Role of Glibenclamide in Brain Injury After Intracerebral Hemorrhage

Translational Stroke Research

Volumn 8, Issue 2, 2017, Pages 183-193

  Jiang, Bing ^a   Li, Lin ^b   Chen, Qianwei ^a   Tao, Yihao ^a   Yang, Liming ^a   Zhang, Bo ^a   Zhang, John H ^c   Feng, Hua ^a   Chen, Zhi ^a   Tang, Jun ^a   Zhu, Gang ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Nanchong Central Hospital   (China)

^c LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BBB; Glibenclamide; Intracerebral hemorrhage; MMPs; Sur1

Indexed keywords

GELATINASE A; GELATINASE B; GLIBENCLAMIDE; GLUCOSE; OCCLUDIN; PROTEIN ZO1; SULFONYLUREA RECEPTOR 1; TIGHT JUNCTION PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4; ABCC8 PROTEIN, RAT; GLUCOSE BLOOD LEVEL; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; OCLN PROTEIN, RAT; SULFONYLUREA RECEPTOR; TJP1 PROTEIN, RAT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN INJURY; BRAIN LEVEL; BRAIN PROTECTION; BRAIN WATER; COGNITIVE DEFECT; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG RESPONSE; GLUCOSE BLOOD LEVEL; IMMUNOFLUORESCENCE; LOADING DRUG DOSE; MALE; MORRIS WATER MAZE TEST; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; WESTERN BLOTTING; AGONISTS; ANIMAL; COMPLICATION; DRUG EFFECTS; ENDOTHELIUM; INJURIES; MAZE TEST; METABOLISM; PSYCHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD GLUCOSE; BLOOD-BRAIN BARRIER; BRAIN EDEMA; CEREBRAL HEMORRHAGE; ENDOTHELIUM; GLYBURIDE; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MAZE LEARNING; OCCLUDIN; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, SPRAGUE-DAWLEY; SULFONYLUREA RECEPTORS; TRPM CATION CHANNELS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84994219806     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-016-0506-2     Document Type: Article

References (44)

