Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil

Advances in Enzyme Regulation

Volumn 41, Issue 1, 2001, Pages 151-157

  Johnson, Martin R ^a   Diasio, Robert B ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; DIHYDROPYRIMIDINE DEHYDROGENASE; DIHYDROURACIL DEHYDROGENASE(NADP); FLUOROURACIL; OXIDOREDUCTASE;

ADULT; AGED; ARTICLE; ATAXIA; CANCER; CANCER CHEMOTHERAPY; CANCER PATIENT; CATABOLISM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DIARRHEA; DISEASE SEVERITY; DRUG CLEARANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; GRANULOCYTOPENIA; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MUCOSA INFLAMMATION; NEUROPATHY; PHENOTYPE;

ATAXIA;

EID: 0034984031     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(00)00011-X     Document Type: Article

References (14)

1. Scrip's Cancer Chemotherapy Report
2. 5-Fluoropyrimidines
3. Fluorinated pyrimidines
4. Antimetabolites
5. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
6. Purification and characterization of dihydropyrimidine dehydrogenase from human liver
7. Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia severe 5-fluorouracil-induced toxicity
8. Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity
9. Life-threatening toxicity in a dihydropyrimidine dehydrogenase deficient patient following treatment with topical 5-fluorouracil
10. Dihydropyrimidine dehydrogenase deficiency: A pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy
11. Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer-implication for 5-fluorouracil-based chemotherapy
12. Semi-automated radioassay for determination of dihydropyrimidine dehydrogenase (DPD) activity. Screening cancer patients for DPD deficiency, a condition associated with 5-fluorouracil toxicity
13. Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy
14. Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency