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Volumn 3, Issue 3, 2012, Pages 251-261

Gastric cancer: Classification, histology and application of molecular pathology

Author keywords

Cdh1; Classification; Dpd; Gastric carcinoma; Her2; Histology; Molecular pathology

Indexed keywords

CAPECITABINE; DIHYDROPYRIMIDINE DEHYDROGENASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; TRASTUZUMAB;

EID: 84995804133     PISSN: 20786891     EISSN: 2219679X     Source Type: Journal    
DOI: 10.3978/j.issn.2078-6891.2012.021     Document Type: Review
Times cited : (461)

References (78)
  • 1
    • 4444244978 scopus 로고    scopus 로고
    • International variation
    • Parkin DM. International variation. Oncogene2004;23:6329-40.
    • (2004) Oncogene , vol.23 , pp. 6329-6340
    • Parkin, D.M.1
  • 2
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008 GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 3
    • 0032533670 scopus 로고    scopus 로고
    • Changing patterns in the incidence of esophageal and gastric carcinoma in the United States
    • Devesa SS, Blot WJ, Fraumeni JF Jr. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998;83:2049-53.
    • (1998) Cancer , vol.83 , pp. 2049-2053
    • Devesa, S.S.1    Blot, W.J.2    Fraumeni Jr., J.F.3
  • 4
    • 0026028040 scopus 로고
    • Rising incidence of adenocarcinoma of the esophagus and gastric cardia
    • Blot WJ, Devesa SS, Kneller RW, et al. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 1991;265:1287-9.
    • (1991) JAMA , vol.265 , pp. 1287-1289
    • Blot, W.J.1    Devesa, S.S.2    Kneller, R.W.3
  • 6
    • 0034092610 scopus 로고    scopus 로고
    • Histology of the gastroesophageal junction: an autopsy study
    • Chandrasoma PT, Der R, Ma Y, et al. Histology of the gastroesophageal junction: an autopsy study. Am J Surg Pathol 2000;24:402-9.
    • (2000) Am J Surg Pathol , vol.24 , pp. 402-409
    • Chandrasoma, P.T.1    Der, R.2    Ma, Y.3
  • 7
    • 0027998622 scopus 로고
    • The gastric cardia in Helicobacter pylori infection
    • Genta RM, Huberman RM, Graham DY. The gastric cardia in Helicobacter pylori infection. Hum Pathol 1994;25:915-9.
    • (1994) Hum Pathol , vol.25 , pp. 915-919
    • Genta, R.M.1    Huberman, R.M.2    Graham, D.Y.3
  • 8
    • 0031784518 scopus 로고    scopus 로고
    • Classification of adenocarcinoma of the oesophagogastric junction
    • Siewert JR, Stein HJ. Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg 1998;85:1457-9.
    • (1998) Br J Surg , vol.85 , pp. 1457-1459
    • Siewert, J.R.1    Stein, H.J.2
  • 10
    • 78650865669 scopus 로고    scopus 로고
    • Gastric cardiac carcinomas involving the esophagus are more adequately staged as gastric cancers by the 7th edition of the American Joint Commission on Cancer Staging System
    • Huang Q, Shi J, Feng A, et al. Gastric cardiac carcinomas involving the esophagus are more adequately staged as gastric cancers by the 7th edition of the American Joint Commission on Cancer Staging System. Mod Pathol 2011;24:138-46.
    • (2011) Mod Pathol , vol.24 , pp. 138-146
    • Huang, Q.1    Shi, J.2    Feng, A.3
  • 12
    • 0002770286 scopus 로고
    • Patholomorphological diagnosis Definition and gross classification of early gastric cancer
    • Murakami T. Patholomorphological diagnosis. Definition and gross classification of early gastric cancer. Gann Monohr Cancer Res 1971;11:53-5.
    • (1971) Gann Monohr Cancer Res , vol.11 , pp. 53-55
    • Murakami, T.1
  • 13
    • 0346326100 scopus 로고    scopus 로고
    • The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002
    • The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. Gastrointest Endosc 2003;58:S3-43.
    • (2003) Gastrointest Endosc , vol.58
  • 14
    • 0030774665 scopus 로고    scopus 로고
    • Early gastric cancer in Europe
    • Everett SM, Axon AT. Early gastric cancer in Europe. Gut 1997;41:142-50.
