메뉴 건너뛰기




Volumn 2016, Issue , 2016, Pages

Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL DEATH; CHEMICAL ACTIVATION; ENZYMES; GENE EXPRESSION; PATHOLOGY;

EID: 84994635782     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/7864150     Document Type: Article
Times cited : (74)

References (55)
  • 1
    • 84905589188 scopus 로고    scopus 로고
    • Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis
    • V. Schick, J. A. Scheiber, F. C. Mooren et al., "Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis, " Gut, vol. 63, no. 9, pp. 1469-1480, 2014.
    • (2014) Gut , vol.63 , Issue.9 , pp. 1469-1480
    • Schick, V.1    Scheiber, J.A.2    Mooren, F.C.3
  • 2
    • 0037350904 scopus 로고    scopus 로고
    • Evolving concepts in the pathophysiology of acute pancreatitis
    • N. Zyromski and M. M. Murr, "Evolving concepts in the pathophysiology of acute pancreatitis, " Surgery, vol. 133, no. 3, pp. 235-237, 2003.
    • (2003) Surgery , vol.133 , Issue.3 , pp. 235-237
    • Zyromski, N.1    Murr, M.M.2
  • 3
    • 33947318807 scopus 로고    scopus 로고
    • Acute pancreatitis: Bench to the bedside
    • S. J. Pandol, A. K. Saluja, C. W. Imrie, and P. A. Banks, "Acute pancreatitis: bench to the bedside, " Gastroenterology, vol. 132, no. 3, pp. 1127-1151, 2007.
    • (2007) Gastroenterology , vol.132 , Issue.3 , pp. 1127-1151
    • Pandol, S.J.1    Saluja, A.K.2    Imrie, C.W.3    Banks, P.A.4
  • 4
    • 70449424176 scopus 로고    scopus 로고
    • Cross-talk between oxidative stress and pro-inflammatory cytokines in acute pancreatitis: A key role for protein phosphatases
    • J. Escobar, J. Pereda, A. Arduini et al., "Cross-talk between oxidative stress and pro-inflammatory cytokines in acute pancreatitis: a key role for protein phosphatases, " Current Pharmaceutical Design, vol. 15, no. 26, pp. 3027-3042, 2009.
    • (2009) Current Pharmaceutical Design , vol.15 , Issue.26 , pp. 3027-3042
    • Escobar, J.1    Pereda, J.2    Arduini, A.3
  • 5
    • 0025059777 scopus 로고
    • Oxygen free radicals in acute pancreatitis of the rat
    • M. H. Schoenberg, M. Buchler, M. Gaspar et al., "Oxygen free radicals in acute pancreatitis of the rat, " Gut, vol. 31, no. 10, pp. 1138-1143, 1990.
    • (1990) Gut , vol.31 , Issue.10 , pp. 1138-1143
    • Schoenberg, M.H.1    Buchler, M.2    Gaspar, M.3
  • 6
    • 0031836766 scopus 로고    scopus 로고
    • Oxidative stress: An important phenomenon with pathogenetic significance in the progression of acute pancreatitis
    • K. Tsai, S.-S. Wang, T.-S. Chen et al., "Oxidative stress: an important phenomenon with pathogenetic significance in the progression of acute pancreatitis, " Gut, vol. 42, no. 6, pp. 850-855, 1998.
    • (1998) Gut , vol.42 , Issue.6 , pp. 850-855
    • Tsai, K.1    Wang, S.-S.2    Chen, T.-S.3
  • 7
    • 0038378322 scopus 로고    scopus 로고
    • Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis
    • P. Talalay, A. T. Dinkova-Kostova, and W. D. Holtzclaw, "Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis, " Advances in Enzyme Regulation, vol. 43, pp. 121-134, 2003.
    • (2003) Advances in Enzyme Regulation , vol.43 , pp. 121-134
    • Talalay, P.1    Dinkova-Kostova, A.T.2    Holtzclaw, W.D.3
  • 8
    • 34249094270 scopus 로고    scopus 로고
    • Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2
    • C. D. Fisher, L. M. Augustine, J. M. Maher et al., "Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2, " Drug Metabolism and Disposition, vol. 35, no. 6, pp. 995-1000, 2007.
