Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size

American Journal of Respiratory Cell and Molecular Biology

Volumn 49, Issue 3, 2013, Pages 348-457

  Bridges, James P ^a   Ludwig, Marie Gabrielle ^b   Mueller, Matthias ^b   Kinzel, Bernd ^b   Sato, Atsuyasu ^a   Xu, Yan ^a   Whitsett, Jeffrey A ^a   Ikegami, Machiko ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Alveolar epithelium; G protein coupled receptors; GPR116; Pulmonary surfactant; Surfactant metabolism

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LUNG SURFACTANT; MESSENGER RNA; PHOSPHATIDYLCHOLINE; PURINERGIC P2Y2 RECEPTOR;

ANIMAL TISSUE; ARTICLE; GENE MUTATION; LIPID ANALYSIS; LUNG GAS EXCHANGE; LUNG VOLUME; MACROPHAGE; MICROARRAY ANALYSIS; MOLECULAR SENSOR; MOUSE; NEUTROPHILIA; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RNA ANALYSIS;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; EPITHELIAL CELLS; EXONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MACROPHAGES; MICE; MICE, KNOCKOUT; PHOSPHATIDYLCHOLINES; PULMONARY ALVEOLI; PULMONARY SURFACTANTS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PURINERGIC P2Y2; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION;

EID: 84880839405     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2012-0439OC     Document Type: Article

References (51)

