Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes

Immunity

Volumn 45, Issue 4, 2016, Pages 774-787

  Stienne, Caroline ^a,b   Michieletto, Michaël F ^a,b   Benamar, Mehdi ^a,b   Carrié, Nadège ^c   Bernard, Isabelle ^a,b   Nguyen, Xuan Hung ^a,b   Lippi, Yannick ^d   Duguet, Fanny ^a,b   Liblau, Roland S ^a,b   Hedrick, Stephen M ^e   Saoudi, Abdelhadi ^a,b   Dejean, Anne S ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c Centre de Physiopathologie de Toulouse Purpan ^*  (France)

^d TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

autoimmunity; CD4 T cell differentiation; EAE; Eomes; GM CSF; IFN ; pathogenic Th1; T bet; transcription factors

Indexed keywords

EOMESODERMIN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LENTIVIRUS VECTOR; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FKHRL1; EOMES PROTEIN, MOUSE; FOXO3 PROTEIN, MOUSE; INTERLEUKIN 1; LYMPHOCYTE ANTIGEN RECEPTOR; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENE OVEREXPRESSION; GENE TARGETING; LYMPHOCYTE DIFFERENTIATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CELL LINE; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; INFLAMMATION; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FORKHEAD BOX PROTEIN O3; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEK293 CELLS; HUMANS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-1; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; T-BOX DOMAIN PROTEINS; TH1 CELLS; TRANSCRIPTION FACTORS;

EID: 84994850612     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.09.010     Document Type: Article

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