Aziz, Q.3    Ford, A.C.4    Farmer, A.D.5
  • 12
    • 84963641693 scopus 로고    scopus 로고
    • Irritable bowel syndrome and microscopic colitis: a systematic review and meta-analysis
    • 12 Kamp, EJ, Kane, JS, Ford, AC, Irritable bowel syndrome and microscopic colitis: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 14 (2016), 659–668.
    • (2016) Clin Gastroenterol Hepatol , vol.14 , pp. 659-668
    • Kamp, E.J.1    Kane, J.S.2    Ford, A.C.3
  • 13
    • 84901736952 scopus 로고    scopus 로고
    • Complicated and uncomplicated peptic ulcer disease: altered symptom response to a nutrient challenge linked to gastric motor dysfunction
    • 13 Gururatsakul, M, Holloway, RH, Bellon, M, Bartholomeusz, D, Talley, NJ, Holtmann, GJ, Complicated and uncomplicated peptic ulcer disease: altered symptom response to a nutrient challenge linked to gastric motor dysfunction. Digestion 89 (2014), 239–246.
    • (2014) Digestion , vol.89 , pp. 239-246
    • Gururatsakul, M.1    Holloway, R.H.2    Bellon, M.3    Bartholomeusz, D.4    Talley, N.J.5    Holtmann, G.J.6
  • 14
    • 0018170811 scopus 로고
    • Colonic myoelectrical activity in irritable-bowel syndrome: effect of eating and anticholinergics
    • 14 Sullivan, MA, Cohen, S, Snape, WJ Jr, Colonic myoelectrical activity in irritable-bowel syndrome: effect of eating and anticholinergics. N Engl J Med 298 (1978), 878–883.
    • (1978) N Engl J Med , vol.298 , pp. 878-883
    • Sullivan, M.A.1    Cohen, S.2    Snape, W.J.3
  • 15
    • 0015581604 scopus 로고
    • Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome
    • 15 Ritchie, J, Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 14 (1973), 125–132.
    • (1973) Gut , vol.14 , pp. 125-132
    • Ritchie, J.1
  • 16
    • 0041843834 scopus 로고    scopus 로고
    • Medically unexplained physical symptoms, anxiety and depression: a meta-analytic review
    • 16 Henningsen, P, Zimmermann, T, Sattel, H, Medically unexplained physical symptoms, anxiety and depression: a meta-analytic review. Psychosom Med 65 (2003), 528–533.
    • (2003) Psychosom Med , vol.65 , pp. 528-533
    • Henningsen, P.1    Zimmermann, T.2    Sattel, H.3
  • 17
    • 84921884584 scopus 로고    scopus 로고
    • Irritable bowel syndrome is significantly associated with somatisation in 840 patients, which may drive bloating
    • 17 Patel, P, Bercik, P, Morgan, DG, et al. Irritable bowel syndrome is significantly associated with somatisation in 840 patients, which may drive bloating. Aliment Pharmacol Ther 41 (2015), 449–458.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 449-458
    • Patel, P.1    Bercik, P.2    Morgan, D.G.3
  • 19
    • 0033547013 scopus 로고    scopus 로고
    • Functional somatic syndromes: one or many?
    • 19 Wessely, S, Nimnuan, C, Sharpe, M, Functional somatic syndromes: one or many?. Lancet 354 (1999), 936–939.
    • (1999) Lancet , vol.354 , pp. 936-939
    • Wessely, S.1    Nimnuan, C.2    Sharpe, M.3
  • 20
    • 84860649408 scopus 로고    scopus 로고
    • The brain-gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study
    • 20 Koloski, NA, Jones, M, Kalantar, J, Weltman, M, Zaguirre, J, Talley, NJ, The brain-gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study. Gut 61 (2012), 1284–1290.
    • (2012) Gut , vol.61 , pp. 1284-1290
    • Koloski, N.A.1    Jones, M.2    Kalantar, J.3    Weltman, M.4    Zaguirre, J.5    Talley, N.J.6
  • 21
    • 84886286555 scopus 로고    scopus 로고
    • Functional gastrointestinal disorders (FGIDs) and psychological disorders: strong evidence that the link is bidirectional, but psychological distress is more likely to precede a new diagnosis of an FGID
    • (abstr).
    • 21 Jones, MP, Van Oudenhove, L, Talley, NJ, Functional gastrointestinal disorders (FGIDs) and psychological disorders: strong evidence that the link is bidirectional, but psychological distress is more likely to precede a new diagnosis of an FGID. Gastroenterology, 142(suppl 1), 2012, S570 (abstr).
    • (2012) Gastroenterology , vol.142 , pp. S570
    • Jones, M.P.1    Van Oudenhove, L.2    Talley, N.J.3
  • 22
    • 84981164813 scopus 로고    scopus 로고
    • Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study
    • 22 Koloski, NA, Jones, MP, Talley, NJ, Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study. Aliment Pharmacol Ther 44 (2016), 592–600.
    • (2016) Aliment Pharmacol Ther , vol.44 , pp. 592-600
    • Koloski, N.A.1    Jones, M.P.2    Talley, N.J.3
  • 23
    • 0038037551 scopus 로고    scopus 로고
    • Psychopathology in irritable bowel syndrome: support for a psychophysiological model
    • 23 Sykes, MA, Blanchard, EB, Lackner, J, Keefer, L, Krasner, S, Psychopathology in irritable bowel syndrome: support for a psychophysiological model. J Behav Med 26 (2003), 361–372.
    • (2003) J Behav Med , vol.26 , pp. 361-372
    • Sykes, M.A.1    Blanchard, E.B.2    Lackner, J.3    Keefer, L.4    Krasner, S.5
  • 24
    • 33947324517 scopus 로고    scopus 로고
    • Immune activation in patients with irritable bowel syndrome
    • 24 Liebregts, T, Adam, B, Bredack, C, et al. Immune activation in patients with irritable bowel syndrome. Gastroenterology 132 (2007), 913–920.
    • (2007) Gastroenterology , vol.132 , pp. 913-920
    • Liebregts, T.1    Adam, B.2    Bredack, C.3
  • 25
    • 84898777631 scopus 로고    scopus 로고
    • Brain-gut microbiome interactions and functional bowel disorders
    • 25 Mayer, EA, Savidge, T, Shulman, RJ, Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology 146 (2014), 1500–1512.
    • (2014) Gastroenterology , vol.146 , pp. 1500-1512
    • Mayer, E.A.1    Savidge, T.2    Shulman, R.J.3
  • 27
    • 84892828465 scopus 로고    scopus 로고
    • Diet rapidly and reproducibly alters the human gut microbiome
    • 27 David, LA, Maurice, CF, Carmody, RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505 (2014), 559–563.
