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Volumn 310, Issue 6, 2016, Pages G439-G447

Interferon-γ is increased in the gut of patients with irritable bowel syndrome and modulates serotonin metabolism

Author keywords

Gut mucosa; Interferon ; Irritable bowel syndrome; Serotonin reuptake transporter; T box expressed in T cells

Indexed keywords

GAMMA INTERFERON; SEROTONIN TRANSPORTER; STAT4 PROTEIN; TRANSCRIPTION FACTOR T BET; RNA; SEROTONIN; SLC6A4 PROTEIN, HUMAN; STAT4 PROTEIN, HUMAN; T BOX TRANSCRIPTION FACTOR;

EID: 84979518497     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00368.2015     Document Type: Article
Times cited : (42)

References (50)
  • 1
    • 30044442329 scopus 로고    scopus 로고
    • Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome
    • Atkinson W, Lockhart S, Whorwell PJ, Keevil B, Houghton LA. Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome. Gastroenterology 130: 34–43, 2006.
    • (2006) Gastroenterology , vol.130 , pp. 34-43
    • Atkinson, W.1    Lockhart, S.2    Whorwell, P.J.3    Keevil, B.4    Houghton, L.A.5
  • 3
    • 84902276814 scopus 로고    scopus 로고
    • Inflammatory bowel disease and irritable bowel syndrome: Similarities and differences
    • Barbara G, Cremon C, Stanghellini V. Inflammatory bowel disease and irritable bowel syndrome: similarities and differences. Curr Opin Gastroenterol 30: 352–358, 2014.
    • (2014) Curr Opin Gastroenterol , vol.30 , pp. 352-358
    • Barbara, G.1    Cremon, C.2    Stanghellini, V.3
  • 10
    • 84878011495 scopus 로고    scopus 로고
    • Genetics of human gastrointestinal sensation
    • Camilleri M. Genetics of human gastrointestinal sensation. Neurogastroenterol Motil 25: 458–466, 2013.
    • (2013) Neurogastroenterol Motil , vol.25 , pp. 458-466
    • Camilleri, M.1
  • 14
    • 84866182203 scopus 로고    scopus 로고
    • Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome
    • Chen J, Zhang Y, Deng Z. Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome. BMC Gastroenterol 12: 91, 2012.
    • (2012) BMC Gastroenterol , vol.12 , pp. 91
    • Chen, J.1    Zhang, Y.2    Deng, Z.3
  • 15
    • 0035882382 scopus 로고    scopus 로고
    • Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters
    • Chen JJ, Li Z, Pan H, Murphy DL, Tamir H, Koepsell H, Gershon MD. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci 21: 6348–6361, 2001.
    • (2001) J Neurosci , vol.21 , pp. 6348-6361
    • Chen, J.J.1    Li, Z.2    Pan, H.3    Murphy, D.L.4    Tamir, H.5    Koepsell, H.6    Gershon, M.D.7
  • 19
    • 84899738704 scopus 로고    scopus 로고
    • Chemotactic chemokines are important in the pathogenesis of irritable bowel syndrome
    • Darkoh C, Comer L, Zewdie G, Harold S, Snyder N, Dupont HL. Chemotactic chemokines are important in the pathogenesis of irritable bowel syndrome. PLoS One 9: e93144, 2014.
    • (2014) Plos One , vol.9
    • Darkoh, C.1    Comer, L.2    Zewdie, G.3    Harold, S.4    Snyder, N.5    Dupont, H.L.6
  • 23
    • 79551686306 scopus 로고    scopus 로고
    • Abdominal pain in irritable bowel syndrome: A review of putative psychological, neural and neuro-immune mechanisms
    • Elsenbruch S. Abdominal pain in irritable bowel syndrome: a review of putative psychological, neural and neuro-immune mechanisms. Brain Behav Immun 25: 386–394, 2011.
    • (2011) Brain Behav Immun , vol.25 , pp. 386-394
    • Elsenbruch, S.1
  • 25
    • 77953899448 scopus 로고    scopus 로고
    • Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients
    • Faure C, Patey N, Gauthier C, Brooks EM, Mawe GM. Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients. Gastroenterology 139: 249–258, 2010.
    • (2010) Gastroenterology , vol.139 , pp. 249-258
    • Faure, C.1    Patey, N.2    Gauthier, C.3    Brooks, E.M.4    Mawe, G.M.5
  • 26
    • 33947318947 scopus 로고    scopus 로고
    • IFN-γ and TNF-α decrease serotonin transporter function and expression in Caco2 cells
    • Foley KF, Pantano C, Ciolino A, Mawe GM. IFN-γ and TNF-α decrease serotonin transporter function and expression in Caco2 cells. Am J Physiol Gastrointest Liver Physiol 292: G779–G784, 2007.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292 , pp. G779-G784
    • Foley, K.F.1    Pantano, C.2    Ciolino, A.3    Mawe, G.M.4
  • 29
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: From basic understanding to drug development for functional GI disorders
    • Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132: 397–414, 2007.
