-
1
-
-
84995434053
-
-
Accessed July 21, 2015
-
Eurostat. Causes of death statistics-statistics explained. Available at http://ec.europa.eu/eurostat/statistics-explained/index.php/Causes_of_death_statistics#Main_statistical_findings. Accessed July 21, 2015.
-
-
-
-
2
-
-
84891418810
-
Deaths: Leading causes for 2010
-
Heron M. Deaths: Leading causes for 2010. Natl Vital Stat Rep 2013;62:1-96.
-
(2013)
Natl Vital Stat Rep
, vol.62
, pp. 1-96
-
-
Heron, M.1
-
3
-
-
84995374417
-
-
Accessed July 21, 2015
-
National Cancer Institute. Targeted cancer therapies fact sheet-National Cancer Institute. Available at http://www.cancer.gov/about-cancer/ treatment/types/targeted-therapies/targeted-therapiesfact-sheet. Accessed July 21, 2015.
-
Targeted Cancer Therapies Fact Sheet-National Cancer Institute
-
-
-
4
-
-
84857502654
-
Erlotinib versus standardchemotherapy asfirst-linetreatment forEuropeanpatientswithadvancedEGFRmutationpositive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
-
Rosell R, Carcereny E, Gervais R et al. Erlotinib versus standardchemotherapy asfirst-linetreatment forEuropeanpatientswithadvancedEGFRmutationpositive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239-246.
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
5
-
-
84865154870
-
First-line erlotinib followed by second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: The TORCH randomized trial
-
Gridelli C, Ciardiello F, Gallo C et al. First-line erlotinib followed by second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: The TORCH randomized trial. J Clin Oncol 2012;30: 3002-3011.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3002-3011
-
-
Gridelli, C.1
Ciardiello, F.2
Gallo, C.3
-
6
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-smallcell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
Zhou C, Wu YL, Chen G et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-smallcell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011;12:735-742.
-
(2011)
Lancet Oncol
, vol.12
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
7
-
-
84878471164
-
Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC)
-
Chen G, Feng J, Zhou C et al. Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). Ann Oncol 2013;24:1615-1622.
-
(2013)
Ann Oncol
, vol.24
, pp. 1615-1622
-
-
Chen, G.1
Feng, J.2
Zhou, C.3
-
8
-
-
84884605223
-
Symptom control and quality of life in LUX-Lung 3: A phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations
-
Yang JC, Hirsh V, Schuler M et al. Symptom control and quality of life in LUX-Lung 3: A phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations. J Clin Oncol 2013;31:3342-3350.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3342-3350
-
-
Yang, J.C.1
Hirsh, V.2
Schuler, M.3
-
9
-
-
84921892043
-
Afatinib versus cisplatin-based chemotherapy for EGFR mutationpositive lung adenocarcinoma (LUX-Lung 3 and LUXLung 6): Analysis of overall survival data from two randomised, phase 3 trials
-
Yang JC-H, Wu YL, Schuler M et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutationpositive lung adenocarcinoma (LUX-Lung 3 and LUXLung 6): Analysis of overall survival data from two randomised, phase 3 trials. Lancet Oncol 2015;16: 141-151.
-
(2015)
Lancet Oncol
, vol.16
, pp. 141-151
-
-
Yang, J.-H.1
Wu, Y.L.2
Schuler, M.3
-
10
-
-
84939991940
-
Safety, tolerability, and pharmacokinetics of single and multiple doses of intravenous cixutumumab (IMCA12), an inhibitor of the insulin-like growth factor-I receptor, administered weekly or every 2 weeks in patients with advanced solid tumors
-
Higano CS, Berlin J, Gordon M et al. Safety, tolerability, and pharmacokinetics of single and multiple doses of intravenous cixutumumab (IMCA12), an inhibitor of the insulin-like growth factor-I receptor, administered weekly or every 2 weeks in patients with advanced solid tumors. Invest New Drugs 2015;33:450-462.
-
(2015)
Invest New Drugs
, vol.33
, pp. 450-462
-
-
Higano, C.S.1
Berlin, J.2
Gordon, M.3
-
11
-
-
84884910107
-
An openlabel, phase 2 study evaluating the efficacy and safety of the anti-IGF-1R antibody cixutumumab in patients with previously treated advanced or metastatic soft-tissue sarcoma or Ewing family of tumours
-
Schöffski P, Adkins D, Blay JY et al. An openlabel, phase 2 study evaluating the efficacy and safety of the anti-IGF-1R antibody cixutumumab in patients with previously treated advanced or metastatic soft-tissue sarcoma or Ewing family of tumours. Eur J Cancer 2013;49:3219-3228.
-
(2013)
Eur J Cancer
, vol.49
, pp. 3219-3228
-
-
Schöffski, P.1
Adkins, D.2
Blay, J.Y.3
-
12
-
-
84892991988
-
Cixutumumab for patients with recurrent or refractory advanced thymic epithelial tumours: Amulticentre, open-label, phase 2 trial
-
Rajan A, Carter CA, Berman A et al. Cixutumumab for patients with recurrent or refractory advanced thymic epithelial tumours: Amulticentre, open-label, phase 2 trial. Lancet Oncol 2014;15: 191-200.