    • (2014) Nature , vol.505 , pp. 559-563
    • David, L.A.1    Maurice, C.F.2    Carmody, R.N.3
  • 28
    • 0028264427 scopus 로고
    • Bran and irritable bowel syndrome: time for reappraisal
    • 28 Francis, CY, Whorwell, PJ, Bran and irritable bowel syndrome: time for reappraisal. Lancet 344 (1994), 39–40.
    • (1994) Lancet , vol.344 , pp. 39-40
    • Francis, C.Y.1    Whorwell, P.J.2
  • 29
    • 45849125772 scopus 로고    scopus 로고
    • Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence
    • 29 Shepherd, SJ, Parker, FC, Muir, JG, Gibson, PR, Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence. Clin Gastroenterol Hepatol 6 (2008), 765–771.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 765-771
    • Shepherd, S.J.1    Parker, F.C.2    Muir, J.G.3    Gibson, P.R.4
  • 30
    • 84891941728 scopus 로고    scopus 로고
    • Differential effects of FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI
    • 30 Murray, K, Wilkinson-Smith, V, Hoad, C, et al. Differential effects of FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI. Am J Gastroenterol 109 (2014), 110–119.
    • (2014) Am J Gastroenterol , vol.109 , pp. 110-119
    • Murray, K.1    Wilkinson-Smith, V.2    Hoad, C.3
  • 31
    • 84958046752 scopus 로고    scopus 로고
    • Evidence for the presence of non-celiac gluten sensitivity in patients with functional gastrointestinal symptoms: results from a multicenter randomized double-blind placebo-controlled gluten challenge
    • 31 Elli, L, Tomba, C, Branchi, F, et al. Evidence for the presence of non-celiac gluten sensitivity in patients with functional gastrointestinal symptoms: results from a multicenter randomized double-blind placebo-controlled gluten challenge. Nutrients, 8, 2016, 84.
    • (2016) Nutrients , vol.8 , pp. 84
    • Elli, L.1    Tomba, C.2    Branchi, F.3
  • 32
    • 84951569687 scopus 로고    scopus 로고
    • Effect of bread gluten content on gastrointestinal function: a crossover MRI study on healthy humans
    • 32 Coletta, M, Gates, FK, Marciani, L, et al. Effect of bread gluten content on gastrointestinal function: a crossover MRI study on healthy humans. Br J Nutr 115 (2016), 55–61.
    • (2016) Br J Nutr , vol.115 , pp. 55-61
    • Coletta, M.1    Gates, F.K.2    Marciani, L.3
  • 33
    • 84876481254 scopus 로고    scopus 로고
    • A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function
    • 33 Vazquez-Roque, MI, Camilleri, M, Smyrk, T, et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology 144 (2013), 903–911.
    • (2013) Gastroenterology , vol.144 , pp. 903-911
    • Vazquez-Roque, M.I.1    Camilleri, M.2    Smyrk, T.3
  • 34
    • 77950518602 scopus 로고    scopus 로고
    • Familial aggregation of irritable bowel syndrome: a family case-control study
    • 34 Saito, YA, Petersen, GM, Larson, JJ, et al. Familial aggregation of irritable bowel syndrome: a family case-control study. Am J Gastroenterol 105 (2010), 833–841.
    • (2010) Am J Gastroenterol , vol.105 , pp. 833-841
    • Saito, Y.A.1    Petersen, G.M.2    Larson, J.J.3
  • 35
    • 34248550837 scopus 로고    scopus 로고
    • Influence of genetics on irritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: a twin study
    • 35 Lembo, A, Zaman, M, Jones, M, Talley, NJ, Influence of genetics on irritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: a twin study. Aliment Pharmacol Ther 25 (2007), 1343–1350.
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 1343-1350
    • Lembo, A.1    Zaman, M.2    Jones, M.3    Talley, N.J.4
  • 36
    • 33744794378 scopus 로고    scopus 로고
    • Gastrointestinal symptoms in families of patients with an SCN5A-encoded cardiac channelopathy: evidence of an intestinal channelopathy
    • 36 Locke, GR 3rd, Ackerman, MJ, Zinsmeister, AR, Thapa, P, Farrugia, G, Gastrointestinal symptoms in families of patients with an SCN5A-encoded cardiac channelopathy: evidence of an intestinal channelopathy. Am J Gastroenterol 101 (2006), 1299–1304.
    • (2006) Am J Gastroenterol , vol.101 , pp. 1299-1304
    • Locke, G.R.1    Ackerman, M.J.2    Zinsmeister, A.R.3    Thapa, P.4    Farrugia, G.5
  • 37
    • 59449091153 scopus 로고    scopus 로고
    • Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy
    • 37 Saito, YA, Strege, PR, Tester, DJ, et al. Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy. Am J Physiol Gastrointest Liver Physiol 296 (2009), G211–G218.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , pp. G211-G218
    • Saito, Y.A.1    Strege, P.R.2    Tester, D.J.3
  • 38
    • 84901230979 scopus 로고    scopus 로고
    • Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome
    • 38 Beyder, A, Mazzone, A, Strege, PR, et al. Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome. Gastroenterology 146 (2014), 1659–1668.
    • (2014) Gastroenterology , vol.146 , pp. 1659-1668
    • Beyder, A.1    Mazzone, A.2    Strege, P.R.3
  • 39
    • 84878767661 scopus 로고    scopus 로고
    • Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα
    • 39 Swan, C, Duroudier, NP, Campbell, E, et al. Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα. Gut 62 (2013), 985–994.
    • (2013) Gut , vol.62 , pp. 985-994
    • Swan, C.1    Duroudier, N.P.2    Campbell, E.3
  • 40
    • 80052862553 scopus 로고    scopus 로고
    • Association of TNFSF15 polymorphism with irritable bowel syndrome
    • 40 Zucchelli, M, Camilleri, M, Andreasson, AN, et al. Association of TNFSF15 polymorphism with irritable bowel syndrome. Gut 60 (2011), 1671–1677.
    • (2011) Gut , vol.60 , pp. 1671-1677
    • Zucchelli, M.1    Camilleri, M.2    Andreasson, A.N.3
  • 41
    • 84960502854 scopus 로고    scopus 로고
    • Associations between single-nucleotide polymorphisms in corticotropin-releasing hormone-related genes and irritable bowel syndrome
    • 41 Sasaki, A, Sato, N, Suzuki, N, et al. Associations between single-nucleotide polymorphisms in corticotropin-releasing hormone-related genes and irritable bowel syndrome. PLoS One, 11, 2016, e0149322.
    • (2016) PLoS One , vol.11 , pp. e0149322
    • Sasaki, A.1    Sato, N.2    Suzuki, N.3
  • 42
    • 84902264271 scopus 로고    scopus 로고
    • Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome
    • 42 Wouters, MM, Lambrechts, D, Knapp, M, et al. Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome. Gut 63 (2014), 1003–1011.
    • (2014) Gut , vol.63 , pp. 1003-1011
    • Wouters, M.M.1    Lambrechts, D.2    Knapp, M.3
  • 43
    • 84887230206 scopus 로고    scopus 로고
    • Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes
    • 43 Grasberger, H, Chang, L, Shih, W, et al. Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. Am J Gastroenterol 108 (2013), 1766–1774.
