Gene expression signatures differentiate adenocarcinoma of lung and breast origin in effusions

Human Pathology

Volumn 43, Issue 5, 2012, Pages 684-694

  Davidson, Ben ^a,b   Stavnes, Helene Tuft ^a   Risberg, Björn ^a   Nesland, Jahn M ^a,b   Wohlschlaeger, Jeremias ^c   Yang, Yanqin ^d   Shih, Ie Ming ^e   Wang, Tian Li ^e  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Breast adenocarcinoma; Differential diagnosis; Gene expression array; Lung adenocarcinoma; Serous effusions

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 3ALPHA; MYC PROTEIN; NUCLEIC ACID BINDING PROTEIN; PROTEIN CA12; PROTEIN EFHD1; PROTEIN ESR1; PROTEIN GPR116; PROTEIN HOP; PROTEIN SCGB3A2; PROTEIN SPDEF; PROTEIN TFAP2A; PROTEIN TFF1; PROTEIN TFF3; PROTEIN TITF1; PROTEIN TOB1; PROTEN EVA; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BREAST ADENOCARCINOMA; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; NUCLEOTIDE SEQUENCE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ADENOCARCINOMA; BREAST; BREAST NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG; LUNG NEOPLASMS; PLEURAL EFFUSION, MALIGNANT;

EID: 84859886008     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2011.06.015     Document Type: Article