    • (2007) Gastroenterology , vol.132 , pp. 397-414
    • Gershon, M.D.1    Tack, J.2
  • 31
    • 53149111135 scopus 로고    scopus 로고
    • Molecular biology of 5-HT receptors
    • Hannon J, Hoyer D. Molecular biology of 5-HT receptors. Behav Brain Res 195: 198–213, 2008.
    • (2008) Behav Brain Res , vol.195 , pp. 198-213
    • Hannon, J.1    Hoyer, D.2
  • 32
    • 84861578319 scopus 로고    scopus 로고
    • An irritable bowel syndrome subtype defined by speciesspecific alterations in faecal microbiota
    • Jeffery IB, O’Toole PW, Ohman L, Claesson MJ, Deane J, Quigley EM, Simren M. An irritable bowel syndrome subtype defined by speciesspecific alterations in faecal microbiota. Gut 61: 997–1006, 2012.
    • (2012) Gut , vol.61 , pp. 997-1006
    • Jeffery, I.B.1    O’Toole, P.W.2    Ohman, L.3    Claesson, M.J.4    Deane, J.5    Quigley, E.M.6    Simren, M.7
  • 33
    • 52049111828 scopus 로고    scopus 로고
    • How interferon-gamma keeps autoimmune diseases in check
    • Kelchtermans H, Billiau A, Matthys P. How interferon-gamma keeps autoimmune diseases in check. Trends Immunol 29: 479–486, 2008.
    • (2008) Trends Immunol , vol.29 , pp. 479-486
    • Kelchtermans, H.1    Billiau, A.2    Matthys, P.3
  • 34
    • 84860503881 scopus 로고    scopus 로고
    • SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine
    • Kerckhoffs AP, ter Linde JJ, Akkermans LM, Samsom M. SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine. Am J Physiol Gastrointest Liver Physiol 302: G1053–G1060, 2012.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , pp. G1053-G1060
    • Kerckhoffs, A.P.1    Ter Linde, J.J.2    Akkermans, L.M.3    Samsom, M.4
  • 36
    • 35248867016 scopus 로고    scopus 로고
    • Hyperexpression of FcgammaRI and Toll-like receptor 4 in the intestinal mast cells of Crohn’s disease patients
    • Kobayashi R, Okamura S, Ohno T, Saito H, Mori M, Ra C, Okayama Y. Hyperexpression of FcgammaRI and Toll-like receptor 4 in the intestinal mast cells of Crohn’s disease patients. Clin Immunol 125: 149–158, 2007.
    • (2007) Clin Immunol , vol.125 , pp. 149-158
    • Kobayashi, R.1    Okamura, S.2    Ohno, T.3    Saito, H.4    Mori, M.5    Ra, C.6    Okayama, Y.7
  • 38
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402–408, 2001.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 42
    • 77949263115 scopus 로고    scopus 로고
    • Pathogenesis of IBS: Role of inflammation, immunity and neuroimmune interactions
    • Ohman L, Simren M. Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions. Nat Rev Gastroenterol Hepatol 7: 163–173, 2010.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 163-173
    • Ohman, L.1    Simren, M.2
  • 43
    • 0035313660 scopus 로고    scopus 로고
    • A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI
    • Okayama Y, Hagaman DD, Metcalfe DD. A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. J Immunol 166: 4705–4712, 2001.
    • (2001) J Immunol , vol.166 , pp. 4705-4712
    • Okayama, Y.1    Hagaman, D.D.2    Metcalfe, D.D.3
  • 45
    • 0029976338 scopus 로고    scopus 로고
    • Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: Role of IGF-II
    • Singh P, Dai B, Yallampalli U, Lu X, Schroy PC. Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II. Endocrinology 137: 1764–1774, 1996.
    • (1996) Endocrinology , vol.137 , pp. 1764-1774
    • Singh, P.1    Dai, B.2    Yallampalli, U.3    Lu, X.4    Schroy, P.C.5
  • 46
    • 79953727524 scopus 로고    scopus 로고
    • Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome
    • Spiller RC. Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome. Curr Opin Pharmacol 11: 68–74, 2011.
    • (2011) Curr Opin Pharmacol , vol.11 , pp. 68-74
    • Spiller, R.C.1
  • 47
    • 55349117409 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination
    • Thieu VT, Yu Q, Chang HC, Yeh N, Nguyen ET, Sehra S, Kaplan MH. Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity 29: 679–690, 2008.
    • (2008) Immunity , vol.29 , pp. 679-690
    • Thieu, V.T.1    Yu, Q.2    Chang, H.C.3    Yeh, N.4    Nguyen, E.T.5    Sehra, S.6    Kaplan, M.H.7
  • 48
    • 13244298599 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
    • Wang F, Graham WV, Wang Y, Witkowski ED, Schwarz BT, Turner JR. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol 166: 409–419, 2005.
    • (2005) Am J Pathol , vol.166 , pp. 409-419
    • Wang, F.1    Graham, W.V.2    Wang, Y.3    Witkowski, E.D.4    Schwarz, B.T.5    Turner, J.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.