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Volumn 6, Issue , 2016, Pages

Fluselenamyl: A novel benzoselenazole derivative for pet detection of amyloid plaques (Aβ) in Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; ORGANOSELENIUM DERIVATIVE; PROTEIN BINDING;

EID: 84994339395     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep35636     Document Type: Article
Times cited : (35)

References (62)
  • 1
    • 29144508843 scopus 로고    scopus 로고
    • Global prevalence of dementia: A delphi consensus study
    • Ferri, C. P., et al. Global prevalence of dementia: a Delphi consensus study. Lancet 366, 2112-2117 (2005
    • (2005) Lancet , vol.366 , pp. 2112-2117
    • Ferri, C.P.1
  • 3
    • 82755193805 scopus 로고    scopus 로고
    • Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-Transgene expression
    • Teipel, S. J., Buchert, R., Thome, J., Hampel, H., & Pahnke, J. Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-Transgene expression. Prog. Neurobiol. 95, 547-556, doi: 10.1016/j. pneurobio.2011.05.004 (2011
    • (2011) Prog. Neurobiol , vol.95 , pp. 547-556
    • Teipel, S.J.1    Buchert, R.2    Thome, J.3    Hampel, H.4    Pahnke, J.5
  • 4
    • 79952793175 scopus 로고    scopus 로고
    • Amyloid beta (abeta), and phospho-Tau (p-Tau) as diagnostic biomarkers in Alzheimer?s disease
    • Prvulovic, D., & Hampel, H. Amyloid beta (Abeta), and phospho-Tau (p-Tau) as diagnostic biomarkers in Alzheimer?s disease. Clin. Chem. Lab. Med. 49, 367-374, doi: 10.1515/CCLM.2011.087 (2011
    • (2011) Clin. Chem. Lab. Med , vol.49 , pp. 367-374
    • Prvulovic, D.1    Hampel, H.2
  • 5
    • 82755161905 scopus 로고    scopus 로고
    • Biomarkers for Alzheimer?s disease therapeutic trials
    • Hampel, H., et al. Biomarkers for Alzheimer?s disease therapeutic trials. Prog. Neurobiol. 95, 579-593, doi: 10.1016/j. pneurobio.2010.11.005 (2011
    • (2011) Prog. Neurobiol , vol.95 , pp. 579-593
    • Hampel, H.1
  • 6
    • 67349184808 scopus 로고    scopus 로고
    • Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease
    • Price, J. L., et al. Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol. Aging 30, 1026-1036, doi: 10.1016/j.neurobiolaging.2009.04.002 (2009
    • (2009) Neurobiol. Aging , vol.30 , pp. 1026-1036
    • Price, J.L.1
  • 7
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer?s disease with pittsburgh compound-b
    • Klunk, W., et al. Imaging brain amyloid in Alzheimer?s disease with Pittsburgh Compound-B. Ann. Neurol 55, 306-319 (2004
    • (2004) Ann Neurol , vol.55 , pp. 306-319
    • Klunk, W.1
  • 8
  • 9
    • 15944366880 scopus 로고    scopus 로고
    • Vivo imaging of Alzheimer disease β-Amyloid with [13C]SB-13 PET
    • Verhoeff, N., et al. In vivo imaging of Alzheimer disease β-Amyloid with [13C]SB-13 PET. Am. J. Geriatr. Psychiatry 12, 584-595 (2004
    • (2004) Am. J. Geriatr. Psychiatry , vol.12 , pp. 584-595
    • Verhoeff, N.1
  • 10
    • 70350716476 scopus 로고    scopus 로고
    • Preclinical properties of 18F-AV-45: A PET agent for Abeta plaques in the brain
    • Choi, S. R., et al. Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. J. Nucl. Med. 50, 1887-1894, doi: 10.2967/jnumed.109.065284 (2009
    • (2009) J. Nucl. Med , vol.50 , pp. 1887-1894
    • Choi, S.R.1
  • 11
    • 84877041796 scopus 로고    scopus 로고
    • Head-To-head comparison of 11C-PiB, and 18F-AZD4694 (NAV4694) for beta-Amyloid imaging in aging, and dementia
    • Rowe, C. C., et al. Head-To-head comparison of 11C-PiB, and 18F-AZD4694 (NAV4694) for beta-Amyloid imaging in aging, and dementia. J. Nucl. Med. 54, 880-886, doi: 10.2967/jnumed.112.114785 (2013
