-
1
-
-
84954400636
-
Cancer statistics, 2016
-
1 Siegel, R.L., Miller, K.D., Jemal, A., Cancer statistics, 2016. CA Cancer J Clin 66:1 (2016), 7–30.
-
(2016)
CA Cancer J Clin
, vol.66
, Issue.1
, pp. 7-30
-
-
Siegel, R.L.1
Miller, K.D.2
Jemal, A.3
-
2
-
-
84902147062
-
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States
-
2 Rahib, L., Smith, B.D., Aizenberg, R., et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 74:11 (2014), 2913–2921.
-
(2014)
Cancer Res
, vol.74
, Issue.11
, pp. 2913-2921
-
-
Rahib, L.1
Smith, B.D.2
Aizenberg, R.3
-
3
-
-
0141742113
-
Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
-
3 Maitra, A., Adsay, N.V., Argani, P., et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol 16:9 (2003), 902–912.
-
(2003)
Mod Pathol
, vol.16
, Issue.9
, pp. 902-912
-
-
Maitra, A.1
Adsay, N.V.2
Argani, P.3
-
4
-
-
33749185439
-
Genetics and pathology of pancreatic cancer
-
4 Winter, J.M., Maitra, A., Yeo, C.J., Genetics and pathology of pancreatic cancer. HPB (Oxford) 8:5 (2006), 324–336.
-
(2006)
HPB (Oxford)
, vol.8
, Issue.5
, pp. 324-336
-
-
Winter, J.M.1
Maitra, A.2
Yeo, C.J.3
-
5
-
-
0242693286
-
Molecular pathogenesis of pancreatic cancer
-
5 Hansel, D.E., Kern, S.E., Hruban, R.H., Molecular pathogenesis of pancreatic cancer. Annu Rev Genomics Hum Genet 4 (2003), 237–256.
-
(2003)
Annu Rev Genomics Hum Genet
, vol.4
, pp. 237-256
-
-
Hansel, D.E.1
Kern, S.E.2
Hruban, R.H.3
-
6
-
-
10744229498
-
Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss
-
6 Iacobuzio-Donahue, C.A., van der Heijden, M.S., Baumgartner, M.R., et al. Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss. Cancer Res 64:3 (2004), 871–875.
-
(2004)
Cancer Res
, vol.64
, Issue.3
, pp. 871-875
-
-
Iacobuzio-Donahue, C.A.1
van der Heijden, M.S.2
Baumgartner, M.R.3
-
7
-
-
0343811679
-
Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q, and losses of 18q, 9p, and 15q in pancreatic cancer
-
7 Mahlamaki, E.H., Hoglund, M., Gorunova, L., et al. Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q, and losses of 18q, 9p, and 15q in pancreatic cancer. Genes Chromosomes Cancer 20:4 (1997), 383–391.
-
(1997)
Genes Chromosomes Cancer
, vol.20
, Issue.4
, pp. 383-391
-
-
Mahlamaki, E.H.1
Hoglund, M.2
Gorunova, L.3
-
8
-
-
0032191919
-
Amplification of DNA sequences from chromosome 19q13.1 in human pancreatic cell lines
-
8 Curtis, L.J., Li, Y., Gerbault-Seureau, M., et al. Amplification of DNA sequences from chromosome 19q13.1 in human pancreatic cell lines. Genomics 53:1 (1998), 42–55.
-
(1998)
Genomics
, vol.53
, Issue.1
, pp. 42-55
-
-
Curtis, L.J.1
Li, Y.2
Gerbault-Seureau, M.3
-
9
-
-
84865062750
-
Translational therapeutic opportunities in ductal adenocarcinoma of the pancreas
-
9 Hidalgo, M., Von Hoff, D.D., Translational therapeutic opportunities in ductal adenocarcinoma of the pancreas. Clin Cancer Res 18:16 (2012), 4249–4256.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.16
, pp. 4249-4256
-
-
Hidalgo, M.1
Von Hoff, D.D.2
-
10
-
-
77957219324
-
KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas
-
10 Smit, V.T., Boot, A.J., Smits, A.M., et al. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res 16:16 (1988), 7773–7782.
