Translational medicine and reliability of single-nucleotide polymorphism studies: Can We believe in SNP reports or not?

International Journal of Medical Sciences

Volumn 8, Issue 6, 2011, Pages 492-500

  Valachis, Antonis ^a,b   Mauri, Davide ^b,c   Neophytou, Christodoulos ^b   Polyzos, Nikolaos P ^b,d   Tsali, Lampriani ^b   Garras, Antonios ^e   Papanikolau, Evangelos G ^d  

^a Onkologkliniken Sörmland   (Sweden)

^b PACMeR   (Greece)

^c General Hospital   (Greece)

^d CENTRE FOR REPRODUCTIVE MEDICINE   (Belgium)

^e GENERAL HOSPITAL   (Greece)

Author keywords

Genetic association studies; Literature bias; Publication bias; Single nucleotide polymorphisms; Translational research

Indexed keywords

ALANINE; ASPARAGINE; ASPARTIC ACID; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; ISOLEUCINE; SERINE; THREONINE; TYROSINE; VALINE;

BREAST CANCER; CANCER CLASSIFICATION; COLORECTAL CANCER; CONTROLLED STUDY; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; LUNG CANCER; MEDICAL RESEARCH; OUTCOME ASSESSMENT; PROTEIN POLYMORPHISM; RELIABILITY; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW; TRANSLATIONAL RESEARCH;

EID: 80053584808     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.8.492     Document Type: Review

References (94)