    • (1997) Gut , vol.41 , pp. 142-150
    • Everett, S.M.1    Axon, A.T.2
  • 15
    • 0022116042 scopus 로고
    • Characteristics of gastric cancer invading to the proper muscle layer--with special reference to mortality and cause of death
    • Yoshikawa K, Maruyama K. Characteristics of gastric cancer invading to the proper muscle layer--with special reference to mortality and cause of death. Jpn J Clin Oncol 1985;15:499-503.
    • (1985) Jpn J Clin Oncol , vol.15 , pp. 499-503
    • Yoshikawa, K.1    Maruyama, K.2
  • 16
    • 33745726677 scopus 로고    scopus 로고
    • Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
    • Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006;355:11-20.
    • (2006) N Engl J Med , vol.355 , pp. 11-20
    • Cunningham, D.1    Allum, W.H.2    Stenning, S.P.3
  • 17
    • 79955576900 scopus 로고    scopus 로고
    • Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial
    • Ychou M, Boige V, Pignon JP, et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J Clin Oncol 2011;29:1715-21.
    • (2011) J Clin Oncol , vol.29 , pp. 1715-1721
    • Ychou, M.1    Boige, V.2    Pignon, J.P.3
  • 18
    • 77649205615 scopus 로고    scopus 로고
    • Preoperative staging of gastric cancer by endoscopic ultrasonography and multidetector-row computed tomography
    • Hwang SW, Lee DH, Lee SH, et al. Preoperative staging of gastric cancer by endoscopic ultrasonography and multidetector-row computed tomography. J Gastroenterol Hepatol 2010;25:512-8.
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 512-518
    • Hwang, S.W.1    Lee, D.H.2    Lee, S.H.3
  • 19
    • 0032586731 scopus 로고    scopus 로고
    • Prognostic value of Laurén classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastroesophageal junction
    • Polkowski W, van Sandick JW, Offerhaus GJ, et al. Prognostic value of Laurén classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastroesophageal junction. Ann Surg Oncol 1999;6:290-7.
    • (1999) Ann Surg Oncol , vol.6 , pp. 290-297
    • Polkowski, W.1    van Sandick, J.W.2    Offerhaus, G.J.3
  • 20
    • 12644292106 scopus 로고
    • The two histological main types of gastric carcinoma: diffuse and so called intestinal-type carcinoma: an attempt at a histo-clinical classification
    • Lauren P. The two histological main types of gastric carcinoma: diffuse and so called intestinal-type carcinoma: an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965;64:31-49.
    • (1965) Acta Pathol Microbiol Scand , vol.64 , pp. 31-49
    • Lauren, P.1
  • 21
    • 0033432725 scopus 로고    scopus 로고
    • Familial gastric cancer: overview and guidelines for management
    • Caldas C, Carneiro F, Lynch HT, et al. Familial gastric cancer: overview and guidelines for management. J Med Genet 1999;36:873-80.
    • (1999) J Med Genet , vol.36 , pp. 873-880
    • Caldas, C.1    Carneiro, F.2    Lynch, H.T.3
  • 22
    • 0035128684 scopus 로고    scopus 로고
    • Time trend analysis of gastric cancer incidence in Japan by histological types 1975-1989
    • Kaneko S, Yoshimura T. Time trend analysis of gastric cancer incidence in Japan by histological types, 1975-1989. Br J Cancer 2001;84:400-5.
    • (2001) Br J Cancer , vol.84 , pp. 400-405
    • Kaneko, S.1    Yoshimura, T.2
  • 23
    • 0025764109 scopus 로고
    • Helicobacter pylori infection in intestinal- and diffuse-type gastric adenocarcinomas
    • Parsonnet J, Vandersteen D, Goates J, et al. Helicobacter pylori infection in intestinal- and diffuse-type gastric adenocarcinomas. J Natl Cancer Inst 1991;83:640-3.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 640-643
    • Parsonnet, J.1    Vandersteen, D.2    Goates, J.3
  • 25
    • 81155161838 scopus 로고    scopus 로고
    • Gastric pseudosignet ring cells: a potential diagnostic pitfall
    • Hughes C, Greywoode G, Chetty R. Gastric pseudosignet ring cells: a potential diagnostic pitfall. Virchows Arch 2011;459:347-9.