    • (2013) J. Nucl. Med , vol.54 , pp. 880-886
    • Rowe, C.C.1
  • 12
    • 84858607421 scopus 로고    scopus 로고
    • Clinical validation of 18F-AZD4694, an amyloid-beta-specific PET radioligand
    • Cselenyi, Z., et al. Clinical validation of 18F-AZD4694, an amyloid-beta-specific PET radioligand. J. Nucl. Med. 53, 415-424, doi: 10.2967/jnumed.111.094029 (2012
    • (2012) J. Nucl. Med , vol.53 , pp. 415-424
    • Cselenyi, Z.1
  • 13
    • 4644283049 scopus 로고    scopus 로고
    • Pet imaging of amyloid in Alzheimer?s disease
    • Nordberg, A. PET imaging of amyloid in Alzheimer?s disease. Lancet neurology 3, 519-527 (2004
    • (2004) Lancet Neurology , vol.3 , pp. 519-527
    • Nordberg, A.1
  • 14
    • 84964649273 scopus 로고    scopus 로고
    • Preclinical properties, and human in vivo assessment of 123I-ABC577 as a novel SPECT agent for imaging amyloidbeta
    • Maya, Y., et al. Preclinical properties, and human in vivo assessment of 123I-ABC577 as a novel SPECT agent for imaging amyloidbeta. Brain 139, 193-203, doi: 10.1093/brain/awv305 (2016
    • (2016) Brain , vol.139 , pp. 193-203
    • Maya, Y.1
  • 15
    • 84920409375 scopus 로고    scopus 로고
    • Vivo spect imaging of amyloid-beta deposition with radioiodinated imidazo[1, 2-A]pyridine derivative drm106 in a mouse model of Alzheimer?s disease
    • Chen, C. J., et al. In vivo SPECT imaging of amyloid-beta deposition with radioiodinated imidazo[1, 2-A]pyridine derivative DRM106 in a mouse model of Alzheimer?s disease. J. Nucl. Med. 56, 120-126, doi: 10.2967/jnumed.114.146944 (2015
    • (2015) J. Nucl. Med , Issue.56 , pp. 120-126
    • Chen, C.J.1
  • 16
    • 84862529821 scopus 로고    scopus 로고
    • Correlation of early-phase 18f-florbetapir (av-45/amyvid) pet images to fdg images: Preliminary studies
    • Hsiao, I. T., et al. Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies. Eur J Nucl Med Mol Imaging 39, 613-620, doi: 10.1007/s00259-011-2051-2 (2012
    • (2012) Eur J Nucl Med Mol Imaging , vol.39 , pp. 613-620
    • Hsiao, I.T.1
  • 17
    • 66149104129 scopus 로고    scopus 로고
    • Whole-body biodistribution, and radiation dosimetry of 18F-GE067: A radioligand for in vivo brain amyloid imaging
    • Koole, M., et al. Whole-body biodistribution, and radiation dosimetry of 18F-GE067: a radioligand for in vivo brain amyloid imaging. J. Nucl. Med. 50, 818-822, doi: 10.2967/jnumed.108.060756 (2009
    • (2009) J. Nucl. Med , vol.50 , pp. 818-822
    • Koole, M.1
  • 18
    • 68249141258 scopus 로고    scopus 로고
    • Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers, and patients with probable Alzheimer disease
    • Nelissen, N., et al. Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers, and patients with probable Alzheimer disease. J. Nucl. Med. 50, 1251-1259, doi: 10.2967/jnumed.109.063305 (2009
    • (2009) J. Nucl. Med , vol.50 , pp. 1251-1259
    • Nelissen, N.1
  • 19
    • 38149081191 scopus 로고    scopus 로고
    • Imaging of amyloid beta in Alzheimer?s disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism
    • Rowe, C. C., et al. Imaging of amyloid beta in Alzheimer?s disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet neurology 7, 129-135, doi: 10.1016/S1474-4422(08)70001-2 (2008
    • (2008) Lancet Neurology , vol.7 , pp. 129-135
    • Rowe, C.C.1
  • 20
    • 80051688987 scopus 로고    scopus 로고
    • Amyloid imaging with 18)F-florbetaben in Alzheimer disease, and other dementias
    • Villemagne, V. L., et al. Amyloid imaging with (18)F-florbetaben in Alzheimer disease, and other dementias. J. Nucl. Med. 52, 1210-1217, doi: 10.2967/jnumed.111.089730 (2011