1. Ioannidis JP. Genetic associations: False or true? Trends Mol Med 2003;9: 135-138
2. Dickersin K, Min YI, Meinert CL. Factors influencing publication of research results. Follow-up of applications submitted to two insti-tutional review boards. JAMA 1992;267:374-8
3. Easterbrook PJ, Berlin JA, Gopalan R, et al. Publication bias in clin-ical research. Lancet 1991;337:867-72
4. Begg CB, Berlin JA. Publication bias: a problem in interpreting medical data. J R Stat SOC A. 1988;151:419-63
5. Littner Y, Mimouni FB, Dollberg S, Mandel D. Negative results and impact factor: A lesson from neonatology. Arch Pediatr Adolesc Med. 2005;159:1036-1037
6. Ravnskov U. Cholesterol lowering trials in coronary heart disease: frequency of citation and outcome. BMJ 1992;305:15-9
7. Kjaergard LL, Gluud C. Citation bias of hepato-biliary randomized clinical trials. Journal of Clinical Epidemiology 2002;55:407-410
8. Olson CM. Publication bias. Acad Emerg Med. 1994;1:207-209
9. [Internet] Thomson Reuters. http://www.isiknowledge.com/jcr.
10. [Internet] Thomson Reuters. http://www.isiknowledge.com.
11. Shapiro SS, Wilk MB. An analysis of variance test for normality (complete samples). Biometrika 1965; 52 (3-4): 591-611.
12. Mann HB, Whitney DR. On a test of whether one of two random variables is stochastically larger than the other. Annals of Mathe-matical Statistics 1947; 18: 50-60.
13. Agalliu I, Lin DW, Salinas CA, Feng Z, Stanford JL. Polymorphisms in the glutathione S-transferase M1, T1, and P1 genes and prostate cancer prognosis. Prostate. 2006;66:1535-41
14. Beeghly A, Katsaros D, Chen H, Fracchioli S, Zhang Y, Massobrio M, Risch H, Jones B, Yu H. Glutathione S-transferase polymor-phisms and ovarian cancer treatment and survival. Gynecol Oncol. 2006;100:330-7
15. Booten R, Ward T, Heighway J, Ashcroft L, Morris J, Thatcher N. Glutathione-S-transferase P1 isoenzyme polymorphisms, plati-num-based chemotherapy, and non-small cell lung cancer. J Thorac Oncol. 2006;1:679-83
16. Cabelguenne A, Loriot MA, Stucker I, Blons H, Koum-Besson E, Brasnu D, Beaune P, Laccourreye O, Laurent-Puig P, De Waziers I. Glutathione-associated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemo-therapy. Int J Cancer. 2001;93:725-30
17. Chacko P, Joseph T, Mathew BS, Rajan B, Pillai MR. Role of xeno-biotic metabolizing gene polymorphisms in breast cancer suscepti-bility and treatment outcome. Mutat Res. 2005;581:153-63
18. Chung HH, Kim MK, Kim JW, Park NH, Song YS, Kang SB, Lee HP. XRCC1 R399Q polymorphism is associated with response to plati-num-based neoadjuvant chemotherapy in bulky cervical cancer. Gynecol Oncol. 2006;103:1031-7
19. Csejtei A, Tibold A, Varga Z, Koltai K, Ember A, Orsos Z, Feher G, Horvath OP, Ember I, Kiss I. GSTM, GSTT and p53 polymorphisms as modifiers of clinical outcome in colorectal cancer. Anticancer Res. 2008;28:1917-22
20. Ge H, Lam WK, Lee J, Wong MP, Yew WW, Lung ML. Analysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung car-cinoma patients. Lung Cancer. 1996;15:355-66
21. Geisler SA, Olshan AF, Cai J, Weissler M, Smith J, Bell D. Glutathi-one S-transferase polymorphisms and survival from head and neck cancer. Head Neck. 2005;27:232-42
22. Goekkurt E, Hoehn S, Wolschke C, Wittmer C, Stueber C, Hossfeld DK, Stoehlmacher J. Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)--novel predictors for response and survival in gastric cancer patients. Br J Cancer. 2006;94:281-6
23. Gonlugur U, Pinarbasi H, Gonlugur TE, Silig Y. The association between polymorphisms in glutathione S-transferase (GSTM1 and GSTT1) and lung cancer outcome. Cancer Invest. 2006;24:497-501
24. Goto I, Yoneda S, Yamamoto M, Kawajiri K. Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer. Cancer Res. 1996;56:3725-30
25. Haque AK, Au W, Cajas-Salazar N, Khan S, Ginzel AW, Jones DV, Zwischenberger JB, Xie J. CYP2E1 polymorphism, cigarette smok-ing, p53 expression, and survival in non-small cell lung cancer: a long term follow-up study. Appl Immunohistochem Mol Morphol. 2004;12:315-22