-
(1988)
Nucleic Acids Res
, vol.16
, Issue.16
, pp. 7773-7782
-
-
Smit, V.T.1
Boot, A.J.2
Smits, A.M.3
-
11
-
-
0035409076
-
Molecular pathology of pancreatic cancer
-
11 Hruban, R.H., Iacobuzio-Donahue, C., Wilentz, R.E., et al. Molecular pathology of pancreatic cancer. Cancer J 7:4 (2001), 251–258.
-
(2001)
Cancer J
, vol.7
, Issue.4
, pp. 251-258
-
-
Hruban, R.H.1
Iacobuzio-Donahue, C.2
Wilentz, R.E.3
-
12
-
-
28844481452
-
The KRAS oncogene: past, present, and future
-
12 Kranenburg, O., The KRAS oncogene: past, present, and future. Biochim Biophys Acta 1756:2 (2005), 81–82.
-
(2005)
Biochim Biophys Acta
, vol.1756
, Issue.2
, pp. 81-82
-
-
Kranenburg, O.1
-
13
-
-
84893468215
-
Kras as a key oncogene and therapeutic target in pancreatic cancer
-
13 Collins, M.A., Pasca di Magliano, M., Kras as a key oncogene and therapeutic target in pancreatic cancer. Front Physiol, 4, 2013, 407.
-
(2013)
Front Physiol
, vol.4
, pp. 407
-
-
Collins, M.A.1
Pasca di Magliano, M.2
-
14
-
-
0028059330
-
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
-
14 Caldas, C., Hahn, S.A., da Costa, L.T., et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 8:1 (1994), 27–32.
-
(1994)
Nat Genet
, vol.8
, Issue.1
, pp. 27-32
-
-
Caldas, C.1
Hahn, S.A.2
da Costa, L.T.3
-
15
-
-
16944367477
-
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
-
15 Schutte, M., Hruban, R.H., Geradts, J., et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res 57:15 (1997), 3126–3130.
-
(1997)
Cancer Res
, vol.57
, Issue.15
, pp. 3126-3130
-
-
Schutte, M.1
Hruban, R.H.2
Geradts, J.3
-
16
-
-
0035810054
-
Regulation of the G2/M transition by p53
-
16 Taylor, W.R., Stark, G.R., Regulation of the G2/M transition by p53. Oncogene 20:15 (2001), 1803–1815.
-
(2001)
Oncogene
, vol.20
, Issue.15
, pp. 1803-1815
-
-
Taylor, W.R.1
Stark, G.R.2
-
17
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
17 Hahn, S.A., Schutte, M., Hoque, A.T., et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271:5247 (1996), 350–353.
-
(1996)
Science
, vol.271
, Issue.5247
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.3
-
18
-
-
0242322012
-
Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation
-
18 Yoo, J., Ghiassi, M., Jirmanova, L., et al. Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J Biol Chem 278:44 (2003), 43001–43007.
-
(2003)
J Biol Chem
, vol.278
, Issue.44
, pp. 43001-43007
-
-
Yoo, J.1
Ghiassi, M.2
Jirmanova, L.3
-
19
-
-
25144519682
-
Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy
-
19 Embuscado, E.E., Laheru, D., Ricci, F., et al. Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Cancer Biol Ther 4:5 (2005), 548–554.
-
(2005)
Cancer Biol Ther
, vol.4
, Issue.5
, pp. 548-554
-
-
Embuscado, E.E.1
Laheru, D.2
Ricci, F.3
-
20
-
-
80051613675
-
Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression
-
20 Crane, C.H., Varadhachary, G.R., Yordy, J.S., et al. Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression. J Clin Oncol 29:22 (2011), 3037–3043.
-
(2011)
J Clin Oncol
, vol.29
, Issue.22
, pp. 3037-3043
-
-
Crane, C.H.1
Varadhachary, G.R.2
Yordy, J.S.3
-
21
-
-
62249176551
-
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
-
21 Iacobuzio-Donahue, C.A., Fu, B., Yachida, S., et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol 27:11 (2009), 1806–1813.