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.6 , pp. 995-1000
    • Fisher, C.D.1    Augustine, L.M.2    Maher, J.M.3
  • 9
    • 0033027090 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathogenesis of caerulein-induced acute pancreatitis
    • A. Dabrowski, S. J. Konturek, J. W. Konturek, and A. Gabryelewicz, "Role of oxidative stress in the pathogenesis of caerulein-induced acute pancreatitis, " European Journal of Pharmacology, vol. 377, no. 1, pp. 1-11, 1999.
    • (1999) European Journal of Pharmacology , vol.377 , Issue.1 , pp. 1-11
    • Dabrowski, A.1    Konturek, S.J.2    Konturek, J.W.3    Gabryelewicz, A.4
  • 10
    • 80054031724 scopus 로고    scopus 로고
    • Antioxidant therapy in acute pancreatitis: Experimental and clinical evidence
    • T. Hackert and J. Werner, "Antioxidant therapy in acute pancreatitis: experimental and clinical evidence, " Antioxidants and Redox Signaling, vol. 15, no. 10, pp. 2767-2777, 2011.
    • (2011) Antioxidants and Redox Signaling , vol.15 , Issue.10 , pp. 2767-2777
    • Hackert, T.1    Werner, J.2
  • 11
    • 0026648158 scopus 로고
    • Effects of antioxidants and free radical scavengers in three different models of acute pancreatitis
    • C. Niederau, M. Niederau, F. Borchard et al., "Effects of antioxidants and free radical scavengers in three different models of acute pancreatitis, " Pancreas, vol. 7, no. 4, pp. 486-496, 1992.
    • (1992) Pancreas , vol.7 , Issue.4 , pp. 486-496
    • Niederau, C.1    Niederau, M.2    Borchard, F.3
  • 12
    • 84907228622 scopus 로고    scopus 로고
    • Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis inmice
    • J.-D. Ren, J. Ma, J. Hou et al., "Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis inmice, "Mediators of Inflammation, vol. 2014, Article ID 930894, 9 pages, 2014.
    • (2014) Mediators of Inflammation , vol.2014
    • Ren, J.-D.1    Ma, J.2    Hou, J.3
  • 13
    • 84888104450 scopus 로고    scopus 로고
    • Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention
    • H. Liu and P. Talalay, "Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention, " Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 47, pp. 19065-19070, 2013.
    • (2013) Proceedings of the National Academy of Sciences of the United States of America , vol.110 , Issue.47 , pp. 19065-19070
    • Liu, H.1    Talalay, P.2
  • 15
    • 67549138277 scopus 로고    scopus 로고
    • Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans
    • A. Yanaka, J. W. Fahey, A. Fukumoto et al., "Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans, " Cancer Prevention Research, vol. 2, no. 4, pp. 353-360, 2009.
    • (2009) Cancer Prevention Research , vol.2 , Issue.4 , pp. 353-360
    • Yanaka, A.1    Fahey, J.W.2    Fukumoto, A.3
  • 17
    • 84870302408 scopus 로고    scopus 로고
    • Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response
    • Y. Zheng, S. Tao, F. Lian et al., "Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response, " Toxicology and Applied Pharmacology, vol. 265, no. 3, pp. 292-299, 2012.
    • (2012) Toxicology and Applied Pharmacology , vol.265 , Issue.3 , pp. 292-299
    • Zheng, Y.1    Tao, S.2    Lian, F.3
  • 18
    • 84953439638 scopus 로고    scopus 로고
    • Sulforaphane inhibits multiple inflammasomes through an nrf2-independentmechanism
    • A. J. Greaney, N. K. Maier, S. H. Leppla, and M. Moayeri, "Sulforaphane inhibits multiple inflammasomes through an nrf2-independentmechanism, " Journal of Leukocyte Biology, vol. 99, no. 1, pp. 189-199, 2016.
    • (2016) Journal of Leukocyte Biology , vol.99 , Issue.1 , pp. 189-199
    • Greaney, A.J.1    Maier, N.K.2    Leppla, S.H.3    Moayeri, M.4
  • 19
    • 79959983521 scopus 로고    scopus 로고
    • TLR9 and the NLRP3 inflammasome link acinar cell deathwith inflammation in acute pancreatitis
    • R. Hoque, M. Sohail, A. Malik et al., "TLR9 and the NLRP3 inflammasome link acinar cell deathwith inflammation in acute pancreatitis, " Gastroenterology, vol. 141, no. 1, pp. 358-369, 2011.