    • (2011) J. Nucl. Med , vol.52 , pp. 1210-1217
    • Villemagne, V.L.1
  • 21
    • 84877106494 scopus 로고    scopus 로고
    • PET quantification of 18F-florbetaben binding to beta-Amyloid deposits in human brains
    • Becker, G. A., et al. PET quantification of 18F-florbetaben binding to beta-Amyloid deposits in human brains. J. Nucl. Med. 54, 723-731, doi: 10.2967/jnumed.112.107185 (2013
    • (2013) J. Nucl. Med , vol.54 , pp. 723-731
    • Becker, G.A.1
  • 22
    • 77953937194 scopus 로고    scopus 로고
    • Vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapircorrected F 18
    • Wong, D F., et al. In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapircorrected] F 18). J. Nucl. Med 51 913-920 10.2967/jnumed.109.069088 2010
    • (2010) J. Nucl. Med , Issue.51 , pp. 913-920
    • Wong, D.F.1
  • 23
    • 84879980176 scopus 로고    scopus 로고
    • Amyloid tracers detect multiple binding sites in Alzheimer?s disease brain tissue
    • Ni, R., Gillberg, P. G., Bergfors, A., Marutle, A., & Nordberg, A. Amyloid tracers detect multiple binding sites in Alzheimer?s disease brain tissue. Brain 136, 2217-2227, doi: 10.1093/brain/awt142 (2013
    • (2013) Brain , vol.136 , pp. 2217-2227
    • Ni, R.1    Gillberg, P.G.2    Bergfors, A.3    Marutle, A.4    Nordberg, A.5
  • 24
    • 14844303913 scopus 로고    scopus 로고
    • Evidence for presence of three distinct binding sites for thioflavin t class of Alzheimer?s disease pet imaging agents on β-Amyloid peptide fibrils
    • Lockhart, A., et al. Evidence for presence of three distinct binding sites for thioflavin T class of Alzheimer?s disease PET imaging agents on β-Amyloid peptide fibrils. J. Biol. Chem. 280, 7677-7684 (2005
    • (2005) J. Biol. Chem , vol.280 , pp. 7677-7684
    • Lockhart, A.1
  • 25
    • 84904568939 scopus 로고    scopus 로고
    • Characterization of a brain permeant fluorescent molecule, and visualization of Aβ parenchymal plaques, using real-Time multiphoton imaging in transgenic mice
    • Sundaram, G., et al. Characterization of a brain permeant fluorescent molecule, and visualization of Aβ parenchymal plaques, using real-Time multiphoton imaging in transgenic mice. Org. Lett. 16, 3640-3643 (2014
    • (2014) Org. Lett , vol.16 , pp. 3640-3643
    • Sundaram, G.1
  • 26
    • 84994347306 scopus 로고    scopus 로고
    • Design and synthesis of a novel pet probe for early detection of Alzheimer?s disease
    • Sundaram, G., Cairns, N., Lee, J.-M., & Sharma, V. Design, and synthesis of a novel PET probe for early detection of Alzheimer?s disease. J. Nucl. Med. 55, 137 (2014
    • (2014) J. Nucl. Med , vol.55 , pp. 137
    • Sundaram, G.1    Cairns, N.2    Lee, J.-M.3    Sharma, V.4
  • 27
    • 84932648805 scopus 로고    scopus 로고
    • Syn thesis characterization, and preclinical validation of a pet radiopharmaceutical for interrogating abeta (beta-Amyloid) plaques in Alzheimer?s disease
    • Sundaram, G. S., et al. Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Abeta (beta-Amyloid) plaques in Alzheimer?s disease. EJNMMI research 5, 112, doi: 10.1186/s13550-015-0112-4 (2015
    • (2015) EJNMMI Research , vol.5 , pp. 112
    • Sundaram, G.S.1
  • 28
    • 35348854372 scopus 로고    scopus 로고
    • Copper I)-catalyzed highly efficient synthesis of benzoselenazoles, and benzotellurazoles
    • Fujiwara, S., Asanuma, Y., Shin-ike, T., & Kambe, N. Copper(I)-catalyzed highly efficient synthesis of benzoselenazoles, and benzotellurazoles. J. Org. Chem. 72, 8087-8090, doi: 10.1021/jo7013164 (2007
    • (2007) J. Org. Chem , Issue.72 , pp. 8087-8090
    • Fujiwara, S.1    Asanuma, Y.2    Shin-Ike, T.3    Kambe, N.4
