Induction of heme oxygenase-1 with hemin alleviates cisplatin-induced reproductive toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line

Toxicology Letters

Volumn 264, Issue , 2016, Pages 38-50

  Heeba, Gehan Hussein ^a   Hamza, Alaaeldin Ahmed ^b   Hassanin, Soha Osama ^c  

^a Minia University   (Egypt)

^b NATIONAL ORGANIZATION FOR DRUG CONTROL AND RESEARCH NODCAR   (Egypt)

^c Technology and Information   (Egypt)

Author keywords

Cisplatin; Heme oxygenase 1; Male rats; Reproductive toxicity; Zinc protoporphyrin

Indexed keywords

CASPASE 3; CATALASE; CISPLATIN; GLUTATHIONE; HEME OXYGENASE 1; HEMIN; MALONALDEHYDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTOPORPHYRIN ZINC; TESTOSTERONE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ZINC PROTOPORPHYRIN IX; ANTINEOPLASTIC AGENT; AUTACOID; PROTECTIVE AGENT; PROTOPORPHYRIN;

ADULT; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INDUCTION; ENZYME INHIBITION; IN VITRO STUDY; MALE; NONHUMAN; OXIDATIVE STRESS; PC3 CELL LINE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; RAT; REPRODUCTIVE TOXICITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTOSTERONE BLOOD LEVEL; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; INFERTILITY, MALE; METABOLISM; PATHOLOGY; PROSTATIC NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; ENZYME INDUCTION; HEME OXYGENASE-1; HEMIN; INFERTILITY, MALE; INFLAMMATION MEDIATORS; MALE; OXIDATIVE STRESS; PROSTATIC NEOPLASMS; PROTECTIVE AGENTS; PROTOPORPHYRINS; RATS;

EID: 84995477562     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2016.10.019     Document Type: Article

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