-
(2009)
J Clin Oncol
, vol.27
, Issue.11
, pp. 1806-1813
-
-
Iacobuzio-Donahue, C.A.1
Fu, B.2
Yachida, S.3
-
22
-
-
84880573095
-
Failure patterns in resected pancreas adenocarcinoma: lack of predicted benefit to SMAD4 expression
-
22 Winter, J.M., Tang, L.H., Klimstra, D.S., et al. Failure patterns in resected pancreas adenocarcinoma: lack of predicted benefit to SMAD4 expression. Ann Surg 258:2 (2013), 331–335.
-
(2013)
Ann Surg
, vol.258
, Issue.2
, pp. 331-335
-
-
Winter, J.M.1
Tang, L.H.2
Klimstra, D.S.3
-
23
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
23 Jones, S., Zhang, X., Parsons, D.W., et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321:5897 (2008), 1801–1806.
-
(2008)
Science
, vol.321
, Issue.5897
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
-
24
-
-
84869091997
-
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
-
24 Biankin, A.V., Waddell, N., Kassahn, K.S., et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491:7424 (2012), 399–405.
-
(2012)
Nature
, vol.491
, Issue.7424
, pp. 399-405
-
-
Biankin, A.V.1
Waddell, N.2
Kassahn, K.S.3
-
25
-
-
84924056345
-
Whole genomes redefine the mutational landscape of pancreatic cancer
-
25 Waddell, N., Pajic, M., Patch, A.M., et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 518:7540 (2015), 495–501.
-
(2015)
Nature
, vol.518
, Issue.7540
, pp. 495-501
-
-
Waddell, N.1
Pajic, M.2
Patch, A.M.3
-
26
-
-
84862907854
-
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
-
26 Wu, J., Jiao, Y., Dal Molin, M., et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A 108:52 (2011), 21188–21193.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.52
, pp. 21188-21193
-
-
Wu, J.1
Jiao, Y.2
Dal Molin, M.3
-
27
-
-
84901604272
-
Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing
-
27 Wong, S.Q., Li, J., Tan, A.Y., et al. Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing. BMC Med Genomics, 7, 2014, 23.
-
(2014)
BMC Med Genomics
, vol.7
, pp. 23
-
-
Wong, S.Q.1
Li, J.2
Tan, A.Y.3
-
28
-
-
33646406052
-
Elegance, silence and nonsense in the mutations literature for solid tumors
-
28 Kern, S.E., Winter, J.M., Elegance, silence and nonsense in the mutations literature for solid tumors. Cancer Biol Ther 5:4 (2006), 349–359.
-
(2006)
Cancer Biol Ther
, vol.5
, Issue.4
, pp. 349-359
-
-
Kern, S.E.1
Winter, J.M.2
-
29
-
-
33646415964
-
Multiple-criterion evaluation of reported mutations: a proposed scoring system for the intragenic somatic mutation literature
-
29 Winter, J.M., Brody, J.R., Kern, S.E., Multiple-criterion evaluation of reported mutations: a proposed scoring system for the intragenic somatic mutation literature. Cancer Biol Ther 5:4 (2006), 360–370.
-
(2006)
Cancer Biol Ther
, vol.5
, Issue.4
, pp. 360-370
-
-
Winter, J.M.1
Brody, J.R.2
Kern, S.E.3
-
30
-
-
84862790479
-
Impact of warm ischemia on gene expression analysis in surgically removed biosamples
-
30 Ma, Y., Dai, H., Kong, X., Impact of warm ischemia on gene expression analysis in surgically removed biosamples. Anal Biochem 423:2 (2012), 229–235.
-
(2012)
Anal Biochem
, vol.423
, Issue.2
, pp. 229-235
-
-
Ma, Y.1
Dai, H.2
Kong, X.3
-
31
-
-
33644975004
-
RNA integrity and the effect on the real-time qRT-PCR performance
-
31 Fleige, S., Pfaffl, M.W., RNA integrity and the effect on the real-time qRT-PCR performance. Mol Aspects Med 27:2–3 (2006), 126–139.