-
(2014)
Lancet Oncol
, vol.15
, pp. 191-200
-
-
Rajan, A.1
Carter, C.A.2
Berman, A.3
-
13
-
-
84892493984
-
A phase II study of cixutumumab (IMC-A12, NSC742460) in advanced hepatocellular carcinoma
-
Abou-Alfa GK, Capanu M, O’Reilly EM et al. A phase II study of cixutumumab (IMC-A12, NSC742460) in advanced hepatocellular carcinoma. J Hepatol 2014;60:319-324.
-
(2014)
J Hepatol
, vol.60
, pp. 319-324
-
-
Abou-Alfa, G.K.1
Capanu, M.2
O’Reilly, E.M.3
-
14
-
-
80053525113
-
Aphase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid tumors
-
Atzori F, Tabernero J, Cervantes A et al. Aphase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res 2011; 17:6304-6312.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6304-6312
-
-
Atzori, F.1
Tabernero, J.2
Cervantes, A.3
-
15
-
-
84866521341
-
A phase 2 study of the insulin-like growth factor-1 receptor inhibitor MK-0646 in patients with metastatic, well-differentiated neuroendocrine tumors
-
Reidy-Lagunes DL, Vakiani E, Segal MF et al. A phase 2 study of the insulin-like growth factor-1 receptor inhibitor MK-0646 in patients with metastatic, well-differentiated neuroendocrine tumors. Cancer 2012;118:4795-4800.
-
(2012)
Cancer
, vol.118
, pp. 4795-4800
-
-
Reidy-Lagunes, D.L.1
Vakiani, E.2
Segal, M.F.3
-
16
-
-
35348815620
-
Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors
-
Haluska P, Shaw HM, Batzel GN et al. Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res 2007;13:5834-5840.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5834-5840
-
-
Haluska, P.1
Shaw, H.M.2
Batzel, G.N.3
-
17
-
-
75749102231
-
Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma
-
Haluska P, Worden F, Olmos D et al. Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma. Cancer Chemother Pharmacol 2010;65:765-773.
-
(2010)
Cancer Chemother Pharmacol
, vol.65
, pp. 765-773
-
-
Haluska, P.1
Worden, F.2
Olmos, D.3
-
18
-
-
84898056516
-
Garcia-CarboneroRet al. Figitumumab in patients with refractory metastatic colorectal cancer previously treated with standard therapies: A nonrandomized, open-label, phase II trial
-
Becerra CR, Salazar R, Garcia-CarboneroRet al. Figitumumab in patients with refractory metastatic colorectal cancer previously treated with standard therapies: A nonrandomized, open-label, phase II trial. Cancer Chemother Pharmacol 2014;73: 695-702.
-
(2014)
Cancer Chemother Pharmacol
, vol.73
, pp. 695-702
-
-
Becerra, C.R.1
Salazar, R.2
-
19
-
-
73349099049
-
Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
-
Tolcher AW, Sarantopoulos J, Patnaik A et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol 2009;27:5800-5807.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5800-5807
-
-
Tolcher, A.W.1
Sarantopoulos, J.2
Patnaik, A.3
-
20
-
-
77950974697
-
A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors
-
Kurzrock R, Patnaik A, Aisner J et al. A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors. Clin Cancer Res 2010;16:2458-2465.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2458-2465
-
-
Kurzrock, R.1
Patnaik, A.2
Aisner, J.3
-
21
-
-
83255163333
-
R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: Results of a phase II Sarcoma Alliance for Research through Collaboration study
-
Pappo AS, Patel SR, Crowley J et al. R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: Results of a phase II Sarcoma Alliance for Research through Collaboration study. J Clin Oncol 2011;29: 4541-4547.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4541-4547
-
-
Pappo, A.S.1
Patel, S.R.2
Crowley, J.3
-
22
-
-
84923188816
-
A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors
-
Puzanov I, Lindsay CR, Goff L et al. A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors. Clin Cancer Res 2015;21:701-711.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 701-711
-
-
Puzanov, I.1
Lindsay, C.R.2
Goff, L.3
-
23
-
-
84923203848
-
Phase I study of intermittent oral dosing of the insulin-like growth factor-1 and insulin receptors inhibitor OSI-906 in patients with advanced solid tumors
-
Jones RL, Kim ES, Nava-Parada P et al. Phase I study of intermittent oral dosing of the insulin-like growth factor-1 and insulin receptors inhibitor OSI-906 in patients with advanced solid tumors. Clin Cancer Res 2015;21:693-700.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 693-700
-
-
Jones, R.L.1
Kim, E.S.2
Nava-Parada, P.3
-
24
-
-
84933522088
-
Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: A double-blind, randomised, phase 3 study
-
Fassnacht M, Berruti A, Baudin E et al. Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: A double-blind, randomised, phase 3 study. Lancet Oncol 2015;16:426-435.