    • (2011) Gastroenterology , vol.141 , Issue.1 , pp. 358-369
    • Hoque, R.1    Sohail, M.2    Malik, A.3
  • 20
    • 78650901935 scopus 로고    scopus 로고
    • Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate
    • G. Kallifatidis, S. Labsch, V. Rausch et al., "Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate, "MolecularTherapy, vol. 19, no. 1, pp. 188-195, 2011.
    • (2011) MolecularTherapy , vol.19 , Issue.1 , pp. 188-195
    • Kallifatidis, G.1    Labsch, S.2    Rausch, V.3
  • 22
    • 33845503069 scopus 로고    scopus 로고
    • Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury
    • M. Bhatia and A. Hegde, "Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury, " Regulatory Peptides, vol. 138, no. 1, pp. 40-48, 2007.
    • (2007) Regulatory Peptides , vol.138 , Issue.1 , pp. 40-48
    • Bhatia, M.1    Hegde, A.2
  • 23
    • 0035179805 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis
    • V. P. Singh, A. K. Saluja, L. Bhagat et al., "Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis, " Journal of Clinical Investigation, vol. 108, no. 9, pp. 1387-1395, 2001.
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.9 , pp. 1387-1395
    • Singh, V.P.1    Saluja, A.K.2    Bhagat, L.3
  • 24
    • 0014421644 scopus 로고
    • Formation ofmalonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation
    • W. G. Niehaus Jr. and B. Samuelsson, "Formation ofmalonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation, " European Journal of Biochemistry, vol. 6, no. 1, pp. 126-130, 1968.
    • (1968) European Journal of Biochemistry , vol.6 , Issue.1 , pp. 126-130
    • Niehaus, W.G.1    Samuelsson, B.2
  • 25
    • 77749310344 scopus 로고    scopus 로고
    • Melatonin ameliorates cerulein-induced pancreatitis by themodulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats
    • K. H. Jung, S.-W. Hong, H.-M. Zheng et al., "Melatonin ameliorates cerulein-induced pancreatitis by themodulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats, " Journal of Pineal Research, vol. 48, no. 3, pp. 239-250, 2010.
    • (2010) Journal of Pineal Research , vol.48 , Issue.3 , pp. 239-250
    • Jung, K.H.1    Hong, S.-W.2    Zheng, H.-M.3
  • 27
    • 77952890132 scopus 로고    scopus 로고
    • Hydrogen sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kB and Src-family kinases pathway
    • R. Tamizhselvi, Y.-H. Koh, J. Sun, H. Zhang, and M. Bhatia, "Hydrogen sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kB and Src-family kinases pathway, " Experimental Cell Research, vol. 316, no. 9, pp. 1625-1636, 2010.
    • (2010) Experimental Cell Research , vol.316 , Issue.9 , pp. 1625-1636
    • Tamizhselvi, R.1    Koh, Y.-H.2    Sun, J.3    Zhang, H.4    Bhatia, M.5
  • 29
    • 84920272210 scopus 로고    scopus 로고
    • Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IkB kinase (IKK)-NF-kB and p38/ERKMAPK pathways
    • K.-W. Zeng, Q. Yu, F.-J. Song et al., "Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IkB kinase (IKK)-NF-kB and p38/ERKMAPK pathways, " European Journal of Pharmacology, vol. 748, pp. 18-29, 2015.
    • (2015) European Journal of Pharmacology , vol.748 , pp. 18-29
    • Zeng, K.-W.1    Yu, Q.2    Song, F.-J.3
  • 30
    • 84871272183 scopus 로고    scopus 로고
    • Activation of nuclear factor-kB in acinar cells increases the severity of pancreatitis in mice
    • H. Huang, Y. Liu, J. Daniluk et al., "Activation of nuclear factor-kB in acinar cells increases the severity of pancreatitis in mice, " Gastroenterology, vol. 144, no. 1, pp. 202-210, 2013.
    • (2013) Gastroenterology , vol.144 , Issue.1 , pp. 202-210
    • Huang, H.1    Liu, Y.2    Daniluk, J.3
  • 31
    • 77749304034 scopus 로고    scopus 로고
    • Critical functions of priming and lysosomal damage for NLRP3 activation
    • V. Hornung and E. Latz, "Critical functions of priming and lysosomal damage for NLRP3 activation, " European Journal of Immunology, vol. 40, no. 3, pp. 620-623, 2010.
