Persistent west nile virus associated with a neurological sequela in hamsters identified by motor unit number estimation

Journal of Virology

Volumn 83, Issue 9, 2009, Pages 4251-4261

  Siddharthan, Venkatraman ^a   Wang, Hong ^a   Motter, Neil E ^a   Hall, Jeffery O ^a   Skinner, Robert D ^b   Skirpstunas, Ramona T ^a   Morrey, John D ^a  

^a UTAH STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE ACETYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL FUNCTION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HAMSTER; MOTONEURON; MOTOR UNIT; NERVE CELL; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PERSISTENT VIRUS INFECTION; PHENOTYPE; POLIOMYELITIS; PRIORITY JOURNAL; SPINAL CORD; STAINING; WEST NILE FLAVIVIRUS;

ANIMALS; ANTIGENS, VIRAL; CRICETINAE; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; MOTOR NEURON DISEASE; RNA, VIRAL; VIRAL ENVELOPE PROTEINS; WEST NILE VIRUS;

CRICETINAE; WEST NILE VIRUS;

EID: 66149102323     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00017-09     Document Type: Article

References (46)

1. Ali, M., Y. Safriel, J. Sohi, A. Llave, and S. Weathers. 2005. West Nile virus infection: MR imaging findings in the nervous system. AJNR Am. J. Neuroradiol. 26:289-297.
2. Cao, N. J., C. Ranganathan, W. J. Kupsky, and J. Li. 2005. Recovery and prognosticators of paralysis in West Nile virus infection. J. Neurol. Sci. 236:73-80.
3. Chan, K. M., N. Amirjani, M. Sumrain, A. Clarke, and F. J. Strohschein. 2003. Randomized controlled trial of strength training in post-polio patients. Muscle Nerve 27:332-338.
4. Chu, J. J., and M. L. Ng. 2003. The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose. J. Gen. Virol. 84:3305-3314.
5. Dantes, M., and A. McComas. 1991. The extent and time course of motoneuron involvement in amyotrophic lateral sclerosis. Muscle Nerve 14:416-421.
6. Darman, J., S. Backovic, S. Dike, N. J. Maragakis, C. Krishnan, J. D. Rothstein, D. N. Irani, and D. A. Kerr. 2004. Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity. J. Neurosci. 24:7566-7575. (Pubitemid 39166748)
7. Davis, C. T., D. W. Beasley, H. Guzman, M. Siirin, R. E. Parsons, R. B. Tesh, and A. D. Barrett. 2004. Emergence of attenuated West Nile virus variants in Texas, 2003. Virology 330:342-350.
8. Davis, J. W., and J. L. Hardy. 1974. Characterization of persistent Modoc viral infections in Syrian hamsters. Infect. Immun. 10:328-334.
9. Ding, X., X. Wu, T. Duan, M. Siirin, H. Guzman, Z. Yang, R. B. Tesh, and S. Y. Xiao. 2005. Nucleotide and amino acid changes in West Nile virus strains exhibiting renal tropism in hamsters. Am. J. Trop. Med. Hyg. 73:803-807. (Pubitemid 41446733)
10. Doron, S. I., J. F. Dashe, L. S. Adelman, W. F. Brown, B. G. Werner, and S. Hadley. 2003. Histopathologically proven poliomyelitis with quadriplegia and loss of brainstem function due to West Nile virus infection. Clin. Infect. Dis. 37:e74-e77.
11. Garcia-Tapia, D., D. E. Hassett, W. J. Mitchell, Jr., G. C. Johnson, and S. B. Kleiboeker. 2007. West Nile virus encephalitis: sequential histopathological and immunological events in a murine model of infection. J. Neurovirol. 13:130-138.
12. Gowen, B. B., J. W. Judge, M. H. Wong, K. H. Jung, C. F. Aylsworth, P. C. Melby, B. Rosenberg, and J. D. Morrey. 2008. Immunoprophylaxis of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen. Int. Immunopharmacol. 8:1089-1094.
13. Hayes, E. B., J. J. Sejvar, S. R. Zaki, R. S. Lanciotti, A. V. Bode, and G. L. Campbell. 2005. Virology, pathology, and clinical manifestations of West Nile virus disease. Emerg. Infect. Dis. 11:1174-1179.