-
(2015)
Lancet Oncol
, vol.16
, pp. 426-435
-
-
Fassnacht, M.1
Berruti, A.2
Baudin, E.3
-
25
-
-
84995434071
-
-
East Hanover, NJ: Novartis Pharmaceuticals Corporation
-
Zykadia (ceritinib) capsules [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corporation, 2014.
-
(2014)
-
-
-
26
-
-
84922070943
-
A phase I and pharmacokinetic study of ganetespib (STA-9090) in advanced hepatocellular carcinoma
-
Goyal L, Wadlow RC, Blaszkowsky LS et al. A phase I and pharmacokinetic study of ganetespib (STA-9090) in advanced hepatocellular carcinoma. Invest New Drugs 2015;33:128-137.
-
(2015)
Invest New Drugs
, vol.33
, pp. 128-137
-
-
Goyal, L.1
Wadlow, R.C.2
Blaszkowsky, L.S.3
-
27
-
-
84875316604
-
Afirst in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies
-
Goldman JW, Raju RN, Gordon GA et al. Afirst in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies. BMC Cancer 2013;13:152.
-
(2013)
BMC Cancer
, vol.13
, pp. 152
-
-
Goldman, J.W.1
Raju, R.N.2
Gordon, G.A.3
-
28
-
-
84878971581
-
A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer
-
Socinski MA, Goldman J, El-Hariry I et al. A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer. Clin Cancer Res 2013;19:3068-3077.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3068-3077
-
-
Socinski, M.A.1
Goldman, J.2
El-Hariry, I.3
-
29
-
-
84899973398
-
A phase II open-label study of ganetespib, a novel heat shock protein 90 inhibitor for patients with metastatic breast cancer
-
Jhaveri K, Chandarlapaty S, Lake D et al. A phase II open-label study of ganetespib, a novel heat shock protein 90 inhibitor for patients with metastatic breast cancer. Clin Breast Cancer 2014; 14:154-160.
-
(2014)
Clin Breast Cancer
, vol.14
, pp. 154-160
-
-
Jhaveri, K.1
Chandarlapaty, S.2
Lake, D.3
-
30
-
-
33644770041
-
Gefitinib in patients with chemo-sensitive and chemorefractory relapsed small cell cancers: A Hoosier Oncology Group phase II trial
-
Moore AM, Einhorn LH, Estes D et al. Gefitinib in patients with chemo-sensitive and chemorefractory relapsed small cell cancers: A Hoosier Oncology Group phase II trial. Lung Cancer 2006;52: 93-97.
-
(2006)
Lung Cancer
, vol.52
, pp. 93-97
-
-
Moore, A.M.1
Einhorn, L.H.2
Estes, D.3
-
31
-
-
84856239290
-
Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab
-
Wadlow RC, Hezel AF, Abrams TA et al. Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab. The Oncologist 2012;17:14.
-
(2012)
The Oncologist
, vol.17
, pp. 14
-
-
Wadlow, R.C.1
Hezel, A.F.2
Abrams, T.A.3
-
32
-
-
84942159469
-
Efficacy of rociletinib (CO-1686) in plasma-genotyped T790M-positive NSCLC patients
-
Sequist LV, Goldman JW, Wakelee HA et al. Efficacy of rociletinib (CO-1686) in plasma-genotyped T790M-positive NSCLC patients. J Clin Oncol 2015; 33:8001.
-
(2015)
J Clin Oncol
, vol.33
, pp. 8001
-
-
Sequist, L.V.1
Goldman, J.W.2
Wakelee, H.A.3
-
33
-
-
84904555503
-
Phase I doseescalation and-expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors
-
Rodon J, Braña I, Siu LL et al. Phase I doseescalation and-expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. Invest New Drugs 2014;32:670-681.
-
(2014)
Invest New Drugs
, vol.32
, pp. 670-681
-
-
Rodon, J.1
Braña, I.2
Siu, L.L.3
-
34
-
-
84920538174
-
First-in-human phase I study of pictilisib (GDC-0941), a potent panclass I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors
-
Sarker D, Ang JE, Baird R et al. First-in-human phase I study of pictilisib (GDC-0941), a potent panclass I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors. Clin Cancer Res 2015;21:77-86.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 77-86
-
-
Sarker, D.1
Ang, J.E.2
Baird, R.3
-
35
-
-
84892181757
-
Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors
-
Shapiro GI, Rodon J, Bedell C et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors. Clin Cancer Res 2014;20:233-245.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 233-245
-
-
Shapiro, G.I.1
Rodon, J.2
Bedell, C.3
-
36
-
-
84907681065
-
The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma
-
Spencer A, Yoon SS, Harrison S J et al. The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma. Blood 2014;124:2190-2195.
