Adhesion GPCR function in pulmonary development and disease

Handbook of Experimental Pharmacology

Volumn 234, Issue , 2016, Pages 309-327

  Ludwig, Marie Gabrielle ^a   Seuwen, Klaus ^a   Bridges, James P ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Alveolar epithelium; COPD; Lung development; Lung disease; Lung homeostasis; Pulmonary surfactant

Indexed keywords

ADHESION G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR; PROTEIN ADGRC1; PROTEIN ADGRF5; PROTEIN ADGRG1; PROTEIN ADGRG6; UNCLASSIFIED DRUG; GPR116 PROTEIN, HUMAN; GPR116 PROTEIN, MOUSE;

GENE TARGETING; GENETIC TRANSCRIPTION; HOMEOSTASIS; HUMAN; LOSS OF FUNCTION MUTATION; LUNG CANCER; LUNG DEVELOPMENT; LUNG DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; CELL ADHESION; CELL LINE; CELL MEMBRANE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LUNG; METABOLISM; MORPHOGENESIS; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ANIMALS; CELL ADHESION; CELL LINE; CELL MEMBRANE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LUNG; LUNG DISEASES; MICE; MORPHOGENESIS; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 84995376306     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-319-41523-9_14     Document Type: Chapter

References (59)

1. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH et al (2013) Molecular determinants of lung development. Ann Am Thorac Soc 10:S12-S16
2. Narayanan M, Owers-Bradley J, Beardsmore CS, Mada M, Ball I et al (2012) Alveolarization continues during childhood and adolescence: new evidence from helium-3 magnetic resonance. Am J Respir Crit Care Med 185:186-191
3. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R et al (2014) Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell 15:123-138
4. Pera T, Penn RB (2014) Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway. Curr Opin Pharmacol 16:72-81
5. Peters T, Henry PJ (2009) Protease-activated receptors and prostaglandins in inflammatory lung disease. Br J Pharmacol 158:1017-1033
6. Alberelli MA, De Candia E (2014) Functional role of protease activated receptors in vascular biology. Vascul Pharmacol 62:72-81
7. Wasilewski NV, Lougheed MD, Fisher JT (2014) Changing face of beta2-adrenergic and muscarinic receptor therapies in asthma. Curr Opin Pharmacol 16:148-156
8. Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM et al (2010) Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med 16:1299-1304
9. Robinett KS, Koziol-White CJ, Akoluk A, An SS, Panettieri RAJ et al (2014) Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells. Am J Respir Cell Mol Biol 50:678-683
10. Kinnamon SC (2012) Taste receptor signalling-from tongues to lungs. Acta Physiol (Oxf) 204:158-168
11. Bridges JP, Ludwig MG, Mueller M, Kinzel B, Sato A et al (2013) Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size. Am J Respir Cell Mol Biol 49:348-357
12. Moriguchi T, Haraguchi K, Ueda N, Okada M, Furuya T et al (2004) DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites. Genes Cells 9:549-560
13. Haitina T, Olsson F, Stephansson O, Alsio J, Roman E et al (2008) Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci 9:43
14. Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ et al (2010) The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mol Genet 19:2251-2267
15. Abe J, Suzuki H, Notoya M, Yamamoto T, Hirose S (1999) Ig-hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs. J Biol Chem 274:19957-19964
16. Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K et al (2013) Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR 116. Cell Rep 3:1457-1464
17. Niaudet C, Hofmann JJ, Mae MA, Jung B, Gaengel K et al (2015) Gpr116 receptor regulates distinctive functions in pneumocytes and vascular endothelium. PLoS One 10:e0137949
18. Waller-Evans H, Promel S, Langenhan T, Dixon J, Zahn D et al (2010) The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS One 5:e14047
19. Monk KR, Oshima K, Jors S, Heller S, Talbot WS (2011) Gpr126 is essential for peripheral nerve development and myelination in mammals. Development 138:2673-2680
20. Petersen SC, Luo R, Liebscher I, Giera S, Jeong SJ et al (2015) The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron 85:755-769
21. Richter GH, Fasan A, Hauer K, Grunewald TG, Berns C et al (2013) G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1. J Pathol 230:70-81
22. Lum AM, Wang BB, Beck-Engeser GB, Li L, Channa N et al (2010) Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer. BMC Cancer 10:40
23. Hasan AN, Ahmad MW, Madar IH, Grace BL, Hasan TN (2015) An in silico analytical study of lung cancer and smokers datasets from gene expression omnibus (GEO) for prediction of differentially expressed genes. Bioinformation 11:229-235
24. Yu XJ, Yang MJ, Zhou B, Wang GZ, Huang YC et al (2015) Characterization of somatic mutations in air pollution-related lung cancer. EBioMed 2:583-590
25. Hatanaka H, Oshika Y, Abe Y, Yoshida Y, Hashimoto T et al (2000) Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1). Int J Mol Med 5:181-183
26. Bari MF, Brown H, Nicholson AG, Kerr KM, Gosney JR et al (2014) BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas. Histopathology 64:547-556