1. Hawgood S, Clements JA. Pulmonary surfactant and its apoproteins. J Clin Invest 1990;86:1-6. (Pubitemid 20226966)
2. Veldhuizen R, Nag K, Orgeig S, Possmayer F. The role of lipids in pulmonary surfactant. Biochim Biophys Acta 1998;1408:90-108. (Pubitemid 28517860)
3. Notter RH. Lung surfactants: basic science and clinical applications. New York: Marcel Dekker; 2000.
4. Goerke J. Pulmonary surfactant: functions and molecular composition. Biochim Biophys Acta 1998;1408:79-89. (Pubitemid 28517859)
5. Rice WR, Singleton FM. P2-purinoceptors regulate surfactant secretion from rat isolated alveolar type II cells. Br J Pharmacol 1986;89:485-491. (Pubitemid 16008386)
6. Gilfillan AM, Rooney SA. Purinoceptor agonists stimulate phosphatidylcholine secretion in primary cultures of adult rat type II pneumocytes. Biochim Biophys Acta 1987;917:18-23. (Pubitemid 17231042)
7. Dobbs LG, Mason RJ. Pulmonary alveolar type II cells isolated from rats: release of phosphatidylcholine in response to beta-adrenergic stimulation. J Clin Invest 1979;63:378-387. (Pubitemid 9130200)
8. Mettler NR, Gray ME, Schuffman S, LeQuire VS. Beta-adrenergic induced synthesis and secretion of phosphatidylcholine by isolated pulmonary alveolar type II cells. Lab Invest 1981;45:575-586. (Pubitemid 12196497)
9. Brown LA, Longmore WJ. Adrenergic and cholinergic regulation of lung surfactant secretion in the isolated perfused rat lung and in the alveolar type II cell in culture. J Biol Chem 1981;256:66-72. (Pubitemid 12207090)
10. Gilfillan AM, Rooney SA. Functional evidence for adenosine A2 receptor regulation of phosphatidylcholine secretion in cultured type II pneumocytes. J Pharmacol Exp Ther 1987;241:907-914.
11. Griese M, Gobran LI, Douglas JS, Rooney SA. Adenosine A2-receptor-mediated phosphatidylcholine secretion in type II pneumocytes. Am J Physiol 1991;260:L52-L60.
12. Wirtz HR, Dobbs LG. Calcium mobilization and exocytosis after one mechanical stretch of lung epithelial cells. Science 1990;250:1266-1269. (Pubitemid 120031841)
13. Ikegami M, Whitsett JA, Jobe A, Ross G, Fisher J, Korfhagen T. Surfactant metabolism in SP-D gene-targeted mice. Am J Physiol Lung Cell Mol Physiol 2000;279:L468-L476.
14. Rebello CM, Jobe AH, Eisele JW, Ikegami M. Alveolar and tissue surfactant pool sizes in humans. Am J Respir Crit Care Med 1996;154:625-628. (Pubitemid 26327282)
15. Jobe A, Ikegami M, Jacobs H. Changes in the amount of lung and airway phosphatidylcholine in 0.5-12.5-day-old rabbits. Biochim Biophys Acta 1981;664:182-187. (Pubitemid 11068035)
16. Ikegami M. Surfactant catabolism. Respirology 2006;11:S24-S27.
17. Rice WR, Hull WM, Dion CA, Hollinger BA, Whitsett JA. Activation of cAMP dependent protein kinase during surfactant release from type II pneumocytes. Exp Lung Res 1985;9:135-149. (Pubitemid 16207637)
18. Sano K, Voelker DR, Mason RJ. Involvement of protein kinase C in pulmonary surfactant secretion from alveolar type II cells. J Biol Chem 1985;260:12725-12729. (Pubitemid 16230562)
19. Voyno-Yasenetskaya TA, Dobbs LG, Williams MC. Regulation of ATP-dependent surfactant secretion and activation of second-messenger systems in alveolar type II cells. Am J Physiol 1991;261:105-109.
20. Liu L. Inhibition of lung surfactant secretion by KN-62, a specific inhibitor of the calcium- and calmodulin-dependent protein kinase II. Biochem Mol Biol Int 1998;45:823-830. (Pubitemid 28393552)
21. Mason RJ, Williams MC, Greenleaf RD, Clements JA. Isolation and properties of type II alveolar cells from rat lung. Am Rev Respir Dis 1977;115:1015-1026. (Pubitemid 8131438)
22. Nicholas TE, Barr HA. The release of surfactant in rat lung by brief periods of hyperventilation. Respir Physiol 1983;52:69-83. (Pubitemid 13124930)
23. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-917.
24. Mason RJ, Nellenbogen J, Clements JA. Isolation of disaturated phosphatidylcholine with osmium tetroxide. J Lipid Res 1976;17:281-284.
25. Ikegami M, Dhami R, Schuchman EH. Alveolar lipoproteinosis in an acid sphingomyelinase-deficient mouse model of Niemann-Pick disease. Am J Physiol Lung Cell Mol Physiol 2003;284:L518-L525. (Pubitemid 36231730)
26. Ikegami M, Ueda T, Hull W, Whitsett JA, Mulligan RC, Dranoff G, Jobe AH. Surfactant metabolism in transgenic mice after granulocyte macrophagecolony stimulating factor ablation. Am J Physiol 1996;270:L650-L658.
27. Bridges JP, Ikegami M, Brilli LL, Chen X, Mason RJ, Shannon JM. LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. J Clin Invest 2010;120:1736-1748.
