BCX4430, a novel nucleoside analog, effectively treats yellow fever in a hamster model

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 11, 2014, Pages 6607-6614

  Julander, Justin G ^a   Bantia, Shanta ^b   Taubenheim, Brian R ^b   Minning, Dena M ^c   Kotian, Pravin ^b   Morrey, John D ^a   Smee, Donald F ^a   Sheridan, William P ^b   Babu, Yarlagadda S ^b  

^a UTAH STATE UNIVERSITY   (United States)

^b BIOCRYST PHARMACEUTICALS INC   (United States)

^c MedExpert Consulting Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIVIRUS AGENT; BCX 4430; NEUTRALIZING ANTIBODY; NUCLEOSIDE ANALOG; RIBAVIRIN; UNCLASSIFIED DRUG; 2-(4-AMINO-5H-PYRROLO(3,2-D)PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)PYRROLIDINE-3,4-DIOL; ADENOSINE; PURINE NUCLEOSIDE; VIRUS ANTIBODY;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIVIRAL THERAPY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; MORTALITY; NONHUMAN; SURVIVAL; SYRIAN HAMSTER; TREATMENT DURATION; VIREMIA; WEIGHT REDUCTION; YELLOW FEVER; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; HAMSTER; IMMUNOLOGY; MESOCRICETUS; TREATMENT OUTCOME; VIRAL PLAQUE ASSAY; VIROLOGY; YELLOW FEVER VIRUS;

ADENOSINE; ALANINE TRANSAMINASE; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIVIRAL AGENTS; CELLS, CULTURED; CRICETINAE; DISEASE MODELS, ANIMAL; FEMALE; MESOCRICETUS; PURINE NUCLEOSIDES; TREATMENT OUTCOME; VIRAL PLAQUE ASSAY; VIREMIA; YELLOW FEVER; YELLOW FEVER VIRUS;

EID: 84908582593     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.03368-14     Document Type: Article

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