    • (2011) Virchows Arch , vol.459 , pp. 347-349
    • Hughes, C.1    Greywoode, G.2    Chetty, R.3
  • 26
    • 0034080973 scopus 로고    scopus 로고
    • Epstein-Barr virusassociated gastric carcinomas: relation to H. pylori infection and genetic alterations
    • Wu MS, Shun CT, Wu CC, et al. Epstein-Barr virusassociated gastric carcinomas: relation to H. pylori infection and genetic alterations. Gastroenterology 2000;118:1031-8.
    • (2000) Gastroenterology , vol.118 , pp. 1031-1038
    • Wu, M.S.1    Shun, C.T.2    Wu, C.C.3
  • 27
    • 0032904099 scopus 로고    scopus 로고
    • Lymphoepitheliomalike carcinoma of the stomach: a subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein-Barr virus infection
    • Wang HH, Wu MS, Shun CT, et al. Lymphoepitheliomalike carcinoma of the stomach: a subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein-Barr virus infection. Hepatogastroenterology 1999;46:1214-9.
    • (1999) Hepatogastroenterology , vol.46 , pp. 1214-1219
    • Wang, H.H.1    Wu, M.S.2    Shun, C.T.3
  • 28
    • 60849132738 scopus 로고    scopus 로고
    • Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U
    • Truong CD, Feng W, Li W, et al. Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U.S.A. J Exp Clin Cancer Res 2009;28:14.
    • (2009) S. A. J Exp Clin Cancer Res , vol.28 , pp. 14
    • Truong, C.D.1    Feng, W.2    Li, W.3
  • 29
    • 53549087773 scopus 로고    scopus 로고
    • Bortezomib-induced enzyme-targeted radiation therapy in herpesvirusassociated tumors
    • Fu DX, Tanhehco Y, Chen J, et al. Bortezomib-induced enzyme-targeted radiation therapy in herpesvirusassociated tumors. Nat Med 2008;14:1118-22.
    • (2008) Nat Med , vol.14 , pp. 1118-1122
    • Fu, D.X.1    Tanhehco, Y.2    Chen, J.3
  • 30
    • 0032984373 scopus 로고    scopus 로고
    • Origin of microsatellite instability in gastric cancer
    • Halling KC, Harper J, Moskaluk CA, et al. Origin of microsatellite instability in gastric cancer. Am J Pathol 1999;155:205-11.
    • (1999) Am J Pathol , vol.155 , pp. 205-211
    • Halling, K.C.1    Harper, J.2    Moskaluk, C.A.3
  • 31
    • 0031710793 scopus 로고    scopus 로고
    • The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different " target genes" : a study of the TGFbeta RII,IGFII R, and BAX genes
    • Oliveira C, Seruca R, Seixas M, et al. The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different " target genes" : a study of the TGFbeta RII,IGFII R, and BAX genes. Am J Pathol 1998;153:1211-9.
    • (1998) Am J Pathol , vol.153 , pp. 1211-1219
    • Oliveira, C.1    Seruca, R.2    Seixas, M.3
  • 32
    • 0035396812 scopus 로고    scopus 로고
    • A genome-wide study of microsatellite instability in advanced gastric carcinoma
    • Wu CW, Chen GD, Jiang KC, et al. A genome-wide study of microsatellite instability in advanced gastric carcinoma. Cancer 2001;92:92-101.
    • (2001) Cancer , vol.92 , pp. 92-101
    • Wu, C.W.1    Chen, G.D.2    Jiang, K.C.3
  • 33
    • 10344228783 scopus 로고    scopus 로고
    • Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes
    • Thibodeau SN, French AJ, Roche PC, et al. Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res 1996;56:4836-40.
    • (1996) Cancer Res , vol.56 , pp. 4836-4840
    • Thibodeau, S.N.1    French, A.J.2    Roche, P.C.3
  • 34
    • 0038446928 scopus 로고    scopus 로고
    • Lymphocyterich gastric cancer: associations with Epstein-Barr virus, microsatellite instability, histology, and survival
    • Grogg KL, Lohse CM, Pankratz VS, et al. Lymphocyterich gastric cancer: associations with Epstein-Barr virus, microsatellite instability, histology, and survival. Mod Pathol 2003;16:641-51.