26. Holley SL, Rajagopal R, Hoban PR, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA. Polymorphisms in the glu-tathione S-transferase mu cluster are associated with tumour pro-gression and patient outcome in colorectal cancer. Int J Oncol. 2006;28:231-6
27. Howells RE, Holland T, Dhar KK, Redman CW, Hand P, Hoban PR, Jones PW, Fryer AA, Strange RC. Glutathione S-transferase GSTM1 and GSTT1 genotypes in ovarian cancer: association with p53 ex-pression and survival. Int J Gynecol Cancer. 2001;11:107-12
28. Howells RE, Dhar KK, Hoban PR, Jones PW, Fryer AA, Redman CW, Strange RC. Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithe-lial ovarian cancer. Int J Gynecol Cancer. 2004;14:242-50
29. Huang MY, Fang WY, Lee SC, Cheng TL, Wang JY, Lin SR. ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study. BMC Cancer. 2008;8:50
30. Huang ZH, Hua D, Du X. Polymorphisms in p53, GSTP1 and XRCC1 predict relapse and survival of gastric cancer patients treated with oxaliplatin-based adjuvant chemotherapy. Cancer Chemother Pharmacol. 2009; In press
31. Jatoi A, Martenson JA, Foster NR, McLeod HL, Lair BS, Nichols F, Tschetter LK, Moore DF Jr, Fitch TR, Alberts SR; North Central Cancer Treatment Group (N0044). Paclitaxel, carboplatin, 5-fluorouracil, and radiation for locally advanced esophageal can-cer: phase II results of preliminary pharmacologic and molecular efforts to mitigate toxicity and predict outcomes: North Central Cancer Treatment Group (N0044). Am J Clin Oncol. 2007;30:507-13
32. Jiao L, Bondy ML, Hassan MM, Chang DZ, Abbruzzese JL, Evans DB, Smolensky MH, Li D. Glutathione S-transferase gene poly-morphisms and risk and survival of pancreatic cancer. Cancer. 2007 Mar 1;109(5):840-8
33. Kim EJ, Jeong P, Quan C, Kim J, Bae SC, Yoon SJ, Kang JW, Lee SC, Jun Wee J, Kim WJ. Genotypes of TNF-alpha, VEGF, hOGG1, GSTM1, and GSTT1: useful determinants for clinical outcome of bladder cancer. Urology. 2005;65:70-5
34. Kim K, Kang SB, Chung HH, Kim JW, Park NH, Song YS. XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine poly-morphisms are associated with response to platinum-based neoad-juvant chemotherapy in cervical cancer. Gynecol Oncol. 2008;111:509-15
35. Kim HS, Kim MK, Chung HH, Kim JW, Park NH, Song YS, Kang SB. Genetic polymorphisms affecting clinical outcomes in epithelial ovarian cancer patients treated with taxanes and platinum com-pounds: a Korean population-based study. Gynecol Oncol. 2009;113:264-9
36. Kweekel DM, Gelderblom H, Antonini NF, Van der Straaten T, Nortier JW, Punt CJ, Guchelaar HJ. Glutathione-S-transferase pi (GSTP1) codon 105 polymorphism is not associated with oxaliplatin efficacy or toxicity in advanced colorectalcancer patients. Eur J Cancer. 2009;45:572-8
37. Lee JM, Wu MT, Lee YC, Yang SY, Chen JS, Hsu HH, Huang PM, Kuo SW, Lee CJ, Chen CJ. Association of GSTP1 polymorphism and survival for esophageal cancer. Clin Cancer Res. 2005;11:4749-53
38. Lima MM Jr, Oliveira MN, Granja F, Trindade AC, De Castro Santos LE, Ward LS. Lack of association of GSTT1, GSTM1, GSTO1, GSTP1 and CYP1A1 polymorphisms for susceptibility and outcome in Brazilian prostate cancer patients. Folia Biol (Praha). 2008;54:102-8
39. Liu B, Wei J, Zou Z, Qian X, Nakamura T, Zhang W, Ding Y, Feng J, Yu L. Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chi-nese population. Eur J Hum Genet. 2007;15:1049-53
40. Lu C, Spitz MR, Zhao H, Dong Q, Truong M, Chang JY, Blu-menschein GR Jr, Hong WK, Wu X. Association between glutathi-one S-transferase pi polymorphisms and survival in patients with advanced nonsmall cell lung carcinoma. Cancer. 2006;106:441-7
41. Luscombe CJ, French ME, Liu S, Saxby MF, Farrell WE, Jones PW, Fryer AA, Strange RC. Glutathione S-transferase GSTP1 genotypes are associated with response to androgen ablation therapy in ad-vanced prostate cancer. Cancer Detect Prev. 2002;26:376-80
42. Marsh S, Paul J, King CR, Gifford G, McLeod HL, Brown R. Phar-macogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Random-ised Trial in Ovarian Cancer. J Clin Oncol. 2007;25:4528-35
43. Matthias C, Harréus U, Strange R. Influential factors on tumor recurrence in head and neck cancer patients. Eur Arch Otorhino-laryngol. 2006 Jan;263(1):37-42