14. Julander, J. G., J. D. Morrey, L. M. Blatt, K. Shafer, and R. W. Sidwell. 2006. Comparison of the inhibitory effects of interferon alfacon-1 and ribavirin on yellow fever virus infection in a hamster model. Antivir. Res. 73:140-146.
15. Julander, J. G., Q. A. Winger, A. L. Olsen, C. W. Day, R. W. Sidwell, and J. D. Morrey. 2005. Treatment of West Nile virus-infected mice with reactive immumoglobulin reduces fetal titers and increases dam survival. Antivir. Res. 65:79-85. (Pubitemid 40222284)
16. Julander, J. G., Q. A. Winger, L. F. Rickords, P. Y. Shi, M. Tilgner, H. M. Gavin, R. W. Sidwell, and J. D. Morrey. 2006. West Nile virus infection of the placenta. Virology 347:175-182.
17. Kapoor, H., K. Signs, P. Somsel, F. P. Downes, P. A. Clark, and J. P. Massey. 2004. Persistence of West Nile Virus (WNV) IgM antibodies in cerebrospinal fluid from patients with CNS disease. J. Clin. Virol. 31:289-291. (Pubitemid 39371062)
18. Lanciotti, R. S., G. D. Ebel, V. Deubel, A. J. Kerst, S. Murri, R. Meyer, M. Bowen, N. McKinney, W. E. Morrill, M. B. Crabtree, L. D. Kramer, and J. T. Roehrig. 2002. Complete genome sequences and phylogenetic analysis of West Nile virus strains isolated from the United States, Europe, and the Middle East. Virology 298:96-105.
19. Lanciotti, R. S., and A. J. Kerst. 2001. Nucleic acid sequence-based amplification assays for rapid detection of West Nile and St. Louis encephalitis viruses. J. Clin. Microbiol. 39:4506-4513.
20. Mathur, A., K. L. Arora, S. Rawat, and U. C. Chaturvedi. 1986. Persistence, latency and reactivation of Japanese encephalitis virus infection in mice. J. Gen. Virol. 67:381-385.
21. McComas, A. J., C. Quartly, and R. C. Griggs. 1997. Early and late losses of motor units after poliomyelitis. Brain 120:1415-1421.
22. Morrey, J. D., V. Siddharthan, A. L. Olsen, G. Y. Roper, H. C. Wang, T. J. Baldwin, S. Koenig, S. Johnson, J. L. Nordstrom, and M. S. Diamond. 2006. Humanized monoclonal antibody against West Nile virus E protein administered after neuronal infection protects against lethal encephalitis in hamsters. J. Infect. Dis. 194:1300-1308. (Pubitemid 44630976)
23. Morrey, J. D., V. Siddharthan, A. L. Olsen, H. Wang, J. G. Julander, J. O. Hall, H. Li, J. L. Nordstrom, S. Koenig, S. Johnson, and M. S. Diamond. 2007. Defining limits of treatment with humanized neutralizing monoclonal antibody for West Nile virus neurological infection in a hamster model. Antimicrob. Agents Chemother. 51:2396-2402. (Pubitemid 47047316)
24. Morrey, J. D., V. Siddharthan, H. Wang, J. O. Hall, R. T. Skirpstunas, J. L. Nordstrom, S. Koenig, S. Johnson, and M. S. Diamond. 2008. West Nile virus-induced acute flaccid paralysis is prevented by monoclonal antibody treatment even after infection of spinal cord neurons. J. Neurovirol. 14:152-163.
25. Ohka, S., and A. Nomoto. 2001. Recent insights into poliovirus pathogenesis. Trends Microbiol. 9:501-506. (Pubitemid 32939358)
26. Petropoulou, K. A., S. M. Gordon, R. A. Prayson, and P. M. Ruggierri. 2005. West Nile virus meningoencephalitis: MR imaging findings. AJNR Am. J. Neuroradiol. 26:1986-1995.
27. Pogodina, V. V., M. P. Frolova, G. V. Malenko, G. I. Fokina, G. V. Koreshkova, L. L. Kiseleva, N. G. Bochkova, and N. M. Ralph. 1983. Study on West Nile virus persistence in monkeys. Arch. Virol. 75:71-86. (Pubitemid 13195729)
28. Pogodina, V. V., L. S. Levina, G. I. Fokina, G. V. Koreshkova, G. V. Malenko, N. G. Bochkova, and O. E. Rzhakhova. 1981. Persistence of tick-borne encephalitis virus in monkeys. III. Phenotypes of the persisting virus. Acta Virol. 25:352-360.