-
(2006)
Mol Aspects Med
, vol.27
, Issue.2-3
, pp. 126-139
-
-
Fleige, S.1
Pfaffl, M.W.2
-
32
-
-
2942617082
-
Tissue ischemia time affects gene and protein expression patterns within minutes following surgical tumor excision
-
32 Spruessel, A., Steimann, G., Jung, M., et al. Tissue ischemia time affects gene and protein expression patterns within minutes following surgical tumor excision. Biotechniques 36:6 (2004), 1030–1037.
-
(2004)
Biotechniques
, vol.36
, Issue.6
, pp. 1030-1037
-
-
Spruessel, A.1
Steimann, G.2
Jung, M.3
-
33
-
-
84953775551
-
Reliable detection of somatic mutations in fine needle aspirates of pancreatic cancer with next-generation sequencing: implications for surgical management
-
33 Valero, V. 3rd, Saunders, T.J., He, J., et al. Reliable detection of somatic mutations in fine needle aspirates of pancreatic cancer with next-generation sequencing: implications for surgical management. Ann Surg 263:1 (2016), 153–161.
-
(2016)
Ann Surg
, vol.263
, Issue.1
, pp. 153-161
-
-
Valero, V.1
Saunders, T.J.2
He, J.3
-
34
-
-
23444462074
-
Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. The Italian Cooperative Study Group on Chronic Myeloid Leukemia
-
34 Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. The Italian Cooperative Study Group on Chronic Myeloid Leukemia. N Engl J Med 330:12 (1994), 820–825.
-
(1994)
N Engl J Med
, vol.330
, Issue.12
, pp. 820-825
-
-
-
35
-
-
84925831666
-
Human epidermal growth factor receptor 2 (HER2) in cancers: overexpression and therapeutic implications
-
35 Iqbal, N., Iqbal, N., Human epidermal growth factor receptor 2 (HER2) in cancers: overexpression and therapeutic implications. Mol Biol Int, 2014, 2014, 852748.
-
(2014)
Mol Biol Int
, vol.2014
, pp. 852748
-
-
Iqbal, N.1
Iqbal, N.2
-
36
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group
-
36 Marty, M., Cognetti, F., Maraninchi, D., et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol 23:19 (2005), 4265–4274.
-
(2005)
J Clin Oncol
, vol.23
, Issue.19
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
-
37
-
-
84923052492
-
Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer
-
37 Swain, S.M., Baselga, J., Kim, S.B., et al. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med 372:8 (2015), 724–734.
-
(2015)
N Engl J Med
, vol.372
, Issue.8
, pp. 724-734
-
-
Swain, S.M.1
Baselga, J.2
Kim, S.B.3
-
38
-
-
84996547291
-
-
Two year estimate of overall survival in COMBI-v, a randomized, open-label, phase III study comparing the combination of dabrafenib and trametinib with vemurafenib as first-line therapy in patients with unresectable or metastatic BRAF V600E/K mutation-positive cutaneous melanoma. The European Cancer Congress 2015. 2015. Available at:. Accessed February 26.
-
38 Robert C, Karaszewska B, Schachter J, et al. Two year estimate of overall survival in COMBI-v, a randomized, open-label, phase III study comparing the combination of dabrafenib and trametinib with vemurafenib as first-line therapy in patients with unresectable or metastatic BRAF V600E/K mutation-positive cutaneous melanoma. The European Cancer Congress 2015. 2015. Available at: https://www.europeancancercongress.org/Vienna2015/Scientific-Programme/Searchable-Programme?trackid=00181-anchorScpr. Accessed February 26, 2016.