-
(2014)
Blood
, vol.124
, pp. 2190-2195
-
-
Spencer, A.1
Yoon, S.S.2
Harrison, S.J.3
-
37
-
-
80054747639
-
Safety, pharmacokinetics (PK), pharmacodynamics (PD), and clinical activity of the oral AKT inhibitor GSK2141795 (GSK795) in a phase I first-in-human study
-
Burris HA, Siu LL, Infante JR et al. Safety, pharmacokinetics (PK), pharmacodynamics (PD), and clinical activity of the oral AKT inhibitor GSK2141795 (GSK795) in a phase I first-in-human study. J Clin Oncol 2011;29:3003.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3003
-
-
Burris, H.A.1
Siu, L.L.2
Infante, J.R.3
-
38
-
-
80054741601
-
Firstin-human phase I study evaluating the safety, pharmacokinetics (PK), and intratumor pharmacodynamics (PD) of the novel, oral, ATP-competitive AKT inhibitor GDC-0068
-
Tabernero J, Saura C, Roda Perez D et al. Firstin-human phase I study evaluating the safety, pharmacokinetics (PK), and intratumor pharmacodynamics (PD) of the novel, oral, ATP-competitive AKT inhibitor GDC-0068. J Clin Oncol 2011;29:3022.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3022
-
-
Tabernero, J.1
Saura, C.2
Roda Perez, D.3
-
39
-
-
84918538482
-
Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers
-
Yap TA, Yan L, Patnaik A et al. Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers. Clin Cancer Res 2014;20:5672-5685.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5672-5685
-
-
Yap, T.A.1
Yan, L.2
Patnaik, A.3
-
40
-
-
84957439058
-
Multicenter phase II study of the AKT inhibitor MK-2206 in recurrent or metastatic nasopharyngeal carcinoma from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group(MC1079)
-
Ma BB, Goh BC, Lim WT et al. Multicenter phase II study of the AKT inhibitor MK-2206 in recurrent or metastatic nasopharyngeal carcinoma from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group(MC1079). Invest New Drugs 2015;33:985-991.
-
(2015)
Invest New Drugs
, vol.33
, pp. 985-991
-
-
Ma, B.B.1
Goh, B.C.2
Lim, W.T.3
-
41
-
-
84931028666
-
Phase 2 study of MK-2206, an allosteric inhibitor ofAKT, as second-line therapy foradvanced gastric and gastroesophageal junction cancer: A SWOG Cooperative Group Trial (S1005)
-
Ramanathan RK, McDonough SL, Kennecke HF et al. Phase 2 study of MK-2206, an allosteric inhibitor ofAKT, as second-line therapy foradvanced gastric and gastroesophageal junction cancer: A SWOG Cooperative Group Trial (S1005). Cancer 2015;121:2193-2197.
-
(2015)
Cancer
, vol.121
, pp. 2193-2197
-
-
Ramanathan, R.K.1
McDonough, S.L.2
Kennecke, H.F.3
-
42
-
-
79851500081
-
Everolimus for advanced pancreatic neuroendocrine tumors
-
Yao JC, Shah MH, Ito T et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 2011;364:514-523.
-
(2011)
N Engl J Med
, vol.364
, pp. 514-523
-
-
Yao, J.C.1
Shah, M.H.2
Ito, T.3
-
43
-
-
84870679939
-
Phase 2 study of everolimus monotherapy in patients with nonfunctioning neuroendocrine tumors or pheochromocytomas/ paragangliomas
-
Oh DY, Kim TW, Park YS et al. Phase 2 study of everolimus monotherapy in patients with nonfunctioning neuroendocrine tumors or pheochromocytomas/ paragangliomas. Cancer 2012;118: 6162-6170.
-
(2012)
Cancer
, vol.118
, pp. 6162-6170
-
-
Oh, D.Y.1
Kim, T.W.2
Park, Y.S.3
-
44
-
-
84891405002
-
Safety and efficacy of everolimus in gastrointestinal and pancreatic neuroendocrine tumors after (177)Luoctreotate
-
Kamp K, Gumz B, Feelders RA et al. Safety and efficacy of everolimus in gastrointestinal and pancreatic neuroendocrine tumors after (177)Luoctreotate. Endocr Relat Cancer 2013;20:825-831.
-
(2013)
Endocr Relat Cancer
, vol.20
, pp. 825-831
-
-
Kamp, K.1
Gumz, B.2
Feelders, R.A.3
-
45
-
-
66649133114
-
A phase 2 study with adaily regimenof the oralmTORinhibitor RAD001 (Everolimus) in patients with metastatic clear cell renal cell cancer
-
Amato RJ, Jac J, Giessinger S et al. A phase 2 study with adaily regimenof the oralmTORinhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer. Cancer 2009;115: 2438-2446.
-
(2009)
Cancer
, vol.115
, pp. 2438-2446
-
-
Amato, R.J.1
Jac, J.2
Giessinger, S.3
-
46
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
Motzer RJ, Escudier B, Oudard S et al. Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449-456.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
47
-
-
58249085318
-
Oralm TOR inhibitor everolimus in patients with gemcitabinerefractory metastatic pancreatic cancer
-
Wolpin BM, Hezel AF, Abrams T et al. Oralm TOR inhibitor everolimus in patients with gemcitabinerefractory metastatic pancreatic cancer. J Clin Oncol 2009;27:193-198.