28. Abe J, Suzuki H, Notoya M, Yamamoto T, Hirose S. Ig-hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs. J Biol Chem 1999;274:19957-19964.
29. Wallgard E, Larsson E, He L, Hellström M, Armulik A, Nisancioglu MH, Genove G, Lindahl P, Betsholtz C. Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature. Arterioscler Thromb Vasc Biol 2008;28:1469-1476.
30. Daneman R, Zhou L, Agalliu D, Cahoy JD, Kaushal A, Barres BA. The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS ONE 2010;5:e13741.
31. Ikegami M, Whitsett JA, Chroneos ZC, Ross GF, Reed JA, Bachurski CJ, Jobe AH. IL-4 increases surfactant and regulates metabolism in vivo. Am J Physiol Lung Cell Mol Physiol 2000;278:L75-L80. (Pubitemid 30104177)
32. Ichinose T, Fukuzawa T, Kato A, Ikegami M, Ishida J, Hirose S. Pulmonary surfactant accumulation in Ig-Hepta/GPR116 knockout mice. J Physiol Sci 2009;59:269.
33. Korfhagen TR, Sheftelyevich V, Burhans MS, Bruno MD, Ross GF, Wert SE, Stahlman MT, Jobe AH, Ikegami M, Whitsett JA, et al. Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo. J Biol Chem 1998;273:28438-28443. (Pubitemid 28496149)
34. Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie AM, Epstein C, et al. Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc Natl Acad Sci USA 1998;95:11869-11874. (Pubitemid 28460506)
35. Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A, Bronson RT, Dickersin GR, Bachurski CJ, Mark EL, Whitsett JA, et al. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science 1994;264:713-716. (Pubitemid 24185882)
36. Suzuki T, Sakagami T, Rubin BK, Nogee LM, Wood RE, Zimmerman SL, Smolarek T, Dishop MK, Wert SE, Whitsett JA, et al. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med 2008;205:2703-2710.
37. Martinez-Moczygemba M, Doan ML, Elidemir O, Fan LL, Cheung SW, Lei JT, Moore JP, Tavana G, Lewis LR, Zhu Y, et al. Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1. J Exp Med 2008;205:2711-2716.
38. Kitamura T, Tanaka N, Watanabe J, Uchida, Kanegasaki S, Yamada Y, Nakata K. Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor. J Exp Med 1999;190:875-880. (Pubitemid 29451632)
39. Ellgaard L, Helenius A. ER quality control: towards an understanding at the molecular level. Curr Opin Cell Biol 2001;13:431-437. (Pubitemid 32709766)
40. Ikegami M, Na CL, Korfhagen TR, Whitsett JA. Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells. Am J Physiol Lung Cell Mol Physiol 2005;288:L552-L561. (Pubitemid 40229522)
41. Shibata Y, Berclaz PY, Chroneos ZC, Yoshida M, Whitsett JA, Trapnell BC. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity 2001;15:557-567. (Pubitemid 33016441)
42. Atochina-Vasserman EN, Bates SR, Zhang P, Abramova H, Zhang Z, Gonzales L, Tao JQ, Gochuico BR, Gahl W, Guo CJ, et al. Early alveolar epithelial dysfunction promotes lung inflammation in a mouse model of Hermansky-Pudlak syndrome. Am J Respir Crit Care Med 2011;184:449-458.
43. Guttentag SH, Akhtar A, Tao JQ, Atochina E, Rusiniak ME, Swank RT, Bates SR. Defective surfactant secretion in a mouse model of Hermansky-Pudlak syndrome. Am J Respir Cell Mol Biol 2005;33:14-21. (Pubitemid 40961009)
44. Lyerla TA, Rusiniak ME, Borchers M, Jahreis G, Tan J, Ohtake P, Novak EK, Swank RT. Aberrant lung structure, composition, and function in a murine model of Hermansky-Pudlak syndrome. Am J Physiol Lung Cell Mol Physiol 2003;285:L643-L653. (Pubitemid 37022866)
45. Nie T, Hui X, Gao X, Li K, Lin W, Xiang X, Ding M, Kuang Y, Xu A, Fei J, et al . Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function. FEBS Lett 2012;586:3618-3625.
46. Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R. The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. EMBO J 2006;25:3012-3023. (Pubitemid 44106754)
47. Tschische P, Tadagaki K, Kamal M, Jockers R, Waldhoer M. Heteromerization of human cytomegalovirus encoded chemokine receptors. Biochem Pharmacol 2011;82:610-619.
48. Homolya L, Watt WC, Lazarowski ER, Koller BH, Boucher RC. Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y(2) receptor (-/-) mice. J Biol Chem 1999;274:26454-26460.
49. Ashino Y, Ying X, Dobbs LG, Bhattacharya J. [Ca(2+)](i) oscillations regulate type II cell exocytosis in the pulmonary alveolus. Am J Physiol Lung Cell Mol Physiol 2000;279:L5-L13. (Pubitemid 30619518)
50. Patel AS, Reigada D, Mitchell CH, Bates SR, Margulies SS, Koval M. Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation. Am J Physiol Lung Cell Mol Physiol 2005;289:L489-L496. (Pubitemid 41192725)
51. Mishra A, Chintagari NR, Guo Y, Weng T, Su L, Liu L. Purinergic P2X7 receptor regulates lung surfactant secretion in a paracrine manner. J Cell Sci 2011;124:657-668.