-
(2016)
-
-
Robert, C.1
Karaszewska, B.2
Schachter, J.3
-
39
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
39 Chapman, P.B., Hauschild, A., Robert, C., et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:26 (2011), 2507–2516.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
40
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
40 Shigematsu, H., Lin, L., Takahashi, T., et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97:5 (2005), 339–346.
-
(2005)
J Natl Cancer Inst
, vol.97
, Issue.5
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
-
41
-
-
84960076336
-
Epidermal growth factor receptor in non-small cell lung cancer
-
41 Prabhakar, C.N., Epidermal growth factor receptor in non-small cell lung cancer. Transl Lung Cancer Res 4:2 (2015), 110–118.
-
(2015)
Transl Lung Cancer Res
, vol.4
, Issue.2
, pp. 110-118
-
-
Prabhakar, C.N.1
-
42
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
-
42 Zhou, C., Wu, Y.L., Chen, G., et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 12:8 (2011), 735–742.
-
(2011)
Lancet Oncol
, vol.12
, Issue.8
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
43
-
-
0034864813
-
HER2 overexpression in various tumor types, focussing on its relationship to the development of invasive breast cancer
-
43 Menard, S., Casalini, P., Campiglio, M., et al. HER2 overexpression in various tumor types, focussing on its relationship to the development of invasive breast cancer. Ann Oncol 12:Suppl 1 (2001), S15–S19.
-
(2001)
Ann Oncol
, vol.12
, pp. S15-S19
-
-
Menard, S.1
Casalini, P.2
Campiglio, M.3
-
44
-
-
34347395733
-
Trastuzumab–mechanism of action and use in clinical practice
-
44 Hudis, C.A., Trastuzumab–mechanism of action and use in clinical practice. N Engl J Med 357:1 (2007), 39–51.
-
(2007)
N Engl J Med
, vol.357
, Issue.1
, pp. 39-51
-
-
Hudis, C.A.1
-
45
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
-
45 Bang, Y.J., Van Cutsem, E., Feyereislova, A., et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 376:9742 (2010), 687–697.
-
(2010)
Lancet
, vol.376
, Issue.9742
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
-
46
-
-
84858296057
-
Multicentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer
-
46 Harder, J., Ihorst, G., Heinemann, V., et al. Multicentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer. Br J Cancer 106:6 (2012), 1033–1038.
-
(2012)
Br J Cancer
, vol.106
, Issue.6
, pp. 1033-1038
-
-
Harder, J.1
Ihorst, G.2
Heinemann, V.3
-
47
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
47 Moore, M.J., Goldstein, D., Hamm, J., et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25:15 (2007), 1960–1966.
-
(2007)
J Clin Oncol
, vol.25
, Issue.15
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
48
-
-
84938632405
-
Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial
-
48 Wang, J.P., Wu, C.Y., Yeh, Y.C., et al. Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial. Oncotarget 6:20 (2015), 18162–18173.
-
(2015)
Oncotarget
, vol.6
, Issue.20
, pp. 18162-18173
-
-
Wang, J.P.1
Wu, C.Y.2
Yeh, Y.C.3
-
49
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
49 Van Cutsem, E., Kohne, C.H., Hitre, E., et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360:14 (2009), 1408–1417.
-
(2009)
N Engl J Med
, vol.360
, Issue.14
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
50
-
-
84884721540
-
Multicenter phase II trial to investigate safety and efficacy of gemcitabine combined with cetuximab as adjuvant therapy in pancreatic cancer (ATIP)
-
50 Fensterer, H., Schade-Brittinger, C., Muller, H.H., et al. Multicenter phase II trial to investigate safety and efficacy of gemcitabine combined with cetuximab as adjuvant therapy in pancreatic cancer (ATIP). Ann Oncol 24:10 (2013), 2576–2581.
-
(2013)
Ann Oncol
, vol.24
, Issue.10
, pp. 2576-2581
-
-
Fensterer, H.1
Schade-Brittinger, C.2
Muller, H.H.3
-
51
-
-
2342645506
-
Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
-
51 Van Cutsem, E., van de Velde, H., Karasek, P., et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 22:8 (2004), 1430–1438.