27. Davidson B, Stavnes HT, Risberg B, Nesland JM, Wohlschlaeger J et al (2012) Gene expression signatures differentiate adenocarcinoma of lung and breast origin in effusions. Hum Pathol 43:684-694
28. Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR et al (2010) Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet 42:45-52
29. Soler Artigas M, Wain LV, Miller S, Kheirallah AK, Huffman JE et al (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nat Commun 6:8658
30. Li S, Jin Z, Koirala S, Bu L, Xu L et al (2008) GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci 28:5817-5826
31. Yang J, Wang Z, Leng D, Dai H, Wang J et al (2014) G protein-coupled receptor 56 regulates matrix production and motility of lung fibroblasts. Exp Biol Med (Maywood) 239:686-696
32. Guo R, Wu G, Li H, Qian P, Han J et al (2013) Promoter methylation profiles between human lung adenocarcinoma multidrug resistant A549/cisplatin (A549/DDP) cells and its progenitor A549 cells. Biol Pharm Bull 36:1310-1316
33. Ariestanti DM, Ando H, Hirose S, Nakamura N (2015) Targeted disruption of Ig-Hepta/ Gpr116 causes emphysema-like symptoms that are associated with alveolar macrophage activation. J Biol Chem 290:11032-11040
34. Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM et al (2013) Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D. PLoS One 8:e69451
35. Korfhagen TR, Sheftelyevich V, Burhans MS, Bruno MD, Ross GF et al (1998) Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo. J Biol Chem 273:28438-28443
36. Botas C, Poulain F, Akiyama J, Brown C, Allen L et al (1998) Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc Natl Acad Sci U S A 95:11869-11874
37. Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A et al (1994) Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science 264:713-716
38. Nishinakamura R, Nakayama N, Hirabayashi Y, Inoue T, Aud D et al (1995) Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal. Immunity 2:211-222
39. Saito A, Nikolaidis NM, Amlal H, Uehara Y, Gardner JC et al (2015) Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment. Sci Transl Med 7:313ra
40. Carey B, Trapnell BC (2010) The molecular basis of pulmonary alveolar proteinosis. Clin Immunol 135:223-235
41. Ikegami M, Ueda T, Hull W, Whitsett JA, Mulligan RC et al (1996) Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation. Am J Physiol Lung Cell Mol Physiol 14:L650-L658
42. Yoshida M, Ikegami M, Reed JA, Chroneos ZC, Whitsett JA (2001) GM-CSF regulates protein and lipid catabolism by alveolar macrophages. Am J Physiol 280:L379-L386
43. Ikegami M, Whitsett JA, Jobe A, Ross G, Fisher J et al (2000) Surfactant metabolism in SP-D gene-targeted mice. Am J Physiol Lung Cell Mol Physiol 279:L468-L476
44. Ikegami M, Na CL, Korfhagen TR, Whitsett JA (2005) Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells. Am J Physiol Lung Cell Mol Physiol 288:L552-L561
45. Tang X, Jin R, Qu G, Wang X, Li Z et al (2013) GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Galphaq-p63RhoGEF-Rho GTPase pathway. Cancer Res 73:6206-6218
46. Fisher JH, Sheftelyevich V, Ho YS, Fligiel S, McCormack FX et al (2000) Pulmonary-specific expression of SP-D corrects pulmonary lipid accumulation in SP-D gene-targeted mice. Am J Physiol Lung Cell Mol Physiol 278:L365-L373
47. Kitamura T, Tanaka N, Watanabe J, Uchida Kanegasaki S et al (1999) Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/ macrophage colony-stimulating factor. J Exp Med 190:875-880
48. Suzuki T, Sakagami T, Rubin BK, Nogee LM, Wood RE et al (2008) Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med 205:2703-2710
49. Matalon S, Bartoszewski R, Collawn JF (2015) Role of epithelial sodium channels in the regulation of lung fluid homeostasis. Am J Physiol Lung Cell Mol Physiol 309:L1229-L1238
50. Berthiaume Y, Matthay MA (2007) Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol 159:350-359
51. Ebbinghaus M, Gajda M, Holtzman MJ, Schulz S, Schaible HG (2014) Does chloride channel accessory 3 have a role in arthritis pain? A study on murine antigen-induced arthritis. Neurosci Lett 576:40-44
52. Nakagami Y, Favoreto SJ, Zhen G, Park SW, Nguyenvu LT et al (2008) The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model. J Immunol 181:2203-2210
53. Romero MF, Chen AP, Parker MD, Boron WF (2013) The SLC4 family of bicarbonate (HCO (3)(-)) transporters. Mol Aspects Med 34:159-182
54. Capasso M, DeCoursey TE, Dyer MJ (2011) pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN 1. Trends Cell Biol 21:20-28
55. Feingold KR (2012) Lamellar bodies: the key to cutaneous barrier function. J Invest Dermatol 132:1951-1953
56. Chintagari NR, Mishra A, Su L, Wang Y, Ayalew S et al (2010) Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium. PLoS One 5:e9228
57. Chander A, Sen N, Wadsworth S, Spitzer AR (2000) Coordinate packaging of newly synthesized phosphatidylcholine and phosphatidylglycerol in lamellar bodies in alveolar type II cells. Lipids 35:35-43
58. Behne MJ, Tu CL, Aronchik I, Epstein E, Bench G et al (2003) Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores. J Invest Dermatol 121:688-694
59. Micaroni M (2012) Calcium around the Golgi apparatus: implications for intracellular membrane trafficking. Adv Exp Med Biol 740:439-460