Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc

Chemico-Biological Interactions

Volumn 199, Issue 3, 2012, Pages 185-191

  Mori Sequeiros García, Mercedes ^a   Acquier, Andrea ^a   Suarez, Guadalupe ^a   Gomez, Natalia V ^a   Gorostizaga, Alejandra ^a   Mendez, Carlos F ^a   Paz, Cristina ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Cisplatin; Leydig cells; P450 scc enzyme; ROS; Steroidogenesis

Indexed keywords

22 HYDROXYCHOLESTEROL; 8 BROMO CYCLIC AMP; ANTIOXIDANT; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CHORIONIC GONADOTROPIN; CISPLATIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; MESSENGER RNA; PREGNENOLONE; REACTIVE OXYGEN METABOLITE; TESTOSTERONE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; HORMONE INHIBITION; HORMONE METABOLISM; IN VITRO STUDY; LEYDIG CELL; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS DISEASE; TESTOSTERONE SYNTHESIS;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL LINE; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CHORIONIC GONADOTROPIN; CISPLATIN; HUMANS; HYDROXYCHOLESTEROLS; LEYDIG CELLS; MALE; MICE; MICE, INBRED BALB C; PREGNENOLONE; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TESTOSTERONE;

EID: 84866500288     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.08.012     Document Type: Article

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