-
(2009)
J Clin Oncol
, vol.27
, pp. 193-198
-
-
Wolpin, B.M.1
Hezel, A.F.2
Abrams, T.3
-
48
-
-
84880781405
-
Phase II study of everolimus in metastatic urothelial cancer
-
Milowsky MI, Iyer G, Regazzi AM et al. Phase II study of everolimus in metastatic urothelial cancer. BJU Int 2013;112:462-470.
-
(2013)
BJU Int
, vol.112
, pp. 462-470
-
-
Milowsky, M.I.1
Iyer, G.2
Regazzi, A.M.3
-
49
-
-
84862824218
-
Phase II studyof everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidineandplatinum
-
Yoon DH, Ryu MH, Park YS et al. Phase II studyof everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidineandplatinum. Br J Cancer 2012;106:1039-1044.
-
(2012)
Br J Cancer
, vol.106
, pp. 1039-1044
-
-
Yoon, D.H.1
Ryu, M.H.2
Park, Y.S.3
-
50
-
-
84888642081
-
Multicenter phase II study of everolimus in patients with metastatic or recurrent bone and soft-tissue sarcomas after failure of anthracycline and ifosfamide
-
Yoo C, Lee J, Rha SY et al. Multicenter phase II study of everolimus in patients with metastatic or recurrent bone and soft-tissue sarcomas after failure of anthracycline and ifosfamide. Invest New Drugs 2013;31:1602-1608.
-
(2013)
Invest New Drugs
, vol.31
, pp. 1602-1608
-
-
Yoo, C.1
Lee, J.2
Rha, S.Y.3
-
51
-
-
43249086546
-
Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
-
O’Donnell A, Faivre S, Burris HA III et al. Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J Clin Oncol 2008;26:1588-1595.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1588-1595
-
-
O’Donnell, A.1
Faivre, S.2
Burris, H.A.3
-
52
-
-
43249131245
-
Dose-and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: A phase I tumor pharmacodynamic study in patients with advanced solid tumors
-
Tabernero J, Rojo F, Calvo E et al. Dose-and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: A phase I tumor pharmacodynamic study in patients with advanced solid tumors. J Clin Oncol 2008;26: 1603-1610.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1603-1610
-
-
Tabernero, J.1
Rojo, F.2
Calvo, E.3
-
53
-
-
33749002279
-
Phase I/II studyofthemammaliantarget of rapamycininhibitor everolimus (RAD001) in patients with relapsed or refractoryhematologicmalignancies
-
Yee KW, Zeng Z, Konopleva M et al. Phase I/II studyofthemammaliantarget of rapamycininhibitor everolimus (RAD001) in patients with relapsed or refractoryhematologicmalignancies. Clin CancerRes 2006;12:5165-5173.
-
(2006)
Clin Cancerres
, vol.12
, pp. 5165-5173
-
-
Yee, K.W.1
Zeng, Z.2
Konopleva, M.3
-
54
-
-
80555126830
-
Phase 1/2 study of everolimus in advanced hepatocellular carcinoma
-
Zhu AX, Abrams TA, Miksad R et al. Phase 1/2 study of everolimus in advanced hepatocellular carcinoma. Cancer 2011;117:5094-5102.
-
(2011)
Cancer
, vol.117
, pp. 5094-5102
-
-
Zhu, A.X.1
Abrams, T.A.2
Miksad, R.3
-
55
-
-
84883063380
-
Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy
-
Demetri GD, Chawla SP, Ray-Coquard I et al. Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy. J Clin Oncol 2013;31:2485-2492.
-
(2013)
J Clin Oncol
, vol.31
, pp. 2485-2492
-
-
Demetri, G.D.1
Chawla, S.P.2
Ray-Coquard, I.3
-
56
-
-
84875435116
-
Ridaforolimus as a single agent in advanced endometrial cancer: Results of a single-arm, phase 2 trial
-
Colombo N, McMeekin DS, Schwartz PE et al. Ridaforolimus as a single agent in advanced endometrial cancer: Results of a single-arm, phase 2 trial. Br J Cancer 2013;108:1021-1026.
-
(2013)
Br J Cancer
, vol.108
, pp. 1021-1026
-
-
Colombo, N.1
McMeekin, D.S.2
Schwartz, P.E.3
-
57
-
-
84947270263
-
Randomized phase II trial of ridaforolimus in advanced endometrial carcinoma
-
Oza AM, Pignata S, Poveda A et al. Randomized phase II trial of ridaforolimus in advanced endometrial carcinoma. J Clin Oncol 2015;33:3576-3582.