    • (2010) European Journal of Immunology , vol.40 , Issue.3 , pp. 620-623
    • Hornung, V.1    Latz, E.2
  • 32
    • 9144244213 scopus 로고    scopus 로고
    • Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming DNA-damaging activities by glucoraphanin, the bioprecursor of the chemopreventive agent sulforaphane found in broccoli
    • M. Paolini, P. Perocco, D. Canistro et al., "Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming DNA-damaging activities by glucoraphanin, the bioprecursor of the chemopreventive agent sulforaphane found in broccoli, " Carcinogenesis, vol. 25, no. 1, pp. 61-67, 2004.
    • (2004) Carcinogenesis , vol.25 , Issue.1 , pp. 61-67
    • Paolini, M.1    Perocco, P.2    Canistro, D.3
  • 33
    • 69949157311 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP)Mice: Implication of induction ofNrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway
    • Y.-S. Keum, T. Oo Khor, W. Lin et al., "Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP)Mice: implication of induction ofNrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway, " Pharmaceutical Research, vol. 26, no. 10, pp. 2324-2331, 2009.
    • (2009) Pharmaceutical Research , vol.26 , Issue.10 , pp. 2324-2331
    • Keum, Y.-S.1    Oo Khor, T.2    Lin, W.3
  • 34
    • 84889011357 scopus 로고    scopus 로고
    • Kinetics of sulforaphane in mice after consumption of sulforaphaneenriched broccoli sprout preparation
    • Y. Li, T. Zhang, X. Li, P. Zou, S. J. Schwartz, and D. Sun, "Kinetics of sulforaphane in mice after consumption of sulforaphaneenriched broccoli sprout preparation, "Molecular Nutrition and Food Research, vol. 57, no. 12, pp. 2128-2136, 2013.
    • (2013) Molecular Nutrition and Food Research , vol.57 , Issue.12 , pp. 2128-2136
    • Li, Y.1    Zhang, T.2    Li, X.3    Zou, P.4    Schwartz, S.J.5    Sun, D.6
  • 35
    • 83555173511 scopus 로고    scopus 로고
    • Metabolismand tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice
    • J. D. Clarke, A. Hsu, D. E. Williams et al., "Metabolismand tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice, " Pharmaceutical Research, vol. 28, no. 12, pp. 3171-3179, 2011.
    • (2011) Pharmaceutical Research , vol.28 , Issue.12 , pp. 3171-3179
    • Clarke, J.D.1    Hsu, A.2    Williams, D.E.3
  • 36
    • 84908409590 scopus 로고    scopus 로고
    • Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane
    • G. V. Bricker, K. M. Riedl, R. A. Ralston, K. L. Tober, T. M. Oberyszyn, and S. J. Schwartz, "Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane, " Molecular Nutrition and Food Research, vol. 58, no. 10, pp. 1991-2000, 2014.
    • (2014) Molecular Nutrition and Food Research , vol.58 , Issue.10 , pp. 1991-2000
    • Bricker, G.V.1    Riedl, K.M.2    Ralston, R.A.3    Tober, K.L.4    Oberyszyn, T.M.5    Schwartz, S.J.6
  • 37
    • 84935458893 scopus 로고    scopus 로고
    • Sulforaphane protects the heart from doxorubicin-induced toxicity
    • P. Singh, R. Sharma, K. McElhanon et al., "Sulforaphane protects the heart from doxorubicin-induced toxicity, " Free Radical Biology and Medicine, vol. 86, pp. 90-101, 2015.
    • (2015) Free Radical Biology and Medicine , vol.86 , pp. 90-101
    • Singh, P.1    Sharma, R.2    McElhanon, K.3
  • 38
    • 84944474536 scopus 로고    scopus 로고
    • Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
    • L. Wang, Z. Tian, Q. Yang et al., "Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway, " Oncotarget, vol. 6, no. 28, pp. 25917-25931, 2015.