References (55)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-49.
2. Wang T, Nelson RA, Bogardus A, Grannis Jr FW. Five-year lung cancer survival. Advanced stage nonsmall cell lung cancer patients attain long-term survival. Cancer 2010;116:1518-25.
3. Fentiman IS, Millis R, Sexton S, Hayward JL. Pleural effusion in breast cancer: a review of 105 cases. Cancer 1981;47:2087-92. (Pubitemid 11153451)
4. Raju RN, Kardinal CG. Pleural effusion in breast carcinoma: analysis of 122 cases. Cancer 1981;48:2524-7. (Pubitemid 12228019)
5. Su AI, Welsh JB, Sapinoso LM, et al. Molecular classification of human carcinomas by use of gene expression signatures. Cancer Res 2001;61:7388-93. (Pubitemid 32995021)
6. Welsh JB, Sapinoso LM, Kern SG, et al. Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci U S A 2003;100:3410-5. (Pubitemid 36356597)
7. Amatschek S, Koenig U, Auer H, et al. Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumor-specific genes. Cancer Res 2004;64:844-56. (Pubitemid 38176883)
8. Pilarsky C, Wenzig M, Specht T, Saeger HD, Grützmann R. Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data. Neoplasia 2004;6:744-50. (Pubitemid 40041492)
9. Axelsen JB, Lotem J, Sachs L, Domany E. Genes overexpressed in different human solid cancers exhibit different tissue-specific expression profiles. Proc Natl Acad Sci U S A 2007;104:13122-7. (Pubitemid 351737603)
10. Davidson B. The biological characteristics of cancers involving the serosal cavities. Crit Rev Oncog 2007;13:189-227. (Pubitemid 351239093)
11. Davidson B, Reich R, Trope' CG, Wang TL, Shih IeM. New determinates of disease progression and outcome in metastatic ovarian carcinoma. Histol Histopathol 2010;25:1591-609.
12. Davidson B, Zhang Z, Kleinberg L, et al. Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from diffuse malignant peritoneal mesothelioma. Clin Cancer Res 2006;12:5944-50. (Pubitemid 44703753)
13. Davidson B, Tuft Stavnes H, Holth A, et al. Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from breast carcinoma in effusions. J Cell Mol Med 2011;15:535-44.
14. Davidson B, Nielsen S, Christensen J, et al. The role of desmin and N-cadherin in effusion cytology: a comparative study using established markers of mesothelial and epithelial cells. Am J Surg Pathol 2001;25:1405-12. (Pubitemid 33022056)
15. Morrison TB, Weis JJ, Wittwer CT. Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification. Biotechniques 1998;24:954-8, 960, 962.
16. Slipicevic A, Øy GF, Askildt IC, et al. The diagnostic and prognostic role of the insulin growth factor pathway members IGF-II and IGFBP3 in serous effusions. HUM PATHOL 2009;40:527-37.
17. Kamby C, Vejborg I, Kristensen B, Olsen LO, Mouridsen HT. Metastatic pattern in recurrent breast cancer. Special reference to intrathoracic recurrences. Cancer 1988;62:2226-33.
18. Bhargava R, Beriwal S, Dabbs DJ. Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity. Am J Clin Pathol 2007;127:103-13. (Pubitemid 46797025)
19. Wang LJ, Greaves WO, Sabo E, et al. GCDFP-15 positive and TTF-1 negative primary lung neoplasms: a tissue microarray study of 381 primary lung tumors. Appl Immunohistochem Mol Morphol 2009;17:505-11.
20. Yang M, Nonaka D. A study of immunohistochemical differential expression in pulmonary and mammary carcinomas. Mod Pathol 2010;23:654-61.
21. Striebel JM, Dacic S, Yousem SA. Gross cystic disease fluid protein - (GCDFP-15): expression in primary lung adenocarcinoma. Am J Surg Pathol 2008;32:426-32. (Pubitemid 351398935)
22. Kjellev S. The trefoil factor family-small peptides with multiple functionalities. Cell Mol Life Sci 2009;66:1350-69.
23. Poulsom R, Hanby AM, Lalani EN, Hauser F, Hoffmann W, Stamp GW. Intestinal trefoil factor (TFF 3) and pS2 (TFF 1), but not spasmolytic polypeptide (TFF 2) mRNAs are co-expressed in normal, hyperplastic, and neoplastic human breast epithelium. J Pathol 1997;183:30-8. (Pubitemid 27368523)
24. Tjensvoll K, Gilje B, Oltedal S, et al. A small subgroup of operable breast cancer patients with poor prognosis identified by quantitative real-time RT-PCR detection of mammaglobin A and trefoil factor 1 mRNA expression in bone marrow. Breast Cancer Res Treat 2009;116:329-38.
25. Potter CP, Harris AL. Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer. Br J Cancer 2003;89:2-7. (Pubitemid 36897927)
26. Barnett DH, Sheng S, Charn TH, et al. Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer. Cancer Res 2008;68:3505-15.
27. Hsieh MJ, Chen KS, Chiou HL, Hsieh YS. Carbonic anhydrase XII promotes invasion and migration ability of MDA-MB-231 breast cancer cells through the p38 MAPK signaling pathway. Eur J Cell Biol 2010;89:598-606.
28. Watson PH, Chia SK, Wykoff CC, et al. Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma. Br J Cancer 2003;88:1065-70. (Pubitemid 36560777)