    • (2013) Am J Gastroenterol , vol.108 , pp. 1766-1774
    • Grasberger, H.1    Chang, L.2    Shih, W.3
  • 44
    • 79551700097 scopus 로고    scopus 로고
    • Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome
    • 44 Jun, S, Kohen, R, Cain, KC, Jarrett, ME, Heitkemper, MM, Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome. Neurogastroenterol Motil 23 (2011), 233–239.
    • (2011) Neurogastroenterol Motil , vol.23 , pp. 233-239
    • Jun, S.1    Kohen, R.2    Cain, K.C.3    Jarrett, M.E.4    Heitkemper, M.M.5
  • 46
    • 84865313567 scopus 로고    scopus 로고
    • Increased bile acid biosynthesis is associated with irritable bowel syndrome with diarrhea
    • 46 Wong, BS, Camilleri, M, Carlson, P, et al. Increased bile acid biosynthesis is associated with irritable bowel syndrome with diarrhea. Clin Gastroenterol Hepatol 10 (2012), 1009–1015.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 1009-1015
    • Wong, B.S.1    Camilleri, M.2    Carlson, P.3
  • 47
    • 79958092986 scopus 로고    scopus 로고
    • A klothoβ variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea
    • 47 Wong, BS, Camilleri, M, Carlson, PJ, et al. A klothoβ variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea. Gastroenterology 140 (2011), 1934–1942.
    • (2011) Gastroenterology , vol.140 , pp. 1934-1942
    • Wong, B.S.1    Camilleri, M.2    Carlson, P.J.3
  • 48
    • 84947569017 scopus 로고    scopus 로고
    • Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts
    • 48 Ek, WE, Reznichenko, A, Ripke, S, et al. Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. Gut 64 (2014), 1774–1782.
    • (2014) Gut , vol.64 , pp. 1774-1782
    • Ek, W.E.1    Reznichenko, A.2    Ripke, S.3
  • 49
    • 84884683078 scopus 로고    scopus 로고
    • Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
    • 49 Beaudoin, M, Goyette, P, Boucher, G, et al. Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genet, 9, 2013, e1003723.
    • (2013) PLoS Genet , vol.9 , pp. e1003723
    • Beaudoin, M.1    Goyette, P.2    Boucher, G.3
  • 50
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • 50 Franke, A, McGovern, DP, Barrett, JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 42 (2010), 1118–1125.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3
  • 51
    • 84928188966 scopus 로고    scopus 로고
    • A meta-analysis of immunogenetic case-control association studies in irritable bowel syndrome
    • 51 Czogalla, B, Schmitteckert, S, Houghton, LA, et al. A meta-analysis of immunogenetic case-control association studies in irritable bowel syndrome. Neurogastroenterol Motil 27 (2015), 717–727.
    • (2015) Neurogastroenterol Motil , vol.27 , pp. 717-727
    • Czogalla, B.1    Schmitteckert, S.2    Houghton, L.A.3
  • 53
    • 77951675412 scopus 로고    scopus 로고
    • Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study
    • 53 Ford, AC, Thabane, M, Collins, SM, et al. Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study. Gastroenterology 138 (2010), 1727–1736.
    • (2010) Gastroenterology , vol.138 , pp. 1727-1736
    • Ford, A.C.1    Thabane, M.2    Collins, S.M.3
  • 54
    • 77951702072 scopus 로고    scopus 로고
    • Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery
    • 54 Marshall, JK, Thabane, M, Garg, AX, et al. Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery. Gut 59 (2010), 605–611.
    • (2010) Gut , vol.59 , pp. 605-611
    • Marshall, J.K.1    Thabane, M.2    Garg, A.X.3
  • 55
    • 33744547408 scopus 로고    scopus 로고
    • Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model
    • 55 Adam, B, Liebregts, T, Gschossmann, JM, et al. Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model. Pain 123 (2006), 179–186.
    • (2006) Pain , vol.123 , pp. 179-186
    • Adam, B.1    Liebregts, T.2    Gschossmann, J.M.3
  • 56
    • 33751407767 scopus 로고    scopus 로고
    • Psychological stress and the severity of post-inflammatory visceral hyperalgesia
    • 56 Liebregts, T, Adam, B, Bertel, A, et al. Psychological stress and the severity of post-inflammatory visceral hyperalgesia. Eur J Pain 11 (2007), 216–222.
    • (2007) Eur J Pain , vol.11 , pp. 216-222
    • Liebregts, T.1    Adam, B.2    Bertel, A.3
  • 57
    • 84931470552 scopus 로고    scopus 로고
    • Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis
    • 57 Wouters, MM, Van Wanrooy, S, Nguyen, A, et al. Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis. Gut 65 (2016), 1279–1288.
    • (2016) Gut , vol.65 , pp. 1279-1288
    • Wouters, M.M.1    Van Wanrooy, S.2    Nguyen, A.3
  • 58
    • 84955357050 scopus 로고    scopus 로고
    • The epidemiology of irritable bowel syndrome in the US military: findings from the millennium cohort study
    • 58 Riddle, MS, Welsh, M, Porter, CK, et al. The epidemiology of irritable bowel syndrome in the US military: findings from the millennium cohort study. Am J Gastroenterol 111 (2016), 93–104.
    • (2016) Am J Gastroenterol , vol.111 , pp. 93-104
    • Riddle, M.S.1    Welsh, M.2    Porter, C.K.3
  • 59
    • 84920945233 scopus 로고    scopus 로고
    • Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden
    • 59 Walker, MM, Talley, NJ, Ingañas, L, et al. Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden. Hum Pathol 46 (2015), 277–283.
    • (2015) Hum Pathol , vol.46 , pp. 277-283
    • Walker, M.M.1    Talley, N.J.2    Ingañas, L.3
  • 60
    • 20044379763 scopus 로고    scopus 로고
    • Effect of E Coli Nissle 1917 on post-inflammatory visceral sensory function in a rat model
    • 60 Liebregts, T, Adam, B, Bertel, A, et al. Effect of E Coli Nissle 1917 on post-inflammatory visceral sensory function in a rat model. Neurogastroenterol Motil 17 (2005), 410–414.
    • (2005) Neurogastroenterol Motil , vol.17 , pp. 410-414
    • Liebregts, T.1    Adam, B.2    Bertel, A.3
  • 61
    • 4444360389 scopus 로고    scopus 로고
    • Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction
    • 61 Verdú, EF, Bercík, P, Bergonzelli, GE, et al. Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction. Gastroenterology 127 (2004), 826–837.
    • (2004) Gastroenterology , vol.127 , pp. 826-837
    • Verdú, E.F.1    Bercík, P.2    Bergonzelli, G.E.3
  • 62
    • 84890985732 scopus 로고    scopus 로고
    • Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome
    • 62 Jalanka-Tuovinen, J, Salojärvi, J, Salonen, A, et al. Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome. Gut 63 (2014), 1737–1745.