  • 29
    • 84906964471 scopus 로고    scopus 로고
    • One pot preparation of 2-(alkyl)arylbenzoselenazoles from the coressponding N-(acetyl)benzoyl-2-iodoanilines via a microwave assisted methodology
    • Redon, S., Kabri, Y., Crozet, M., & Vanelle, P. One pot preparation of 2-(alkyl)arylbenzoselenazoles from the coressponding N-(acetyl)benzoyl-2-iodoanilines via a microwave assisted methodology. Tet Lett 55, 5052-5054 (2014
    • (2014) Tet Lett , vol.55 , pp. 5052-5054
    • Redon, S.1    Kabri, Y.2    Crozet, M.3    Vanelle, P.4
  • 30
    • 2542457758 scopus 로고    scopus 로고
    • Synthesis of [18F] Fluorocholine analogues as potential imaging agents for PET studies
    • Yu, K., Park, J., & Yang, S. Synthesis of [18F]Fluorocholine analogues as potential imaging agents for PET studies. Bull Korean Chem Soc 25, 506-510 (2004
    • (2004) Bull Korean Chem Soc , vol.25 , pp. 506-510
    • Yu, K.1    Park, J.2    Yang, S.3
  • 31
    • 84867356027 scopus 로고    scopus 로고
    • Vaccine development to treat Alzheimer?s disease neuropathology in app/ps1 transgenic mice
    • Carrera, I., et al. Vaccine Development to Treat Alzheimer?s Disease Neuropathology in APP/PS1 Transgenic Mice. International journal of Alzheimer?s disease 2012, 376138, doi: 10.1155/2012/376138 (2012
    • (2012) International Journal of Alzheimer?s Disease , vol.2012 , pp. 376138
    • Carrera, I.1
  • 32
    • 84868319492 scopus 로고    scopus 로고
    • Intravenous delivery of targeted liposomes to amyloid-beta pathology in app/psen1 transgenic mice
    • Tanifum, E. A., et al. Intravenous delivery of targeted liposomes to amyloid-beta pathology in APP/PSEN1 transgenic mice. PloS one 7, e48515, doi: 10.1371/journal.pone.0048515 (2012
    • (2012) PloS One , vol.7 , pp. e48515
    • Tanifum, E.A.1
  • 33
    • 0036678856 scopus 로고    scopus 로고
    • Clusterin promotes amyloid plaque formation, and is critical for neuritic toxicity in a mouse model of Alzheimer?s disease
    • DeMattos, R., O'dell, M., Parsadanian, M., Holtzman, D., et al. Clusterin promotes amyloid plaque formation, and is critical for neuritic toxicity in a mouse model of Alzheimer?s disease. Proc Natl Acad Sci USA 99, 10843-10848 (2002
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10843-10848
    • DeMattos, R.1    O'Dell, M.2    Parsadanian, M.3    Holtzman, D.4
  • 34
    • 80052574523 scopus 로고    scopus 로고
    • Serotonin signaling is associated with lower amyloid-beta levels, and plaques in transgenic mice, and humans
    • Cirrito, J. R., et al. Serotonin signaling is associated with lower amyloid-beta levels, and plaques in transgenic mice, and humans. Proc. Natl. Acad. Sci. USA 108, 14968-14973, doi: 10.1073/pnas.1107411108 (2011
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 14968-14973
    • Cirrito, J.R.1
  • 35
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer?s disease (cerad part II standardization of the neuropathologic assessment of Alzheimer?s disease
    • Mirra, S., et al. The Consortium to Establish a Registry for Alzheimer?s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer?s disease. Neurology 41, 479-486 (1991
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.1
  • 36
    • 0031255112 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the national institute on aging, and the reagan institute working group on diagnostic criteria for the neuropathological assessment of Alzheimer disease
    • Hyman, B., & Trojanowski, J. Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging, and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J. Neuropathol. Exp. Neurol. 56, 1095-1097 (1997