    • (2003) Mod Pathol , vol.16 , pp. 641-651
    • Grogg, K.L.1    Lohse, C.M.2    Pankratz, V.S.3
  • 35
    • 77955129010 scopus 로고    scopus 로고
    • Micropapillary carcinoma of stomach: a clinicopathologic and immunohistochemical study of 11 cases
    • Roh JH, Srivastava A, Lauwers GY, et al. Micropapillary carcinoma of stomach: a clinicopathologic and immunohistochemical study of 11 cases. Am J Surg Pathol 2010;34:1139-46.
    • (2010) Am J Surg Pathol , vol.34 , pp. 1139-1146
    • Roh, J.H.1    Srivastava, A.2    Lauwers, G.Y.3
  • 36
    • 84855949468 scopus 로고    scopus 로고
    • Gastric carcinoma with invasive micropapillary pattern and its association with lymph node metastasis
    • Ushiku T, Matsusaka K, Iwasaki Y, et al. Gastric carcinoma with invasive micropapillary pattern and its association with lymph node metastasis. Histopathology 2011;59:1081-9.
    • (2011) Histopathology , vol.59 , pp. 1081-1089
    • Ushiku, T.1    Matsusaka, K.2    Iwasaki, Y.3
  • 37
    • 33846145676 scopus 로고    scopus 로고
    • Molecular pathobiology of gastric cancer
    • Yasui W, Sentani K, Motoshita J, et al. Molecular pathobiology of gastric cancer. Scand J Surg 2006;95:225-31.
    • (2006) Scand J Surg , vol.95 , pp. 225-231
    • Yasui, W.1    Sentani, K.2    Motoshita, J.3
  • 38
    • 0032928670 scopus 로고    scopus 로고
    • Role of copper accumulation in spontaneous renal carcinogenesis in Long-Evans Cinnamon rats
    • Kitaura K, Chone Y, Satake N, et al. Role of copper accumulation in spontaneous renal carcinogenesis in Long-Evans Cinnamon rats. Jpn J Cancer Res 1999;90:385-92.
    • (1999) Jpn J Cancer Res , vol.90 , pp. 385-392
    • Kitaura, K.1    Chone, Y.2    Satake, N.3
  • 40
    • 0029862873 scopus 로고    scopus 로고
    • Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis
    • Vasen HF, Wijnen JT, Menko FH, et al. Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology 1996;110:1020-7.
    • (1996) Gastroenterology , vol.110 , pp. 1020-1027
    • Vasen, H.F.1    Wijnen, J.T.2    Menko, F.H.3
  • 41
    • 0031945119 scopus 로고    scopus 로고
    • Microsatellite instability and loss of heterozygosity in gastric carcinoma in comparison to family history
    • Keller G, Rudelius M, Vogelsang H, et al. Microsatellite instability and loss of heterozygosity in gastric carcinoma in comparison to family history. Am J Pathol 1998;152:1281-9.
    • (1998) Am J Pathol , vol.152 , pp. 1281-1289
    • Keller, G.1    Rudelius, M.2    Vogelsang, H.3
  • 42
    • 0028786036 scopus 로고
    • An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53
    • Varley JM, McGown G, Thorncroft M, et al. An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53. J Med Genet 1995;32:942-5.
    • (1995) J Med Genet , vol.32 , pp. 942-945
    • Varley, J.M.1    McGown, G.2    Thorncroft, M.3
  • 43
    • 0035211026 scopus 로고    scopus 로고
    • International Gastric Cancer Linkage Consortium Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families
    • Pharoah PD, Guilford P, Caldas C. International Gastric Cancer Linkage Consortium. Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. Gastroenterology 2001;121:1348-53.
    • (2001) Gastroenterology , vol.121 , pp. 1348-1353
    • Pharoah, P.D.1    Guilford, P.2    Caldas, C.3
  • 44
    • 55249091627 scopus 로고    scopus 로고
    • Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer
    • Barber M, Murrell A, Ito Y, et al. Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer. J Pathol 2008;216:295-306.
    • (2008) J Pathol , vol.216 , pp. 295-306
    • Barber, M.1    Murrell, A.2    Ito, Y.3
  • 45
    • 66149108352 scopus 로고    scopus 로고
    • Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression
    • Oliveira C, Sousa S, Pinheiro H, et al. Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology 2009;136:2137-48.
    • (2009) Gastroenterology , vol.136 , pp. 2137-2148
    • Oliveira, C.1    Sousa, S.2    Pinheiro, H.3
  • 46
    • 0033432725 scopus 로고    scopus 로고
    • Familial gastric cancer: overview and guidelines for management
    • Caldas C, Carneiro F, Lynch HT, et al. Familial gastric cancer: overview and guidelines for management. J Med Genet 1999;36:873-80.