-
(2015)
J Clin Oncol
, vol.33
, pp. 3576-3582
-
-
Oza, A.M.1
Pignata, S.2
Poveda, A.3
-
58
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356: 2271-2281.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
59
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins MB, Hidalgo M, Stadler WM et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004;22: 909-918.
-
(2004)
J Clin Oncol
, vol.22
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
-
60
-
-
83455181801
-
Safety and efficacy of temsirolimus in heavily pretreated patients with metastatic renal cell carcinoma
-
Lamm W, Vogl UM, Bojic M et al. Safety and efficacy of temsirolimus in heavily pretreated patients with metastatic renal cell carcinoma. Acta Oncol 2012;51:101-106.
-
(2012)
Acta Oncol
, vol.51
, pp. 101-106
-
-
Lamm, W.1
Vogl, U.M.2
Bojic, M.3
-
61
-
-
84885175489
-
Aphase II study evaluating the toxicity and efficacy of singleagenttemsirolimusinchemotherapy-na¨ıvecastrationresistant prostate cancer
-
Kruczek K, Ratterman M, Tolzien K et al. Aphase II study evaluating the toxicity and efficacy of singleagenttemsirolimusinchemotherapy-na¨ıvecastrationresistant prostate cancer. Br J Cancer 2013;109: 1711-1716.
-
(2013)
Br J Cancer
, vol.109
, pp. 1711-1716
-
-
Kruczek, K.1
Ratterman, M.2
Tolzien, K.3
-
62
-
-
84888000901
-
A phase II trial of temsirolimus in men with castration-resistant metastatic prostate cancer
-
Armstrong AJ, Shen T, Halabi S et al. A phase II trial of temsirolimus in men with castration-resistant metastatic prostate cancer. Clin Genitourin Cancer 2013;11:397-406.
-
(2013)
Clin Genitourin Cancer
, vol.11
, pp. 397-406
-
-
Armstrong, A.J.1
Shen, T.2
Halabi, S.3
-
63
-
-
33750510023
-
A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas
-
Duran I, Kortmansky J, Singh D et al. A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas. Br J Cancer 2006;95:1148-1154.
-
(2006)
Br J Cancer
, vol.95
, pp. 1148-1154
-
-
Duran, I.1
Kortmansky, J.2
Singh, D.3
-
64
-
-
23944453425
-
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
-
Galanis E, Buckner JC, Maurer MJ et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study. J Clin Oncol 2005;23:5294-5304.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5294-5304
-
-
Galanis, E.1
Buckner, J.C.2
Maurer, M.J.3
-
65
-
-
84862133526
-
Brief report: A phase II “window-of-opportunity” frontline study of the MTOR inhibitor, temsirolimus given as a single agent in patients with advanced NSCLC, an NCCTG study
-
Reungwetwattana T, Molina JR, Mandrekar SJ et al. Brief report: A phase II “window-of-opportunity” frontline study of the MTOR inhibitor, temsirolimus given as a single agent in patients with advanced NSCLC, an NCCTG study. J Thorac Oncol 2012;7: 919-922.
-
(2012)
J Thorac Oncol
, vol.7
, pp. 919-922
-
-
Reungwetwattana, T.1
Molina, J.R.2
Mandrekar, S.J.3
-
66
-
-
23944439945
-
Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
-
Chan S, Scheulen ME, Johnston S et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 2005;23:5314-5322.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5314-5322
-
-
Chan, S.1
Scheulen, M.E.2
Johnston, S.3
-
67
-
-
84939949523
-
Aphase1 studyof the sachet formulation of the oral dual PI3K/ mTOR inhibitor BEZ235 given twice daily (BID) in patients with advanced solid tumors
-
Bendell JC, Kurkjian C, Infante JR et al. Aphase1 studyof the sachet formulation of the oral dual PI3K/ mTOR inhibitor BEZ235 given twice daily (BID) in patients with advanced solid tumors. Invest New Drugs 2015;33:463-471.
-
(2015)
Invest New Drugs
, vol.33
, pp. 463-471
-
-
Bendell, J.C.1
Kurkjian, C.2
Infante, J.R.3
-
68
-
-
84923115280
-
Phase II trial of GDC-0980 (dual PI3K/mTOR inhibitor) in patients with advanced endometrial carcinoma: Final study results
-
Makker V, Recio FO, Ma L et al. Phase II trial of GDC-0980 (dual PI3K/mTOR inhibitor) in patients with advanced endometrial carcinoma: Final study results. J Clin Oncol 2014;32:5513.
-
(2014)
J Clin Oncol
, vol.32
, pp. 5513
-
-
Makker, V.1
Recio, F.O.2
Ma, L.3
-
69
-
-
84904622446
-
Phase I study of PF-04691502, a small-molecule, oral, dual inhibitor of PI3K and mTOR, in patients with advanced cancer
-
Britten CD, Adjei AA, Millham R et al. Phase I study of PF-04691502, a small-molecule, oral, dual inhibitor of PI3K and mTOR, in patients with advanced cancer. Invest New Drugs 2014;32: 510-517.