    • (1997) J. Neuropathol. Exp. Neurol , vol.56 , pp. 1095-1097
    • Hyman, B.1    Trojanowski, J.2
  • 37
    • 77955479272 scopus 로고    scopus 로고
    • Autopsy consent, brain collection, and standardized neuropathologic assessment of ADNI participants: The essential role of the neuropathology core
    • Cairns, N. J., Taylor-Reinwald, L., & Morris, J. C. Autopsy consent, brain collection, and standardized neuropathologic assessment of ADNI participants: the essential role of the neuropathology core. Alzheimer?s & dementia: the journal of the Alzheimer?s Association 6, 274-279, doi: 10.1016/j.jalz.2010.03.012 (2010
    • (2010) Alzheimer?s & Dementia the Journal of the Alzheimer?s Association , vol.6 , pp. 274-279
    • Cairns, N.J.1    Taylor-Reinwald, L.2    Morris, J.C.3
  • 38
    • 84869021291 scopus 로고    scopus 로고
    • Development of positron emission tomography beta-Amyloid plaque imaging agents
    • Mathis, C. A., Mason, N. S., Lopresti, B. J., & Klunk, W. E. Development of positron emission tomography beta-Amyloid plaque imaging agents. Semin. Nucl. Med. 42, 423-432, doi: 10.1053/j.semnuclmed.2012.07.001 (2012
    • (2012) Semin. Nucl. Med , vol.42 , pp. 423-432
    • Mathis, C.A.1    Mason, N.S.2    Lopresti, B.J.3    Klunk, W.E.4
  • 39
    • 84873564460 scopus 로고    scopus 로고
    • Binding of the radioligand SIL23 to alpha-synuclein fibrils in Parkinson disease brain tissue establishes feasibility, and screening approaches for developing a Parkinson disease imaging agent
    • Bagchi, D. P., et al. Binding of the radioligand SIL23 to alpha-synuclein fibrils in Parkinson disease brain tissue establishes feasibility, and screening approaches for developing a Parkinson disease imaging agent. PloS one 8, e55031, doi: 10.1371/journal.pone.0055031 (2013
    • (2013) PloS One , vol.8 , pp. e55031
    • Bagchi, D.P.1
  • 41
    • 84863230382 scopus 로고    scopus 로고
    • Correlation of amyloid PET ligand florbetapir F 18 binding with Abeta aggregation, and neuritic plaque deposition in postmortem brain tissue
    • Choi, S. R., et al. Correlation of amyloid PET ligand florbetapir F 18 binding with Abeta aggregation, and neuritic plaque deposition in postmortem brain tissue. Alzheimer Dis. Assoc. Disord. 26, 8-16, doi: 10.1097/WAD.0b013e31821300bc (2012
    • (2012) Alzheimer Dis. Assoc. Disord , vol.26 , pp. 8-16
    • Choi, S.R.1
  • 43
    • 59449097248 scopus 로고    scopus 로고
    • AZD2184: A radioligand for sensitive detection of beta-Amyloid deposits
    • Johnson, A. E., et al. AZD2184: a radioligand for sensitive detection of beta-Amyloid deposits. J. Neurochem. 108, 1177-1186, doi: 10.1111/j.1471-4159.2008.05861.x (2009
    • (2009) J. Neurochem , vol.108 , pp. 1177-1186
    • Johnson, A.E.1
  • 44
    • 84942305817 scopus 로고    scopus 로고
    • Structure-Activity relationship study of heterocyclic phenylethenyl, and pyridinylethenyl derivatives as tau-imaging agents that selectively detect neurofibrillary tangles in Alzheimer?s disease brains
    • Matsumura, K., et al. Structure-Activity Relationship Study of Heterocyclic Phenylethenyl, and Pyridinylethenyl Derivatives as Tau-Imaging Agents That Selectively Detect Neurofibrillary Tangles in Alzheimer?s Disease Brains. J. Med. Chem. 58, 7241-7257, doi: 10.1021/acs.jmedchem.5b00440 (2015
    • (2015) J. Med. Chem , vol.58 , pp. 7241-7257
    • Matsumura, K.1
  • 45
    • 0038792263 scopus 로고    scopus 로고
    • Syn thesis, and evaluation of 11C-labeled 6-substituted 2-Arylbenzothiazoles as amyloid imaging agents