    • (2015) Oncotarget , vol.6 , Issue.28 , pp. 25917-25931
    • Wang, L.1    Tian, Z.2    Yang, Q.3
  • 39
    • 0035543010 scopus 로고    scopus 로고
    • Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile
    • N. V. Matusheski and E. H. Jeffery, "Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile, " Journal of Agricultural and Food Chemistry, vol. 49, no. 12, pp. 5743-5749, 2001.
    • (2001) Journal of Agricultural and Food Chemistry , vol.49 , Issue.12 , pp. 5743-5749
    • Matusheski, N.V.1    Jeffery, E.H.2
  • 40
    • 33748089664 scopus 로고    scopus 로고
    • Inhibition of 7, 12-Dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
    • C. Xu, M.-T. Huang, G. Shen et al., "Inhibition of 7, 12-Dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2, " Cancer Research, vol. 66, no. 16, pp. 8293-8296, 2006.
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 8293-8296
    • Xu, C.1    Huang, M.-T.2    Shen, G.3
  • 41
    • 18144407246 scopus 로고    scopus 로고
    • Green tea extract and ()-epigallocatechin-3-gallate, themajor tea catechin, exert oxidant but lack antioxidant activities
    • L. Elbling, R.-M. Weiss, O. Teufelhofer et al., "Green tea extract and ()-epigallocatechin-3-gallate, themajor tea catechin, exert oxidant but lack antioxidant activities, " The FASEB Journal, vol. 19, no. 7, pp. 807-809, 2005.
    • (2005) The FASEB Journal , vol.19 , Issue.7 , pp. 807-809
    • Elbling, L.1    Weiss, R.-M.2    Teufelhofer, O.3
  • 42
    • 0035153227 scopus 로고    scopus 로고
    • High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
    • A. Enomoto, K. Itoh, E. Nagayoshi et al., "High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes, " Toxicological Sciences, vol. 59, no. 1, pp. 169-177, 2001.
    • (2001) Toxicological Sciences , vol.59 , Issue.1 , pp. 169-177
    • Enomoto, A.1    Itoh, K.2    Nagayoshi, E.3
  • 43
    • 79952585899 scopus 로고    scopus 로고
    • Haem oxygenase-I and cardiovascular disease: Mechanisms and therapeutic potential
    • K. H. Chan, M. K. C. Ng, and R. Stocker, "Haem oxygenase-I and cardiovascular disease: mechanisms and therapeutic potential, " Clinical Science, vol. 120, no. 12, pp. 493-504, 2011.
    • (2011) Clinical Science , vol.120 , Issue.12 , pp. 493-504
    • Chan, K.H.1    Ng, M.K.C.2    Stocker, R.3
  • 44
    • 84940676188 scopus 로고    scopus 로고
    • Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia-reperfusion injury: Role of Nrf2/ARE pathway
    • L. Cheng, Z. Jin, R. Zhao, K. Ren, C. Deng, and S. Yu, "Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia-reperfusion injury: role of Nrf2/ARE pathway, " International Journal of Clinical and Experimental Medicine, vol. 8, no. 7, pp. 10420-10428, 2015.
    • (2015) International Journal of Clinical and Experimental Medicine , vol.8 , Issue.7 , pp. 10420-10428
    • Cheng, L.1    Jin, Z.2    Zhao, R.3    Ren, K.4    Deng, C.5    Yu, S.6
  • 45
    • 84939887400 scopus 로고    scopus 로고
    • Danhong injection attenuates ischemia/reperfusion-induced brain damage which is associating with Nrf2 levels in vivo and in vitro
    • H. Guo, M.-J. Li, Q.-Q. Liu et al., "Danhong injection attenuates ischemia/reperfusion-induced brain damage which is associating with Nrf2 levels in vivo and in vitro, " Neurochemical Research, vol. 39, no. 9, pp. 1817-1824, 2014.
    • (2014) Neurochemical Research , vol.39 , Issue.9 , pp. 1817-1824
    • Guo, H.1    Li, M.-J.2    Liu, Q.-Q.3
  • 46
    • 84904766351 scopus 로고    scopus 로고
    • Protective effects of BML-111 on cerulein-induced acute pancreatitis-associated lung injury via activation of Nrf2/ARE signaling pathway
    • Y.-Z. Wang, Y.-C. Zhang, J.-S. Cheng et al., "Protective effects of BML-111 on cerulein-induced acute pancreatitis-associated lung injury via activation of Nrf2/ARE signaling pathway, " Inflammation, vol. 37, no. 4, pp. 1120-1133, 2014.