    • (2014) Gut , vol.63 , pp. 1737-1745
    • Jalanka-Tuovinen, J.1    Salojärvi, J.2    Salonen, A.3
  • 63
    • 84921438829 scopus 로고    scopus 로고
    • Altered faecal and mucosal microbial composition in post-infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress
    • 63 Sundin, J, Rangel, I, Fuentes, S, et al. Altered faecal and mucosal microbial composition in post-infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress. Aliment Pharmacol Ther 41 (2015), 342–351.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 342-351
    • Sundin, J.1    Rangel, I.2    Fuentes, S.3
  • 64
    • 84861185968 scopus 로고    scopus 로고
    • Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome
    • 64 Carroll, IM, Ringel-Kulka, T, Siddle, JP, Ringel, Y, Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil 24 (2012), 521–530.
    • (2012) Neurogastroenterol Motil , vol.24 , pp. 521-530
    • Carroll, I.M.1    Ringel-Kulka, T.2    Siddle, J.P.3    Ringel, Y.4
  • 65
    • 84862829772 scopus 로고    scopus 로고
    • Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome
    • 65 Chassard, C, Dapoigny, M, Scott, KP, et al. Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome. Aliment Pharmacol Ther 35 (2012), 828–838.
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 828-838
    • Chassard, C.1    Dapoigny, M.2    Scott, K.P.3
  • 66
    • 84969422034 scopus 로고    scopus 로고
    • Altered colonic bacterial fermentation as a potential pathophysiological factor in irritable bowel syndrome
    • 66 Ringel-Kulka, T, Choi, CH, Temas, D, et al. Altered colonic bacterial fermentation as a potential pathophysiological factor in irritable bowel syndrome. Am J Gastroenterol 110 (2015), 1339–1346.
    • (2015) Am J Gastroenterol , vol.110 , pp. 1339-1346
    • Ringel-Kulka, T.1    Choi, C.H.2    Temas, D.3
  • 67
    • 84871627299 scopus 로고    scopus 로고
    • Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath
    • 67 Kim, G, Deepinder, F, Morales, W, et al. Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath. Dig Dis Sci 57 (2012), 3213–3218.
    • (2012) Dig Dis Sci , vol.57 , pp. 3213-3218
    • Kim, G.1    Deepinder, F.2    Morales, W.3
  • 68
    • 4043116899 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome
    • 68 Lin, HC, Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome. JAMA 292 (2004), 852–858.
    • (2004) JAMA , vol.292 , pp. 852-858
    • Lin, H.C.1
  • 69
    • 0033636668 scopus 로고    scopus 로고
    • Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome
    • 69 Pimentel, M, Chow, EJ, Lin, HC, Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 95 (2000), 3503–3506.
    • (2000) Am J Gastroenterol , vol.95 , pp. 3503-3506
    • Pimentel, M.1    Chow, E.J.2    Lin, H.C.3
  • 70
    • 41849111638 scopus 로고    scopus 로고
    • Lactulose breath testing does not discriminate patients with irritable bowel syndrome from healthy controls
    • 70 Bratten, JR, Spanier, J, Jones, MP, Lactulose breath testing does not discriminate patients with irritable bowel syndrome from healthy controls. Am J Gastroenterol 103 (2008), 958–963.
    • (2008) Am J Gastroenterol , vol.103 , pp. 958-963
    • Bratten, J.R.1    Spanier, J.2    Jones, M.P.3
  • 71
    • 34249790127 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth in patients with irritable bowel syndrome
    • 71 Posserud, I, Stotzer, PO, Björnsson, ES, Abrahamsson, H, Simrén, M, Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut 56 (2007), 802–808.
    • (2007) Gut , vol.56 , pp. 802-808
    • Posserud, I.1    Stotzer, P.O.2    Björnsson, E.S.3    Abrahamsson, H.4    Simrén, M.5
  • 72
    • 33750721328 scopus 로고    scopus 로고
    • The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial
    • 72 Pimentel, M, Park, S, Mirocha, J, Kane, SV, Kong, Y, The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann Int Med 145 (2006), 557–563.
    • (2006) Ann Int Med , vol.145 , pp. 557-563
    • Pimentel, M.1    Park, S.2    Mirocha, J.3    Kane, S.V.4    Kong, Y.5
  • 73
    • 78650864077 scopus 로고    scopus 로고
    • Rifaximin therapy for patients with irritable bowel syndrome without constipation
    • 73 Pimentel, M, Lembo, A, Chey, WD, et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med 364 (2011), 22–32.
    • (2011) N Engl J Med , vol.364 , pp. 22-32
    • Pimentel, M.1    Lembo, A.2    Chey, W.D.3
  • 74
    • 84892825869 scopus 로고    scopus 로고
    • Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats
    • 74 Xu, D, Gao, J, Gillilland, M 3rd, et al. Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats. Gastroenterology 146 (2014), 484–496.
    • (2014) Gastroenterology , vol.146 , pp. 484-496
    • Xu, D.1    Gao, J.2    Gillilland, M.3
  • 75
    • 84924921458 scopus 로고    scopus 로고
    • Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis
    • 75 Ford, AC, Quigley, EM, Lacy, BE, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol 109 (2014), 1547–1561.
    • (2014) Am J Gastroenterol , vol.109 , pp. 1547-1561
    • Ford, A.C.1    Quigley, E.M.2    Lacy, B.E.3
  • 76
    • 79959859340 scopus 로고    scopus 로고
    • Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review
    • 76 Ford, AC, Talley, NJ, Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review. J Gastroenterol 46 (2011), 421–431.
    • (2011) J Gastroenterol , vol.46 , pp. 421-431
    • Ford, A.C.1    Talley, N.J.2
  • 77
    • 0026641447 scopus 로고
    • Is the irritable gut an inflamed gut?
    • 77 Collins, SM, Is the irritable gut an inflamed gut?. Scand J Gastroenterol Suppl 192 (1992), 102–105.
    • (1992) Scand J Gastroenterol Suppl , vol.192 , pp. 102-105
    • Collins, S.M.1
  • 78
    • 84855189415 scopus 로고    scopus 로고
    • Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study
    • 78 Wensaas, KA, Langeland, N, Hanevik, K, Mørch, K, Eide, GE, Rortveit, G, Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study. Gut 61 (2012), 214–219.
    • (2012) Gut , vol.61 , pp. 214-219
    • Wensaas, K.A.1    Langeland, N.2    Hanevik, K.3    Mørch, K.4    Eide, G.E.5    Rortveit, G.6
  • 79
    • 84903189712 scopus 로고    scopus 로고
    • Salmonella gastroenteritis during childhood is a risk factor for irritable bowel syndrome in adulthood
    • 79 Cremon, C, Stanghellini, V, Pallotti, F, et al. Salmonella gastroenteritis during childhood is a risk factor for irritable bowel syndrome in adulthood. Gastroenterology 147 (2014), 69–77.