    • Mathis, C., et al. Synthesis, and evaluation of 11C-labeled 6-substituted 2-Arylbenzothiazoles as amyloid imaging agents. J. Med. Chem. 46, 2740-2754 (2003
    • (2003) J. Med. Chem , vol.46 , pp. 2740-2754
    • Mathis, C.1
  • 46
    • 84868317595 scopus 로고    scopus 로고
    • Preclinical characterization of a novel class of 18F-labeled PET tracers for amyloid-beta
    • Brockschnieder, D., et al. Preclinical characterization of a novel class of 18F-labeled PET tracers for amyloid-beta. J. Nucl. Med. 53, 1794-1801, doi: 10.2967/jnumed.112.104810 (2012
    • (2012) J. Nucl. Med , vol.53 , pp. 1794-1801
    • Brockschnieder, D.1
  • 47
    • 0021020662 scopus 로고
    • Relationship between lipophilicity, and brain extraction of C-11 labeled radiopharmaceuticals
    • Dischino, D., Welch, M., Kilbourn, M., & Raichle, M. Relationship between lipophilicity, and brain extraction of C-11 labeled radiopharmaceuticals. J Nucl Med 24, 1030-1038 (1983
    • (1983) J Nucl Med , vol.24 , pp. 1030-1038
    • Dischino, D.1    Welch, M.2    Kilbourn, M.3    Raichle, M.4
  • 48
    • 84863658569 scopus 로고    scopus 로고
    • Molecular imaging of atherosclerosis for improving diagnostic, and therapeutic development
    • Quillard, T., & Libby, P. Molecular imaging of atherosclerosis for improving diagnostic, and therapeutic development. Circ. Res. 111, 231-244, doi: 10.1161/CIRCRESAHA.112.268144 (2012
    • (2012) Circ. Res , vol.111 , pp. 231-244
    • Quillard, T.1    Libby, P.2
  • 49
    • 77955924351 scopus 로고    scopus 로고
    • Multiphoton in vivo imaging of amyloid in animal models of Alzheimer?s disease
    • Dong, J., Revilla-Sanchez, R., Moss, S., & Haydon, P. G. Multiphoton in vivo imaging of amyloid in animal models of Alzheimer?s disease. Neuropharmacology 59, 268-275, doi: 10.1016/j.neuropharm.2010.04.007 (2010
    • (2010) Neuropharmacology , vol.59 , pp. 268-275
    • Dong, J.1    Revilla-Sanchez, R.2    Moss, S.3    Haydon, P.G.4
  • 51
    • 0034014950 scopus 로고    scopus 로고
    • F V. L. Single, and multiple transgenic mice as models for Alzheimer?s disease
    • F, v. L. Single, and multiple transgenic mice as models for Alzheimer?s disease. Prog. Neurobiol 61, 305-312 (2000
    • (2000) Prog. Neurobiol 61 , pp. 305-312
  • 52
    • 4243215848 scopus 로고    scopus 로고
    • Apolipoprotein e isoform-dependent amyloid deposition, and neuritic degeneration in a mouse model of Alzheimer?s disease
    • Holtzman, D., Bales, K., Tenkova, T., Paul, S., et al. Apolipoprotein E isoform-dependent amyloid deposition, and neuritic degeneration in a mouse model of Alzheimer?s disease. Proc Natl Acad Sci USA 97, 2892-2897 (2000
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2892-2897
    • Holtzman, D.1    Bales, K.2    Tenkova, T.3    Paul, S.4
  • 53
    • 0034992339 scopus 로고    scopus 로고
    • Tau and transgenic animal models
    • Gotz, J. Tau, and transgenic animal models. Brain Res. Brain Res. Rev. 35, 266-286 (2001
    • (2001) Brain Res. Brain Res. Rev , vol.35 , pp. 266-286
    • Gotz, J.1
  • 54
    • 77950461116 scopus 로고    scopus 로고
    • APP transgenic modeling of Alzheimer?s disease: Mechanisms of neurodegeneration, and aberrant neurogenesis
    • Crews, L., Rockenstein, E., & Masliah, E. APP transgenic modeling of Alzheimer?s disease: mechanisms of neurodegeneration, and aberrant neurogenesis. Brain structure & function 214, 111-126, doi: 10.1007/s00429-009-0232-6 (2010
    • (2010) Brain Structure & Function , vol.214 , pp. 111-126
    • Crews, L.1    Rockenstein, E.2    Masliah, E.3
  • 55
    • 0034847176 scopus 로고    scopus 로고
    • Neurodegenerative changes associated with beta-Amyloid deposition in the brains of mice carrying mutant amyloid precursor protein, and mutant presenilin-1 transgenes
