In vivo SPECT imaging of amyloid-β deposition with radioiodinated imidazo[1, 2-α]pyridine derivative DRM106 in a mouse model of alzheimer's disease

Journal of Nuclear Medicine

Volumn 56, Issue 1, 2015, Pages 120-126

  Chen, Chun Jen ^a,b,c   Bando, Kazunori ^a   Ashino, Hiroki ^a   Taguchi, Kazumi ^a   Shiraishi, Hideaki ^a   Shima, Keiji ^a   Fujimoto, Osuke ^a   Kitamura, Chiemi ^a   Matsushima, Satoshi ^a   Uchida, Keisuke ^a   Nakahara, Yuto ^a   Kasahara, Hiroyuki ^a   Minamizawa, Takao ^a   Jiang, Cheng ^d   Zhang, Ming Rong ^b   Ono, Maiko ^b   Tokunaga, Masaki ^b   Suhara, Tetsuya ^b   Higuchi, Makoto ^b   Yamada, Kazutaka ^c   Ji, Bin ^b   more..

^a Fujifilm RI Pharma Co Ltd   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c GIFU UNIVERSITY   (Japan)

^d FUDAN UNIVERSITY   (China)

Author keywords

Alzheimer's disease (AD); Amyloid imaging; Amyloid precursor protein (APP) transgenic mouse; DRM106; Single photon emission computed tomography (SPECT)

Indexed keywords

2 [4' DIMETHYLAMINOPHENYL] 6 IODO IMIDAZO (1,2 A)PYRIDINE; 6 IODO 2 [4 [1H 3 PYRAZOLYL]PHENYL]IMIDAZO [1,2 A]PYRIDINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CARBON 11; IMIDAZO [1,2 A]PYRIDINE DERIVATIVE; PITTSBURGH COMPOUND B; PYRIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TAU PROTEIN; UNCLASSIFIED DRUG; 6-IODO-2-(4-(1H-3-PYRAZOLYL)PHENYL)IMIDAZO(1,2-A)PYRIDINE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); IMIDAZOLE DERIVATIVE; PEPTIDE FRAGMENT; PYRIDINE; RADIOACTIVE IODINE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPSY; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CONTROLLED STUDY; DISSOCIATION CONSTANT; HIPPOCAMPAL CA1 REGION; HUMAN; IN VIVO STUDY; INTERMETHOD COMPARISON; MOUSE; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN AGGREGATION; PROTEIN BINDING; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SIGNAL NOISE RATIO; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TEMPORAL CORTEX; WHITE MATTER; ANIMAL; BRAIN; CHEMISTRY; DIAGNOSTIC USE; DISEASE MODEL; MALE; METABOLISM; SCINTISCANNING;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; HUMANS; IMIDAZOLES; IODINE RADIOISOTOPES; MALE; MICE; PEPTIDE FRAGMENTS; PYRIDINES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84920409375     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.114.146944     Document Type: Article

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