    • (2014) Gastroenterology , vol.147 , pp. 69-77
    • Cremon, C.1    Stanghellini, V.2    Pallotti, F.3
  • 80
    • 70350658232 scopus 로고    scopus 로고
    • Pathogenic mechanisms of postinfectious functional gastrointestinal disorders: results 3 years after gastroenteritis
    • 80 Mearin, F, Perelló, A, Balboa, A, et al. Pathogenic mechanisms of postinfectious functional gastrointestinal disorders: results 3 years after gastroenteritis. Scand J Gastroenterol 44 (2009), 1173–1185.
    • (2009) Scand J Gastroenterol , vol.44 , pp. 1173-1185
    • Mearin, F.1    Perelló, A.2    Balboa, A.3
  • 81
    • 0037378888 scopus 로고    scopus 로고
    • Increased rectal mucosal expression of interleukin 1β in recently acquired post-infectious irritable bowel syndrome
    • 81 Gwee, KA, Collins, SM, Read, NW, et al. Increased rectal mucosal expression of interleukin 1β in recently acquired post-infectious irritable bowel syndrome. Gut 52 (2003), 523–526.
    • (2003) Gut , vol.52 , pp. 523-526
    • Gwee, K.A.1    Collins, S.M.2    Read, N.W.3
  • 82
    • 77951975962 scopus 로고    scopus 로고
    • Increased proteasome-mediated degradation of occludin in irritable bowel syndrome
    • 82 Coëffier, M, Gloro, R, Boukhettala, N, et al. Increased proteasome-mediated degradation of occludin in irritable bowel syndrome. Am J Gastroenterol 105 (2010), 1181–1188.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1181-1188
    • Coëffier, M.1    Gloro, R.2    Boukhettala, N.3
  • 83
    • 84940495158 scopus 로고    scopus 로고
    • Imbalance of tumor necrosis factor-α, interleukin-8 and interleukin-10 production evokes barrier dysfunction, severe abdominal symptoms and psychological disorders in patients with irritable bowel syndrome-associated diarrhea
    • 83 Zhen, Y, Chu, C, Zhou, S, Qi, M, Shu, R, Imbalance of tumor necrosis factor-α, interleukin-8 and interleukin-10 production evokes barrier dysfunction, severe abdominal symptoms and psychological disorders in patients with irritable bowel syndrome-associated diarrhea. Mol Med Rep 12 (2015), 5239–5245.
    • (2015) Mol Med Rep , vol.12 , pp. 5239-5245
    • Zhen, Y.1    Chu, C.2    Zhou, S.3    Qi, M.4    Shu, R.5
  • 84
    • 65949087893 scopus 로고    scopus 로고
    • B-cell activation in patients with irritable bowel syndrome (IBS)
    • 84 Ohman, L, Lindmark, AC, Isaksson, S, et al. B-cell activation in patients with irritable bowel syndrome (IBS). Neurogastroenterol Motil 21 (2009), 644–650.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 644-650
    • Ohman, L.1    Lindmark, A.C.2    Isaksson, S.3
  • 85
    • 84941299655 scopus 로고    scopus 로고
    • Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations
    • 85 Vicario, M, González-Castro, AM, Martínez, C, et al. Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations. Gut 64 (2015), 1379–1388.
    • (2015) Gut , vol.64 , pp. 1379-1388
    • Vicario, M.1    González-Castro, A.M.2    Martínez, C.3
  • 86
    • 84884283276 scopus 로고    scopus 로고
    • Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes
    • 86 Hughes, PA, Harrington, AM, Castro, J, et al. Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes. Gut 62 (2013), 1456–1465.
    • (2013) Gut , vol.62 , pp. 1456-1465
    • Hughes, P.A.1    Harrington, A.M.2    Castro, J.3
  • 87
    • 84908618118 scopus 로고    scopus 로고
    • Immune derived opioidergic inhibition of viscerosensory afferents is decreased in irritable bowel syndrome patients
    • 87 Hughes, PA, Moretta, M, Lim, A, et al. Immune derived opioidergic inhibition of viscerosensory afferents is decreased in irritable bowel syndrome patients. Brain Behav Immun 42 (2014), 191–203.
    • (2014) Brain Behav Immun , vol.42 , pp. 191-203
    • Hughes, P.A.1    Moretta, M.2    Lim, A.3
  • 88
    • 11144330063 scopus 로고    scopus 로고
    • Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario
    • 88 Marshall, JK, Thabane, M, Garg, AX, et al. Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario. Aliment Pharmacol Ther 20 (2004), 1317–1322.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 1317-1322
    • Marshall, J.K.1    Thabane, M.2    Garg, A.X.3
  • 89
    • 84870530192 scopus 로고    scopus 로고
    • Association of HLA-DQ gene with bowel transit, barrier function, and inflammation in irritable bowel syndrome with diarrhea
    • 89 Vazquez-Roque, MI, Camilleri, M, Smyrk, T, et al. Association of HLA-DQ gene with bowel transit, barrier function, and inflammation in irritable bowel syndrome with diarrhea. Am J Physiol Gastrointest Liver Physiol 303 (2012), G1262–G1269.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303 , pp. G1262-G1269
    • Vazquez-Roque, M.I.1    Camilleri, M.2    Smyrk, T.3
  • 90
    • 84926666952 scopus 로고    scopus 로고
    • Associations among gut permeability, inflammatory markers, and symptoms in patients with irritable bowel syndrome
    • 90 Shulman, RJ, Jarrett, ME, Cain, KC, Broussard, EK, Heitkemper, MM, Associations among gut permeability, inflammatory markers, and symptoms in patients with irritable bowel syndrome. J Gastroenterol 49 (2014), 1467–1476.
    • (2014) J Gastroenterol , vol.49 , pp. 1467-1476
    • Shulman, R.J.1    Jarrett, M.E.2    Cain, K.C.3    Broussard, E.K.4    Heitkemper, M.M.5
  • 91
    • 84875212395 scopus 로고    scopus 로고
    • Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos)
    • 91 Turcotte, JF, Kao, D, Mah, SJ, et al. Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos). Gastrointest Endosc 77 (2013), 624–630.
    • (2013) Gastrointest Endosc , vol.77 , pp. 624-630
    • Turcotte, J.F.1    Kao, D.2    Mah, S.J.3
  • 92
    • 82955233025 scopus 로고    scopus 로고
    • The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype
    • 92 Bertiaux-Vandaële, N, Youmba, SB, Belmonte, L, et al. The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype. Am J Gastroenterol 106 (2011), 2165–2173.