    • (2014) Inflammation , vol.37 , Issue.4 , pp. 1120-1133
    • Wang, Y.-Z.1    Zhang, Y.-C.2    Cheng, J.-S.3
  • 47
    • 84865716255 scopus 로고    scopus 로고
    • Theprotection by Octreotide against experimental ischemic stroke: Up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-kB expression
    • L. Chen, L. Wang, X. Zhang et al., "Theprotection by Octreotide against experimental ischemic stroke: up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-kB expression, " Brain Research, vol. 1475, pp. 80-87, 2012.
    • (2012) Brain Research , vol.1475 , pp. 80-87
    • Chen, L.1    Wang, L.2    Zhang, X.3
  • 48
    • 84886237017 scopus 로고    scopus 로고
    • Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice
    • B. Li, W. Cui, J. Liu et al., "Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice, " Experimental Neurology, vol. 250, pp. 239-249, 2013.
    • (2013) Experimental Neurology , vol.250 , pp. 239-249
    • Li, B.1    Cui, W.2    Liu, J.3
  • 49
    • 84940039877 scopus 로고    scopus 로고
    • Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells
    • P. Santofimia-Castaño, D. Clea Ruy, L. Garcia-Sanchez et al., "Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells, " Free Radical Biology and Medicine, vol. 87, pp. 226-236, 2015.
    • (2015) Free Radical Biology and Medicine , vol.87 , pp. 226-236
    • Santofimia-Castaño, P.1    Clea Ruy, D.2    Garcia-Sanchez, L.3
  • 50
    • 59149098593 scopus 로고    scopus 로고
    • Sulforaphane protects against cytokine-and streptozotocin-induced α-cell damage by suppressing the NF-kB pathway
    • M.-Y. Song, E.-K. Kim, W.-S. Moon et al., "Sulforaphane protects against cytokine-and streptozotocin-induced α-cell damage by suppressing the NF-kB pathway, " Toxicology and Applied Pharmacology, vol. 235, no. 1, pp. 57-67, 2009.
    • (2009) Toxicology and Applied Pharmacology , vol.235 , Issue.1 , pp. 57-67
    • Song, M.-Y.1    Kim, E.-K.2    Moon, W.-S.3
  • 52
    • 9144220803 scopus 로고    scopus 로고
    • Attenuated cerulein-induced pancreatitis in nuclear factor-kB-deficient mice
    • D. Altavilla, C. Famulari, M. Passaniti et al., "Attenuated cerulein-induced pancreatitis in nuclear factor-kB-deficient mice, " Laboratory Investigation, vol. 83, no. 12, pp. 1723-1732, 2003.
    • (2003) Laboratory Investigation , vol.83 , Issue.12 , pp. 1723-1732
    • Altavilla, D.1    Famulari, C.2    Passaniti, M.3
  • 53
    • 59549099432 scopus 로고    scopus 로고
    • Disruption of Nrf2 enhances upregulation of nuclear factor-kB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury
    • W. Jin, H. Wang, W. Yan et al., "Disruption of Nrf2 enhances upregulation of nuclear factor-kB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury, " Mediators of Inflammation, vol. 2008, Article ID 725174, 7 pages, 2008.
    • (2008) Mediators of Inflammation , vol.2008
    • Jin, W.1    Wang, H.2    Yan, W.3
  • 54
    • 33645530745 scopus 로고    scopus 로고
    • Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
    • R. K. Thimmulappa, H. Lee, T. Rangasamy et al., "Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis, " The Journal of Clinical Investigation, vol. 116, no. 4, pp. 984-995, 2006.
    • (2006) The Journal of Clinical Investigation , vol.116 , Issue.4 , pp. 984-995
    • Thimmulappa, R.K.1    Lee, H.2    Rangasamy, T.3
  • 55
    • 73949086542 scopus 로고    scopus 로고
    • Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner
    • H. S. Youn, Y. S. Kim, Z. Y. Park et al., "Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner, " The Journal of Immunology, vol. 184, no. 1, pp. 411-419, 2010.
    • (2010) The Journal of Immunology , vol.184 , Issue.1 , pp. 411-419
    • Youn, H.S.1    Kim, Y.S.2    Park, Z.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.