    • (1999) J Med Genet , vol.36 , pp. 873-880
    • Caldas, C.1    Carneiro, F.2    Lynch, H.T.3
  • 47
    • 18344384564 scopus 로고    scopus 로고
    • Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred
    • Oliveira C, Bordin MC, Grehan N, et al. Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. Hum Mutat 2002;19:510-7.
    • (2002) Hum Mutat , vol.19 , pp. 510-517
    • Oliveira, C.1    Bordin, M.C.2    Grehan, N.3
  • 48
    • 77956110372 scopus 로고    scopus 로고
    • Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research
    • Fitzgerald RC, Hardwick R, Huntsman D, et al. Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. J Med Genet 2010;47:436-44.
    • (2010) J Med Genet , vol.47 , pp. 436-444
    • Fitzgerald, R.C.1    Hardwick, R.2    Huntsman, D.3
  • 49
    • 15244362093 scopus 로고    scopus 로고
    • Role of pathology in the identification of hereditary diffuse gastric cancer: report of a Portuguese family
    • Oliveira C, Moreira H, Seruca R, et al. Role of pathology in the identification of hereditary diffuse gastric cancer: report of a Portuguese family. Virchows Arch 2005;446:181-4.
    • (2005) Virchows Arch , vol.446 , pp. 181-184
    • Oliveira, C.1    Moreira, H.2    Seruca, R.3
  • 50
    • 64549109715 scopus 로고    scopus 로고
    • Germline CDH1 deletions in hereditary diffuse gastric cancer families
    • Oliveira C, Senz J, Kaurah P, et al. Germline CDH1 deletions in hereditary diffuse gastric cancer families. Hum Mol Genet 2009;18:1545-55.
    • (2009) Hum Mol Genet , vol.18 , pp. 1545-1555
    • Oliveira, C.1    Senz, J.2    Kaurah, P.3
  • 51
    • 36348986039 scopus 로고    scopus 로고
    • Germline E-cadherin mutations in familial lobular breast cancer
    • Masciari S, Larsson N, Senz J, et al. Germline E-cadherin mutations in familial lobular breast cancer. J Med Genet 2007;44:726-31.
    • (2007) J Med Genet , vol.44 , pp. 726-731
    • Masciari, S.1    Larsson, N.2    Senz, J.3
  • 52
    • 0022647432 scopus 로고
    • The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity
    • Akiyama T, Sudo C, Ogawara H, et al. The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity. Science 1986;232:1644-6.
    • (1986) Science , vol.232 , pp. 1644-1646
    • Akiyama, T.1    Sudo, C.2    Ogawara, H.3
  • 53
    • 0024651788 scopus 로고
    • Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21 32
    • Popescu NC, King CR, Kraus MH. Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32. Genomics 1989;4:362-6.
    • (1989) Genomics , vol.4 , pp. 362-366
    • Popescu, N.C.1    King, C.R.2    Kraus, M.H.3
  • 54
    • 0022588467 scopus 로고
    • Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor
    • Yamamoto T, Ikawa S, Akiyama T, et al. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature 1986;319:230-4.
    • (1986) Nature , vol.319 , pp. 230-234
    • Yamamoto, T.1    Ikawa, S.2    Akiyama, T.3
  • 55
    • 0025974889 scopus 로고
    • Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer
    • Yonemura Y, Ninomiya I, Yamaguchi A, et al. Evaluation of immunoreactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer. Cancer Res 1991;51:1034-8.
    • (1991) Cancer Res , vol.51 , pp. 1034-1038
    • Yonemura, Y.1    Ninomiya, I.2    Yamaguchi, A.3
  • 56
    • 0022486379 scopus 로고
    • Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo
    • Yokota J, Yamamoto T, Toyoshima K, et al. Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet 1986;1:765-7.
    • (1986) Lancet , vol.1 , pp. 765-767
    • Yokota, J.1    Yamamoto, T.2    Toyoshima, K.3
  • 57
    • 70350204423 scopus 로고    scopus 로고
    • Efficacy results from the ToGA trial: A phase III study of trastuzumab added to standard chemotherapy (CT) in first-line human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (GC)
    • LBA
    • Van Cutsem E, Kang Y, Chung H, et al. Efficacy results from the ToGA trial: A phase III study of trastuzumab added to standard chemotherapy (CT) in first-line human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (GC). J Clin Oncol 2009;27:LBA 4509.