    • (2011) Am J Gastroenterol , vol.106 , pp. 2165-2173
    • Bertiaux-Vandaële, N.1    Youmba, S.B.2    Belmonte, L.3
  • 93
    • 84880235634 scopus 로고    scopus 로고
    • Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome
    • 93 Wilcz-Villega, EM, McClean, S, O'Sullivan, MA, Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome. Am J Gastroenterol 108 (2013), 1140–1151.
    • (2013) Am J Gastroenterol , vol.108 , pp. 1140-1151
    • Wilcz-Villega, E.M.1    McClean, S.2    O'Sullivan, M.A.3
  • 94
    • 84877575913 scopus 로고    scopus 로고
    • Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier
    • 94 Martínez, C, Lobo, B, Pigrau, M, et al. Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut 62 (2013), 1160–1168.
    • (2013) Gut , vol.62 , pp. 1160-1168
    • Martínez, C.1    Lobo, B.2    Pigrau, M.3
  • 95
    • 84855463406 scopus 로고    scopus 로고
    • Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells
    • 95 Vivinus-Nébot, M, Dainese, R, Anty, R, et al. Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells. Am J Gastroenterol 107 (2012), 75–81.
    • (2012) Am J Gastroenterol , vol.107 , pp. 75-81
    • Vivinus-Nébot, M.1    Dainese, R.2    Anty, R.3
  • 96
    • 84908299927 scopus 로고    scopus 로고
    • Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome
    • 96 Fritscher-Ravens, A, Schuppan, D, Ellrichmann, M, et al. Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome. Gastroenterology 147 (2014), 1012–1020.
    • (2014) Gastroenterology , vol.147 , pp. 1012-1020
    • Fritscher-Ravens, A.1    Schuppan, D.2    Ellrichmann, M.3
  • 97
    • 80054855719 scopus 로고    scopus 로고
    • Bugs, stool, and the irritable bowel syndrome: too much is as bad as too little?
    • 97 Talley, NJ, Fodor, AA, Bugs, stool, and the irritable bowel syndrome: too much is as bad as too little?. Gastroenterology 141 (2011), 1555–1559.
    • (2011) Gastroenterology , vol.141 , pp. 1555-1559
    • Talley, N.J.1    Fodor, A.A.2
  • 98
    • 33751115468 scopus 로고    scopus 로고
    • Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man
    • 98 Lundåsen, T, Gälman, C, Angelin, B, Rudling, M, Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J Intern Med 260 (2006), 530–536.
    • (2006) J Intern Med , vol.260 , pp. 530-536
    • Lundåsen, T.1    Gälman, C.2    Angelin, B.3    Rudling, M.4
  • 99
    • 77955697988 scopus 로고    scopus 로고
    • Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1
    • 99 Triantis, V, Saeland, E, Bijl, N, Oude-Elferink, RP, Jansen, PL, Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1. Hepatology 52 (2010), 656–666.
    • (2010) Hepatology , vol.52 , pp. 656-666
    • Triantis, V.1    Saeland, E.2    Bijl, N.3    Oude-Elferink, R.P.4    Jansen, P.L.5
  • 100
    • 0014071178 scopus 로고
    • The syndrome of ileal disease and the broken enterohepatic circulation: cholerhetic enteropathy
    • 100 Hofmann, AF, The syndrome of ileal disease and the broken enterohepatic circulation: cholerhetic enteropathy. Gastroenterology 52 (1967), 752–757.
    • (1967) Gastroenterology , vol.52 , pp. 752-757
    • Hofmann, A.F.1
  • 101
    • 0017036391 scopus 로고
    • Idiopathic bile acid catharsis
    • 101 Thaysen, EH, Pedersen, L, Idiopathic bile acid catharsis. Gut 17 (1976), 965–970.
    • (1976) Gut , vol.17 , pp. 965-970
    • Thaysen, E.H.1    Pedersen, L.2
  • 102
    • 84919714351 scopus 로고    scopus 로고
    • Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS
    • 102 Bajor, A, Tornblom, H, Rudling, M, Ung, KA, Simrén, M, Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS. Gut 64 (2015), 84–92.
    • (2015) Gut , vol.64 , pp. 84-92
    • Bajor, A.1    Tornblom, H.2    Rudling, M.3    Ung, K.A.4    Simrén, M.5
  • 103
    • 84939567588 scopus 로고    scopus 로고
    • High prevalence of idiopathic bile acid diarrhea among patients with diarrhea-predominant irritable bowel syndrome based on Rome III criteria
    • 103 Aziz, I, Mumtaz, S, Bholah, H, Chowdhury, FU, Sanders, DS, Ford, AC, High prevalence of idiopathic bile acid diarrhea among patients with diarrhea-predominant irritable bowel syndrome based on Rome III criteria. Clin Gastroenterol Hepatol 13 (2015), 1650–1655.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 1650-1655
    • Aziz, I.1    Mumtaz, S.2    Bholah, H.3    Chowdhury, F.U.4    Sanders, D.S.5    Ford, A.C.6
  • 104
    • 84884355706 scopus 로고    scopus 로고
    • Bowel functions, fecal unconjugated primary and secondary bile acids, and colonic transit in patients with irritable bowel syndrome
    • 104 Shin, A, Camilleri, M, Vijayvargiya, P, et al. Bowel functions, fecal unconjugated primary and secondary bile acids, and colonic transit in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 11 (2013), 1270–1275.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 1270-1275
    • Shin, A.1    Camilleri, M.2    Vijayvargiya, P.3
  • 105
    • 84924925529 scopus 로고    scopus 로고
    • Effect of increased bile acid synthesis or fecal excretion in irritable bowel syndrome-diarrhea
    • 105 Camilleri, M, Busciglio, I, Acosta, A, et al. Effect of increased bile acid synthesis or fecal excretion in irritable bowel syndrome-diarrhea. Am J Gastroenterol 109 (2014), 1621–1630.
    • (2014) Am J Gastroenterol , vol.109 , pp. 1621-1630
    • Camilleri, M.1    Busciglio, I.2    Acosta, A.3
  • 106
    • 84861201380 scopus 로고    scopus 로고
    • Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome
    • 106 Duboc, H, Rainteau, D, Rajca, S, et al. Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil 24 (2012), 513–520.
    • (2012) Neurogastroenterol Motil , vol.24 , pp. 513-520
    • Duboc, H.1    Rainteau, D.2    Rajca, S.3
  • 107
    • 84983543551 scopus 로고    scopus 로고
    • Interplay between bile acid metabolism and microbiota in irritable bowel syndrome
    • published online April 5.
    • 107 Dior, M, Delagrèverie, H, Duboc, H, et al. Interplay between bile acid metabolism and microbiota in irritable bowel syndrome. Neurogastroenterol Motil, 2016 published online April 5. http://dx.doi.org/10.1111/nmo.12829.
    • (2016) Neurogastroenterol Motil
    • Dior, M.1    Delagrèverie, H.2    Duboc, H.3
  • 108
    • 64549158645 scopus 로고    scopus 로고
    • The expanded biology of serotonin
    • 108 Berger, M, Gray, JA, Roth, BL, The expanded biology of serotonin. Annu Rev Med 60 (2009), 355–366.