29. Turner BC, Zhang J, Gumbs AA, et al. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Res 1998;58:5466-72. (Pubitemid 28551131)
30. Gee JM, Robertson JF, Ellis IO, Nicholson RI, Hurst HC. Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer. J Pathol 1999;189:514-20.
31. Li H, Watts GS, Oshiro MM, Futscher BW, Domann FE. AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells. Oncogene 2006;25:5405-15. (Pubitemid 44330283)
32. Ghadersohi A, Sood AK. Prostate epithelium-derived Ets transcription factor mRNA is overexpressed in human breast tumors and is a candidate breast tumor marker and a breast tumor antigen. Clin Cancer Res 2001;7:2731-8. (Pubitemid 32911378)
33. Feldman RJ, Sementchenko VI, Gayed M, Fraig MM, Watson DK. Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression. Cancer Res 2003;63:4626-31. (Pubitemid 36951040)
34. Ghadersohi A, Pan D, Fayazi Z, Hicks DG, Winston JS, Li F. Prostate-derived Ets transcription factor (PDEF) downregulates survivin expression and inhibits breast cancer cell growth in vitro and xenograft tumor formation in vivo. Breast Cancer Res Treat 2007;102:19-30.
35. Turcotte S, Forget MA, Beauseigle D, Nassif E, Lapointe R. Prostate-derived Ets transcription factor overexpression is associated with nodal metastasis and hormone receptor positivity in invasive breast cancer. Neoplasia 2007;9:788-96. (Pubitemid 47623418)
36. Park KS, Korfhagen TR, Bruno MD, et al. SPDEF regulates goblet cell hyperplasia in the airway epithelium. J Clin Invest 2007;117:978-88. (Pubitemid 46556754)
37. Kook H, Epstein JA. Hopping to the beat. Hop regulation of cardiac gene expression. Trends Cardiovasc Med 2003;13:261-4. (Pubitemid 37159389)
38. Lemaire F, Millon R, Muller D, et al. Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma. Br J Cancer 2004;91:258-61. (Pubitemid 39037069)
39. Asanoma K, Matsuda T, Kondo H, et al. NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. Genomics 2003;81:15-25. (Pubitemid 36263355)
40. Chen Y, Petersen S, Pacyna-Gengelbach M, Pietas A, Petersen I. Identification of a novel homeobox-containing gene, LAGY, is downregulated in lung cancer. Oncology 2003;64:450-8. (Pubitemid 36682961)
41. Chen Y, Pacyna-Gengelbach M, Deutschmann N, Niesporek S, Petersen I. Homeobox gene HOP has a potential tumor suppressive activity in human lung cancer. Int J Cancer 2007;121:1021-7. (Pubitemid 47101638)
42. Fukuzawa T, Hirose S. Multiple processing of Ig-Hepta/GPR116, a G protein-coupled receptor with immunoglobulin (Ig)-like repeats, and generation of EGF2-like fragment. J Biochem 2006;140:445-52. (Pubitemid 44703163)
43. Bjarnadóttir TK, Geirardsdóttir K, Ingemansson M, et al. Identification of novel splice variants of Adhesion G protein-coupled receptors. Gene 2007;387:38-48. (Pubitemid 44959561)
44. Abe J, Suzuki H, Notoya M, Yamamoto T, Hirose S. Ig-hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs. J Biol Chem 1999;274:19957-64.
45. Guttinger M, Sutti F, Panigada M, et al. Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis. J Cell Biol 1998;141:1061-71. (Pubitemid 28243972)
46. Teesalu T, Grassi F, Guttinger M. Expression pattern of the epithelial v-like antigen (Eva) transcript suggests a possible role in placental morphogenesis. Dev Genet 1998;23:317-23. (Pubitemid 29019100)
47. Difilippantonio S, Chen Y, Pietas A, et al. Gene expression profiles in human non-small and small-cell lung cancers. Eur J Cancer 2003;39:1936-47. (Pubitemid 37311192)
48. Jarzab B, Wiench M, Fujarewicz K, et al. Gene expression profile of papillary thyroid cancer: sources of variability and diagnostic implications. Cancer Res 2005;65:1587-97. (Pubitemid 40270189)
49. Reynolds SD, Reynolds PR, Pryhuber GS, Finder JD, Stripp BR. Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. Am J Respir Crit Care Med 2002;166:1498-509. (Pubitemid 35387301)
50. Kurotani R, Tomita T, Yang Q, Carlson BA, Chen C, Kimura S. Role of secretoglobin 3A2 in lung development. Am J Respir Crit Care Med 2008;178:389-98.
51. Kurotani R, Kumaki N, Naizhen X, Ward JM, Linnoila RI, Kimura S. Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans. Lung Cancer 2011;71:42-8.
52. Liu D, Nakano J, Ishikawa S, et al. Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small cell lung cancer. Lung Cancer 2007;58:384-91. (Pubitemid 350051513)
53. Liu H, Zhang T, Li X, et al. Predictive value of MMP-7 expression for response to chemotherapy and survival in patients with non-small cell lung cancer. Cancer Sci 2008;99:2185-92.
54. Leinonen T, Pirinen R, Böhm J, Johansson R, Ropponen K, Kosma VM. Expression of matrix metalloproteinases 7 and 9 in non-small cell lung cancer. Relation to clinicopathological factors, beta-catenin and prognosis. Lung Cancer 2006;51:313-21. (Pubitemid 43265814)
55. Konstantinovsky S, Smith Y, Zilber S. Breast carcinoma cells in primary tumors and effusions have different gene array profiles. J Oncol 2010;2010:969084.