-
(2014)
Invest New Drugs
, vol.32
, pp. 510-517
-
-
Britten, C.D.1
Adjei, A.A.2
Millham, R.3
-
70
-
-
84927624149
-
First-in-human study of PF-05212384 (PKI-587), a small-molecule, intravenous, dual inhibitor of PI3K and mTOR in patients with advanced cancer
-
Shapiro GI, Bell-McGuinn KM, Molina JR et al. First-in-human study of PF-05212384 (PKI-587), a small-molecule, intravenous, dual inhibitor of PI3K and mTOR in patients with advanced cancer. Clin Cancer Res 2015;21:1888-1895.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1888-1895
-
-
Shapiro, G.I.1
Bell-McGuinn, K.M.2
Molina, J.R.3
-
71
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
Robert C, Long GV, Brady B et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl JMed 2015;372:320-330.
-
(2015)
N Engl Jmed
, vol.372
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
-
72
-
-
84995531663
-
-
Whitehouse Station, NJ: Merck & Co., Inc
-
Keytruda (pembrolizumab) for injection [prescribing information]. Whitehouse Station, NJ: Merck & Co., Inc., 2015.
-
(2015)
-
-
-
73
-
-
84865074467
-
Management of metabolic effects associated with anticancer agents targeting the PI3K-Akt-mTOR pathway
-
Busaidy NL, Farooki A, Dowlati A et al. Management of metabolic effects associated with anticancer agents targeting the PI3K-Akt-mTOR pathway. J Clin Oncol 2012;30:2919-2928.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2919-2928
-
-
Busaidy, N.L.1
Farooki, A.2
Dowlati, A.3
-
74
-
-
84893051766
-
Insulin signaling, resistance, and the metabolic syndrome: Insights from mouse models into disease mechanisms
-
Guo S. Insulin signaling, resistance, and the metabolic syndrome: Insights from mouse models into disease mechanisms. J Endocrinol 2014;220: T1-T23.
-
(2014)
J Endocrinol
, vol.220
, pp. TT1-T23
-
-
Guo, S.1
-
75
-
-
84859778293
-
MTOR signaling in growth controland disease
-
Laplante M, Sabatini DM. mTOR signaling in growth controland disease. Cell 2012;149:274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
76
-
-
84877313224
-
IGF-1R as an anti-cancer target-trials and tribulations
-
Chen HX, Sharon E. IGF-1R as an anti-cancer target-trials and tribulations. Chin J Cancer 2013; 32:242-252.
-
(2013)
Chin J Cancer
, vol.32
, pp. 242-252
-
-
Chen, H.X.1
Sharon, E.2
-
78
-
-
84901297343
-
The adverse events profile of anti-IGF-1R monoclonal antibodies in cancer therapy
-
Ma H, Zhang T, Shen H et al. The adverse events profile of anti-IGF-1R monoclonal antibodies in cancer therapy. Br J Clin Pharmacol 2014;77: 917-928.
-
(2014)
Br J Clin Pharmacol
, vol.77
, pp. 917-928
-
-
Ma, H.1
Zhang, T.2
Shen, H.3
-
79
-
-
70349148288
-
Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: Implications for cancer therapy
-
van der Veeken J, Oliveira S, Schiffelers RM et al. Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: Implications for cancer therapy. Curr Cancer Drug Targets 2009;9:748-760.
-
(2009)
Curr Cancer Drug Targets
, vol.9
, pp. 748-760
-
-
van Der Veeken, J.1
Oliveira, S.2
Schiffelers, R.M.3
-
80
-
-
83455236504
-
Insulin-like growth factor: Current concepts and new developments in cancer therapy
-
King ER, Wong KK. Insulin-like growth factor: Current concepts and new developments in cancer therapy. Recent Patents Anticancer Drug Discov 2012;7:14-30.
-
(2012)
Recent Patents Anticancer Drug Discov
, vol.7
, pp. 14-30
-
-
King, E.R.1
Wong, K.K.2
-
81
-
-
84957049551
-
Update on third-generation EGFR tyrosine kinase inhibitors
-
Gray J, Haura E. Update on third-generation EGFR tyrosine kinase inhibitors. Transl Lung Cancer Res 2014;3:360-362.
-
(2014)
Transl Lung Cancer Res
, vol.3
, pp. 360-362
-
-
Gray, J.1
Haura, E.2
-
82
-
-
84960130421
-
Management of hyperglycemia from epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) targeting T790M-mediated resistance
-
Villadolid J, Ersek JL, Fong MK et al. Management of hyperglycemia from epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) targeting T790M-mediated resistance. Transl Lung Cancer Res 2015;4:576-583.
-
(2015)
Transl Lung Cancer Res
, vol.4
, pp. 576-583
-
-
Villadolid, J.1
Ersek, J.L.2
Fong, M.K.3
-
83
-
-
84928746232
-
Rociletinib in EGFR-mutated non-small-cell lung cancer
-
Sequist LV, Soria JC, Goldman JW et al. Rociletinib in EGFR-mutated non-small-cell lung cancer. N Engl J Med 2015;372:1700-1709.