-
(2004)
J Clin Oncol
, vol.22
, Issue.8
, pp. 1430-1438
-
-
Van Cutsem, E.1
van de Velde, H.2
Karasek, P.3
-
52
-
-
0030988302
-
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
-
52 Moskaluk, C.A., Hruban, R.H., Kern, S.E., p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 57:11 (1997), 2140–2143.
-
(1997)
Cancer Res
, vol.57
, Issue.11
, pp. 2140-2143
-
-
Moskaluk, C.A.1
Hruban, R.H.2
Kern, S.E.3
-
53
-
-
0033872039
-
Genetic progression in the pancreatic ducts
-
53 Hruban, R.H., Wilentz, R.E., Kern, S.E., Genetic progression in the pancreatic ducts. Am J Pathol 156:6 (2000), 1821–1825.
-
(2000)
Am J Pathol
, vol.156
, Issue.6
, pp. 1821-1825
-
-
Hruban, R.H.1
Wilentz, R.E.2
Kern, S.E.3
-
54
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
54 Hingorani, S.R., Wang, L., Multani, A.S., et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7:5 (2005), 469–483.
-
(2005)
Cancer Cell
, vol.7
, Issue.5
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
-
55
-
-
77956904030
-
Colorectal tumors are effectively eradicated by combined inhibition of {beta}-catenin, KRAS, and the oncogenic transcription factor ITF2
-
55 Mologni, L., Dekhil, H., Ceccon, M., et al. Colorectal tumors are effectively eradicated by combined inhibition of {beta}-catenin, KRAS, and the oncogenic transcription factor ITF2. Cancer Res 70:18 (2010), 7253–7263.
-
(2010)
Cancer Res
, vol.70
, Issue.18
, pp. 7253-7263
-
-
Mologni, L.1
Dekhil, H.2
Ceccon, M.3
-
56
-
-
84918495709
-
Therapeutic silencing of KRAS using systemically delivered siRNAs
-
56 Pecot, C.V., Wu, S.Y., Bellister, S., et al. Therapeutic silencing of KRAS using systemically delivered siRNAs. Mol Cancer Ther 13:12 (2014), 2876–2885.
-
(2014)
Mol Cancer Ther
, vol.13
, Issue.12
, pp. 2876-2885
-
-
Pecot, C.V.1
Wu, S.Y.2
Bellister, S.3
-
57
-
-
84890824325
-
Mutant KRAS is a druggable target for pancreatic cancer
-
57 Zorde Khvalevsky, E., Gabai, R., Rachmut, I.H., et al. Mutant KRAS is a druggable target for pancreatic cancer. Proc Natl Acad Sci U S A 110:51 (2013), 20723–20728.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.51
, pp. 20723-20728
-
-
Zorde Khvalevsky, E.1
Gabai, R.2
Rachmut, I.H.3
-
58
-
-
60149095359
-
Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo
-
58 Shi, X.H., Liang, Z.Y., Ren, X.Y., et al. Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo. Cancer Gene Ther 16:3 (2009), 227–236.
-
(2009)
Cancer Gene Ther
, vol.16
, Issue.3
, pp. 227-236
-
-
Shi, X.H.1
Liang, Z.Y.2
Ren, X.Y.3
-
59
-
-
84939864059
-
Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations
-
59 Hyman, D.M., Puzanov, I., Subbiah, V., et al. Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations. N Engl J Med 373:8 (2015), 726–736.
-
(2015)
N Engl J Med
, vol.373
, Issue.8
, pp. 726-736
-
-
Hyman, D.M.1
Puzanov, I.2
Subbiah, V.3
-
60
-
-
0141425732
-
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets
-
60 Calhoun, E.S., Jones, J.B., Ashfaq, R., et al. BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol 163:4 (2003), 1255–1260.
-
(2003)
Am J Pathol
, vol.163
, Issue.4
, pp. 1255-1260
-
-
Calhoun, E.S.1
Jones, J.B.2
Ashfaq, R.3
-
61
-
-
0037420026
-
BRCA2 germline mutations in familial pancreatic carcinoma
-
61 Hahn, S.A., Greenhalf, B., Ellis, I., et al. BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst 95:3 (2003), 214–221.