1. Xi G, Keep RF, Hoff JT. Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg. 1998;89(6):991–6. doi:10.3171/jns. 1998.89.6.0991.
2. Yang GY, Betz AL, Chenevert TL, Brunberg JA, Hoff JT. Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats. J Neurosurg. 1994;81(1):93–102. doi:10.3171/jns. 1994.81.1.0093.
3. Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. The Lancet Neurology. 2006;5(1):53–63. doi:10.1016/S1474-4422(05)70283-0.
4. Shi Y, Leak RK, Keep RF, Chen J. Translational stroke research on blood-brain barrier damage: challenges, perspectives, and goals. Translational stroke research. 2016;7(2):89–92. doi:10.1007/s12975-016-0447-9.
5. Ballabh P, Braun A, Nedergaard M. The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis. 2004;16(1):1–13. doi:10.1016/j.nbd. 2003.12.016.
6. Bodmer D, Vaughan KA, Zacharia BE, Hickman ZL, Connolly ES. The molecular mechanisms that promote edema after intracerebral hemorrhage. Translational Stroke Research. 2012;3(Suppl 1):52–61. doi:10.1007/s12975-012-0162-0.
7. Shin JW, Kang HC, Shim J, Sohn NW. Scutellaria baicalensis attenuates blood-brain barrier disruption after intracerebral hemorrhage in rats. The American Journal of Chinese Medicine. 2012;40(1):85–96. doi:10.1142/S0192415X12500073.
8. Marble A. Glibenclamide, a new sulphonylurea: whither oral hypoglycaemic agents? Drugs. 1971;1(2):109–15.
9. Chen M, Dong Y, Simard JM. Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain. J Neurosci Off J Soc Neurosci. 2003;23(24):8568–77.
10. Simard JM, Tsymbalyuk N, Tsymbalyuk O, Ivanova S, Yurovsky V, Gerzanich V. Glibenclamide is superior to decompressive craniectomy in a rat model of malignant stroke. Stroke; a journal of cerebral circulation. 2010;41(3):531–7. doi:10.1161/STROKEAHA.109.572644.
11. Simard JM, Tsymbalyuk O, Ivanov A, Ivanova S, Bhatta S, Geng Z, et al. Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury. J Clin Invest. 2007;117(8):2105–13. doi:10.1172/JCI32041.
12. Thompson EM, Pishko GL, Muldoon LL, Neuwelt EA. Inhibition of SUR1 decreases the vascular permeability of cerebral metastases. Neoplasia. 2013;15(5):535–43. doi:10.1593/neo.13164.
13. Simard JM, Woo SK, Bhatta S, Gerzanich V. Drugs acting on SUR1 to treat CNS ischemia and trauma. Curr Opin Pharmacol. 2008;8(1):42–9. doi:10.1016/j.coph. 2007.10.004.
14. Simard JM, Geng Z, Woo SK, Ivanova S, Tosun C, Melnichenko L, et al. Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism. 2009;29(2):317–30. doi:10.1038/jcbfm. 2008.120.
15. Sheth KN. Novel approaches to the primary prevention of edema after ischemia. Stroke; a journal of cerebral circulation. 2013;44(6 Suppl 1):S136. doi:10.1161/STROKEAHA.113.001821.
16. Simard JM, Geng Z, Silver FL, Sheth KN, Kimberly WT, Stern BJ, et al. Does inhibiting Sur1 complement rt-PA in cerebral ischemia? Ann N Y Acad Sci. 2012;1268:95–107. doi:10.1111/j.1749-6632. 2012.06705.x.
17. Tan Q, Chen Q, Niu Y, Feng Z, Li L, Tao Y, et al. Urokinase, a promising candidate for fibrinolytic therapy for intracerebral hemorrhage. J Neurosurg. 2016:1–10. doi:10.3171/2016.1.JNS152287.
18. Schlunk F, Greenberg SM. The pathophysiology of intracerebral hemorrhage formation and expansion. Translational stroke research. 2015;6(4):257–63. doi:10.1007/s12975-015-0410-1.
19. Simard JM, Woo SK, Tsymbalyuk N, Voloshyn O, Yurovsky V, Ivanova S, et al. Glibenclamide-10-h treatment window in a clinically relevant model of stroke. Translational stroke research. 2012;3(2):286–95. doi:10.1007/s12975-012-0149-x.
20. Li L, Tao Y, Tang J, Chen Q, Yang Y, Feng Z, et al. A cannabinoid receptor 2 agonist prevents thrombin-induced blood-brain barrier damage via the inhibition of microglial activation and matrix metalloproteinase expression in rats. Translational stroke research. 2015;6(6):467–77. doi:10.1007/s12975-015-0425-7.
21. Tang J, Chen Q, Guo J, Yang L, Tao Y, Li L, et al. Minocycline attenuates neonatal germinal-matrix-hemorrhage-induced neuroinflammation and brain edema by activating cannabinoid receptor 2. Mol Neurobiol. 2015; doi:10.1007/s12035-015-9154-x.
22. Chen Q, Zhang J, Guo J, Tang J, Tao Y, Li L, et al. Chronic hydrocephalus and perihematomal tissue injury developed in a rat model of intracerebral hemorrhage with ventricular extension. Translational stroke research. 2015;6(2):125–32. doi:10.1007/s12975-014-0367-5.