    • (2009) Annu Rev Med , vol.60 , pp. 355-366
    • Berger, M.1    Gray, J.A.2    Roth, B.L.3
  • 109
    • 0025640876 scopus 로고
    • 5-HT receptor subtypes outside the central nervous system: roles in the physiology of the gut
    • 109 Gershon, MD, Wade, PR, Kirchgessner, AL, Tamir, H, 5-HT receptor subtypes outside the central nervous system: roles in the physiology of the gut. Neuropsychopharmacology 3 (1990), 385–395.
    • (1990) Neuropsychopharmacology , vol.3 , pp. 385-395
    • Gershon, M.D.1    Wade, P.R.2    Kirchgessner, A.L.3    Tamir, H.4
  • 110
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: from basic understanding to drug development for functional GI disorders
    • 110 Gershon, MD, Tack, J, The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132 (2007), 397–414.
    • (2007) Gastroenterology , vol.132 , pp. 397-414
    • Gershon, M.D.1    Tack, J.2
  • 111
    • 0345059404 scopus 로고    scopus 로고
    • Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS
    • 111 Dunlop, SP, Jenkins, D, Neal, KR, Spiller, RC, Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology 125 (2003), 1651–1659.
    • (2003) Gastroenterology , vol.125 , pp. 1651-1659
    • Dunlop, S.P.1    Jenkins, D.2    Neal, K.R.3    Spiller, R.C.4
  • 112
    • 16844380691 scopus 로고    scopus 로고
    • Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome
    • 112 Dunlop, SP, Coleman, NS, Blackshaw, E, et al. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin Gastroenterol Hepatol 3 (2005), 349–357.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 349-357
    • Dunlop, S.P.1    Coleman, N.S.2    Blackshaw, E.3
  • 113
    • 30044442329 scopus 로고    scopus 로고
    • Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome
    • 113 Atkinson, W, Lockhart, S, Whorwell, PJ, Keevil, B, Houghton, LA, Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome. Gastroenterology 130 (2006), 34–43.
    • (2006) Gastroenterology , vol.130 , pp. 34-43
    • Atkinson, W.1    Lockhart, S.2    Whorwell, P.J.3    Keevil, B.4    Houghton, L.A.5
  • 114
    • 79955383575 scopus 로고    scopus 로고
    • Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation
    • 114 Foley, S, Garsed, K, Singh, G, et al. Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation. Gastroenterology 140 (2011), 1434–1443.
    • (2011) Gastroenterology , vol.140 , pp. 1434-1443
    • Foley, S.1    Garsed, K.2    Singh, G.3
  • 115
    • 84955183378 scopus 로고    scopus 로고
    • Alterations in serotonin metabolism in the irritable bowel syndrome
    • 115 Thijssen, AY, Mujagic, Z, Jonkers, DM, et al. Alterations in serotonin metabolism in the irritable bowel syndrome. Aliment Pharmacol Ther 43 (2016), 272–282.
    • (2016) Aliment Pharmacol Ther , vol.43 , pp. 272-282
    • Thijssen, A.Y.1    Mujagic, Z.2    Jonkers, D.M.3
  • 116
    • 84892412208 scopus 로고    scopus 로고
    • The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies
    • 116 Zhang, ZF, Duan, ZJ, Wang, LX, Yang, D, Zhao, G, Zhang, L, The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies. BMC Gastroenterol, 14, 2014, 23.
    • (2014) BMC Gastroenterol , vol.14 , pp. 23
    • Zhang, Z.F.1    Duan, Z.J.2    Wang, L.X.3    Yang, D.4    Zhao, G.5    Zhang, L.6
  • 117
    • 79960055079 scopus 로고    scopus 로고
    • Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome
    • 117 Cremon, C, Carini, G, Wang, B, et al. Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am J Gastroenterol 106 (2011), 1290–1298.
    • (2011) Am J Gastroenterol , vol.106 , pp. 1290-1298
    • Cremon, C.1    Carini, G.2    Wang, B.3
  • 118
    • 84979518497 scopus 로고    scopus 로고
    • Interferon-gamma is increased in the gut of patients with irritable bowel syndrome and modulates serotonin metabolism
    • 118 Barbaro, MR, Di Sabatino, A, Cremon, C, et al. Interferon-gamma is increased in the gut of patients with irritable bowel syndrome and modulates serotonin metabolism. Am J Physiol Gastrointest Liver Physiol 310 (2016), G439–G447.
    • (2016) Am J Physiol Gastrointest Liver Physiol , vol.310 , pp. G439-G447
    • Barbaro, M.R.1    Di Sabatino, A.2    Cremon, C.3
  • 119
    • 84937976151 scopus 로고    scopus 로고
    • Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism—a preliminary study
    • 119 Keszthelyi, D, Troost, FJ, Jonkers, DM, et al. Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism—a preliminary study. Neurogastroenterol Motil 27 (2015), 1127–1137.
    • (2015) Neurogastroenterol Motil , vol.27 , pp. 1127-1137
    • Keszthelyi, D.1    Troost, F.J.2    Jonkers, D.M.3
  • 120
    • 84978877472 scopus 로고    scopus 로고
    • Adverse childhood experiences are associated with irritable bowel syndrome and gastrointestinal symptom severity
    • 120 Park, SH, Videlock, EJ, Shih, W, Presson, AP, Mayer, EA, Chang, L, Adverse childhood experiences are associated with irritable bowel syndrome and gastrointestinal symptom severity. Neurogastroenterol Motil 28 (2016), 1252–1260.
    • (2016) Neurogastroenterol Motil , vol.28 , pp. 1252-1260
    • Park, S.H.1    Videlock, E.J.2    Shih, W.3    Presson, A.P.4    Mayer, E.A.5    Chang, L.6
  • 121
    • 84908228349 scopus 로고    scopus 로고
    • Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis
    • 121 Ford, AC, Quigley, EM, Lacy, BE, et al. Effect of antidepressants and psychological therapies, including hypnotherapy, in irritable bowel syndrome: systematic review and meta-analysis. Am J Gastroenterol 109 (2014), 1350–1365.
    • (2014) Am J Gastroenterol , vol.109 , pp. 1350-1365
    • Ford, A.C.1    Quigley, E.M.2    Lacy, B.E.3
  • 122
    • 76349107112 scopus 로고    scopus 로고
    • Heightened central affective response to visceral sensations of pain and discomfort in IBS
    • 122 Hall, GB, Kamath, MV, Collins, S, et al. Heightened central affective response to visceral sensations of pain and discomfort in IBS. Neurogastroenterol Motil 22 (2010), 276–280.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 276-280
    • Hall, G.B.1    Kamath, M.V.2    Collins, S.3
  • 123
    • 78650505214 scopus 로고    scopus 로고
    • Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome
    • 123 Tillisch, K, Mayer, EA, Labus, JS, Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology 140 (2011), 91–100.