44. Morari EC, Lima AB, Bufalo NE, Leite JL, Granja F, Ward LS. Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithe-lial ovarian cancer patients. J Cancer Res Clin Oncol. 2006;132:521-8
45. Nagle CM, Chenevix-Trench G, Spurdle AB, Webb PM. The role of glutathione-S-transferase polymorphisms in ovarian cancer surviv-al. Eur J Cancer 2007;43:283-90
46. Okcu MF, Selvan M, Wang LE, Stout L, Erana R, Airewele G, Adatto P, Hess K, Ali-Osman F, Groves M, Yung AW, Levin VA, Wei Q, Bondy M. Glutathione S-transferase polymorphisms and survival in primary malignant glioma. Clin Cancer Res. 2004 Apr 15;10(8):2618-25
47. Okuno T, Tamura T, Yamamori M, Chayahara N, Yamada T, Miki I, Okamura N, Kadowaki Y, Shirasaka D, Aoyama N, Nakamura T, Okumura K, Azuma T, Kasuga M, Sakaeda T. Favorable genetic polymorphisms predictive of clinical outcome of chemoradiother-apy for stage II/III esophageal squamous cell carcinoma in Japa-nese. Am J Clin Oncol. 2007;30:252-7
48. Ott K, Lordick F, Becker K, Ulm K, Siewert J, Höfler H, Keller G. Glutathione-S-transferase P1, T1 and M1 genetic polymorphisms in neoadjuvant-treated locally advanced gastric cancer: GSTM1-present genotype is associated with better prognosis in completely resected patients. Int J Colorectal Dis. 2008;23:773-82
49. Pillot GA, Read WL, Hennenfent KL, Marsh S, Gao F, Viswanathan A, Cummings K, McLeod HL, Govindan R. A phase II study of iri-notecan and carboplatin in advanced non-small cell lung cancer with pharmacogenomic analysis: final report. J Thorac Oncol. 2006;1:972-8
50. Rajagopal R, Deakin M, Fawole AS, Elder JB, Elder J, Smith V, Strange RC, Fryer AA. Glutathione S-transferase T1 polymorphisms are associated with outcome in colorectal cancer. Carcinogenesis. 2005;26:2157-63
51. Rajkumar T, Samson M, Rama R, Sridevi V, Mahji U, Swaminathan R, Nancy NK. TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGF-beta1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemo-radiotherapy. Breast Cancer Res Treat. 2008;112:81-7
52. Stoehlmacher J, Park DJ, Zhang W, Yang D, Groshen S, Zahedy S, Lenz HJ. A multivariate analysis of genomic polymorphisms: pre-diction of clinical outcome to 5-FU/oxaliplatin combination chem-otherapy in refractory colorectal cancer. Br J Cancer. 2004;91:344-54
53. Sweeney C, Nazar-Stewart V, Stapleton PL, Eaton DL, Vaughan TL. Glutathione S-transferase M1, T1, and P1 polymorphisms and sur-vival among lung cancer patients. Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):527-33
54. Wrensch M, Wiencke JK, Wiemels J, Miike R, Patoka J, Moghadassi M, McMillan A, Kelsey KT, Aldape K, Lamborn KR, Parsa AT, Sison JD, Prados MD. Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival. Cancer Res. 2006;66:4531-41
55. Yang P, Yokomizo A, Tazelaar HD, Marks RS, Lesnick TG, Miller DL, Sloan JA, Edell ES, Meyer RL, Jett J, Liu W. Genetic determi-nants of lung cancer short-term survival: the role of glutathi-one-related genes. Lung Cancer. 2002;35:221-9
56. Rigual NR, Anderson GR, Loree TR, Wiseman S, Alrawi S, Stoler DL. Molecular prognosticators and genomic instability in papillary thyroid cancer. Laryngoscope. 2005;115:1479-85
57. Ruzzo A, Graziano F, Kawakami K, Watanabe G, Santini D, Cata-lano V, Bisonni R, Canestrari E, Ficarelli R, Menichetti ET, Mari D, Testa E, Silva R, Vincenzi B, Giordani P, Cascinu S, Giustini L, To-nini G, Magnani M. Pharmacogenetic profiling and clinical outcome of patients with advanced gastric cancer treated with palliative chemotherapy. J Clin Oncol. 2006;24:1883-91
58. Ruzzo A, Graziano F, Loupakis F, Rulli E, Canestrari E, Santini D, Catalano V, Ficarelli R, Maltese P, Bisonni R, Masi G, Schiavon G, Giordani P, Giustini L, Falcone A, Tonini G, Silva R, Mattioli R, Floriani I, Magnani M. Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chem-otherapy. J Clin Oncol. 2007;25:1247-54
59. Sanyal S, Ryk C, De Verdier PJ, Steineck G, Larsson P, Onelöv E, Hemminki K, Kumar R. Polymorphisms in NQO1 and the clinical course of urinary bladder neoplasms. Scand J Urol Nephrol. 2007;41:182-90