-
(2003)
J Natl Cancer Inst
, vol.95
, Issue.3
, pp. 214-221
-
-
Hahn, S.A.1
Greenhalf, B.2
Ellis, I.3
-
62
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
62 Farmer, H., McCabe, N., Lord, C.J., et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434:7035 (2005), 917–921.
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
-
63
-
-
49249119415
-
A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
-
63 Ashworth, A., A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol 26:22 (2008), 3785–3790.
-
(2008)
J Clin Oncol
, vol.26
, Issue.22
, pp. 3785-3790
-
-
Ashworth, A.1
-
64
-
-
48549084778
-
A syngeneic variance library for functional annotation of human variation: application to BRCA2
-
64 Hucl, T., Rago, C., Gallmeier, E., et al. A syngeneic variance library for functional annotation of human variation: application to BRCA2. Cancer Res 68:13 (2008), 5023–5030.
-
(2008)
Cancer Res
, vol.68
, Issue.13
, pp. 5023-5030
-
-
Hucl, T.1
Rago, C.2
Gallmeier, E.3
-
65
-
-
84859523588
-
Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer
-
65 Ledermann, J., Harter, P., Gourley, C., et al. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N Engl J Med 366:15 (2012), 1382–1392.
-
(2012)
N Engl J Med
, vol.366
, Issue.15
, pp. 1382-1392
-
-
Ledermann, J.1
Harter, P.2
Gourley, C.3
-
66
-
-
84946019429
-
DNA-repair defects and olaparib in metastatic prostate cancer
-
66 Mateo, J., Carreira, S., Sandhu, S., et al. DNA-repair defects and olaparib in metastatic prostate cancer. N Engl J Med 373:18 (2015), 1697–1708.
-
(2015)
N Engl J Med
, vol.373
, Issue.18
, pp. 1697-1708
-
-
Mateo, J.1
Carreira, S.2
Sandhu, S.3
-
67
-
-
27144532118
-
In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor
-
67 van der Heijden, M.S., Brody, J.R., Dezentje, D.A., et al. In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor. Clin Cancer Res 11:20 (2005), 7508–7515.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.20
, pp. 7508-7515
-
-
van der Heijden, M.S.1
Brody, J.R.2
Dezentje, D.A.3
-
68
-
-
80054820265
-
An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions
-
68 Lowery, M.A., Kelsen, D.P., Stadler, Z.K., et al. An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions. Oncologist 16:10 (2011), 1397–1402.
-
(2011)
Oncologist
, vol.16
, Issue.10
, pp. 1397-1402
-
-
Lowery, M.A.1
Kelsen, D.P.2
Stadler, Z.K.3
-
69
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
69 Conroy, T., Desseigne, F., Ychou, M., et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 364:19 (2011), 1817–1825.
-
(2011)
N Engl J Med
, vol.364
, Issue.19
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
-
70
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
-
70 Von Hoff, D.D., Ervin, T., Arena, F.P., et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 369:18 (2013), 1691–1703.
-
(2013)
N Engl J Med
, vol.369
, Issue.18
, pp. 1691-1703
-
-
Von Hoff, D.D.1
Ervin, T.2
Arena, F.P.3
-
71
-
-
84908365902
-
Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers
-
71 Golan, T., Kanji, Z.S., Epelbaum, R., et al. Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers. Br J Cancer 111:6 (2014), 1132–1138.
-
(2014)
Br J Cancer
, vol.111
, Issue.6
, pp. 1132-1138
-
-
Golan, T.1
Kanji, Z.S.2
Epelbaum, R.3
-
72
-
-
79961228580
-
Complete remission, in BRCA2 mutation carrier with metastatic pancreatic adenocarcinoma, treated with cisplatin based therapy
-
72 Sonnenblick, A., Kadouri, L., Appelbaum, L., et al. Complete remission, in BRCA2 mutation carrier with metastatic pancreatic adenocarcinoma, treated with cisplatin based therapy. Cancer Biol Ther 12:3 (2011), 165–168.