-
(2015)
N Engl J Med
, vol.372
, pp. 1700-1709
-
-
Sequist, L.V.1
Soria, J.C.2
Goldman, J.W.3
-
84
-
-
84891719799
-
Evidence for rapamycin toxicity in pancreatic b-cells and a review of the underlying molecular mechanisms
-
Barlow AD, Nicholson ML, Herbert TP. Evidence for rapamycin toxicity in pancreatic b-cells and a review of the underlying molecular mechanisms. Diabetes 2013;62:2674-2682.
-
(2013)
Diabetes
, vol.62
, pp. 2674-2682
-
-
Barlow, A.D.1
Nicholson, M.L.2
Herbert, T.P.3
-
85
-
-
79955785100
-
Pushing the envelope in the mTOR pathway: The second generation of inhibitors
-
Vilar E, Perez-Garcia J, Tabernero J. Pushing the envelope in the mTOR pathway: The second generation of inhibitors. Mol Cancer Ther 2011;10: 395-403.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 395-403
-
-
Vilar, E.1
Perez-Garcia, J.2
Tabernero, J.3
-
86
-
-
84874746597
-
Everolimus for angiomyolipoma associated with tuberous sclerosis complexor sporadic lymphangioleiomyomatosis (EXIST-2): A multicentre, randomised, double-blind, placebo-controlled trial
-
Bissler JJ, Kingswood JC, Radzikowska E et al. Everolimus for angiomyolipoma associated with tuberous sclerosis complexor sporadic lymphangioleiomyomatosis (EXIST-2): A multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2013;381:817-824.
-
(2013)
Lancet
, vol.381
, pp. 817-824
-
-
Bissler, J.J.1
Kingswood, J.C.2
Radzikowska, E.3
-
87
-
-
78049510428
-
Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
-
Krueger DA, Care MM, Holland K et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med 2010;363: 1801-1811.
-
(2010)
N Engl J Med
, vol.363
, pp. 1801-1811
-
-
Krueger, D.A.1
Care, M.M.2
Holland, K.3
-
88
-
-
84872088946
-
Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): A multicentre, randomised, placebo-controlled phase 3 trial
-
Franz DN, Belousova E, Sparagana S et al. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): A multicentre, randomised, placebo-controlled phase 3 trial. Lancet 2013;381:125-132.
-
(2013)
Lancet
, vol.381
, pp. 125-132
-
-
Franz, D.N.1
Belousova, E.2
Sparagana, S.3
-
89
-
-
84995523257
-
-
East Hanover, NJ: Novartis Pharmaceuticals Corporation
-
Afinitor (everolimus) tablets for oral administration afinitor disperz (everolimus tablets for oral suspension) [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corporation, 2016.
-
(2016)
-
-
-
90
-
-
84962198249
-
Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy
-
Hughes J, Vudattu N, Sznol M et al. Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy. Diabetes Care 2015;38:e55-e57.
-
(2015)
Diabetes Care
, vol.38
, pp. e55-e57
-
-
Hughes, J.1
Vudattu, N.2
Sznol, M.3
-
91
-
-
84962385750
-
Anti-PD1 pembrolizumab can induce exceptional fulminant type 1 diabetes
-
Gaudy C, Clévy C, Monestier S et al. Anti-PD1 pembrolizumab can induce exceptional fulminant type 1 diabetes. Diabetes Care 2015;38:e182-e183.
-
(2015)
Diabetes Care
, vol.38
, pp. e182-e183
-
-
Gaudy, C.1
Clévy, C.2
Monestier, S.3
-
92
-
-
84896530741
-
Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes
-
Kochupurakkal NM, Kruger AJ, Tripathi S et al. Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes. PLoS One 2014;9:e89561.
-
(2014)
Plos One
, pp. 9
-
-
Kochupurakkal, N.M.1
Kruger, A.J.2
Tripathi, S.3
-
93
-
-
84894532177
-
Endocrine side effects of anti-cancer drugs: Effects of anti-cancer targeted therapies on lipid and glucose metabolism
-
Vergès B, Walter T, Cariou B. Endocrine side effects of anti-cancer drugs: Effects of anti-cancer targeted therapies on lipid and glucose metabolism. Eur J Endocrinol 2014;170:R43-R55.
-
(2014)
Eur J Endocrinol
, vol.170
, pp. R43-R55
-
-
Vergès, B.1
Walter, T.2
Cariou, B.3
-
94
-
-
84856071447
-
Phase I, dose-escalation studyofBKM120,anoral pan-Class I PI3K inhibitor, in patients with advanced solid tumors
-
Bendell JC, Rodon J, Burris HA et al. Phase I, dose-escalation studyofBKM120,anoral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol 2012;30:282-290.
-
(2012)
J Clin Oncol
, vol.30
, pp. 282-290
-
-
Bendell, J.C.1
Rodon, J.2
Burris, H.A.3
|