    • Kurt, M. A., et al. Neurodegenerative changes associated with beta-Amyloid deposition in the brains of mice carrying mutant amyloid precursor protein, and mutant presenilin-1 transgenes. Exp. Neurol. 171, 59-71, doi: 10.1006/exnr.2001.7717 (2001
    • (2001) Exp. Neurol , vol.171 , pp. 59-71
    • Kurt, M.A.1
  • 56
    • 0142123057 scopus 로고    scopus 로고
    • Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice
    • Bacskai, B., et al. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice. Proc Natl Acad Sci USA 100, 12462-12467 (2003
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12462-12467
    • Bacskai, B.1
  • 57
    • 84923804486 scopus 로고    scopus 로고
    • Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models
    • Brendel, M., et al. Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models. PloS one 10, e0116678, doi: 10.1371/journal.pone.0116678 (2015
    • (2015) PloS One , vol.10 , pp. e0116678
    • Brendel, M.1
  • 58
    • 35348821915 scopus 로고    scopus 로고
    • Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-Amyloid treatment in a living mouse model of Alzheimer?s disease enabled by positron emission tomography
    • Maeda, J., et al. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-Amyloid treatment in a living mouse model of Alzheimer?s disease enabled by positron emission tomography. J. Neurosci. 27, 10957-10968, doi: 10.1523/JNEUROSCI.0673-07.2007 (2007
    • (2007) J. Neurosci , vol.27 , pp. 10957-10968
    • Maeda, J.1
  • 59
    • 84857959777 scopus 로고    scopus 로고
    • Small-Animal pet imaging of amyloid-beta plaques with [11c] pib, and its multi-modal validation in an app/ps1 mouse model of Alzheimer?s disease
    • Manook, A., et al. Small-Animal PET imaging of amyloid-beta plaques with [11C]PiB, and its multi-modal validation in an APP/PS1 mouse model of Alzheimer?s disease. PloS one 7, e31310, doi: 10.1371/journal.pone.0031310 (2012
    • (2012) PloS One , vol.7 , pp. e31310
    • Manook, A.1
  • 60
    • 84879911625 scopus 로고    scopus 로고
    • Longitudinal assessment of cerebral beta-Amyloid deposition in mice overexpressing Swedish mutant betaamyloid precursor protein using 18F-florbetaben PET
    • Rominger, A., et al. Longitudinal assessment of cerebral beta-Amyloid deposition in mice overexpressing Swedish mutant betaamyloid precursor protein using 18F-florbetaben PET. J. Nucl. Med. 54, 1127-1134, doi: 10.2967/jnumed.112.114660 (2013
    • (2013) J. Nucl. Med , vol.54 , pp. 1127-1134
    • Rominger, A.1
  • 61
    • 84881392145 scopus 로고    scopus 로고
    • Longitudinal amyloid imaging in mouse brain with 11c-pib: Comparison of app23 tg2576, and appswe-ps1de9 mouse models of Alzheimer disease
    • Snellman, A., et al. Longitudinal amyloid imaging in mouse brain with 11C-PIB: comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease. J. Nucl. Med. 54, 1434-1441, doi: 10.2967/jnumed.112.110163 (2013
    • (2013) J. Nucl. Med , vol.54 , pp. 1434-1441
    • Snellman, A.1
  • 62
    • 84905880432 scopus 로고    scopus 로고
    • Vivo PET imaging of beta-Amyloid deposition in mouse models of Alzheimer?s disease with a high specific activity PET imaging agent [18)F]flutemetamol
    • Snellman, A., et al. In vivo PET imaging of beta-Amyloid deposition in mouse models of Alzheimer?s disease with a high specific activity PET imaging agent [(18)F]flutemetamol. EJNMMI research 4, 37, doi: 10.1186/s13550-014-0037-3 (2014
    • (2014) EJNMMI Research , vol.4 , pp. 37
    • Snellman, A.1


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