29. Pogodina, V. V., G. V. Malenko, G. I. Fokina, L. S. Levina, G. V. Koreshkova, O. E. Rzhakhova, N. G. Bochkova, and L. L. Mamonenko. 1981. Persistence of tick-borne encephalitis virus in monkeys. II. Effectiveness of methods used for virus detection. Acta Virol. 25:344-351.
30. Rashidipour, O., and K. M. Chan. 2008. Motor unit number estimation in neuromuscular disease. Can. J. Neurol. Sci. 35:153-159.
31. Samuel, M. A., and M. S. Diamond. 2005. Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J. Virol. 79:13350-13361. (Pubitemid 41508149)
32. Samuel, M. A., J. D. Morrey, and M. S. Diamond. 2006. Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. J. Virol. 81:2614-2623.
33. Samuel, M. A., H. Wang, V. Siddharthan, J. D. Morrey, and M. S. Diamond. 2007. Axonal transport mediates West Nile virus entry into the central nervous system and induces acute flaccid paralysis. Proc. Natl. Acad. Sci. USA 104:17140-17145.
34. Sejvar, J. J. 2007. The long-term outcomes of human West Nile virus infection. Clin. Infect. Dis. 44:1617-1624. (Pubitemid 46871510)
35. Sejvar, J. J., A. A. Leis, D. S. Stokic, J. A. Van Gerpen, A. A. Marfin, R. Webb, M. B. Haddad, B. C. Tierney, S. A. Slavinski, J. L. Polk, V. Dostrow, M. Winkelmann, and L. R. Petersen. 2003. Acute flaccid paralysis and West Nile virus infection. Emerg. Infect. Dis. 9:788-793. (Pubitemid 36801577)
36. Shefner, J. M., M. Cudkowicz, and R. H. Brown, Jr. 2006. Motor unit number estimation predicts disease onset and survival in a transgenic mouse model of amyotrophic lateral sclerosis. Muscle Nerve 34:603-607.
37. Shefner, J. M., M. E. Cudkowicz, and R. H. Brown, Jr. 2002. Comparison of incremental with multipoint MUNE methods in transgenic ALS mice. Muscle Nerve 25:39-42.
38. Shrestha, B., D. Gottlieb, and M. S. Diamond. 2003. Infection and injury of neurons by West Nile encephalitis virus. J. Virol. 77:13203-13213. (Pubitemid 37494316)
39. Shrestha, B., T. Wang, M. A. Samuel, K. Whitby, J. Craft, E. Fikrig, and M. S. Diamond. 2006. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J. Virol. 80:5338-5348. (Pubitemid 43752779)
40. Siirin, M. T., T. Duan, H. Lei, H. Guzman, A. P. da Rosa, D. M. Watts, S. Y. Xiao, and R. B. Tesh. 2007. Chronic St. Louis encephalitis virus infection in the golden hamster (Mesocricetus auratus). Am. J. Trop. Med. Hyg. 76:299-306.
41. + T-cell responses are required for clearance of West Nile virus from the central nervous system. J. Virol. 80:12060-12069.
42. Tesh, R. B., M. Siirin, H. Guzman, A. P. Travassos da Rosa, X. Wu, T. Duan, H. Lei, M. R. Nunes, and S. Y. Xiao. 2005. Persistent West Nile virus infection in the golden hamster: studies on its mechanism and possible implications for other flavivirus infections. J. Infect. Dis. 192:287-295.
43. Tonry, J. H., S. Y. Xiao, M. Siirin, H. Chen, A. P. da Rosa, and R. B. Tesh. 2005. Persistent shedding of West Nile virus in urine of experimentally infected hamsters. Am. J. Trop. Med. Hyg. 72:320-324.
44. Weber, U. J., T. Bock, K. Buschard, and B. Pakkenberg. 1997. Total number and size distribution of motor neurons in the spinal cord of normal and EMC-virus infected mice - a stereological study. J. Anat. 191:347-353. (Pubitemid 27510696)
45. Wu, X., L. Lu, H. Guzman, R. B. Tesh, and S. Y. Xiao. 2008. Persistent infection and associated nucleotide changes of West Nile virus serially passaged in hamsters. J. Gen. Virol. 89:3073-3079.
46. Xiao, S. Y., H. Guzman, H. Zhang, A. P. Travassos da Rosa, and R. B. Tesh. 2001. West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis. Emerg. Infect. Dis. 7:714-721.