23. Chen Y, Zhang Y, Tang J, Liu F, Hu Q, Luo C, et al. Norrin protected blood-brain barrier via frizzled-4/beta-catenin pathway after subarachnoid hemorrhage in rats. Stroke; a journal of cerebral circulation. 2015;46(2):529–36. doi:10.1161/STROKEAHA.114.007265.
24. Tang J, Tao Y, Jiang B, Chen Q, Hua F, Zhang J, et al. Pharmacological preventions of brain injury following experimental germinal matrix hemorrhage: an up-to-date review. Translational stroke research. 2016;7(1):20–32. doi:10.1007/s12975-015-0432-8.
25. Zarruk JG, Fernandez-Lopez D, Garcia-Yebenes I, Garcia-Gutierrez MS, Vivancos J, Nombela F, et al. Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to neuroprotection. Stroke; a journal of cerebral circulation. 2012;43(1):211–9. doi:10.1161/STROKEAHA.111.631044.
26. Tao Y, Tang J, Chen Q, Guo J, Li L, Yang L, et al. Cannabinoid CB2 receptor stimulation attenuates brain edema and neurological deficits in a germinal matrix hemorrhage rat model. Brain Res. 2015;1602:127–35. doi:10.1016/j.brainres. 2015.01.025.
27. Chen Z, Gao C, Hua Y, Keep RF, Muraszko K, Xi G. Role of iron in brain injury after intraventricular hemorrhage. Stroke; a journal of cerebral circulation. 2011;42(2):465–70. doi:10.1161/STROKEAHA.110.602755.
28. Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc. 2006;1(2):848–58. doi:10.1038/nprot. 2006.116.
29. Shohami E, Novikov M, Bass R. Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat. Brain Res. 1995;674(1):55–62.
30. Simard JM, Yurovsky V, Tsymbalyuk N, Melnichenko L, Ivanova S, Gerzanich V. Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke. Stroke; a journal of cerebral circulation. 2009;40(2):604–9. doi:10.1161/STROKEAHA.108.522409.
31. Wass CT, Lanier WL. Glucose modulation of ischemic brain injury: review and clinical recommendations. Mayo Clin Proc. 1996;71(8):801–12. doi:10.1016/S0025-6196(11)64847-7.
32. Zhou Y, Fathali N, Lekic T, Tang J, Zhang JH. Glibenclamide improves neurological function in neonatal hypoxia-ischemia in rats. Brain Res. 2009;1270:131–9. doi:10.1016/j.brainres. 2009.03.010.
33. Simard JM, Woo SK, Norenberg MD, Tosun C, Chen Z, Ivanova S, et al. Brief suppression of Abcc 8 prevents autodestruction of spinal cord after trauma. Sci Transl Med. 2010;2(28):28ra9. doi:10.1126/scitranslmed.3000522.
34. Simard JM, Chen M, Tarasov KV, Bhatta S, Ivanova S, Melnitchenko L, et al. Newly expressed SUR1-regulated NC (Ca-ATP) channel mediates cerebral edema after ischemic stroke. Nat Med. 2006;12(4):433–40. doi:10.1038/nm 1390.
35. Tosun C, Kurland DB, Mehta R, Castellani RJ, deJong JL, Kwon MS, et al. Inhibition of the Sur1-Trpm 4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage. Stroke; a journal of cerebral circulation. 2013;44(12):3522–8. doi:10.1161/STROKEAHA.113.002904.
36. Simard JM, Sheth KN, Kimberly WT, Stern BJ, del Zoppo GJ, Jacobson S, et al. Glibenclamide in cerebral ischemia and stroke. Neurocrit Care. 2014;20(2):319–33. doi:10.1007/s12028-013-9923-1.
37. Woo SK, Kwon MS, Ivanov A, Gerzanich V, Simard JM. The sulfonylurea receptor 1 (Sur1)-transient receptor potential melastatin 4 (Trpm 4) channel. J Biol Chem. 2013;288(5):3655–67. doi:10.1074/jbc.M112.428219.
38. Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ. Structure and function of the blood-brain barrier. Neurobiol Dis. 2010;37(1):13–25. doi:10.1016/j.nbd. 2009.07.030.
39. Chen M, Li X, Zhang X, He X, Lai L, Liu Y, et al. The inhibitory effect of mesenchymal stem cell on blood-brain barrier disruption following intracerebral hemorrhage in rats: contribution of TSG-6. J Neuroinflammation. 2015;12:61. doi:10.1186/s12974-015-0284-x.
40. Romanic AM, Madri JA. Extracellular matrix-degrading proteinases in the nervous system. Brain Pathol. 1994;4(2):145–56.
41. Yong VW, Power C, Forsyth P, Edwards DR. Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci. 2001;2(7):502–11. doi:10.1038/35081571.
42. Florczak-Rzepka M, Grond-Ginsbach C, Montaner J, Steiner T. Matrix metalloproteinases in human spontaneous intracerebral hemorrhage: an update. Cerebrovasc Dis 2012; 34(4):249–262. doi:10.1159/000341686.
43. Chen S, Yang Q, Chen G, Zhang JH. An update on inflammation in the acute phase of intracerebral hemorrhage. Translational stroke research. 2015;6(1):4–8. doi:10.1007/s12975-014-0384-4.
44. Ortega FJ, Jolkkonen J, Mahy N, Rodriguez MJ. Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013;33(3):356–64. doi:10.1038/jcbfm. 2012.166.