    • (2009) J Clin Oncol , vol.27 , pp. 4509
    • Van Cutsem, E.1    Kang, Y.2    Chung, H.3
  • 58
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010;376:687-97.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 59
    • 20044372721 scopus 로고    scopus 로고
    • Amplification of HER-2 in gastric carcinoma: association withTopoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab
    • Tanner M, Hollmén M, Junttila TT, et al. Amplification of HER-2 in gastric carcinoma: association withTopoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol 2005;16:273-8.
    • (2005) Ann Oncol , vol.16 , pp. 273-278
    • Tanner, M.1    Hollmén, M.2    Junttila, T.T.3
  • 60
    • 50849123421 scopus 로고    scopus 로고
    • HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target
    • Gravalos C, Jimeno A. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann Oncol 2008;19:1523-9.
    • (2008) Ann Oncol , vol.19 , pp. 1523-1529
    • Gravalos, C.1    Jimeno, A.2
  • 61
    • 67349222954 scopus 로고    scopus 로고
    • HER-2 amplification is highly homogenous in gastric cancer
    • Marx AH, Tharun L, Muth J, et al. HER-2 amplification is highly homogenous in gastric cancer. Hum Pathol 2009;40:769-77.
    • (2009) Hum Pathol , vol.40 , pp. 769-777
    • Marx, A.H.1    Tharun, L.2    Muth, J.3
  • 62
    • 84860487790 scopus 로고    scopus 로고
    • HER2 testing in gastric cancer: a practical approach
    • Rüschoff J, Hanna W, Bilous M, et al. HER2 testing in gastric cancer: a practical approach. Mod Pathol 2012;25:637-50.
    • (2012) Mod Pathol , vol.25 , pp. 637-650
    • Rüschoff, J.1    Hanna, W.2    Bilous, M.3
  • 63
    • 33747169515 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase deficiency: impact of pharmacogenetics on 5-fluorouracil therapy
    • Lee A, Ezzeldin H, Fourie J, et al. Dihydropyrimidine dehydrogenase deficiency: impact of pharmacogenetics on 5-fluorouracil therapy. Clin Adv Hematol Oncol 2004;2:527-32.
    • (2004) Clin Adv Hematol Oncol , vol.2 , pp. 527-532
    • Lee, A.1    Ezzeldin, H.2    Fourie, J.3
  • 64
    • 43749114271 scopus 로고    scopus 로고
    • Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group
    • Schwab M, Zanger UM, Marx C, et al. Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J Clin Oncol 2008;26:2131-8.
    • (2008) J Clin Oncol , vol.26 , pp. 2131-2138
    • Schwab, M.1    Zanger, U.M.2    Marx, C.3
  • 65
    • 79955998006 scopus 로고    scopus 로고
    • Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer
    • Deenen MJ, Tol J, Burylo AM, et al. Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer. Clin Cancer Res 2011;17:3455-68.
    • (2011) Clin Cancer Res , vol.17 , pp. 3455-3468
    • Deenen, M.J.1    Tol, J.2    Burylo, A.M.3
  • 66
    • 58049196845 scopus 로고    scopus 로고
    • Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients
    • Gross E, Busse B, Riemenschneider M, et al. Strong association of a common dihydropyrimidine dehydrogenase gene polymorphism with fluoropyrimidine-related toxicity in cancer patients. PLoS One 2008;3:e4003.
    • (2008) PLoS One , vol.3
    • Gross, E.1    Busse, B.2    Riemenschneider, M.3
  • 67
    • 80052944892 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity
    • Amstutz U, Froehlich TK, Largiadèr CR. Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity. Pharmacogenomics 2011;12:1321-36.
    • (2011) Pharmacogenomics , vol.12 , pp. 1321-1336
    • Amstutz, U.1    Froehlich, T.K.2    Largiadèr, C.R.3
  • 68
    • 77955523615 scopus 로고    scopus 로고
    • Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity
    • Kim SR, Park CH, Park S, et al. Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity. Chemotherapy 2010;56:313-7.