-
(2011)
Cancer Biol Ther
, vol.12
, Issue.3
, pp. 165-168
-
-
Sonnenblick, A.1
Kadouri, L.2
Appelbaum, L.3
-
73
-
-
84924262796
-
An update on PARP inhibitors for the treatment of cancer
-
73 Benafif, S., Hall, M., An update on PARP inhibitors for the treatment of cancer. Onco Targets Ther 8 (2015), 519–528.
-
(2015)
Onco Targets Ther
, vol.8
, pp. 519-528
-
-
Benafif, S.1
Hall, M.2
-
74
-
-
80055004748
-
A 67-year-old woman with BRCA 1 mutation associated with pancreatic adenocarcinoma
-
74 Lowery, M., Shah, M.A., Smyth, E., et al. A 67-year-old woman with BRCA 1 mutation associated with pancreatic adenocarcinoma. J Gastrointest Cancer 42:3 (2011), 160–164.
-
(2011)
J Gastrointest Cancer
, vol.42
, Issue.3
, pp. 160-164
-
-
Lowery, M.1
Shah, M.A.2
Smyth, E.3
-
75
-
-
84937863457
-
Clinical outcomes in pancreatic adenocarcinoma associated with BRCA-2 mutation
-
75 Vyas, O., Leung, K., Ledbetter, L., et al. Clinical outcomes in pancreatic adenocarcinoma associated with BRCA-2 mutation. Anticancer Drugs 26:2 (2015), 224–226.
-
(2015)
Anticancer Drugs
, vol.26
, Issue.2
, pp. 224-226
-
-
Vyas, O.1
Leung, K.2
Ledbetter, L.3
-
76
-
-
84926453964
-
Phase I study of olaparib plus gemcitabine in patients with advanced solid tumours and comparison with gemcitabine alone in patients with locally advanced/metastatic pancreatic cancer
-
76 Bendell, J., O'Reilly, E.M., Middleton, M.R., et al. Phase I study of olaparib plus gemcitabine in patients with advanced solid tumours and comparison with gemcitabine alone in patients with locally advanced/metastatic pancreatic cancer. Ann Oncol 26:4 (2015), 804–811.
-
(2015)
Ann Oncol
, vol.26
, Issue.4
, pp. 804-811
-
-
Bendell, J.1
O'Reilly, E.M.2
Middleton, M.R.3
-
77
-
-
84921771510
-
Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation
-
77 Kaufman, B., Shapira-Frommer, R., Schmutzler, R.K., et al. Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol 33:3 (2015), 244–250.
-
(2015)
J Clin Oncol
, vol.33
, Issue.3
, pp. 244-250
-
-
Kaufman, B.1
Shapira-Frommer, R.2
Schmutzler, R.K.3
-
78
-
-
34247532726
-
Clinical significant and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
-
78 Nomi, T., Sho, M., Akahori, T., et al. Clinical significant and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res 13:7 (2007), 2151–2157.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.7
, pp. 2151-2157
-
-
Nomi, T.1
Sho, M.2
Akahori, T.3
-
79
-
-
79953154967
-
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
-
79 Beatty, G.L., Chiorean, E.G., Fishman, M.P., et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331:6024 (2011), 1612–1616.
-
(2011)
Science
, vol.331
, Issue.6024
, pp. 1612-1616
-
-
Beatty, G.L.1
Chiorean, E.G.2
Fishman, M.P.3
-
80
-
-
84946547794
-
T cells engineered against a native antigen can surmount immunologic and physical barriers to treat pancreatic ductal adenocarcinoma
-
80 Stromnes, I.M., Schmitt, T.M., Hulbert, A., et al. T cells engineered against a native antigen can surmount immunologic and physical barriers to treat pancreatic ductal adenocarcinoma. Cancer Cell 28:5 (2015), 638–652.
-
(2015)
Cancer Cell
, vol.28
, Issue.5
, pp. 638-652
-
-
Stromnes, I.M.1
Schmitt, T.M.2
Hulbert, A.3
|