    • (2011) Gastroenterology , vol.140 , pp. 91-100
    • Tillisch, K.1    Mayer, E.A.2    Labus, J.S.3
  • 124
    • 84880425146 scopus 로고    scopus 로고
    • Patients with chronic visceral pain show sex-related alterations in intrinsic oscillations of the resting brain
    • 124 Hong, JY, Kilpatrick, LA, Labus, J, et al. Patients with chronic visceral pain show sex-related alterations in intrinsic oscillations of the resting brain. J Neurosci 33 (2013), 11994–12002.
    • (2013) J Neurosci , vol.33 , pp. 11994-12002
    • Hong, J.Y.1    Kilpatrick, L.A.2    Labus, J.3
  • 125
    • 84881644234 scopus 로고    scopus 로고
    • Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome
    • 125 Ellingson, BM, Mayer, E, Harris, RJ, et al. Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome. Pain 154 (2013), 1528–1541.
    • (2013) Pain , vol.154 , pp. 1528-1541
    • Ellingson, B.M.1    Mayer, E.2    Harris, R.J.3
  • 126
    • 84883503300 scopus 로고    scopus 로고
    • Sex-related differences of cortical thickness in patients with chronic abdominal pain
    • 126 Jiang, Z, Dinov, ID, Labus, J, et al. Sex-related differences of cortical thickness in patients with chronic abdominal pain. PLoS One, 8, 2013, e73932.
    • (2013) PLoS One , vol.8 , pp. e73932
    • Jiang, Z.1    Dinov, I.D.2    Labus, J.3
  • 127
    • 84885022164 scopus 로고    scopus 로고
    • Thicker posterior insula is associated with disease duration in women with irritable bowel syndrome (IBS) whereas thicker orbitofrontal cortex predicts reduced pain inhibition in both IBS patients and controls
    • 127 Piche, M, Chen, JI, Roy, M, Poitras, P, Bouin, M, Rainville, P, Thicker posterior insula is associated with disease duration in women with irritable bowel syndrome (IBS) whereas thicker orbitofrontal cortex predicts reduced pain inhibition in both IBS patients and controls. J Pain 14 (2013), 1217–1226.
    • (2013) J Pain , vol.14 , pp. 1217-1226
    • Piche, M.1    Chen, J.I.2    Roy, M.3    Poitras, P.4    Bouin, M.5    Rainville, P.6
  • 128
    • 77957351785 scopus 로고    scopus 로고
    • Patients with irritable bowel syndrome have altered emotional modulation of neural responses to visceral stimuli
    • 128 Elsenbruch, S, Rosenberger, C, Bingel, U, Forsting, M, Schedlowski, M, Gizewski, ER, Patients with irritable bowel syndrome have altered emotional modulation of neural responses to visceral stimuli. Gastroenterology 139 (2010), 1310–1319.
    • (2010) Gastroenterology , vol.139 , pp. 1310-1319
    • Elsenbruch, S.1    Rosenberger, C.2    Bingel, U.3    Forsting, M.4    Schedlowski, M.5    Gizewski, E.R.6
  • 129
    • 77950804750 scopus 로고    scopus 로고
    • Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study
    • 129 Elsenbruch, S, Rosenberger, C, Enck, P, Forsting, M, Schedlowski, M, Gizewski, ER, Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study. Gut 59 (2010), 489–495.
    • (2010) Gut , vol.59 , pp. 489-495
    • Elsenbruch, S.1    Rosenberger, C.2    Enck, P.3    Forsting, M.4    Schedlowski, M.5    Gizewski, E.R.6
  • 130
    • 84857633645 scopus 로고    scopus 로고
    • Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome
    • 130 Larsson, MB, Tillisch, K, Craig, AD, et al. Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome. Gastroenterology 142 (2012), 463–472.
    • (2012) Gastroenterology , vol.142 , pp. 463-472
    • Larsson, M.B.1    Tillisch, K.2    Craig, A.D.3
  • 131
    • 84868029961 scopus 로고    scopus 로고
    • Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on fMRI and dynamic causal modeling
    • 131 Aizawa, E, Sato, Y, Kochiyama, T, et al. Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on fMRI and dynamic causal modeling. Gastroenterology 143 (2012), 1188–1198.
    • (2012) Gastroenterology , vol.143 , pp. 1188-1198
    • Aizawa, E.1    Sato, Y.2    Kochiyama, T.3
  • 132
    • 84904722875 scopus 로고    scopus 로고
    • Early adverse life events and resting state neural networks in patients with chronic abdominal pain: evidence for sex differences
    • 132 Gupta, A, Kilpatrick, L, Labus, J, et al. Early adverse life events and resting state neural networks in patients with chronic abdominal pain: evidence for sex differences. Psychosom Med 76 (2014), 404–412.
    • (2014) Psychosom Med , vol.76 , pp. 404-412
    • Gupta, A.1    Kilpatrick, L.2    Labus, J.3
  • 133
    • 85029261824 scopus 로고    scopus 로고
    • In patients with Crohn's disease functional MRI reveals an alteration of amygdala function induced by anti-TNFα that is associated with positive self-attribution biases and reduced symptom response to a standardised nutrient challenge
    • (abstr).
    • 133 Gray, M, Chao, C-Y, Talley, NJ, Koloski, NA, Holtmann, G, In patients with Crohn's disease functional MRI reveals an alteration of amygdala function induced by anti-TNFα that is associated with positive self-attribution biases and reduced symptom response to a standardised nutrient challenge. Gastroenterology 150:suppl 1 (2016), S526–S527 (abstr).
    • (2016) Gastroenterology , vol.150 , pp. S526-S527
    • Gray, M.1    Chao, C.-Y.2    Talley, N.J.3    Koloski, N.A.4    Holtmann, G.5
  • 134
    • 77449123620 scopus 로고    scopus 로고
    • Evidence for pelvic floor dyssynergia in patients with irritable bowel syndrome
    • 134 Suttor, VP, Prott, GM, Hansen, RD, Kellow, JE, Malcolm, A, Evidence for pelvic floor dyssynergia in patients with irritable bowel syndrome. Dis Colon Rectum 53 (2010), 156–160.
    • (2010) Dis Colon Rectum , vol.53 , pp. 156-160
    • Suttor, V.P.1    Prott, G.M.2    Hansen, R.D.3    Kellow, J.E.4    Malcolm, A.5
  • 135
    • 84983095630 scopus 로고    scopus 로고
    • Immune dysregulation in the functional gastrointestinal disorders
    • 135 Keely, S, Walker, MM, Marks, E, Talley, NJ, Immune dysregulation in the functional gastrointestinal disorders. Eur J Clin Invest 45 (2015), 1350–1359.
    • (2015) Eur J Clin Invest , vol.45 , pp. 1350-1359
    • Keely, S.1    Walker, M.M.2    Marks, E.3    Talley, N.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.