    • (2010) Chemotherapy , vol.56 , pp. 313-317
    • Kim, S.R.1    Park, C.H.2    Park, S.3
  • 69
    • 0034984031 scopus 로고    scopus 로고
    • Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil
    • Johnson MR, Diasio RB. Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil. Adv Enzyme Regul 2001;41:151-7.
    • (2001) Adv Enzyme Regul , vol.41 , pp. 151-157
    • Johnson, M.R.1    Diasio, R.B.2
  • 70
    • 33947587702 scopus 로고    scopus 로고
    • Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression
    • Zhang X, Soong R, Wang K, et al. Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression. Biochem Cell Biol 2007;85:337-46.
    • (2007) Biochem Cell Biol , vol.85 , pp. 337-346
    • Zhang, X.1    Soong, R.2    Wang, K.3
  • 71
    • 37349090420 scopus 로고    scopus 로고
    • Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism
    • Thomas HR, Ezzeldin HH, Guarcello V, et al. Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism. Pharmacogenet Genomics 2007;17:973-87.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 973-987
    • Thomas, H.R.1    Ezzeldin, H.H.2    Guarcello, V.3
  • 72
    • 0035667063 scopus 로고    scopus 로고
    • Detection of beta-ureidopropionase deficiency with HPLC-electrospray tandem mass spectrometry and confirmation of the defect at the enzyme level
    • Van Kuilenburg AB, Van Lenthe H, Assmann B, et al. Detection of beta-ureidopropionase deficiency with HPLC-electrospray tandem mass spectrometry and confirmation of the defect at the enzyme level. J Inherit Metab Dis 2001;24:725-32.
    • (2001) J Inherit Metab Dis , vol.24 , pp. 725-732
    • Van Kuilenburg, A.B.1    Van Lenthe, H.2    Assmann, B.3
  • 73
    • 38549153294 scopus 로고    scopus 로고
    • Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism
    • Thomas HR, Ezzeldin HH, Guarcello V, et al. Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism. Pharmacogenet Genomics 2008;18:25-35.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 25-35
    • Thomas, H.R.1    Ezzeldin, H.H.2    Guarcello, V.3
  • 74
    • 1942502420 scopus 로고    scopus 로고
    • Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test
    • Mattison LK, Ezzeldin H, Carpenter M, et al. Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test. Clin Cancer Res 2004;10:2652-8.
    • (2004) Clin Cancer Res , vol.10 , pp. 2652-2658
    • Mattison, L.K.1    Ezzeldin, H.2    Carpenter, M.3
  • 75
    • 0032748608 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase: its role in 5-fluorouracil clinical toxicity and tumor resistance
    • Diasio RB, Johnson MR. Dihydropyrimidine dehydrogenase: its role in 5-fluorouracil clinical toxicity and tumor resistance. Clin Cancer Res 1999;5:2672-3.
    • (1999) Clin Cancer Res , vol.5 , pp. 2672-2673
    • Diasio, R.B.1    Johnson, M.R.2
  • 76
    • 43749109160 scopus 로고    scopus 로고
    • Predicting fluorouracil toxicity: can we finally do it?
    • Ezzeldin HH, Diasio RB. Predicting fluorouracil toxicity: can we finally do it? J Clin Oncol 2008;26:2080-2.
    • (2008) J Clin Oncol , vol.26 , pp. 2080-2082
    • Ezzeldin, H.H.1    Diasio, R.B.2
  • 77
    • 77951163222 scopus 로고    scopus 로고
    • Deriving chemosensitivity from cell lines: forensic bioinformatics and reproducible research in high-throughput biology
    • Baggerly KA, Combes KR. Deriving chemosensitivity from cell lines: forensic bioinformatics and reproducible research in high-throughput biology. Ann Appl Stat 2009;3:1309-34.
    • (2009) Ann Appl Stat , vol.3 , pp. 1309-1334
    • Baggerly, K.A.1    Combes, K.R.2
  • 78
    • 80053584808 scopus 로고    scopus 로고
    • Translational medicine and reliability of single-nucleotide polymorphism studies: can we believe in SNP reports or not?
    • Valachis A, Mauri D, Neophytou C, et al. Translational medicine and reliability of single-nucleotide polymorphism studies: can we believe in SNP reports or not? Int J Med Sci 2011;8:492-500.
    • (2011) Int J Med Sci , vol.8 , pp. 492-500
    • Valachis, A.1    Mauri, D.2    Neophytou, C.3


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