Cisplatin-induced testicular toxicity in rats: The protective effect of arjunolic acid

Journal of Biochemical and Molecular Toxicology

Volumn 28, Issue 11, 2014, Pages 515-521

  Sherif, Iman O ^a   Abdel Aziz, Azza ^a   Sarhan, Osama M ^b  

^a MANSOURA UNIVERSITY   (Egypt)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Arjunolic acid; Cisplatin; Oxidative stress; Rat; Testis; Toxicity

Indexed keywords

ANTIOXIDANT; ARJUNOLIC ACID; CISPLATIN; COMPLEMENTARY DNA; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE P38; SYNAPTOPHYSIN; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; GENE EXPRESSION; GERM CELL; HISTOPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATID; SPERMATOGENESIS; TESTIS INJURY; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; ANIMAL; BLOOD; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; MALE; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TESTIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CISPLATIN; GLUTATHIONE; HUMANS; MALE; MALONDIALDEHYDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS, SPRAGUE-DAWLEY; SERTOLI CELLS; TESTIS; TESTOSTERONE; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84911400940     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.21593     Document Type: Article

References (30)

1. Kostova I. Platinum complexes as anticancer agents. Recent Patent Anticancer Drug Discov 2006;1:1-22.
2. Azu O, Duru F, Osinubi A, Oremosu AA, Noronha CC, Elesha SO, Okanlawon AO. Histomorphometric effects of Kigelia Africana (Bignoniaceae) fruit extract on the testis following short-term treatment with cisplatin in male Sprague-Dawley rats. Middle East Fertil Soc J 2010;15:200-208.
3. Awadalla E. Ameliorative effect of the crude oil of the Nigella sativa on oxidative stress induced in rat testes by cisplatin treatment. Biomed Prev Nutr 2012;2:265-268.
4. Amin A, Abraham C, Hamza A, Abdalla ZA, Al-Shamsi SB, Harethi SS, Daoud S. A standardized extract of Ginkgo biloba neutralizes cisplatin-mediated reproductive toxicity in rats. J Biomed Biotechnol 2012;2012:362049.
5. Amin A, Hamza AA, Kambal A, Daoud S. Herbal extracts counteract cisplatin-mediated cell death in rat testis. Asian J Androl 2008;10:291-297.
6. Lirdi LC, Stumpp T, Sasso-Cerri E, Miraglia SM. Amifostine protective effect on cisplatin-treated rat testis. Anat Rec 2008;291:797-808.
7. Türk G, Ateşşahin A, Sönmez M, Ceribaşi AO, Yüce A. Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid. Fertil Steril 2008;89:1474-1481.
8. Ateşşahin A, Karahan I, Türk G, Gür S, Yilmaz S, Ceribaşi AO. Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod Toxicol 2006;21:42-47.
9. Choudhury RC, Jagdale MB. Vitamin E protection from potentiation of the cytogenetic toxicity of cisplatin in Swiss mice. J Chemother 2002;14:397-405.
10. Ghosh J, Sil PC. Arjunolic acid: a new multifunctional therapeutic promise of alternative medicine. Biochimie 2013;95:1098-1109.
11. Abdel-Zaher AO, Abdel-Hady RH, Mahmoud MM, Farrag MM. The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology 2008;243:261-270.
12. Djoukeng JD, Abou-Mansour E, Tabacchi RJ, Tapondjou AL, Bouda H, Lontsi D. Antibacterial triterpenes from Syzygium guineense (Myrtaceae). Ethnopharmacol 2005;101:283-286.
13. Masoko P, Mdee LK, Mampuru LJ, Eloff JN. Biological activity of two related triterpenes isolated from Combretum nelsonii (Combretaceae) leaves. Nat Prod Res 2008;22:1074-1084.
14. Kalola J, Rajani M. Extraction and TLC desitometric determination of triterapenoid acids (arjungenin, arjunolic acid) from Terminalia arjuna stem bark without interference of tannins. Chromatographia 2006;63:475-481.
15. Kim DH, Han KM, Chung IS, Kim DK, Kim SH, Kwon BM, Jeong TS, Park MH, Ahn EM, Baek NI. Triterpenoids from the flower of Campsis grandiflora K. Schum. as human acyl-CoA: cholesterol acyltransferase inhibitors. Arch Pharm Res 2005;28:550-556.
16. Chaudhari M, Mengi S. Evaluation of phytoconstituents of Terminalia arjuna for wound healing activity in rats. Phytother Res 2006;20:799-805.
17. Manna P, Sinha M, Pal P, Sil PC. Arjunolic acid, a triterpenoid saponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes. Chem Biol Interact 2007;170:187-200.
18. Ghosh J, Das J, Manna P, Sil PC. Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: therapeutic potential of arjunolic acid. Toxicology 2010;268:8-18.
19. Ghosh J, Das J, Manna P, Sil PC. The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis. Biomaterials 2011;32:4857-4866.
20. Manna P, Sinha M, Sil PC. Protection of arsenic-induced testicular oxidative stress by arjunolic acid. Redox Rep 2008;13:67-77.
21. Ilbey YO, Ozbek E, Cekmen M. Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. Hum Reprod 2009;24:1717-1725.
22. Rezvanfar MA, Rezvanfar MA, Shahverdi AR, Ahmadi A, Baeeri M, Mohammadirad A, Abdollahi M. Protection of cisplatin-induced spermatotoxicity, DNA damage and chromatin abnormality by selenium nano-particles. Toxicol Appl Pharmacol 2013;266:356-365.
23. Livak K, Schmittgen T. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402-408.
24. Stumpp T, Sasso-Cerri E, Freymuller E, Miraglia SM. Apoptosis and testicular alterations in albino rats treated with etoposide during the prepubertal phase. Anat Rec 2004;279:611-622.
25. Johnson L, Petty CS, Neaves WB. The relationship of biopsy evaluation and testicular measurement to over-all daily sperm production in human testes. Fertil Steril 1980;34:36-40.
26. Salem EA, Salem NA, Maarouf AM, Serefoglu EC, Hellstrom WJ. Selenium and lycopene attenuate cisplatin-induced testicular toxicity associated with oxidative stress in Wistar rats. Urology 2012;79:1184e1-1184e6.
27. Sajjad H. Toxicity effect of cisplatin-treatment on rat testis tissue. Annal Bio Res 2012;3:2297-2303.
28. Zhang C, Walker LM, Mayeux PR. Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney. Biochem Pharmacol 2000;59:203-209.
29. Chirino YI, Trujillo J, Sánchez-González DJ, Martínez-Martínez CM, Cruz C, Bobadilla NA, Pedraza-Chaverri J. Selective iNOS inhibition reduces renal damage induced by cisplatin. Toxicol Lett 2008;176:48-57.
30. Riccioli A, Starace D, D'Alessio A, Starace G, Padula F, De Cesaris P, Filippini A, Ziparo E. TNF-alpha and IFN-gamma regulate expression and function of the Fas system in the seminiferous epithelium. J Immunol 2000;165:743-749.