60. Stoehlmacher J, Park DJ, Zhang W, Groshen S, Tsao-Wei DD, Yu MC, Lenz HJ. Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with meta-static colorectal cancer. J Natl Cancer Inst. 2002;94:936-42
61. Sreeja L, Syamala V, Hariharan S, Syamala VS, Raveendran PB, Sivanandan CD, Madhavan J, Ankathil R. Glutathione S-transferase M1, T1 and P1 polymorphisms: susceptibility and outcome in lung cancer patients. J Exp Ther Oncol. 2008;7:73-85
62. Medeiros R, Pereira D, Afonso N, Palmeira C, Faleiro C, Afon-so-Lopes C, Freitas-Silva M, Vasconcelos A, Costa S, Osório T, Lopes C. Platinum/paclitaxel based chemotherapy in advanced ovarian carcinoma: glutathione S-transferase genetic polymor-phisms as predictive biomarkers of disease outcome. Int J Clin On-col. 2003;8:156-61
63. Worrall SF, Corrigan M, High A, Starr D, Matthias C, Wolf CR, Jones PW, Hand P, Gilford J, Farrell WE, Hoban P, Fryer AA, Strange RC. Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6. Pharmacogenetics. 1998;8:433-9
64. Kweekel DM, Koopman M, Antonini NF, Van der Straaten T, Nortier JW, Gelderblom H, Punt CJ, Guchelaar HJ. GSTP1 Ile105Val polymorphism correlates with progression-free survival in MCRC patients treated with or without irinotecan: a study of the Dutch Colorectal Cancer Group. Br J Cancer. 2008;99:1316-21
65. Ambrosone CB, Sweeney C, Coles BF, Thompson PA, McClure GY, Korourian S, Fares MY, Stone A, Kadlubar FF, Hutchins LF. Poly-morphisms in glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer. Cancer Res. 2001;61:7130-5
66. Bewick MA, Conlon MS, Lafrenie RM. Polymorphisms in manga-nese superoxide dismutase, myeloperoxidase and glutathi-one-S-transferase and survival after treatment for metastatic breast cancer. Breast Cancer Res Treat. 2008;111:93-101
67. Braun MS, Richman SD, Quirke P, Daly C, Adlard JW, Elliott F, Barrett JH, Selby P, Meade AM, Stephens RJ, Parmar MK, Seymour MT. Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. J Clin Oncol. 2008;26:2690-8
68. Kondratieva TV, Imyanitov EN, Togo AV, Zaitseva OA, Yatsuk OS, Romanenko SM, Bersnev VP, Hanson KP. L-MYC and GSTM1 polymorphisms are associated with unfavourable clinical parame-ters of gliomas. J Exp Clin Cancer Res. 2000;19:197-200
69. Lallas TA, McClain SK, Shahin MS, Buller RE. The glutathione S-transferase M1 genotype in ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2000;9:587-90
70. DeMichele A, Aplenc R, Botbyl J, Colligan T, Wray L, Klein-Cabral M, Foulkes A, Gimotty P, Glick J, Weber B, Stadtmauer E, Rebbeck TR. Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort. J Clin Oncol. 2005;23:5552-9
71. Goode EL, Dunning AM, Kuschel B, Healey CS, Day NE, Ponder BA, Easton DF, Pharoah PP. Effect of germ-line genetic variation on breast cancer survival in a population-based study. Cancer Res. 2002;62:3052-7
72. Khedhaier A, Remadi S, Corbex M, Ahmed SB, Bouaouina N, Mestiri S, Azaiez R, Helal AN, Chouchane L. Glutathione S-transferases (GSTT1 and GSTM1) gene deletions in Tunisians: susceptibility and prognostic implications in breast carcinoma. Br J Cancer. 2003;89:1502-7
73. Lizard-Nacol S, Coudert B, Colosetti P, Riedinger JM, Fargeot P, Brunet-Lecomte P. Glutathione S-transferase M1 null genotype: lack of association with tumour characteristics and survival in advanced breast cancer. Breast Cancer Res. 1999;1:81-7
74. Nedelcheva Kristensen V, Andersen TI, Erikstein B, Geitvik G, Skovlund E, Nesland JM, Borresen-Dale AL. Single tube multiplex polymerase chain reaction genotype analysis of GSTM1, GSTT1 and GSTP1: relation of genotypes to TP53 tumor status and clinico-pathological variables in breast cancer patients. Pharmacogenetics. 1998;8:441-7
75. Petros WP, Hopkins PJ, Spruill S, Broadwater G, Vredenburgh JJ, Colvin OM, Peters WP, Jones RB, Hall J, Marks JR. Associations between drug metabolism genotype, chemotherapy pharmacoki-netics, and overall survival in patients with breast cancer. J Clin Oncol. 2005;23(25):6117-25
76. Sweeney C, McClure GY, Fares MY, Stone A, Coles BF, Thompson PA, Korourian S, Hutchins LF, Kadlubar FF, Ambrosone CB. Asso-ciation between survival after treatment for breast cancer and glu-tathione S-transferase P1 Ile105Val polymorphism. Cancer Res. 2000;60:5621-4
77. Syamala VS, Sreeja L, Syamala V, Raveendran PB, Balakrishnan R, Kuttan R, Ankathil R. Influence of germline polymorphisms of GSTT1, GSTM1, and GSTP1 in familial versus sporadic breast can-cer susceptibility and survival. Fam Cancer. 2008;7:213-20
78. Yang G, Shu XO, Ruan ZX, Cai QY, Jin F, Gao YT, Zheng W. Genetic polymorphisms in glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1) and survival after chemotherapy for invasive breast carci-noma. Cancer. 2005;103:52-8
79. Sun XF, Ahmadi A, Arbman G, Wallin A, Asklid D, Zhang H. Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and pa-tients' survival. World J Gastroenterol. 2005;11:6875-9
80. Wu X, Gu J, Wu TT, Swisher SG, Liao Z, Correa AM, Liu J, Etzel CJ, Amos CI, Huang M, Chiang SS, Milas L, Hittelman WN, Ajani JA. Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer. J Clin Oncol. 2006;24:3789-98
81. Le Morvan V, Smith D, Laurand A, Brouste V, Bellott R, Soubeyran I, Mathoulin-Pelissier S, Robert J. Determination of ERCC2 Lys751Gln and GSTP1 Ile105Val gene polymorphisms in colorectal cancer patients: relationships with treatment outcome. Phar-macogenomics. 2007;8:1693-703
82. Kalikaki A, Kanaki M, Vassalou H, Souglakos J, Voutsina A, Geor-goulias V, Mavroudis D. DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer. Clin Lung Cancer. 2009;10:118-23
83. Gordon MA, Gil J, Lu B, Zhang W, Yang D, Yun J, Schneider S, Groshen S, Iqbal S, Press OA, Rhodes K, Lenz HJ. Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation. Pharmacogenomics. 2006;7:67-88
84. Paré L, Marcuello E, Altés A, del Río E, Sedano L, Salazar J, Cortés A, Barnadas A, Baiget M. Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxali-platin/5-fluorouracil as first-line chemotherapy. Br J Cancer. 2008;99:1050-5
85. Ashton LJ, Murray JE, Haber M, Marshall GM, Ashley DM, Norris MD. Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma. Pharmacogenet Genomics. 2007;17:709-17
86. Przygodzki RM, Bennett WP, Guinee DG Jr, Khan MA, Freedman A, Shields PG, Travis WD, Jett JR, Tazelaar H, Pairolero P, Trastek V, Liotta LA, Harris CC, Caporaso NE. p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated pa-tients with non-small cell lung cancer. Pharmacogenetics. 1998;8:503-11
87. Goekkurt E, Al-Batran SE, Hartmann JT, Mogck U, Schuch G, Kra-mer M, Jaeger E, Bokemeyer C, Ehninger G, Stoehlmacher J. Phar-macogenetic analyses of a phase III trial in metastatic gastroesoph-ageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin: a study of the arbeitsgemeinschaft internis-tische onkologie. J Clin Oncol. 2009;27:2863-73
88. Keam B, Im SA, Han SW, Ham HS, Kim MA, Oh DY, Lee SH, Kim JH, Kim DW, Kim TY, Heo DS, Kim WH, Bang YJ. Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker. BMC Cancer. 2008;8:148
89. Ruwali M, Pant MC, Shah PP, Mishra BN, Parmar D. Polymorphism in cytochrome P450 2A6 and glutathione S-transferase P1 modifies head and neck cancer risk and treatment outcome. Mutat Res. 2009; In press
90. Huang MY, Wang YH, Chen FM, Lee SC, Fang WY, Cheng TL, Hou MF, Wang JY, Lin SR. Multiple Genetic Polymorphisms of GSTP1 313AG, MDR1 3435CC, and MTHFR 677CC highly correlated with early relapse of breast cancer patients in Taiwan. Ann Surg Oncol. 2008;15:872-80
91. Sweeney C, Ambrosone CB, Joseph L, Stone A, Hutchins LF, Kad-lubar FF, Coles BF. Association between a glutathione s-transferase A1 promoter polymorphism and survival after breast cancer treat-ment. Int J Cancer 2003;103:810-814
92. Dickersin K., Min YI., and Meinert CL. Factors influencing publica-tion of research results. J. Am. Med. Assoc., 1992;267: 374-378
93. Callaham M, Wears RL, Weber E. Journal prestige, publication bias, and other characteristics associated with citation of published studies in peer-reviewed journals. JAMA. 2002;287(21):2847-2850.
94. Tan NC, Mulley JC, Berkovic SF. Genetic association studies in epilepsy: the truth is out there. Epilepsia. 2004 Nov;45(11):1429-42